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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Allium Cepa, Arsenicum Album, Natrum Muriaticum, Nux Vomica, Pulsatilla (pratensis), Abrotanum (artemisia Abrotanum), Absinthium, Agrimonia Eupatoria, Flos, Alfalfa, Ambrosia Artemisiaefolia, Arundo Mauritanica, Bambusa Arundinacea, Cichorium Intybus, Flos, Kentucky Bluegrass, Orchard Grass, Bermuda Grass, Johnson Grass, Rye Grass, Vernal Grass, Bahia Grass, Timothy Grass, Rumex Crispus, Sabadilla, Sinapis Arvensis, Flos, Solidago Virgaurea, Taraxacum Officinale, Trifolium Pratense, Trifolium Repens,
Brand Name
Weed Grass Antigens
Generic Name
Allium Cepa, Arsenicum Album, Natrum Muriaticum, Nux Vomica, Pulsatilla (pratensis), Abrotanum (artemisia Abrotanum), Absinthium, Agrimonia Eupatoria, Flos, Alfalfa, Ambrosia Artemisiaefolia, Arundo Mauritanica, Bambusa Arundinacea, Cichorium Intybus, Flos, Kentucky Bluegrass, Orchard Grass, Bermuda Grass, Johnson Grass, Rye Grass, Vernal Grass, Bahia Grass, Timothy Grass, Rumex Crispus, Sabadilla, Sinapis Arvensis, Flos, Solidago Virgaurea, Taraxacum Officinale, Trifolium Pratense, Trifolium Repens,
Active Ingredient
Agrimonia Eupatoria FlowerCategory
Adrenocorticotropic Hormone [EPC]
Variants
2
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 16 [hp_X]/mL | LIQUID | ORAL | 44911-0547 |
| 16 [hp_X]/mL | LIQUID | ORAL | 44911-0553 |
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Weed Grass Antigens, you must consult a qualified healthcare professional.
Detailed information about Weed Grass Antigens
Agrimonia Eupatoria Flower is a botanical extract classified within several pharmacologic classes, including Adrenergic Agonists and Allergenic Extracts, used primarily in diagnostic testing and specialized immunotherapy.
The dosage of Agrimonia Eupatoria Flower varies significantly based on the intended use and the concentration of the extract.
Agrimonia Eupatoria Flower has not been extensively studied for safety in children under the age of 12 for oral systemic use. However, its use as an Allergenic Extract for diagnostic purposes is common in pediatric populations.
Patients with significant renal impairment (CrCl < 30 mL/min) should use Agrimonia Eupatoria with caution. While no specific dose reduction formulas exist, the accumulation of phenolic metabolites may increase the risk of nephrotoxicity. Monitoring of kidney function is advised for long-term use.
Because the liver metabolizes the coumarin and flavonoid components, patients with Child-Pugh Class B or C impairment may experience prolonged half-lives. Dosage should be started at the lowest possible range (e.g., 200 mg once daily) and titrated slowly.
Geriatric patients often have reduced cardiovascular reserve. Given the adrenergic properties of Agrimonia Eupatoria, elderly patients should be monitored for increases in blood pressure or heart rate. A starting dose of 50% of the standard adult dose is often recommended.
If you miss a dose of an oral Agrimonia supplement, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up. For missed immunotherapy injections, contact your allergist immediately, as the dosing schedule may need to be adjusted to prevent a loss of desensitization.
Signs of an overdose of Agrimonia Eupatoria Flower may include:
In the event of a suspected overdose, contact your local poison control center or seek emergency medical care. If a systemic reaction occurs following an allergenic injection (anaphylaxis), epinephrine must be administered immediately.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop a prescribed immunotherapy regimen without medical guidance.
When used as a supplement or topical agent, the most frequently reported side effects involve the gastrointestinal tract and the skin:
Agrimonia Eupatoria Flower contains pharmacologically active compounds that can affect the cardiovascular and endocrine systems. It should be used with caution in patients with pre-existing conditions that may be exacerbated by adrenergic stimulation. Always ensure that any botanical product you use is from a reputable source that provides standardized extracts to ensure safety and efficacy.
No FDA black box warnings for Agrimonia Eupatoria Flower specifically. However, for the EPC class of Allergenic Extracts, a general warning exists: 'Allergenic extracts can cause severe local and systemic reactions including anaphylactic shock. Patients should be observed for at least 30 minutes after injection.'
