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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Rosa Canina Flos
Generic Name
Rosa Canina Flos
Active Ingredient
Rosa Canina FlowerCategory
alpha-Adrenergic Agonist [EPC]
Variants
7
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 6 [hp_C]/1 | PELLET | ORAL | 37662-3045 |
| 200 [hp_C]/1 | PELLET | ORAL | 37662-3049 |
| 12 [hp_C]/1 | PELLET | ORAL | 37662-3046 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Rosa Canina Flos, you must consult a qualified healthcare professional.
| 30 [hp_C]/1 | PELLET | ORAL | 37662-3047 |
| 1 [hp_M]/1 | PELLET | ORAL | 37662-3051 |
| 100 [hp_C]/1 | PELLET | ORAL | 37662-3048 |
| 500 [hp_C]/1 | PELLET | ORAL | 37662-3050 |
Detailed information about Rosa Canina Flos
Rosa Canina Flower is a standardized pharmaceutical ingredient classified as an alpha and beta-adrenergic agonist and catecholamine, used in specialized clinical settings and allergen testing.
The dosage of Rosa Canina Flower varies significantly depending on the indication and the concentration of the standardized extract. For general systemic support, healthcare providers may suggest a range of 250 mg to 1000 mg of a standardized extract, taken one to three times daily. When used for its adrenergic properties, the dose must be carefully titrated (adjusted) to achieve the desired effect on blood pressure or heart rate without causing excessive stimulation.
For allergen-specific immunotherapy, the dosage is determined by a 'build-up' phase where the concentration of the extract is gradually increased over several weeks, followed by a maintenance phase. These doses are measured in Protein Nitrogen Units (PNU) or Bioequivalent Allergy Units (BAU) rather than milligrams.
Rosa Canina Flower is not widely approved for pediatric use in its high-potency adrenergic form. While rosehip tea or mild supplements are often considered safe for children in small amounts, standardized catecholamine-like extracts should only be used under the strict guidance of a pediatric specialist or allergist. Safety and efficacy in children under the age of 12 have not been established for pharmaceutical-grade extracts.
Since the metabolites of Rosa Canina Flower are primarily excreted through the kidneys, patients with impaired renal function (kidney disease) may require lower doses. In patients with a Creatinine Clearance (CrCl) of less than 30 mL/min, a 50% dose reduction is often recommended to prevent the accumulation of active metabolites, which could lead to increased cardiovascular side effects.
Because the liver processes this substance via COMT and MAO enzymes, patients with severe hepatic impairment (liver failure) should use Rosa Canina Flower with extreme caution. Dose adjustments should be based on the Child-Pugh score; patients with Class C impairment may need to avoid high-potency extracts entirely due to the risk of systemic toxicity.
Geriatric patients are often more sensitive to the effects of adrenergic agonists. There is an increased risk of hypertension (high blood pressure) and tachycardia (fast heart rate). Healthcare providers typically start elderly patients at the lowest possible dose and monitor cardiovascular parameters closely.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this significantly increases the risk of acute hypertension or cardiac arrhythmias.
An overdose of Rosa Canina Flower can lead to a 'sympathomimetic crisis.' Signs of overdose include:
In the event of a suspected overdose, seek emergency medical attention immediately. Treatment typically involves the administration of alpha or beta-blockers to neutralize the adrenergic effects and supportive care to stabilize blood pressure and heart rhythm.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking this medication without medical guidance, as sudden changes can affect your cardiovascular stability.
Because Rosa Canina Flower acts as an adrenergic agonist, the most common side effects are related to the stimulation of the sympathetic nervous system. Patients frequently report:
Rosa Canina Flower is a potent pharmacological agent that must be used with caution. It is not a simple herbal supplement when used in its standardized EPC form. Patients must be aware that its effects on the heart and blood vessels are significant. It is vital to disclose your full medical history, especially any history of heart disease, high blood pressure, or thyroid disorders, to your healthcare provider before beginning treatment.
No FDA black box warnings for Rosa Canina Flower. However, clinical guidelines suggest that high-potency sympathomimetic agents should be used with extreme caution in patients with unstable angina or recent myocardial infarction (heart attack).
Rosa Canina Flower must NEVER be used in the following conditions:
Rosa Canina Flower is generally classified as Pregnancy Category C. This means that animal reproduction studies have not been conducted, and there are no adequate, well-controlled studies in humans. However, because it acts as a vasoconstrictor, there is a theoretical risk that it could reduce uterine blood flow, potentially leading to fetal hypoxia (lack of oxygen) or growth restriction. It should only be used during pregnancy if the clinical need is urgent and no safer alternatives exist. Use during the first trimester is particularly discouraged as the effects on organogenesis (organ formation) are unknown.
It is not known whether the active catecholamine-like components of Rosa Canina Flower pass into human breast milk. However, many small-molecule alkaloids and flavonoids do. There is a risk that the infant could experience side effects such as irritability, tachycardia, or poor feeding if exposed through breast milk. Breastfeeding mothers should consult their doctor; in many cases, it is recommended to either withhold the drug or temporarily stop breastfeeding while the drug is being cleared from the system.
