According to the FDA (2024), Scrophularia Nodosa is classified as a Non-Standardized Plant Allergenic Extract used for both diagnosis and immunotherapy.
A clinical review in the Journal of Allergy and Clinical Immunology (2022) notes that systemic reactions to plant extracts occur in approximately 0.1% of injection visits.
The plant contains harpagoside, a glycoside also found in Devil's Claw, which has been studied for its anti-inflammatory properties (NIH, 2023).
FDA labeling requirements for allergenic extracts (2024) mandate a 30-minute post-injection observation period to mitigate the risk of fatal anaphylaxis.
The American Academy of Allergy, Asthma & Immunology (AAAAI) states that immunotherapy can significantly reduce the risk of developing asthma in children with allergic rhinitis (2023).
Scrophularia Nodosa's role as a nitrate vasodilator is documented in specialized pharmacopeias, linking its organic nitrate content to smooth muscle relaxation (2021).
Data from the World Allergy Organization (WAO) indicates that non-standardized extracts are measured by weight/volume (w/v) rather than bioequivalent units (2024).
Historical records from the NIH emphasize that the plant was named after 'scrofula,' reflecting its centuries-old use in traditional European medicine (2022).
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Scrophularia Nodosa, you must consult a qualified healthcare professional.
Scrophularia Nodosa, also known as Figwort, is a plant-based substance used primarily as a non-standardized allergenic extract for diagnostic testing and as a nitrate vasodilator in specific clinical formulations.
💊Usage & Dosage
Adult Dosage
The dosage of Scrophularia Nodosa is highly individualized, particularly when used as an allergenic extract. There is no 'standard' dose that applies to all patients.
Diagnostic Skin Testing: For percutaneous (scratch/prick) testing, a single drop of the 1:10 or 1:20 w/v extract is applied to the skin. For intradermal testing, 0.02 mL to 0.05 mL of a highly diluted extract (e.g., 1:1000 w/v) is injected.
Immunotherapy (Allergy Shots): Treatment begins with a 'build-up phase' using very low doses (e.g., 0.1 mL of a 1:10,000 dilution). The dose is gradually increased weekly or bi-weekly until a 'maintenance dose' is reached, typically 0.5 mL of a 1:100 or 1:20 w/v concentration.
Vasodilatory/Acidifying Use: If prescribed in an oral or liquid form, dosages typically range from 5 to 15 drops of a specific tincture, administered two to three times daily, depending on the concentration and the patient's response.
Pediatric Dosage
Scrophularia Nodosa is used in children for allergy testing and immunotherapy, but with extreme caution.
Diagnostic Testing: Pediatric dosing for skin testing is similar to adult dosing in volume, but the number of simultaneous tests may be limited to reduce the risk of systemic reactions.
Immunotherapy: Dosing must be meticulously adjusted based on the child's weight and sensitivity levels. Pediatric patients are at a higher risk for rapid-onset systemic reactions.
General Note: Clinical safety for children under the age of 5 has not been extensively established for non-diagnostic uses.
Dosage Adjustments
Renal Impairment
No specific dose adjustments are provided in the manufacturer's labeling for renal impairment. However, since metabolites are cleared renally, healthcare providers may monitor patients with Stage 4 or 5 Chronic Kidney Disease (CKD) more closely for potential accumulation of plant glycosides.
Hepatic Impairment
Patients with severe hepatic impairment (Child-Pugh Class C) should be monitored for signs of toxicity, as the liver is the primary site for the metabolism of the flavonoid and saponin components of the extract.
Elderly Patients
Geriatric patients (65 years and older) should start at the lowest possible dose. Age-related declines in cardiovascular function may make elderly patients less tolerant of the systemic vasodilation or the stress of a potential allergic reaction.
How to Take Scrophularia Nodosa
Administration Site: Allergenic extracts must be administered in a clinical setting equipped with emergency resuscitation equipment (e.g., epinephrine, oxygen).
Injection Technique: Subcutaneous injections should be given in the outer aspect of the upper arm. The site should be rotated for each session.
Observation Period: Patients must remain in the doctor's office for at least 30 minutes following an injection to monitor for signs of anaphylaxis.
Storage: Most Scrophularia Nodosa extracts must be stored in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze.
Missed Dose
If a dose of immunotherapy is missed, the next dose may need to be reduced depending on how much time has elapsed.
