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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Oxycodone Hydrochloride
Generic Name
Oxycodone Hydrochloride
Active Ingredient
OxycodoneCategory
Opioid Agonist [EPC]
Salt Form
Hydrochloride
Variants
117
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Oxycodone Hydrochloride, you must consult a qualified healthcare professional.
| 30 mg/1 | TABLET | ORAL | 71335-2816 |
| 15 mg/1 | TABLET | ORAL | 76420-758 |
| 5 mg/1 | TABLET | ORAL | 76420-897 |
| 5 mg/1 | TABLET | ORAL | 13107-055 |
| 30 mg/1 | TABLET | ORAL | 13107-057 |
| 30 mg/1 | TABLET | ORAL | 42806-008 |
| 5 mg/1 | TABLET | ORAL | 47781-263 |
| 15 mg/1 | TABLET | ORAL | 47781-264 |
| 5 mg/1 | TABLET | ORAL | 60760-954 |
+ 38 more variants
Detailed information about Oxycodone Hydrochloride
Oxycodone is a potent semi-synthetic opioid agonist prescribed for the management of severe pain. It works by altering the brain's perception of pain through specific receptors in the central nervous system.
Dosage for oxycodone must be highly individualized based on the patient's pain severity, prior opioid exposure, and individual response. Healthcare providers follow the principle of "start low and go slow" to minimize side effects.
Oxycodone use in children is generally restricted. The immediate-release formulations are sometimes used off-label in pediatric populations for severe post-operative pain under strict hospital supervision, often calculated by weight (e.g., 0.05 mg/kg to 0.15 mg/kg). The extended-release formulation (OxyContin) is FDA-approved only for opioid-tolerant children aged 11 years and older who have a condition requiring daily, long-term opioid treatment. Use in children younger than 11 for chronic pain is not recommended and has not been established as safe.
Because oxycodone is excreted by the kidneys, patients with reduced renal function (CrCl < 60 mL/min) may experience drug accumulation. Healthcare providers typically start these patients at 50% to 75% of the standard dose and monitor closely for signs of sedation or respiratory depression.
Since the liver metabolizes oxycodone, patients with hepatic insufficiency (liver failure) will have higher plasma concentrations. For patients with mild to moderate liver impairment, the starting dose should be reduced, and the interval between doses may be lengthened.
Older adults are more sensitive to the effects of opioids. Providers often start with the lowest possible dose (e.g., 2.5 mg to 5 mg) due to the increased risk of confusion, falls, and slowed breathing in this population.
If you miss a dose of immediate-release oxycodone, take it as soon as you remember, unless it is almost time for your next dose. For extended-release forms, if you miss a dose, skip it and return to your regular schedule. Never double the dose to make up for a missed one, as this significantly increases the risk of overdose.
An oxycodone overdose is a medical emergency. Signs include pinpoint pupils, extreme drowsiness, cold/clammy skin, limp muscles, and dangerously slow or stopped breathing. If an overdose is suspected, call 911 immediately. If available, administer Naloxone (Narcan) according to the package instructions. Naloxone is an opioid antagonist that can temporarily reverse the effects of the overdose while waiting for emergency responders.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Most patients taking oxycodone will experience at least one side effect. These are generally manageable but should be monitored:
Oxycodone is a high-alert medication. It must only be used by the person for whom it was prescribed. Sharing this medication with others is illegal and dangerous. Patients should be screened for a personal or family history of substance abuse before starting treatment. It is also essential to inform your doctor if you have a history of depression or other mental health conditions, as opioids can exacerbate these issues.
As detailed in the side effects section, the FDA mandates a Black Box Warning for oxycodone regarding its potential for addiction, fatal respiratory depression, and dangerous interactions with benzodiazepines and alcohol. These warnings emphasize that oxycodone should only be used when other non-opioid treatments are insufficient. The warning also highlights the risk of Neonatal Opioid Withdrawal Syndrome (NOWS) if used during pregnancy.
Oxycodone must NEVER be used in the following circumstances:
Oxycodone is traditionally classified as FDA Pregnancy Category C (under the old system). There are no adequate and well-controlled studies in pregnant women. However, prolonged use of oxycodone during pregnancy can result in Neonatal Opioid Withdrawal Syndrome (NOWS). This is a life-threatening condition for the newborn, characterized by irritability, hyperactivity, abnormal sleep patterns, high-pitched cry, tremors, vomiting, diarrhea, and failure to gain weight. Use during labor can also cause respiratory depression in the newborn. Oxycodone should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
Oxycodone is excreted in human milk. Low levels of oxycodone have been detected in the plasma of breastfed infants. There is a risk of sedation and respiratory depression in the nursing infant. If a breastfeeding mother must take oxycodone, the infant should be closely monitored for excessive sleepiness, difficulty breastfeeding, or limpness. Withdrawal symptoms can also occur in the infant when the mother stops taking the medication or stops breastfeeding.
