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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Shine Ph Moisture
Generic Name
Sodium Hyaluronate
Active Ingredient
Sodium HyaluronateCategory
Other
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| .5 g/100g | GEL | VAGINAL | 73305-0012 |
Detailed information about Shine Ph Moisture
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Shine Ph Moisture, you must consult a qualified healthcare professional.
Sodium hyaluronate is a high-molecular-weight polysaccharide and the salt form of hyaluronic acid. It is primarily used as a viscosupplement for osteoarthritis of the knee and as an ophthalmic surgical aid to protect delicate eye tissues.
Dosage for sodium hyaluronate is highly specific to the condition being treated and the specific brand of product used.
For the treatment of knee pain, the standard regimen typically involves a series of intra-articular (into the joint) injections. Depending on the product's molecular weight, the schedule may be:
During surgery, the surgeon instills the amount of sodium hyaluronate necessary to maintain the anterior chamber or coat the surgical instruments. This usually ranges from 0.2 mL to 1.0 mL of a 1% or 1.4% solution.
For topical ophthalmic use, patients typically instill 1 to 2 drops into the affected eye(s) 3 to 4 times daily, or as needed for comfort.
Sodium hyaluronate is not typically indicated for pediatric use. The safety and effectiveness of intra-articular injections for osteoarthritis in children have not been established, as osteoarthritis is primarily a disease of aging or specific joint trauma in adults. In ophthalmic surgery, use in children is at the discretion of the surgeon and is based on the specific surgical requirement rather than a standardized pediatric dose.
Because sodium hyaluronate is administered locally (into the joint or eye) and has negligible systemic absorption, no dosage adjustments are required for patients with kidney disease. The drug is not cleared by the kidneys in significant amounts.
Similarly, liver disease does not necessitate a dose adjustment for local applications. The small amount of hyaluronate that might reach the liver is easily handled by normal metabolic pathways for sugars.
No specific dosage adjustments are required for the elderly. In fact, the elderly are the primary population for this medication. However, healthcare providers should monitor for increased sensitivity to injection-site reactions.
For joint injections, if you miss an appointment for your weekly injection, contact your doctor immediately to reschedule. The effectiveness of the series depends on maintaining the schedule. For eye drops, if you miss a dose, apply it as soon as you remember, unless it is almost time for the next dose.
Systemic overdose is virtually impossible with local administration. However, an "overdose" within the joint (injecting too much volume) can cause significant pain, pressure, and swelling. If this occurs, the healthcare provider may need to aspirate (withdraw) the excess fluid from the joint. Signs of an adverse reaction to an injection include severe pain, warmth, and redness that does not go away within 48 hours.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not attempt to self-inject or use products not prescribed by a licensed professional.
Side effects of sodium hyaluronate are most frequently related to the site of administration rather than systemic toxicity. For patients receiving joint injections, common experiences include:
For ophthalmic use, common side effects include:
> Warning: Stop using Sodium Hyaluronate products and call your doctor or emergency services immediately if you experience any of the following:
Sodium hyaluronate is not associated with the long-term systemic side effects seen with drugs like corticosteroids (e.g., bone loss, weight gain). However, repeated injections over many years can occasionally lead to:
There are currently no FDA Black Box Warnings for sodium hyaluronate. It is considered a safe medical device/drug when used as directed by a qualified professional.
Report any unusual symptoms or persistent pain to your healthcare provider. While most side effects are mild and self-limiting, monitoring is essential for preventing complications.
Sodium hyaluronate is generally considered safe because it mimics a substance already present in the body. However, its use requires careful clinical oversight, particularly regarding the source of the product and the technique used for administration. Patients must inform their doctors of all known allergies, especially to birds or bird products, as some formulations are derived from rooster combs.
No FDA black box warnings have been issued for Sodium Hyaluronate. It has a high safety profile compared to systemic anti-inflammatory drugs or corticosteroids.
Sodium hyaluronate injections for the joint do not typically affect the ability to drive, although temporary joint stiffness might make operating pedals slightly uncomfortable. For ophthalmic drops or surgical use, vision may be temporarily blurred. Patients should not drive or operate heavy machinery until their vision is completely clear.
There are no direct chemical interactions between sodium hyaluronate and alcohol. However, alcohol can increase systemic inflammation and may interfere with the body's natural healing processes. It is generally advisable to limit alcohol consumption following any medical procedure involving an injection.
There is no withdrawal syndrome associated with stopping sodium hyaluronate. If a patient decides to stop a series of injections, the only consequence is that the therapeutic benefit of joint lubrication will not be achieved, and the pain from osteoarthritis may persist or return to its baseline level.
> Important: Discuss all your medical conditions, including any history of blood clots or lymphatic circulation problems, with your healthcare provider before starting Sodium Hyaluronate.