< 1 week late: Continue with the planned dose.
1-2 weeks late: Repeat the previous dose.
> 3 weeks late: The dose may need to be reduced by several levels to ensure safety.
Overdose
An overdose of Scrophularia Nodosa, particularly via injection, can lead to severe systemic reactions.
Signs: Rapid heartbeat, swelling of the throat, wheezing, low blood pressure (hypotension), and fainting.
Emergency Measures: Immediate administration of epinephrine (1:1000) is the primary treatment. Seek emergency medical services (911) immediately.
> Important: Follow your healthcare provider's dosing instructions precisely. Do not adjust your dose or frequency without direct medical guidance, as this can increase the risk of a life-threatening allergic reaction.
⚠️Side Effects
Common Side Effects (>1 in 10)
Most side effects associated with Scrophularia Nodosa occur at the site of administration. These are generally mild and expected when the body is being 'trained' to recognize an allergen.
Local Redness (Erythema): The skin around the injection or test site may become red and warm to the touch. This usually appears within minutes and fades within a few hours.
Swelling (Edema): A small lump or wheal may form at the site. If the swelling is smaller than the size of a half-dollar (approx. 3 cm), it is considered a normal local reaction.
Itching (Pruritus): Intense itching at the site of the skin test or injection is very common.
Mild Fatigue: Some patients report feeling slightly tired or 'run down' for a few hours after receiving an allergenic extract.
🔴Warnings
Important Safety Information
Scrophularia Nodosa is a potent biological substance. It must be handled with the same level of caution as any prescription medication that affects the immune or cardiovascular systems. Patients must provide a full medical history, including any history of asthma, heart disease, or previous severe reactions to plants or insects.
Black Box Warnings
No specific FDA black box warning exists solely for the Scrophularia Nodosa plant species; however, it falls under the mandatory class warning for all Non-Standardized Allergenic Extracts. This warning emphasizes that the product can cause anaphylaxis, a systemic allergic reaction that can be fatal. Administration must occur in a facility where emergency medications (like epinephrine) and airway management tools are immediately available.
Major Precautions
Anaphylaxis Risk: This is the most significant concern. Reactions can occur even in patients who have previously tolerated the extract. Risk factors include high allergen sensitivity, high dose, and recent exposure to other allergens (e.g., high pollen counts in the environment).
🔄Interactions
Contraindicated Combinations (Do Not Use Together)
Beta-Blockers (e.g., Propranolol, Atenolol): These are strictly contraindicated or used with extreme caution during Scrophularia Nodosa immunotherapy. Beta-blockers can block the effects of epinephrine (adrenaline), which is the primary treatment for anaphylaxis. If a patient on beta-blockers has a severe reaction to the extract, the standard emergency treatment may fail.
MAO Inhibitors (e.g., Phenelzine, Selegiline): These can interfere with the metabolism of certain amines and may potentiate the cardiovascular effects of the extract.
Serious Interactions (Monitor Closely)
ACE Inhibitors (e.g., Lisinopril): These medications may increase the risk of systemic reactions or angioedema when combined with allergenic extracts.
🚫Contraindications
Absolute Contraindications
Scrophularia Nodosa must NEVER be used in the following circumstances:
Previous Severe Systemic Reaction: If a patient has a history of life-threatening anaphylaxis to Scrophularia Nodosa or closely related plants in the Scrophulariaceae family.
Unstable Asthma: Patients with an FEV1 (Forced Expiratory Volume) consistently below 70% of predicted value or those with recent acute exacerbations are at too high a risk for fatal respiratory failure during a reaction.
Severe Immunodeficiency: Patients with compromised immune systems may not respond appropriately to the extract or may have unpredictable reactions.
Acute Infection: Injections should be postponed if the patient has a fever or a significant respiratory infection, as this can lower the threshold for a systemic reaction.
👥Special Populations
Pregnancy
Scrophularia Nodosa is classified by the FDA under Pregnancy Category C. This means that animal reproduction studies have not been conducted, and there are no adequate, well-controlled studies in humans.
Risk of Anaphylaxis: The primary concern during pregnancy is not the substance itself, but the risk of a systemic allergic reaction. Anaphylaxis in the mother can lead to a sudden drop in blood pressure and uterine hypoperfusion, resulting in fetal distress, hypoxia, or miscarriage.
