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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Quatriderm Anti-itch
Generic Name
Hydrocortisone
Active Ingredient
HydrocortisoneCategory
Corticosteroid [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 1 g/100g | CREAM | TOPICAL | 69729-269 |
Detailed information about Quatriderm Anti-itch
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Quatriderm Anti-itch, you must consult a qualified healthcare professional.
Hydrocortisone is a corticosteroid medication used to treat a wide range of inflammatory, allergic, and autoimmune conditions, as well as adrenal insufficiency. It acts as a synthetic version of the hormone cortisol to regulate the body's immune response.
Dosage of hydrocortisone is highly individualized based on the specific disease being treated and the patient's response.
Hydrocortisone is approved for use in children, but dosing is usually calculated based on body surface area or weight rather than age alone.
Specific dose adjustments are not typically required for renal impairment, but patients should be monitored for fluid retention and electrolyte imbalances.
Since hydrocortisone is metabolized by the liver, patients with severe hepatic disease (e.g., cirrhosis) may experience increased drug levels. Dose reductions may be necessary to avoid toxicity.
Lower starting doses are often recommended for elderly patients due to a higher frequency of decreased hepatic or cardiac function and concomitant diseases or other drug therapies.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
Acute overdose with hydrocortisone rarely causes life-threatening symptoms. However, chronic overdose can lead to Cushingoid features (moon face, weight gain). In case of a massive acute ingestion, contact a poison control center or emergency services immediately.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking this medication without medical guidance, as sudden discontinuation can lead to a life-threatening adrenal crisis.
Most patients taking systemic hydrocortisone will experience some side effects, particularly with higher doses. These may include:
> Warning: Stop taking Hydrocortisone and call your doctor immediately if you experience any of these.
Prolonged use of hydrocortisone can lead to Cushing's Syndrome, characterized by a rounded "moon face," a fatty hump between the shoulders ("buffalo hump"), and central obesity. It can also cause permanent suppression of the Hypothalamic-Pituitary-Adrenal (HPA) axis, meaning the body stops producing its own cortisol.
There are currently no FDA black box warnings for hydrocortisone. However, the FDA mandates warnings regarding the risk of secondary infections and the necessity of tapering the dose after long-term use.
Report any unusual symptoms to your healthcare provider to ensure your treatment remains safe and effective.
Hydrocortisone is a potent medication that affects multiple organ systems. It should be used for the shortest duration possible at the lowest effective dose. Patients should carry a medical alert card or wear a bracelet indicating they are on corticosteroid therapy in case of emergencies.
No FDA black box warnings for Hydrocortisone.
Healthcare providers will typically monitor the following during long-term therapy:
Hydrocortisone does not usually affect the ability to drive; however, some patients experience dizziness or mood changes. Ensure you know how you react to the medication before operating heavy machinery.
Alcohol should be used with caution. Both alcohol and hydrocortisone can irritate the stomach lining, increasing the risk of peptic ulcers or gastrointestinal bleeding.
Never stop taking hydrocortisone abruptly if you have been taking it for more than a few weeks. Your doctor will provide a tapering schedule to gradually reduce the dose, allowing your adrenal glands to resume natural hormone production.
> Important: Discuss all your medical conditions, especially history of tuberculosis, herpes simplex, or peptic ulcers, with your healthcare provider before starting Hydrocortisone.
Hydrocortisone may produce false-negative results in the nitroblue tetrazolium test for systemic bacterial infection and may suppress skin test reactions (e.g., allergy tests or TB tests).
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter creams or vitamins.
Healthcare providers will perform a careful risk-benefit analysis in patients with:
Patients allergic to other corticosteroids (such as prednisone or dexamethasone) may also be allergic to hydrocortisone. Always inform your provider of any previous reactions to steroid medications.
> Important: Your healthcare provider will evaluate your complete medical history, including any dormant infections like tuberculosis, before prescribing Hydrocortisone.
Hydrocortisone is generally classified as Pregnancy Category C. While human data is limited, animal studies have shown an increased incidence of cleft palate when corticosteroids are administered during pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who received substantial doses of steroids during pregnancy should be carefully observed for signs of hypoadrenalism.
Hydrocortisone is excreted in human milk. While low doses are unlikely to harm the infant, high systemic doses could potentially suppress growth or interfere with endogenous corticosteroid production in the nursing child. Consult your doctor regarding the timing of doses to minimize infant exposure.
Hydrocortisone is FDA-approved for pediatric use in conditions like congenital adrenal hyperplasia and severe asthma. However, long-term use can cause growth suppression. Pediatricians must monitor height and weight frequently. Alternating-day therapy may be considered to minimize these effects.
Elderly patients are at a higher risk for side effects such as osteoporosis, hypertension, and diabetes. Healthcare providers typically start at the lowest end of the dosing range. There is also an increased risk of skin thinning and bruising in this population.
No specific dose adjustment is required based on GFR; however, the mineralocorticoid effects (sodium retention) may be more dangerous in patients with pre-existing kidney disease.
In patients with liver cirrhosis, the metabolism of hydrocortisone is slowed, leading to an increased clinical effect. Dose adjustments are often necessary to prevent Cushingoid side effects.
> Important: Special populations require individualized medical assessment and more frequent monitoring by a specialist.
Hydrocortisone is a short-acting corticosteroid. It diffuses across cell membranes and binds with high affinity to specific cytoplasmic receptors. This complex enters the nucleus, binds to DNA, and modifies gene expression. It inhibits the production of inflammatory mediators like prostaglandins and leukotrienes by inducing lipocortins, which inhibit phospholipase A2. Additionally, it suppresses the immune system by reducing the activity and volume of the lymphatic system.