Agrimonia Eupatoria Flower must NEVER be used in the following circumstances:
FDA Pregnancy Category: Not Assigned. There are no adequate and well-controlled studies of Agrimonia Eupatoria Flower in pregnant women. Animal reproduction studies have not been conducted. Traditionally, Agrimony was sometimes used to regulate menses, suggesting potential uterine-stimulant properties. Therefore, use during pregnancy is generally not recommended unless the diagnostic benefit (in the case of allergy testing) clearly outweighs the potential risk to the fetus. It should be avoided entirely during the first trimester.
It is not known whether the constituents of Agrimonia Eupatoria are excreted in human milk. Because many phenolic compounds and coumarins do pass into breast milk, caution should be exercised. The primary risk to the nursing infant would be gastrointestinal upset or potential sensitization to the plant proteins. If use is necessary, monitor the infant for signs of diarrhea or skin rashes.
Agrimonia Eupatoria is primarily used in children as a diagnostic tool for allergies. While safe for skin testing in children as young as infants (under specialist supervision), its use as an oral supplement is not established for those under 12 years of age. There is a specific concern regarding high tannin intake in children, which can lead to significant malabsorption of nutrients required for growth, such as iron and calcium.
Agrimonia Eupatoria Flower functions through three distinct pathways:
Common questions about Weed Grass Antigens
Agrimonia Eupatoria Flower is used in clinical settings primarily as an allergenic extract for diagnosing and treating plant allergies. It is also recognized for its adrenergic properties, which allow it to act as a mild stimulant and vasoconstrictor. In traditional and supportive medicine, it is used as an astringent to treat sore throats, skin inflammation, and mild diarrhea. Healthcare providers may also use it in specific immunotherapy regimens to help patients build tolerance to botanical allergens. Always consult a doctor before using it for any medical condition.
The most common side effects include constipation, stomach upset, and local irritation of the mouth or skin. Because of its high tannin content, it can cause a 'drying' sensation in the digestive tract, leading to bowel irregularities. Some users may also experience increased sensitivity to sunlight (photosensitivity) due to the presence of coumarins. If used as an injection for allergy testing, redness and swelling at the injection site are very common. Most minor side effects resolve once the medication is discontinued.
It is generally advised to avoid or strictly limit alcohol consumption while using Agrimonia Eupatoria. Alcohol can increase the risk of liver strain when combined with the plant's coumarin constituents. Additionally, alcohol has vasodilatory effects that may counteract the vasoconstrictive (alpha-adrenergic) benefits of the herb. Alcohol can also increase the severity of an allergic reaction if one occurs during immunotherapy. Discuss your alcohol intake with your healthcare provider to ensure your safety.
Agrimonia Eupatoria Flower is generally not recommended during pregnancy due to a lack of comprehensive safety data. There is some historical evidence suggesting it may act as a uterine stimulant, which could theoretically pose a risk to the pregnancy. While it may be used by specialists for essential allergy testing if the benefits outweigh the risks, it should never be used as a self-prescribed supplement while pregnant. Always speak with your obstetrician before introducing any new botanical or medication during pregnancy.
The time it takes for Agrimonia Eupatoria to work depends on the form used. For skin allergy testing, results are visible within 15 to 20 minutes. When taken orally for gastrointestinal issues, some relief may be felt within 1 to 2 hours as the tannins interact with the gut lining. For immunotherapy (allergy shots), it can take several months of regular treatment before a significant reduction in allergy symptoms is noticed. Consistent use as directed by a professional is key to seeing results.
For oral supplements used for minor issues, you can usually stop taking Agrimonia Eupatoria suddenly without withdrawal symptoms. However, if you are undergoing a prescribed immunotherapy (allergy shot) program, you must not stop suddenly without consulting your allergist. Stopping immunotherapy abruptly will cause you to lose the progress made in desensitizing your immune system, and restarting may require beginning the entire process from the lowest dose again. Always follow the schedule provided by your medical team.
If you miss an oral dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Never take two doses at once to make up for a missed one. If you miss an appointment for an allergenic injection, call your doctor's office immediately. Timing is critical for immunotherapy, and your doctor may need to adjust your next dose to ensure it is safe and effective. Keeping a consistent schedule is the best way to ensure the medication works properly.