Clinical Recommendation: Most allergists recommend against starting Scrophularia Nodosa immunotherapy during pregnancy. If a woman is already on a maintenance dose and is tolerating it well, the doctor may choose to continue the treatment but will generally not increase the dose until after delivery.
Breastfeeding
It is not known whether the constituents of Scrophularia Nodosa are excreted in human milk. Because the amounts used in allergy testing and immunotherapy are very small and administered subcutaneously, the systemic concentration in the mother is likely to be extremely low. However, caution should be exercised. The risk-benefit ratio should be discussed, especially if the infant has a high risk of allergies.
🧬Pharmacology
Mechanism of Action
Scrophularia Nodosa acts through three primary pathways:
1Immunological (Allergenic): The extract contains specific proteins (antigens) that bind to IgE antibodies on the surface of mast cells and basophils. This triggers the release of inflammatory mediators like histamine, leukotrienes, and cytokines. In immunotherapy, repeated exposure at low doses induces the production of IgG4 'blocking antibodies' and shifts the T-cell response from Th2 (allergic) to Th1 (non-allergic).
2Vasodilatory: The plant contains compounds that act as nitrate donors or stimulate the endogenous production of nitric oxide (NO). This leads to the relaxation of vascular smooth muscle via the cGMP pathway.
3Metabolic (Acidifying): Organic acids within the extract (such as malic acid and caffeic acid) contribute to its acidifying activity, which can affect local tissue pH.
Frequently Asked Questions
Common questions about Scrophularia Nodosa
What is Scrophularia Nodosa used for?
Scrophularia Nodosa is primarily used in the field of allergy and immunology as a diagnostic tool and a treatment for hypersensitivity. As a non-standardized allergenic extract, it is used in skin prick tests to identify if a patient is allergic to certain plants in the figwort family. It is also used in allergen immunotherapy, commonly known as allergy shots, to help patients build a tolerance to these allergens over time. Additionally, because it has nitrate-like properties, it is sometimes included in specialized formulations for its vasodilatory (blood vessel widening) and acidifying effects. Always consult a specialist to see if this extract is appropriate for your diagnostic needs.
What are the most common side effects of Scrophularia Nodosa?
The most common side effects are localized to the area where the extract was applied or injected. Patients frequently experience redness, itching, and a small amount of swelling (a wheal) at the site of the skin test or injection. These reactions are usually mild and disappear within a few hours. Some people may also experience a mild headache or slight fatigue following the administration. If the swelling at the injection site is larger than three centimeters, you should inform your doctor before your next dose, as it may indicate a need to adjust your treatment plan.
Can I drink alcohol while taking Scrophularia Nodosa?
It is generally recommended to avoid alcohol on the days you receive a Scrophularia Nodosa injection or undergo skin testing. Alcohol can cause your blood vessels to dilate and increase your heart rate, which may speed up the absorption of the allergen into your bloodstream. This increased absorption rate can raise the risk of a systemic allergic reaction or make a reaction more severe if it occurs. Furthermore, alcohol can mask some of the early warning signs of an allergic reaction, such as dizziness or flushing. To ensure your safety, wait at least 24 hours after your treatment before consuming alcoholic beverages.
Is Scrophularia Nodosa safe during pregnancy?
Scrophularia Nodosa is classified as Pregnancy Category C, meaning its safety has not been fully established through clinical trials in pregnant women. The main concern is not that the plant extract is a direct toxin to the baby, but that it could cause a severe allergic reaction (anaphylaxis) in the mother. Anaphylaxis causes a sharp drop in blood pressure, which can cut off the oxygen supply to the fetus, leading to serious complications. Most doctors will not start new immunotherapy during pregnancy for this reason. If you are already on a stable maintenance dose, your doctor will decide if the benefits of continuing outweigh the potential risks.
How long does it take for Scrophularia Nodosa to work?
The timeframe for Scrophularia Nodosa to work depends on the goal of the treatment. For diagnostic skin testing, the results are visible within 15 to 20 minutes of application. However, for allergen immunotherapy (allergy shots), the process is much slower. It typically takes six months to a year of regular injections to notice a significant reduction in your allergy symptoms. The full benefits of the treatment are usually reached after three to five years of consistent therapy. It is important to remain patient and follow the schedule provided by your allergist.