Hydrocortisone has a 1:1 ratio of glucocorticoid to mineralocorticoid potency. This means it is effective at reducing inflammation but also has a significant effect on water and electrolyte balance compared to synthetic analogs like dexamethasone. The onset of action for oral hydrocortisone is roughly 1-2 hours, while intravenous forms act more rapidly.
| Parameter | Value |
|---|---|
| Bioavailability | >90% (Oral) |
| Protein Binding | 90% (CBG and Albumin) |
| Half-life | 1.5 - 2 hours |
| Tmax | 1 - 2 hours |
| Metabolism | Hepatic (primarily CYP3A4) |
| Excretion | Renal (90% as metabolites) |
Hydrocortisone is the prototype of the Glucocorticoid class. It is the standard against which the potency of all other synthetic corticosteroids is measured.
Common questions about Quatriderm Anti-itch
Hydrocortisone is primarily used to treat inflammation and immune system disorders, such as severe allergies, asthma, arthritis, and skin conditions. It is also the standard replacement therapy for people whose bodies do not produce enough natural cortisol, a condition known as Addison's disease or adrenal insufficiency. Because it mimics a natural hormone, it helps regulate metabolism, blood pressure, and the body's response to stress. Your doctor may also prescribe it for certain types of cancer, ulcerative colitis, or severe episodes of multiple sclerosis. Always use this medication only for the specific condition for which it was prescribed.
The most common side effects of systemic hydrocortisone include increased appetite, weight gain, insomnia, and mood changes such as irritability or anxiety. Some patients may also experience upset stomach, increased sweating, or mild dizziness. If you are using a topical form, common side effects include skin thinning, redness, or a burning sensation at the application site. Most mild side effects resolve as your body adjusts to the medication or when the dose is lowered. However, you should report any persistent or worsening symptoms to your healthcare provider immediately.
It is generally advised to limit or avoid alcohol consumption while taking oral hydrocortisone. Both alcohol and corticosteroids can irritate the lining of the stomach and intestines, and using them together significantly increases your risk of developing stomach ulcers or gastrointestinal bleeding. Additionally, alcohol can interfere with blood sugar management, which is already a concern with steroid use. If you have a history of liver issues, the combination can place extra stress on your hepatic system. Discuss your alcohol intake with your doctor to understand your specific risks.
Hydrocortisone is classified as Pregnancy Category C, meaning it should only be used if the potential benefits to the mother outweigh the potential risks to the fetus. Some studies in animals have suggested a link between steroid use in the first trimester and an increased risk of cleft palate, though human data is less conclusive. If used during pregnancy, the lowest effective dose is recommended, and the newborn should be monitored for signs of adrenal insufficiency. It is essential to have a detailed discussion with your obstetrician and endocrinologist if you are pregnant or planning to become pregnant while taking this medication.
The time it takes for hydrocortisone to work depends on the formulation and the condition being treated. For acute allergic reactions, an intravenous injection can begin working within minutes to an hour. Oral tablets typically reach peak levels in the blood within 1 to 2 hours, but it may take several days of consistent use to see a full reduction in chronic inflammation. Topical creams used for skin rashes often provide relief from itching within a few hours. Always follow the full course prescribed by your doctor, even if you begin to feel better quickly.
No, you should never stop taking hydrocortisone suddenly if you have been using it for more than two weeks. Long-term use causes your adrenal glands to stop producing natural cortisol, and stopping abruptly can lead to a life-threatening condition called an adrenal crisis. Symptoms of adrenal crisis include severe weakness, confusion, low blood pressure, and fainting. Your doctor will provide a tapering schedule to slowly lower your dose over weeks or months. This allows your body's natural hormone production to safely return to normal levels.
If you miss a dose of hydrocortisone, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing plan. You should never take two doses at the same time to make up for a missed one, as this can increase the risk of side effects. If you are taking hydrocortisone for adrenal insufficiency, missing doses is more critical, so you should contact your doctor for advice if you miss more than one dose. Keeping a medication log can help you stay on track.
Weight gain is a very common side effect of systemic hydrocortisone treatment, especially with long-term use or high doses. The medication can increase your appetite and cause the body to redistribute fat to the face, back of the neck, and abdomen. It also causes the body to retain sodium and water, which leads to fluid weight and bloating. To manage this, doctors often recommend a low-sodium, high-protein diet and regular physical activity. Weight usually returns to baseline once the medication is tapered and discontinued under medical supervision.
Hydrocortisone can interact with many other medications, so it is vital to provide your doctor with a complete list of what you are taking. It can reduce the effectiveness of blood thinners and diabetes medications, requiring dose adjustments for those drugs. Taking it with NSAIDs like ibuprofen increases your risk of stomach ulcers. Some antifungal and antibiotic medications can change how your body processes hydrocortisone, leading to either toxicity or reduced efficacy. Always check with a pharmacist before starting any new over-the-counter supplements or herbal remedies.
Yes, hydrocortisone is widely available as a generic medication in almost all its forms, including oral tablets, topical creams, and injections. Generic versions are typically much more affordable than brand-name versions like Cortef or Solu-Cortef and are required by the FDA to be bioequivalent. This means the generic version contains the same active ingredient and works in the same way as the brand-name drug. Most insurance plans prefer the generic version. You can discuss with your pharmacist which version is most cost-effective for your specific prescription.
Other drugs with the same active ingredient (Hydrocortisone)