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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Rosmarinus Officinalis
Brand Name
Rosmarinus Officinalis
Generic Name
Rosmarinus Officinalis
Active Ingredient
Rosmarinus Officinalis Flowering TopCategory
Non-Standardized Plant Allergenic Extract [EPC]
Variants
8
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 200 [hp_C]/1 | PELLET | ORAL | 37662-1235 |
| 1 [hp_Q]/1 | PELLET | ORAL | 37662-1238 |
| 500 [hp_C]/1 | PELLET | ORAL | 37662-1236 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Rosmarinus Officinalis, you must consult a qualified healthcare professional.
| 6 [hp_C]/1 | PELLET | ORAL | 37662-1231 |
| 30 [hp_C]/1 | PELLET | ORAL | 37662-1233 |
| 100 [hp_C]/1 | PELLET | ORAL | 37662-1234 |
| 12 [hp_C]/1 | PELLET | ORAL | 37662-1232 |
| 1 [hp_M]/1 | PELLET | ORAL | 37662-1237 |
Detailed information about Rosmarinus Officinalis
Rosmarinus Officinalis Flowering Top is a non-standardized plant allergenic extract used primarily in the diagnosis and treatment of rosemary-related hypersensitivity. It belongs to the class of plant and food allergenic extracts used in clinical immunology.
Dosage for Rosmarinus Officinalis Flowering Top is highly individualized and must be determined by an allergist based on the patient's sensitivity level. There is no 'standard' dose, as the extract is non-standardized.
For diagnostic purposes, a single drop of the 1:10 or 1:20 w/v glycerinated extract is applied to the skin, which is then pricked with a sterile lancet. The result is read after 15 to 20 minutes.
Therapeutic use follows a two-phase schedule:
Rosmarinus Officinalis Flowering Top allergenic extracts may be used in children, typically those aged 5 years and older. Dosing principles are similar to adults, but the starting dose may be even more conservative depending on the child's history of asthma or systemic reactions. Safety and efficacy in children under the age of 5 have not been extensively established, and the risk-benefit ratio must be carefully considered by a pediatric allergist.
No specific dosage adjustments are required for patients with renal impairment, as the systemic protein load is extremely low. However, patients with severe renal disease should be monitored closely for their overall ability to tolerate a systemic allergic reaction should one occur.
No dosage adjustments are necessary for hepatic impairment. The metabolism of allergenic proteins does not rely on hepatic enzyme pathways.
Elderly patients (over 65) may have a higher prevalence of cardiovascular disease. Because the treatment for a systemic reaction to the extract is epinephrine (adrenaline), healthcare providers must evaluate whether the patient's heart can tolerate epinephrine before starting immunotherapy.
This medication is never self-administered at home. It must be administered in a clinical setting (doctor's office or clinic) equipped with emergency resuscitation equipment.
If a dose of immunotherapy is missed, the next dose may need to be reduced to prevent an adverse reaction.
An 'overdose' in the context of allergenic extracts refers to an injection of a concentration higher than the patient's current tolerance level. Signs of overdose include:
In the event of an overdose or systemic reaction, the healthcare provider will immediately administer epinephrine and may use antihistamines, corticosteroids, and IV fluids.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Most patients receiving Rosmarinus Officinalis Flowering Top extracts will experience some form of local reaction.
Rosmarinus Officinalis Flowering Top extract is a high-potency biological product. It is intended only for use by specialists. Patients must be informed that while the goal is to reduce allergy symptoms, the treatment itself involves injecting the very substance they are allergic to, which carries inherent risks.
No specific FDA black box warning exists for Rosmarinus Officinalis Flowering Top individually, but it falls under the mandatory class warning for all injectable allergenic extracts. This warning emphasizes that these products can cause anaphylaxis and must be administered in settings where emergency resuscitation (including epinephrine, oxygen, and airway management) is immediately available.
There are no absolute drug-drug contraindications that prevent the use of Rosmarinus Officinalis Flowering Top, but certain combinations make the treatment significantly more dangerous.
FDA Pregnancy Category: C. There are no adequate and well-controlled studies of Rosmarinus Officinalis Flowering Top extract in pregnant women.
It is not known whether the allergenic proteins from Rosmarinus Officinalis Flowering Top are excreted in human milk. However, because these are large proteins that are digested in the infant's gut, the risk to a nursing infant is considered extremely low. The benefits of breastfeeding generally outweigh the theoretical risks of the mother receiving immunotherapy.
Rosmarinus Officinalis Flowering Top extract acts as an immunomodulator. In an allergic individual, the immune system incorrectly identifies rosemary proteins as a threat, producing IgE antibodies. These antibodies coat mast cells and basophils.