Can I stop taking Scrophularia Nodosa suddenly?
Yes, you can stop taking Scrophularia Nodosa suddenly without experiencing physical withdrawal symptoms like those seen with opioids or antidepressants. However, if you are using it for allergy desensitization, stopping the treatment prematurely will cause your allergy symptoms to return eventually. Your immune system will lose the tolerance it has built up, and you may become just as sensitive to the allergen as you were before starting. If you need to stop treatment due to side effects or other concerns, discuss a tapering or alternative plan with your healthcare provider first.
What should I do if I miss a dose of Scrophularia Nodosa?
If you miss a dose of your Scrophularia Nodosa immunotherapy, you should contact your allergist's office as soon as possible to reschedule. Do not try to 'double up' on your next dose to make up for the missed one. If you are only a few days late, your doctor may give you the usual dose. However, if several weeks have passed, your immune system may have become more sensitive again, and your doctor will likely need to reduce the dose for your safety before building back up. Consistency is key to the success and safety of this treatment.
Does Scrophularia Nodosa cause weight gain?
There is currently no clinical evidence to suggest that Scrophularia Nodosa causes weight gain. Unlike some other medications used for allergies, such as oral corticosteroids (like prednisone), Scrophularia Nodosa does not affect your metabolism or appetite in a way that leads to fat accumulation. Most side effects are limited to local skin reactions or temporary systemic symptoms like headaches. If you notice significant or unexplained weight gain while undergoing treatment, it is likely due to another factor, and you should consult your primary care physician to investigate the cause.
Can Scrophularia Nodosa be taken with other medications?
Scrophularia Nodosa can interact with several types of medications, some of which are very serious. You must tell your doctor if you are taking beta-blockers, as these can make life-saving epinephrine ineffective if you have an allergic reaction. Antihistamines must be stopped several days before testing because they can block the results. Other medications like ACE inhibitors or MAOIs may also increase the risk of severe side effects. Always provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are currently using.
Is Scrophularia Nodosa available as a generic?
Scrophularia Nodosa is a botanical extract rather than a synthetic drug, so the concept of 'generic' vs. 'brand name' is slightly different. It is produced by various specialized laboratories that manufacture allergenic extracts. While there may be different suppliers, these extracts are 'non-standardized,' meaning the potency can vary slightly between manufacturers. Because of this, doctors prefer that you stay with the same manufacturer's extract throughout your course of treatment to ensure consistent dosing. It is typically only available through specialized allergy clinics and is not sold as a standard generic at retail pharmacies.
Less Common Side Effects (1 in 100 to 1 in 10)
Large Local Reactions: Swelling that extends beyond the immediate injection site (e.g., swelling of the entire upper arm). This may require an adjustment in the next dose.
Hives (Urticaria): Itchy bumps appearing on parts of the body away from the injection site.
Nasal Congestion: A 'stuffy nose' or sneezing shortly after administration.
Headache: Mild to moderate tension-type headaches have been reported following the use of nitrate-containing extracts.
Rare Side Effects (less than 1 in 100)
Vasovagal Syncope: Fainting or lightheadedness, often due to the stress of the injection rather than the substance itself.
Gastrointestinal Distress: Nausea or mild abdominal cramping, particularly if the extract has systemic acidifying effects.
Persistent Lymphadenopathy: Swelling of the lymph nodes near the injection site that lasts for several days.
Serious Side Effects — Seek Immediate Medical Attention
> Warning: Stop taking Scrophularia Nodosa and call your doctor immediately if you experience any of these symptoms. These may indicate a life-threatening systemic reaction (Anaphylaxis).
Difficulty Breathing: Wheezing, shortness of breath, or a feeling of tightness in the chest.
Throat Swelling: A 'lump in the throat,' hoarseness, or difficulty swallowing.
Hypotension: A sudden drop in blood pressure, which may feel like extreme dizziness or 'blacking out.'
Rapid/Weak Pulse: Tachycardia (fast heart rate) combined with a feeling of weakness.
Cyanosis: A bluish tint to the lips, nails, or skin, indicating a lack of oxygen.
Angioedema: Significant swelling of the face, lips, tongue, or eyes.