Oxycodone is a semi-synthetic pure opioid agonist. Its primary therapeutic action is analgesia. It interacts predominantly with the mu-opioid receptors, which are coupled with G-protein receptors. By activating these receptors, oxycodone inhibits the release of neurotransmitters such as substance P, glutamate, and acetylcholine. This inhibition occurs at both the pre-synaptic and post-synaptic levels in the spinal cord and brain, effectively blocking the transmission of pain impulses to the cerebral cortex.
Oxycodone exerts its effects mainly on the central nervous system (CNS) and the smooth muscles. In addition to analgesia, it causes respiratory depression by direct action on brainstem respiratory centers. It also suppresses the cough reflex and causes miosis (pupillary constriction). In the digestive system, it decreases the motility of the stomach and intestines, leading to increased smooth muscle tone and constipation.
| Parameter | Value |
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Common questions about Oxycodone Hydrochloride
Oxycodone is a potent prescription medication used primarily to manage moderate to severe pain that cannot be controlled by non-opioid treatments. It is commonly prescribed for acute pain following major surgery or trauma, as well as for chronic pain associated with conditions like cancer. The medication works by changing how the brain and nervous system perceive and respond to pain signals. Because of its high potency and risk for addiction, it is typically reserved for cases where other pain relief options have failed. It is available in both immediate-release forms for breakthrough pain and extended-release forms for around-the-clock management.
The most frequent side effects experienced by patients taking oxycodone include constipation, nausea, sleepiness, and dizziness. Constipation is particularly common because opioids slow down the movement of the digestive tract; most doctors recommend a preventative bowel regimen. Nausea and vomiting often occur when first starting the drug but usually subside as the body builds a tolerance. Some patients also experience itching (pruritus) or dry mouth. While these are common, any side effect that becomes severe or persistent should be reported to a healthcare provider immediately.
No, you should never drink alcohol while taking oxycodone. Combining alcohol with opioids significantly increases the risk of life-threatening respiratory depression, which can lead to coma or death. Alcohol enhances the sedative effects of oxycodone, making you dangerously drowsy and slowing your breathing to critical levels. Additionally, for certain extended-release versions of oxycodone, alcohol can cause the medication to release into your system too quickly, a dangerous phenomenon known as 'dose dumping.' Always check with your pharmacist about hidden alcohol in over-the-counter medicines like cough syrups as well.
Oxycodone is generally not recommended during pregnancy unless the benefits clearly outweigh the risks, as determined by a doctor. Prolonged use of oxycodone during pregnancy can lead to Neonatal Opioid Withdrawal Syndrome (NOWS), where the baby is born addicted to the drug and requires specialized medical care. There is also a risk of respiratory depression in the newborn if the drug is taken close to the time of delivery. Women who are pregnant or planning to become pregnant should discuss alternative pain management strategies with their healthcare provider. If you find out you are pregnant while taking oxycodone, do not stop suddenly, but contact your doctor immediately for a safe tapering plan.
The time it takes for oxycodone to work depends on the formulation you are taking. Immediate-release (IR) tablets or solutions typically begin to provide pain relief within 15 to 30 minutes, with the peak effect occurring between 1 and 2 hours after ingestion. Extended-release (ER) formulations are designed to release the medication slowly over a 12-hour period, so they do not provide immediate relief for acute pain. Instead, ER versions are used to maintain a steady level of pain control throughout the day. Factors like your metabolism, weight, and whether you have eaten a high-fat meal can slightly alter these times.
You should never stop taking oxycodone suddenly if you have been using it consistently for more than a few days. Abruptly stopping the medication can trigger severe withdrawal symptoms, which include anxiety, intense muscle aches, sweating, chills, diarrhea, and insomnia. While opioid withdrawal is rarely life-threatening for healthy adults, it is extremely uncomfortable and can lead to complications. Your healthcare provider will help you safely discontinue the drug by gradually reducing your dose over several days or weeks. This process, known as tapering, allows your body to adjust to the absence of the drug slowly.
If you miss a dose of immediate-release oxycodone, take it as soon as you remember, provided it is not almost time for your next scheduled dose. If it is nearly time for the next dose, skip the missed one and continue with your regular schedule. For extended-release formulations, if you miss a dose, you should skip it entirely and wait for your next scheduled time. Never take two doses at once to make up for a missed one, as this can lead to a dangerous overdose. If you are unsure what to do, contact your pharmacist or doctor for specific guidance based on your prescription.