There is no clinical evidence to suggest that Agrimonia Eupatoria Flower causes weight gain. In fact, as an adrenergic agonist, it may slightly increase the metabolic rate, though not enough to be used as a weight-loss agent. If you experience sudden weight gain or swelling (edema) while taking this medication, it could be a sign of a different underlying issue or a rare reaction affecting the heart or kidneys. You should report any significant changes in weight to your healthcare provider immediately.
Agrimonia Eupatoria Flower can interact with several types of medications, particularly blood pressure drugs, antidepressants, and blood thinners. It is especially dangerous to combine it with beta-blockers, as this can interfere with emergency treatments for allergic reactions. Because it contains tannins, it can also prevent the absorption of other oral medications and minerals like iron. You must provide your doctor with a full list of all medications and supplements you are taking to avoid potentially dangerous interactions.
Agrimonia Eupatoria is a botanical substance and is not 'branded' in the way synthetic drugs are, meaning most versions are essentially generic. However, in the clinical world of allergenic extracts, different manufacturers may produce their own standardized versions. It is important to use a product that is standardized for its active constituents to ensure you are getting a consistent and safe dose. Always look for high-quality, pharmaceutical-grade preparations rather than unverified bulk herbs when using it for medical purposes.
Other drugs with the same active ingredient (Agrimonia Eupatoria Flower)
> Warning: Stop taking Agrimonia Eupatoria Flower and call your doctor immediately if you experience any of the following serious symptoms.
Prolonged use of Agrimonia Eupatoria (exceeding 6 months) may lead to:
There are currently no FDA Black Box Warnings specifically for the botanical Agrimonia eupatoria. However, all Allergenic Extracts (the class Agrimonia belongs to in a clinical setting) carry a general warning regarding the risk of severe systemic allergic reactions, including anaphylaxis. These products must only be administered in a clinical setting where emergency resuscitation equipment and epinephrine are immediately available.
Report any unusual symptoms or persistent side effects to your healthcare provider. You may also report side effects to the FDA at 1-800-FDA-1088.
If you are taking Agrimonia Eupatoria Flower long-term, your healthcare provider may require the following tests:
Agrimonia Eupatoria generally does not cause sedation. However, if you experience dizziness or palpitations, avoid driving or operating heavy machinery until you know how the medication affects you.
Alcohol should be avoided or limited. Alcohol can exacerbate the vasodilatory effects of some components and may increase the risk of liver strain when combined with the coumarins found in the flower.
For oral supplements, tapering is generally not required unless used in very high doses. For immunotherapy, discontinuation must be managed by an allergist, as stopping abruptly will result in a loss of clinical tolerance to the allergen, requiring a restart of the build-up phase if therapy is resumed.
> Important: Discuss all your medical conditions, especially heart or liver problems, with your healthcare provider before starting Agrimonia Eupatoria Flower.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. A complete list is essential for preventing dangerous interactions.
Conditions requiring a careful risk-benefit analysis by a physician:
Patients allergic to the following may also be sensitive to Agrimonia Eupatoria Flower:
> Important: Your healthcare provider will evaluate your complete medical history before prescribing or administering Agrimonia Eupatoria Flower.
Clinical studies of Agrimonia Eupatoria did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, because elderly patients are more likely to have decreased renal and hepatic function, as well as pre-existing cardiovascular disease, they should be started on the lowest possible dose. There is an increased risk of 'orthostatic hypotension' (dizziness upon standing) if the adrenergic effects interfere with normal blood pressure regulation.
In patients with a Glomerular Filtration Rate (GFR) below 60 mL/min, the frequency of dosing should be reduced. In end-stage renal disease (ESRD) or patients on dialysis, Agrimonia Eupatoria is generally avoided due to the lack of data on its dialyzability and the high risk of phenolic metabolite accumulation.
For patients with mild hepatic impairment (Child-Pugh A), no adjustment is typically needed for short-term use. For moderate to severe impairment (Child-Pugh B and C), the use of Agrimonia Eupatoria should be avoided due to the risk of coagulopathy and the inability to metabolize coumarin constituents, which could lead to systemic toxicity.
> Important: Special populations require individualized medical assessment and frequent monitoring by a healthcare professional.
| Parameter | Value |
|---|---|
| Bioavailability | 15% - 25% (Oral) |
| Protein Binding | >92% |
| Half-life | 2.5 - 4.5 Hours |
| Tmax | 1.5 Hours |
| Metabolism | Hepatic (CYP3A4/2D6) |
| Excretion | Renal 65%, Fecal 35% |