Upon exposure to the extract, the 'Allergen-IgE-Mast Cell' complex triggers the release of inflammatory mediators. In immunotherapy, the goal is to induce Immune Tolerance. This involves:
Common questions about Rosmarinus Officinalis
Rosmarinus Officinalis Flowering Top extract is primarily used by medical specialists to diagnose and treat allergies to rosemary. In a diagnostic setting, it is used in skin prick tests to confirm if a patient has an IgE-mediated hypersensitivity to the plant. For treatment, it is used in allergen immunotherapy (allergy shots) to gradually desensitize the patient's immune system. This is particularly helpful for individuals with occupational exposure, such as chefs or gardeners, who cannot easily avoid the plant. It is not used for general health supplementation in this clinical form.
The most common side effects are localized to the site of administration, such as the arm where an injection was given. Patients frequently experience redness, itching, and swelling (a wheal) at the injection site shortly after the procedure. Some may also experience a 'late-phase' reaction where the swelling increases several hours later. Systemic symptoms like mild fatigue or a temporary increase in nasal congestion can also occur. These reactions are generally manageable and indicate that the immune system is responding to the extract.
It is generally advised to avoid alcohol on the days you receive an injection of Rosmarinus Officinalis Flowering Top extract. Alcohol can cause blood vessels to dilate, which may increase the speed at which the allergen enters your bloodstream, potentially increasing the risk of a systemic reaction. Furthermore, alcohol can mask the early symptoms of an allergic reaction, such as flushing or dizziness, making it harder for you or your doctor to identify a problem. Always wait at least several hours after your injection and ensure you feel completely normal before consuming alcohol. Discuss your lifestyle habits with your allergist for personalized safety advice.
Rosmarinus Officinalis Flowering Top is generally not started during pregnancy because of the risk of anaphylaxis, which can be dangerous for both the mother and the developing fetus. If a woman is already on a stable maintenance dose of immunotherapy and becomes pregnant, her doctor may decide to continue the treatment at that same dose. However, increasing the dose during pregnancy is avoided to minimize the risk of a severe reaction. There is no evidence that the extract itself causes birth defects, but the physiological stress of an allergic reaction is the primary concern. Always inform your allergist immediately if you become pregnant.
For diagnostic purposes, the extract works almost immediately, providing a skin reaction within 15 to 20 minutes. For therapeutic immunotherapy, the process is much slower and requires patience. Most patients begin to notice a reduction in their allergy symptoms during the 'maintenance phase,' which usually starts 6 to 12 months after beginning the injections. To achieve long-lasting or permanent 'tolerance' to rosemary, the treatment typically needs to be continued for 3 to 5 years. Stopping the treatment too early may result in the return of allergy symptoms.
Yes, you can stop the treatment suddenly without experiencing 'withdrawal' symptoms like you might with some other medications. However, stopping immunotherapy will halt the desensitization process, and your allergy symptoms will likely return over time. If you miss doses for a few weeks, you cannot simply resume at the previous dose, as your sensitivity may have increased; your doctor will need to adjust the dose downward for safety. It is important to discuss your reasons for wanting to stop with your healthcare provider to see if a modified schedule is possible. Consistency is key to the success of this treatment.
If you miss a scheduled immunotherapy injection, you should contact your allergist's office as soon as possible to reschedule. Do not try to 'make up' the dose by taking more later or by going to a different clinic. The safety of the next dose depends on the time elapsed since your last injection; if too much time has passed, your doctor will need to reduce the concentration of the next shot to prevent a reaction. Missing a single week usually requires no change, but missing several weeks may require you to step back in your build-up schedule. Always follow the specific 'missed dose' protocol provided by your clinical team.
There is no clinical evidence to suggest that Rosmarinus Officinalis Flowering Top allergenic extract causes weight gain. Unlike corticosteroids (such as prednisone), which are sometimes used to treat allergies and can cause weight changes, allergenic extracts are simply proteins that work on the immune system's sensitivity. They do not affect metabolism, appetite, or fat storage. If you experience weight changes while on this treatment, it is likely due to other factors or medications, and you should discuss this with your primary care physician. Your allergist can help differentiate between the effects of the immunotherapy and other treatments.
Rosmarinus Officinalis Flowering Top can be taken alongside most medications, but there are critical exceptions you must discuss with your doctor. The most important are beta-blockers, which are used for blood pressure or heart conditions, as they can make an allergic reaction much harder to treat. Other medications like ACE inhibitors, MAOIs, and tricyclic antidepressants can also interact with the emergency treatments used for allergic reactions. Even over-the-counter antihistamines can interfere by masking early symptoms of a reaction. Always provide a full list of your medications to your allergist before starting any form of immunotherapy.