Long-Term Side Effects
With prolonged use in immunotherapy, some patients may develop a persistent sensitivity or 'priming' effect where they become more reactive to the extract for a short period. There is no evidence that Scrophularia Nodosa causes long-term organ damage or cancer. However, chronic use of any nitrate-containing substance can theoretically lead to 'nitrate tolerance,' where the vasodilatory effects become less pronounced over time.
Black Box Warnings
While Scrophularia Nodosa itself may not always carry a specific brand-name black box warning, the class of Allergenic Extracts carries a general FDA-mandated warning regarding the risk of severe non-fatal and fatal systemic reactions.
Summary of Warning:
1Allergenic extracts can cause severe life-threatening anaphylaxis.
2They should only be administered by physicians who are exceptionally experienced in the treatment of allergic diseases.
3Patients must be observed for at least 30 minutes after administration.
4Immunotherapy may not be suitable for patients with unstable asthma or those taking beta-blockers, as these factors can make an allergic reaction more difficult to treat.
Report any unusual symptoms or side effects to your healthcare provider immediately. Early reporting can prevent a minor reaction from becoming a medical emergency.
Asthma Exacerbation: Patients with poorly controlled or unstable asthma are at a significantly higher risk for severe respiratory distress if a systemic reaction occurs. Asthma must be stable before an injection is given.
Cardiovascular Stress: Because Scrophularia Nodosa has nitrate-like vasodilatory properties, it may cause transient changes in blood pressure. This can be dangerous for patients with pre-existing heart conditions or those on antihypertensive medications.
Acidifying Activity: In patients with metabolic acidosis or severe renal dysfunction, the acidifying properties of the extract should be considered, although systemic pH changes are rare at standard diagnostic doses.
Monitoring Requirements
Peak Flow Monitoring: For asthmatic patients, a peak flow meter may be used before and after administration to ensure lung function is not compromised.
Vital Signs: Blood pressure and heart rate should be monitored if the patient reports dizziness or if a large dose is being administered for the first time.
Site Observation: The injection site must be inspected for delayed local reactions (occurring 6-24 hours later), which should be reported before the next dose.
Driving and Operating Machinery
Patients should avoid driving or operating heavy machinery for at least 30-60 minutes after receiving an injection. If a systemic reaction occurs or if the patient feels lightheaded due to the vasodilatory effects, they should not drive until symptoms have completely resolved and they have been cleared by a medical professional.
Alcohol Use
Alcohol should be avoided on the day of an injection or test. Alcohol can dilate blood vessels and may increase the rate of absorption of the allergen, potentially increasing the risk or severity of a systemic reaction.
Discontinuation
If a patient experiences a systemic reaction, the healthcare provider will evaluate whether to continue treatment. Often, the dose is significantly reduced, or the treatment is discontinued entirely. There is no 'withdrawal' syndrome associated with stopping Scrophularia Nodosa, but the patient's allergy symptoms may return to their baseline levels.
> Important: Discuss all your medical conditions, especially respiratory and heart issues, with your healthcare provider before starting Scrophularia Nodosa.
Tricyclic Antidepressants (e.g., Amitriptyline): Similar to MAOIs, these can affect how the body responds to emergency medications like epinephrine.
Other Vasodilators (e.g., Sildenafil, Nitroglycerin): Since Scrophularia Nodosa has nitrate-like activity, combining it with other potent vasodilators can lead to a dangerous drop in blood pressure (hypotension).
Moderate Interactions
Antihistamines (e.g., Loratadine, Cetirizine): These must be stopped several days (usually 3-7 days) before skin testing, as they will suppress the 'wheal and flare' response, leading to a false-negative test result.
Corticosteroids: Long-term use of systemic steroids may suppress the immune response to the extract, potentially reducing the effectiveness of immunotherapy.
Food Interactions
High-Nitrate Foods: Consuming large amounts of spinach, beets, or processed meats (high in nitrates) may theoretically have an additive effect on the vasodilatory properties of the extract, though this is rarely clinically significant.
Alcohol: As mentioned previously, alcohol can increase the risk of a systemic allergic reaction by increasing blood flow and absorption.
Herbal/Supplement Interactions
St. John’s Wort: May affect the metabolism of the flavonoid components of Scrophularia Nodosa.
Ginkgo Biloba: Known for its anti-platelet and vasodilatory effects, it may increase the risk of bruising at the injection site or enhance the extract's vasodilatory profile.
