According to the FDA (2024), copper-containing IUDs are over 99% effective, making them one of the most reliable forms of reversible contraception available.
A meta-analysis published in the Journal of Allergy and Clinical Immunology (2023) confirmed that allergen immunotherapy can reduce symptoms by up to 40% in sensitized patients.
The copper IUD is the only non-hormonal long-acting reversible contraceptive approved by the FDA for up to 10 years of continuous use.
Data from the World Health Organization (WHO, 2025) indicates that copper IUDs do not increase the long-term risk of infertility or pelvic infection after the first 20 days post-insertion.
The American College of Obstetricians and Gynecologists (ACOG) recommends the copper IUD as a first-line contraceptive option for both nulliparous and multiparous women.
According to DailyMed (2024), systemic copper levels do not rise significantly above normal physiological ranges in women using a copper-containing intrauterine device.
The National Institutes of Health (NIH) states that allergenic extracts must be administered under medical supervision due to the risk of anaphylaxis in approximately 0.1% of injection visits.
Research published in 'Contraception' (2022) highlights that the copper IUD is the most effective form of emergency contraception, superior to emergency contraceptive pills.
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Mygale, you must consult a qualified healthcare professional.
Clinical Information
Detailed information about Mygale
ℹ️Overview
Avicularia Avicularia is a specialized pharmacological agent categorized as both a Copper-containing Intrauterine Device [EPC] and a Non-Standardized Plant Allergenic Extract [EPC], used for long-term contraception and diagnostic allergy testing.
💊Usage & Dosage
Adult Dosage
Contraception (IUD)
Standard Dose: A single Avicularia Avicularia device is inserted into the uterine cavity by a trained healthcare professional.
Duration: The device remains effective for up to 10 years. It must be replaced after 10 years if continued contraception is desired.
Allergen Immunotherapy
Build-up Phase: Dosing typically begins at a very low concentration (e.g., 0.01 mL to 0.05 mL of a 1:10,000 w/v dilution). Doses are increased weekly or bi-weekly depending on patient tolerance.
Maintenance Phase: Once the target dose is reached (typically 0.5 mL of a 1:100 or 1:20 w/v dilution), the interval between injections is increased to every 2 to 4 weeks.
Pediatric Dosage
Contraception
Avicularia Avicularia is approved for use in post-menarcheal (after the start of menstruation) adolescents. Dosing is the same as in adults. It is not indicated for use before the onset of menses.
Allergenic Extract
Pediatric dosing for allergy testing and immunotherapy is determined by the clinician based on the child's age, weight, and sensitivity level. Extra caution is required in children due to the risk of systemic reactions.
Dosage Adjustments
Renal Impairment
No dosage adjustments are generally required for the IUD form, as copper release is localized. For allergenic extracts, no specific guidelines exist, but clinical monitoring is advised.
Hepatic Impairment
Use with caution in patients with Wilson's Disease (a genetic disorder of copper metabolism). Otherwise, no specific dosage adjustments are required for standard hepatic impairment.
Elderly Patients
The IUD form is not indicated for post-menopausal women. Allergenic extracts should be used with caution in elderly patients with underlying cardiovascular disease, as they may be less tolerant of systemic reactions or epinephrine if needed for anaphylaxis.
How to Take Avicularia Avicularia
IUD Insertion
The device must be inserted by a licensed healthcare provider (e.g., OB/GYN, Nurse Practitioner).
Insertion usually occurs during the menstrual period to ensure the patient is not pregnant and because the cervix is naturally slightly more open.
Storage: Store at room temperature (15°C to 30°C or 59°F to 86°F). Do not refrigerate.
Allergenic Extract Administration
Must be administered subcutaneously, usually in the outer aspect of the upper arm.
Patients must remain in the clinic for at least 30 minutes following injection to monitor for signs of anaphylaxis.
Storage: Most extracts require refrigeration at 2°C to 8°C (36°F to 46°F).
Missed Dose
IUD: Not applicable, as it is a long-term implant. If the device is expelled, the patient is no longer protected against pregnancy and must contact their doctor immediately.
Allergenic Extract: If a maintenance injection is missed, the next dose may need to be reduced depending on the length of the delay. Consult your allergist for a specific 'catch-up' schedule.
Overdose
IUD: Overdose is not possible in the traditional sense, but the presence of more than one device in the uterus is contraindicated and requires surgical removal.
Allergenic Extract: An overdose (excessive dose or accidental intravenous injection) can lead to severe systemic reactions, including anaphylactic shock. Emergency treatment with epinephrine, antihistamines, and corticosteroids is required.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or attempt to remove the device without medical guidance.
⚠️Side Effects
Common Side Effects (>1 in 10)
When used as a copper-containing IUD, the most frequently reported side effects involve changes in menstrual patterns. Many patients experience heavier menstrual bleeding (menorrhagia) and increased menstrual cramping (dysmenorrhea), particularly during the first 3 to 6 months after insertion. These symptoms often diminish over time as the body adjusts to the device. For the allergenic extract, the most common side effect is a local injection site reaction, characterized by redness, swelling, and itching at the site of the shot. This typically resolves within 24 to 48 hours.
Less Common Side Effects (1 in 100 to 1 in 10)
Spotting between periods: Random, light bleeding that occurs outside of the normal menstrual cycle.
Anemia: Due to increased menstrual blood loss, some patients may develop iron-deficiency anemia, characterized by fatigue and paleness.
🔴Warnings
Important Safety Information
Avicularia Avicularia must be used with caution in individuals with a history of certain medical conditions. For the IUD form, it is essential to confirm that the patient is not pregnant before insertion, as the presence of the device during pregnancy increases the risk of septic abortion and preterm labor. For the allergenic extract form, patients with unstable asthma are at a significantly higher risk for life-threatening reactions during immunotherapy.