There are no known interactions between sodium hyaluronate and specific foods, including grapefruit, dairy, or high-fat meals. Because the drug is not absorbed systemically in significant amounts, diet does not affect its metabolism or efficacy.
Sodium hyaluronate does not typically interfere with standard blood or urine laboratory tests. It does not affect liver enzymes, kidney function markers, or blood cell counts.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially if you are on therapy to prevent blood clots.
Sodium hyaluronate must NEVER be used in the following circumstances:
In these cases, the healthcare provider will perform a careful risk-benefit analysis:
Patients who are allergic to certain types of birds or egg products should be screened carefully. While many modern hyaluronate products are synthesized via biofermentation (using Streptococcus bacteria), older or specific brands still use avian sources. Cross-reactivity is possible, leading to localized or systemic urticaria (hives) or, in extreme cases, anaphylaxis.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of autoimmune disease or circulatory issues, before prescribing or administering Sodium Hyaluronate.
FDA Pregnancy Category C. Animal reproduction studies have not been conducted with sodium hyaluronate injections, and it is not known whether it can cause fetal harm when administered to a pregnant woman. Because systemic absorption is negligible, the risk to the fetus is theoretically very low. However, clinical guidelines generally recommend that sodium hyaluronate be used during pregnancy only if clearly needed and if the potential benefits outweigh the unknown risks. There is no data regarding its use in fertility treatments.
It is not known whether sodium hyaluronate is excreted in human milk. However, given its high molecular weight and the fact that it is administered locally, it is highly unlikely that significant amounts would reach the breast milk or be absorbed by a nursing infant's digestive tract. Nevertheless, caution should be exercised, and nursing mothers should discuss the timing of injections with their healthcare provider.
Sodium hyaluronate is not approved for use in pediatric patients for the treatment of osteoarthritis. The safety and effectiveness in children have not been established. In ophthalmology, it is used during specialized pediatric eye surgeries, but this is considered a highly specialized use case and is not part of standard pediatric primary care.
The majority of clinical data for sodium hyaluronate comes from patients aged 65 and older. No overall differences in safety or effectiveness have been observed between these patients and younger adults. However, elderly patients may be more prone to injection-site bruising if they have fragile skin or are on multiple medications (polypharmacy). There is no evidence that sodium hyaluronate increases the risk of falls, though temporary joint stiffness post-injection should be noted.
No dose adjustment is required for patients with renal impairment. The drug is not significantly absorbed into the bloodstream, and the kidneys do not play a major role in its clearance. It is safe for patients on hemodialysis, provided the injection site is not near a dialysis access point (fistula).
No dose adjustment is required for patients with hepatic impairment. The liver is the primary site for the metabolism of any hyaluronate that reaches systemic circulation, but the amounts involved in therapeutic injections are well within the liver's metabolic capacity, even in the presence of mild to moderate cirrhosis.
> Important: Special populations require individualized medical assessment. Always inform your specialist if you are pregnant, planning to become pregnant, or breastfeeding before undergoing any injection procedure.
Sodium hyaluronate acts as a biological lubricant and shock absorber. In the joint, it binds to the CD44 receptor on type B synoviocytes and chondrocytes. This binding triggers several intracellular signaling pathways that may stimulate the body's own production of high-molecular-weight hyaluronic acid (an effect known as the "metabolic effect"). Furthermore, it acts as a physical barrier, coating the pain receptors (nociceptors) within the joint capsule, which helps to reduce the transmission of pain signals. In the eye, its long-chain molecular structure creates a cohesive, viscoelastic gel that maintains space and protects the corneal endothelial cells from the high-frequency vibrations of phacoemulsification (ultrasound used in cataract surgery).
The onset of pain relief from intra-articular injections is not immediate. Most patients begin to feel a reduction in pain after the third weekly injection, with the peak effect occurring between weeks 8 and 12. The duration of effect is remarkably long compared to the drug's residence time in the joint, often lasting 6 months or more. This suggests that the drug works not just as a lubricant, but by modifying the inflammatory environment of the joint.
| Parameter | Value |
|---|---|
| Bioavailability | Negligible (systemic) |
| Protein Binding | Minimal |
| Half-life (Synovial) | 20 hours to 4 days (depending on cross-linking) |
| Tmax | N/A (local administration) |
| Metabolism | Local hyaluronidase; Hepatic (if systemic) |
| Excretion | CO2 and H2O (metabolic end products) |
Sodium hyaluronate is classified as a Viscosupplement for orthopedic use and an Ophthalmic Viscosurgical Device (OVD) for surgical use. It is often grouped with other joint-health treatments like glucosamine, though its route of administration and mechanical action are distinct.