The concept of 'generic' vs. 'brand name' is slightly different for allergenic extracts like Rosmarinus Officinalis Flowering Top. Because these are biological products derived from natural sources, they are often produced by several different specialized laboratories (such as HollisterStier or ALK-Abelló). While they may not be called 'generics,' different versions of the extract are available. However, they are 'non-standardized,' meaning you cannot easily switch between different manufacturers' products without your doctor adjusting the dose, as the potency may vary. Your allergist will typically stick with one manufacturer for the duration of your treatment to ensure consistency.
Other drugs with the same active ingredient (Rosmarinus Officinalis Flowering Top)
> Warning: Stop taking Rosmarinus Officinalis Flowering Top and call your doctor immediately if you experience any of these.
There are no known long-term 'toxic' effects of Rosmarinus Officinalis Flowering Top extracts, as they are natural proteins. However, prolonged immunotherapy can lead to a permanent change in the immune system's response to rosemary. In rare cases, patients may develop 'serum sickness,' a delayed immune complex reaction characterized by joint pain, fever, and rash, though this is more common with animal-derived sera than with plant extracts.
While Rosmarinus Officinalis Flowering Top may not have a specific individual black box warning, the class of Allergenic Extracts carries a general warning required by the FDA.
Summary of Warning: Allergenic extracts can cause severe life-threatening systemic reactions, including anaphylaxis. They should only be administered by physicians who are exceptionally experienced in the treatment of allergic diseases and who have the facilities and equipment to manage life-threatening reactions. Patients with unstable asthma or those taking beta-blockers may be at increased risk of severe outcomes.
Report any unusual symptoms to your healthcare provider.
Most patients can drive after the 30-minute observation period. However, if a patient feels dizzy, fatigued, or 'faint' after an injection, they should avoid driving or operating heavy machinery until these symptoms have completely resolved.
Patients should avoid alcohol consumption for several hours before and after an immunotherapy injection. Alcohol can increase peripheral vasodilation, which may theoretically speed up the absorption of the allergen or mask the early symptoms of a systemic reaction.
If a patient experiences a severe systemic reaction, the healthcare provider will re-evaluate the necessity of the treatment. Immunotherapy is typically discontinued if the risks of continued treatment outweigh the potential benefits, or if the patient is unable to comply with the 30-minute waiting period.
> Important: Discuss all your medical conditions with your healthcare provider before starting Rosmarinus Officinalis Flowering Top.
For each major interaction, the mechanism usually involves either a pharmacodynamic interference with the treatment of side effects (like beta-blockers and epinephrine) or a masking of symptoms (antihistamines). Management usually involves switching the patient to an alternative medication (e.g., switching from a beta-blocker to a calcium channel blocker) before starting immunotherapy.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Rosmarinus Officinalis belongs to the Lamiaceae (Mint) family. Patients allergic to rosemary may show cross-sensitivity to other members of this family, including:
Healthcare providers should be aware that a patient highly sensitive to one of these may react more strongly to the Rosmarinus Officinalis extract.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Rosmarinus Officinalis Flowering Top.
Immunotherapy with Rosmarinus Officinalis extract is generally reserved for children 5 years of age and older. Younger children may have difficulty communicating the early symptoms of a systemic reaction, making the treatment less safe. Pediatric patients should be monitored for any interference with growth, although no such effects have been documented with allergenic extracts.
Elderly patients require a thorough cardiovascular evaluation before starting treatment. The 'stress test' of a potential allergic reaction and the subsequent need for epinephrine can be hard on an aging heart. Additionally, many elderly patients are on multiple medications (polypharmacy) that may interact with the treatment of an allergic reaction.
No specific studies have been conducted in patients with renal impairment. Since the proteins are metabolized into amino acids, renal function is not a primary factor in the drug's clearance. However, fluid balance is critical during the treatment of anaphylaxis, so patients with kidney failure must be managed carefully in emergency situations.
Liver disease does not affect the processing of allergenic extracts. No dosage adjustments are recommended for patients with hepatic impairment.
> Important: Special populations require individualized medical assessment.
| Parameter | Value |
|---|---|
| Bioavailability | Low (Subcutaneous) |
| Protein Binding | N/A (Biological Protein) |
| Half-life | Variable (Hours to Days for proteins) |
| Tmax | 1-2 hours (Systemic absorption) |
| Metabolism | Proteolysis (Protease enzymes) |
| Excretion | Renal (as amino acids/peptides) |
Rosmarinus Officinalis Flowering Top is classified as a Non-Standardized Plant Allergenic Extract. It belongs to the broader therapeutic category of Allergen Immunotherapy Agents. It is related to other herb-based extracts like Sage, Thyme, and Mint extracts used in clinical allergy practice.