Weight gain is not a direct or common side effect of oxycodone, but it can occur indirectly. Some patients may experience fluid retention (edema), which can lead to a slight increase in weight. Additionally, because the drug causes sedation and drowsiness, patients may become less physically active, leading to weight gain over time. On the other hand, some patients experience nausea and a loss of appetite, which can lead to weight loss. If you notice significant or rapid changes in your weight while taking this medication, you should discuss them with your healthcare provider to rule out other underlying issues.
Oxycodone has many potentially dangerous drug interactions, so it must be used with caution alongside other medications. It is especially dangerous to combine it with other central nervous system depressants, such as benzodiazepines (like Valium or Xanax), muscle relaxants, or sleep aids. Certain antidepressants and antifungal medications can also change how your body processes oxycodone, leading to either reduced effectiveness or toxic levels in the blood. Always provide your doctor and pharmacist with a complete list of all medications, herbal supplements, and vitamins you are taking to ensure there are no harmful interactions.
Yes, oxycodone is available in several generic versions, which are typically more affordable than brand-name products like Roxicodone or OxyContin. Generic versions are required by the FDA to have the same active ingredient, strength, dosage form, and route of administration as the brand-name drug. They must also prove bioequivalence, meaning they work in the body the same way. Both immediate-release and extended-release versions have generic equivalents. When your doctor writes a prescription, you can ask if a generic version is available and appropriate for your specific treatment plan.
Other drugs with the same active ingredient (Oxycodone)
> Warning: Stop taking Oxycodone and call your doctor immediately if you experience any of these.
With prolonged use (months to years), oxycodone can cause lasting physiological changes:
The FDA has issued several "Black Box" warnings for oxycodone, the highest level of caution for prescription drugs:
Report any unusual symptoms to your healthcare provider.
Patients on long-term oxycodone therapy require regular monitoring:
Oxycodone causes significant impairment of mental and physical abilities. Do not drive a car, operate heavy machinery, or engage in potentially hazardous activities until you know how the medication affects you. Dizziness and sleepiness are most common during the first week of treatment.
Do not drink alcohol while taking oxycodone. Alcohol significantly increases the risk of life-threatening respiratory depression. Combining alcohol with extended-release oxycodone can cause "dose dumping," where the entire dose is released into the bloodstream at once, often leading to a fatal overdose.
Do not stop taking oxycodone suddenly if you have been using it for more than a few days. Abrupt discontinuation can lead to severe withdrawal symptoms, including anxiety, sweating, muscle aches, insomnia, diarrhea, and tremors. Your healthcare provider will provide a tapering schedule to slowly reduce the dose over time.
> Important: Discuss all your medical conditions with your healthcare provider before starting Oxycodone.
Oxycodone does not typically interfere with standard blood chemistry or hematology tests. However, it will show up on a standard 5-panel or 10-panel urine drug screen as an opiate. Specific "expanded" panels are often required to distinguish oxycodone from other opioids like morphine or codeine.
For each major interaction, the management strategy usually involves dose adjustment or increased monitoring by the healthcare provider.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
These conditions require a careful risk-benefit analysis by a physician:
Patients with a true anaphylactic allergy to codeine, morphine, or hydrocodone may experience a cross-allergic reaction to oxycodone, as they share a similar phenanthrene chemical structure. However, many "allergies" reported to codeine (like nausea) are side effects rather than true allergies. A specialist should evaluate true hypersensitivity.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Oxycodone.
In patients over 65, the clearance of oxycodone is reduced by approximately 15% to 20%. Older adults are at a much higher risk for confusion, delirium, and falls while taking oxycodone. Furthermore, the risk of respiratory depression is higher in the elderly, especially those with underlying lung disease. Starting doses should be conservative, usually 1/2 of the normal adult dose.
In patients with end-stage renal disease or significant impairment (GFR < 30 mL/min), the peak plasma concentration of oxycodone increases by about 50%. These patients require careful titration and frequent monitoring for signs of CNS toxicity.
In patients with hepatic cirrhosis, the half-life of oxycodone can increase to 14 hours or more (compared to the normal 3-4 hours). For patients with any degree of liver failure, the starting dose should be reduced by 50-66%, and the frequency of dosing should be decreased.
> Important: Special populations require individualized medical assessment.
| Protein Binding | 38% - 45% |
| Half-life | 3.2 hours (IR), 4.5 hours (ER) |
| Tmax | 1 - 2 hours (IR) |
| Metabolism | Hepatic (CYP3A4, CYP2D6) |
| Excretion | Renal (8% - 14% unchanged) |
The molecular formula for oxycodone hydrochloride is C18H21NO4•HCl. It has a molecular weight of 351.82 g/mol. It is a white, odorless crystalline powder that is soluble in water and slightly soluble in alcohol. Its structure is closely related to morphine and codeine but contains an additional hydroxyl group at the C14 position.
Oxycodone is classified as an Opioid Agonist. It belongs to the phenanthrene chemical class of opioids, which also includes morphine, codeine, and hydrocodone.