Common questions about Shine Ph Moisture
Sodium hyaluronate is primarily used to treat knee pain in patients with osteoarthritis who have not found relief from other treatments like physical therapy or simple pain relievers. It is also extensively used in eye surgeries, such as cataract removal, to protect the internal structures of the eye and maintain its shape during the procedure. Additionally, it is a common ingredient in high-quality eye drops for dry eye syndrome because it holds moisture effectively on the eye's surface. Some topical forms are also used to help heal skin wounds and ulcers. It works by acting as a lubricant and shock absorber, mimicking the body's natural fluids.
The most common side effects are localized to the area where the medication was applied or injected. For joint injections, patients frequently report mild pain, swelling, heat, and redness at the injection site for a day or two. In some cases, the joint may feel stiff or slightly more painful immediately after the procedure before it begins to improve. When used in the eye, the most common effects are temporary blurred vision and a mild stinging or burning sensation. These effects are usually short-lived and do not require medical intervention unless they become severe or persistent.
There is no known direct chemical interaction between sodium hyaluronate and alcohol that would cause a dangerous reaction. However, because the treatment often involves a procedure like a joint injection, doctors may advise you to avoid alcohol for 24 to 48 hours to help reduce the risk of inflammation and support the body's healing process. Alcohol can sometimes increase the risk of bruising or minor bleeding at the injection site. It is always best to follow the specific post-procedure instructions provided by your orthopedic specialist or surgeon. Generally, moderate alcohol consumption does not interfere with the long-term effectiveness of the treatment.
Sodium hyaluronate is classified as FDA Pregnancy Category C, meaning there is limited data from human studies regarding its safety during pregnancy. Because the medication is injected locally into a joint or used topically in the eye, very little of it enters the bloodstream, which theoretically makes it low-risk for the developing fetus. However, medical professionals typically only recommend its use during pregnancy if the potential benefits significantly outweigh any unknown risks. If you are pregnant or planning to become pregnant, you should discuss alternative pain management strategies with your doctor. Always inform your healthcare provider of your pregnancy status before receiving any injection.
Unlike a steroid injection, which may provide relief within days, sodium hyaluronate usually takes longer to show its full effect. Most patients receive a series of three to five weekly injections and begin to notice a significant reduction in pain after the third or fourth dose. The peak benefit is typically felt about 8 to 12 weeks after the first injection has been administered. The results can be long-lasting, with many patients experiencing improved joint mobility and decreased pain for six months or even up to a year. Patience is key when undergoing viscosupplementation therapy.
Yes, you can stop the treatment at any time without experiencing withdrawal symptoms or physical rebound effects. Since sodium hyaluronate is a lubricant and not a systemic medication like an antidepressant or a steroid, your body does not become dependent on it. However, if you stop a series of injections before it is completed, you may not achieve the full pain-relieving benefits of the treatment. If you decide to discontinue the therapy, your joint pain will likely return to its previous level as the underlying osteoarthritis continues its natural progression. Always consult your doctor before deciding to end a treatment plan early.
If you miss an appointment for a scheduled joint injection, you should contact your healthcare provider's office as soon as possible to reschedule. The effectiveness of sodium hyaluronate often depends on receiving the injections at regular weekly intervals to build up the necessary concentration in the joint fluid. Missing a week may delay the onset of pain relief, but it is not a medical emergency. For eye drops used for dry eye, simply apply the missed dose as soon as you remember. If it is almost time for your next scheduled drop, skip the missed one and continue with your regular routine.
No, sodium hyaluronate does not cause weight gain. Unlike oral or injectable corticosteroids, which can affect metabolism and lead to water retention or increased appetite, sodium hyaluronate stays primarily within the joint or eye where it is applied. It does not have the systemic hormonal effects associated with weight changes. In fact, by reducing knee pain and improving mobility, many patients find that sodium hyaluronate actually helps them become more active, which can assist in weight management. Any sudden or unexplained weight gain while on this treatment should be discussed with a doctor to find the actual cause.
Sodium hyaluronate is generally safe to use alongside most other medications because it does not enter the bloodstream in large amounts. However, you should avoid using skin disinfectants that contain quaternary ammonium salts (like benzalkonium chloride) at the injection site, as they can cause the hyaluronate to clump together. If you are taking blood thinners like warfarin or aspirin, you must tell your doctor, as there is a higher risk of bleeding into the joint during the injection. Always provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are currently using.
Sodium hyaluronate is available under many different brand names (such as Hyalgan, Euflexxa, Orthovisc, and Healon), and while there are many versions, they are often considered 'biosimilars' or 'medical devices' rather than traditional generic drugs. This is because the molecular weight and the way the molecules are linked can vary between manufacturers, which may affect how well the product works for you. Some insurance companies may prefer one brand over another. You should talk to your doctor about which specific formulation is most appropriate for your condition and check with your insurance provider regarding coverage for the specific brand prescribed.
Other drugs with the same active ingredient (Sodium Hyaluronate)