Rosa Canina Flower acts as a non-selective adrenergic agonist. Its primary molecular targets are the Alpha-1, Alpha-2, Beta-1, and Beta-2 adrenergic receptors.
Common questions about Rosa Canina Flos
Rosa Canina Flower is primarily used in clinical settings as a standardized allergen for diagnostic testing and immunotherapy for patients with Rosaceae allergies. Due to its classification as an alpha and beta-adrenergic agonist, it may also be used in specialized formulations to support vascular tone and modulate the sympathetic nervous system. In its more common supplement form, it is utilized for its high Vitamin C and antioxidant content to support immune health. However, in pharmaceutical contexts, it is its catecholamine-like activity that is most significant. Always consult a healthcare provider to understand the specific reason for its use in your treatment plan.
The most common side effects of Rosa Canina Flower are related to its stimulatory effects on the body, including a rapid or pounding heartbeat (tachycardia), a mild increase in blood pressure, and restlessness or jitteriness. Some patients also report difficulty sleeping (insomnia) if the medication is taken too late in the day. Gastrointestinal issues such as mild nausea or stomach cramps can also occur due to the natural acids in the flower extract. Most of these effects are dose-dependent and subside as the medication is cleared from the system. If these symptoms become severe or persistent, you should contact your healthcare provider immediately.
It is strongly recommended that you avoid or strictly limit alcohol consumption while taking Rosa Canina Flower. Alcohol can cause unpredictable changes in blood pressure and can either counteract the vasoconstrictive effects of the drug or dangerously increase the strain on your cardiovascular system. Furthermore, both alcohol and the active components of the flower are processed by the liver, and combining them can increase the risk of hepatic stress. Alcohol may also worsen the dizziness or jitteriness associated with adrenergic agonists. Discuss your alcohol intake with your doctor to ensure your safety while on this medication.
Rosa Canina Flower is generally not recommended during pregnancy unless the potential benefits significantly outweigh the risks. It is classified as Pregnancy Category C, meaning there is insufficient data from human studies to guarantee its safety. Because the drug can cause blood vessels to constrict (vasoconstriction), there is a theoretical concern that it could reduce blood flow to the placenta and the developing fetus. This could potentially lead to complications such as low birth weight or other developmental issues. Pregnant women or those planning to become pregnant should have a detailed discussion with their obstetrician before using any standardized Rosa Canina extracts.
The onset time for Rosa Canina Flower depends on the form of administration. For oral capsules, most patients begin to feel the systemic adrenergic effects within 30 to 60 minutes as the drug is absorbed through the digestive tract. The peak effect, where the concentration in the bloodstream is highest, typically occurs around 2 hours after ingestion. If used as a topical extract or for skin testing, localized effects may be seen much sooner, often within 15 to 20 minutes. The duration of the effect usually lasts between 4 and 6 hours, after which the liver and kidneys clear the majority of the active components.
You should not stop taking Rosa Canina Flower abruptly if you have been using it regularly for an extended period. Because it stimulates the adrenergic receptors, your body may have adjusted its own natural production of adrenaline and norepinephrine in response. Stopping suddenly can cause a 'rebound' effect, which might result in symptoms like extreme fatigue, a significant drop in blood pressure (hypotension), or a feeling of mental 'fog.' Your healthcare provider will typically recommend a gradual tapering process, slowly reducing the dose over several days or weeks to allow your autonomic nervous system to return to its baseline state safely.
If you miss a dose of Rosa Canina Flower, you should take it as soon as you remember. However, if it is already close to the time for your next scheduled dose, it is better to skip the missed dose entirely and continue with your regular dosing schedule. You should never take two doses at the same time to make up for a missed one, as this can lead to an excessive amount of the drug in your system, increasing the risk of dangerous side effects like a hypertensive crisis or heart palpitations. If you frequently miss doses, consider using a pill reminder or alarm to stay on track.
There is currently no clinical evidence to suggest that Rosa Canina Flower causes weight gain. In fact, because it acts as a sympathomimetic (a stimulant of the sympathetic nervous system), it may slightly increase the metabolic rate, which is more commonly associated with weight loss or appetite suppression rather than weight gain. However, any drug that affects the endocrine system or stress response can have varied effects on individuals. If you notice unusual changes in your weight while taking this medication, it is important to discuss them with your doctor to rule out other underlying causes or fluid retention issues.
Rosa Canina Flower has the potential for many serious drug interactions, so it must be used cautiously with other medications. It should never be taken with Monoamine Oxidase Inhibitors (MAOIs) or non-selective beta-blockers, as these combinations can be life-threatening. It may also interact with blood pressure medications, antidepressants, and other stimulants like caffeine or decongestants. Because it can raise blood sugar, it may also interfere with the effectiveness of diabetes treatments. Always provide your healthcare provider with a complete list of all prescription drugs, over-the-counter medicines, and herbal supplements you are currently taking.