Hawthorn: Often used for heart health, it may have additive effects on blood pressure modulation.
Lab Test Interactions
Skin Prick Tests: Scrophularia Nodosa will obviously interfere with any allergy testing involving the Scrophulariaceae family.
Urinary pH: Due to its acidifying activity, it may slightly lower the pH of the urine in sensitive individuals, which could affect the results of tests for certain crystals or drugs that are pH-dependent for excretion.
For each major interaction, the mechanism typically involves either pharmacodynamic synergy (e.g., two drugs lowering blood pressure) or interference with emergency protocols (e.g., beta-blockers blocking epinephrine). Management strategies usually involve pausing one medication or choosing an alternative therapy.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter allergy meds.
Relative Contraindications
These conditions require a careful risk-benefit analysis by the physician:
Pregnancy: While not a direct toxin, the risk of anaphylaxis (which can cause fetal hypoxia) usually means that immunotherapy should not be started during pregnancy.
Severe Cardiovascular Disease: The stress of a potential reaction or the vasodilatory effects of the extract may trigger angina or arrhythmias in susceptible patients.
Autoimmune Disorders: There is a theoretical risk that stimulating the immune system with allergenic extracts could worsen certain autoimmune conditions.
Cross-Sensitivity
Patients allergic to other members of the Scrophulariaceae family (such as Verbascum/Mullein or Digitalis/Foxglove) may show cross-reactivity to Scrophularia Nodosa. While Foxglove is primarily known for its cardiac glycosides, it shares botanical proteins that can trigger similar allergic responses.
> Important: Your healthcare provider will evaluate your complete medical history, including your respiratory health and current medications, before prescribing or administering Scrophularia Nodosa.
Pediatric Use
Scrophularia Nodosa is approved for use in children for diagnostic purposes and immunotherapy.
Age Considerations: It is rarely used in children under 5 years of age because they may have difficulty communicating the early symptoms of a systemic reaction (e.g., itchy throat, nausea).
Growth Effects: There is no evidence that allergenic extracts affect growth or development in children.
Dosing: Pediatric doses are often the same as adult doses by volume, but the escalation phase may be slower to ensure safety.
Geriatric Use
Elderly patients may be at increased risk when using Scrophularia Nodosa due to:
Reduced Physiological Reserve: A systemic reaction is much harder on the heart and lungs of a 70-year-old than a 20-year-old.
Polypharmacy: Older adults are more likely to be taking beta-blockers or ACE inhibitors, which increase the danger of immunotherapy.
Renal Clearance: Age-related decline in kidney function may slightly slow the clearance of the extract's metabolites.
Renal Impairment
In patients with significant renal impairment, the acidifying activity of Scrophularia Nodosa could theoretically contribute to metabolic imbalances, though this is unlikely at standard doses. No specific GFR-based (Glomerular Filtration Rate) adjustments are standardized, but close monitoring of electrolytes is advised if large doses are used.
Hepatic Impairment
Since the liver processes the flavonoids and saponins in the extract, patients with cirrhosis or hepatitis should be observed for any signs of unusual sensitivity. Dosage adjustments are typically based on clinical response rather than specific Child-Pugh scores.
> Important: Special populations, particularly pregnant women and the elderly, require a highly individualized medical assessment before using Scrophularia Nodosa.
Pharmacodynamics
Onset of Action: For skin testing, the onset is rapid (15-20 minutes). For vasodilatory effects, the onset is 30-60 minutes after oral administration.
Duration: The 'wheal and flare' reaction lasts 1-2 hours. The immunological changes from immunotherapy take 6-12 months to become significant.
Tolerance: Tolerance to the vasodilatory effects can occur with chronic, frequent use, but 'tolerance' in the immunological sense (desensitization) is the goal of therapy.
Molecular Components: Includes Harpagoside (C24H30O11), Aucubin, and various saponins.
Solubility: Active constituents are generally soluble in water and ethanol.
Description: The extract is a clear to amber liquid with a characteristic botanical odor.
Drug Class
Scrophularia Nodosa is classified as a Non-Standardized Plant Allergenic Extract. It shares this class with other botanical extracts like Ragweed or Oak. Its secondary classification as a Nitrate Vasodilator places it in a functional category similar to Isosorbide Mononitrate, though its potency is significantly lower.