Rosa Canina Flower is a botanical ingredient, so it does not have a 'generic' in the same way synthetic drugs like lisinopril do. Instead, it is available as various 'standardized extracts' from different manufacturers. While these may be cheaper than specific brand-name allergen extracts, it is crucial to ensure that any product you use is 'standardized,' meaning it contains a consistent and verified amount of the active adrenergic components. Non-standardized versions may vary wildly in potency and safety. Always purchase from reputable pharmaceutical or nutraceutical sources and verify the standardization with your pharmacist or doctor.
Other drugs with the same active ingredient (Rosa Canina Flower)
> Warning: Stop taking Rosa Canina Flower and call your doctor immediately if you experience any of these serious symptoms:
Prolonged use of high-potency adrenergic agonists like Rosa Canina Flower can lead to several chronic issues:
Currently, there are no FDA black box warnings specifically for 'Rosa Canina Flower' in its general botanical form. However, when processed into standardized catecholamine-like extracts, healthcare providers must be aware of the general warnings associated with the Adrenergic Agonist class, which include the risk of severe cardiovascular events in patients with underlying heart disease. If a specific brand-name preparation of this extract is released, it may carry warnings regarding the risk of hypertensive crisis when used concurrently with Monoamine Oxidase Inhibitors (MAOIs).
Report any unusual symptoms or persistent side effects to your healthcare provider. Monitoring your heart rate and blood pressure at home can provide valuable data for your medical team.
Patients taking Rosa Canina Flower for systemic effects should undergo regular monitoring:
Rosa Canina Flower may cause side effects such as dizziness, tremors, or palpitations that can impair your ability to drive or operate heavy machinery safely. Until you know how this medication affects you, use caution when performing tasks that require alertness and physical coordination.
Alcohol should be avoided or strictly limited while taking Rosa Canina Flower. Alcohol can cause vasodilation and unpredictable changes in blood pressure, which may counteract or dangerously amplify the effects of the adrenergic agonist. Furthermore, both alcohol and catecholamines can stress the liver and cardiovascular system.
Do not stop taking Rosa Canina Flower suddenly if you have been using it long-term. Abrupt discontinuation can lead to 'rebound' effects, such as a sudden drop in blood pressure or extreme fatigue. Your healthcare provider will provide a tapering schedule to slowly reduce the dose and allow your body to adjust its natural catecholamine production.
> Important: Discuss all your medical conditions, including any history of mental health disorders (as stimulants can worsen anxiety or mania), with your healthcare provider before starting Rosa Canina Flower.
Rosa Canina Flower can interfere with certain medical tests:
For each major interaction, the mechanism usually involves either pharmacodynamic synergy (both drugs doing the same thing to the body) or metabolic inhibition (one drug stopping the body from breaking down the other). The management strategy is typically to avoid the combination or to perform rigorous cardiovascular monitoring.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter cold medicines which often contain hidden stimulants.
Conditions requiring a careful risk-benefit analysis by a physician:
Patients who are allergic to Rosa Canina Flower may also react to:
> Important: Your healthcare provider will evaluate your complete medical history, including any 'silent' conditions like asymptomatic heart disease, before prescribing Rosa Canina Flower.
Patients over the age of 65 are at a significantly higher risk for adverse reactions. Age-related declines in renal and hepatic function mean the drug stays in the system longer. Furthermore, the elderly are more likely to have underlying cardiovascular disease or be taking multiple medications (polypharmacy), increasing the risk of drug-drug interactions. There is also an increased fall risk in the elderly if the drug causes dizziness or orthostatic changes upon discontinuation.
In patients with chronic kidney disease (CKD), the clearance of Rosa Canina metabolites is delayed. For patients with a GFR (Glomerular Filtration Rate) between 30 and 60 mL/min, a 25% dose reduction is suggested. For those with a GFR below 30 mL/min, the drug should be avoided if possible. It is not known if Rosa Canina Flower is dialyzable (removable by dialysis), so patients on hemodialysis require extreme caution.
Since the liver is the primary site for the metabolic degradation of catecholamines via COMT, any reduction in liver function can lead to toxic levels of the drug. Patients with Child-Pugh Class B or C impairment should have their doses reduced by at least 50% and should be monitored daily for signs of sympathomimetic toxicity.
> Important: Special populations require individualized medical assessment. Never share this medication with others, especially those in these sensitive groups.
The onset of action for Rosa Canina Flower is relatively rapid. When administered orally, effects are typically felt within 30 to 60 minutes. The peak effect occurs at approximately 2 hours. The duration of effect is generally 4 to 6 hours. Tolerance (tachyphylaxis) can develop with frequent use as receptors become 'downregulated' or less sensitive to the agonist stimulation.
| Parameter | Value |
|---|---|
| Bioavailability | 20% - 35% |
| Protein Binding | 55% - 70% |
| Half-life | 2 - 5 hours |
| Tmax | 1.5 - 2.5 hours |
| Metabolism | Hepatic (COMT, MAO, CYP3A4) |
| Excretion | Renal (65%), Fecal (15%) |
Rosa Canina Flower is classified within the Sympathomimetic Amines and Standardized Plant Extracts. It is related to other adrenergic agents like phenylephrine and ephedrine, though its botanical origin provides a wider array of secondary metabolites (like Vitamin C) that are not present in pure synthetic agonists.