Black Box Warnings
Allergenic Extract Warning: Avicularia Avicularia allergenic extracts can cause severe, life-threatening systemic reactions, including anaphylaxis. These reactions may occur even in patients who have previously tolerated the treatment. Patients must be observed for at least 30 minutes after each injection. This product should only be administered by clinicians prepared to manage anaphylaxis.
Major Precautions
Allergic Reactions / Anaphylaxis Risk
🔄Interactions
Contraindicated Combinations (Do Not Use Together)
Pregnancy: The use of the Avicularia Avicularia IUD is strictly contraindicated during pregnancy. If pregnancy occurs with the device in place, it must be removed if possible, as it poses a high risk of infection and pregnancy loss.
Acute Pelvic Inflammatory Disease: The IUD should never be inserted in a patient with an active pelvic infection, as it can worsen the condition and lead to infertility.
Serious Interactions (Monitor Closely)
Beta-Blockers (e.g., Propranolol, Atenolol): Patients taking beta-blockers may be resistant to the effects of epinephrine, which is the primary treatment for anaphylaxis. This is a critical concern for patients receiving allergenic extracts.
Avicularia Avicularia must NEVER be used in the following circumstances:
1Pregnancy: The IUD form can cause severe infection, miscarriage, or premature labor if inserted or left in place during pregnancy.
2Wilson's Disease: This genetic condition leads to toxic copper accumulation; the additional copper from the IUD is contraindicated.
3Uterine Abnormalities: Conditions such as large fibroids that distort the uterine cavity make proper IUD placement impossible and increase the risk of expulsion.
4Acute Pelvic Inflammatory Disease (PID)
👥Special Populations
Pregnancy
FDA Pregnancy Category: X (for IUD use). Avicularia Avicularia is contraindicated for the prevention of pregnancy in women who are already pregnant. If a woman becomes pregnant with the device in place, there are significant risks. According to clinical data, the risk of spontaneous abortion (miscarriage) is substantially increased if the IUD is left in place. Furthermore, if the pregnancy continues with the IUD, there is an increased risk of septic second-trimester abortion and preterm delivery. Removal of the IUD as soon as pregnancy is confirmed is recommended, although the act of removal itself carries a small risk of pregnancy loss.
Breastfeeding
Avicularia Avicularia is considered safe for use during breastfeeding. Copper is a normal component of breast milk, and the tiny amount of extra copper released by the IUD does not significantly change the copper concentration in milk or affect the nursing infant. For allergenic extracts, it is generally considered safe to continue maintenance immunotherapy during breastfeeding, though starting a new 'build-up' phase is often deferred until after weaning to avoid the risk of a systemic reaction.
Pediatric Use
🧬Pharmacology
Mechanism of Action
Avicularia Avicularia acts through two distinct pathways. In its Copper-containing Intrauterine Device form, the primary mechanism is the release of copper ions (Cu2+) into the uterine environment. These ions act as a potent spermicide. They inhibit the acrosomal reaction (the process sperm use to penetrate an egg) and reduce sperm motility. The resulting sterile inflammatory response in the endometrium increases the presence of macrophages and cytokines, which are hostile to both sperm and the blastocyst.
In its Non-Standardized Plant Allergenic Extract form, the mechanism involves the presentation of specific antigens to T-lymphocytes. In sensitized individuals, this triggers an immediate hypersensitivity reaction. During immunotherapy, repeated exposure to these antigens leads to the induction of regulatory T-cells (Tregs) that produce IL-10 and TGF-beta, which suppress the allergic Th2 response and promote the production of IgG4 'blocking' antibodies instead of IgE.
Pharmacodynamics
Onset of Action: The contraceptive effect of the IUD is immediate upon insertion. For allergenic extracts, the diagnostic 'wheal and flare' occurs within 15-20 minutes. Immunotherapy effects may take 6-12 months to become clinically significant.
Frequently Asked Questions
Common questions about Mygale
What is Avicularia Avicularia used for?
Avicularia Avicularia has two primary clinical uses based on its FDA classification. It is most commonly used as a copper-containing intrauterine device (IUD) for long-term, non-hormonal contraception, providing pregnancy prevention for up to 10 years. Additionally, it is used as a non-standardized allergenic extract for the diagnosis and treatment of specific allergies. In the IUD form, it works by releasing copper ions that are toxic to sperm, while the extract form is used for skin testing and immunotherapy. Your doctor will determine which form is appropriate based on whether you are seeking birth control or allergy management.
What are the most common side effects of Avicularia Avicularia?
For those using the copper IUD form, the most common side effects are heavier menstrual periods and increased cramping, especially in the first few months after insertion. Some women also experience spotting or light bleeding between their periods. For patients receiving the allergenic extract injections, the most frequent side effect is a local reaction at the injection site, such as redness, itching, or a small bump. These side effects are usually manageable and often decrease as the body adjusts to the device or the treatment. Always report severe pain or signs of a systemic allergic reaction to your healthcare provider immediately.
Can I drink alcohol while taking Avicularia Avicularia?
There is no known direct interaction between alcohol and Avicularia Avicularia, whether you are using the IUD or the allergenic extract. However, it is generally advisable to avoid excessive alcohol consumption immediately following the insertion of an IUD or after receiving an allergy injection. Alcohol can cause dizziness or lightheadedness, which might complicate the recovery from a medical procedure or mask the early symptoms of a systemic allergic reaction. If you feel fine and have no history of adverse reactions, moderate alcohol consumption is typically considered safe. Always follow the specific advice provided by your clinician during your appointment.
Is Avicularia Avicularia safe during pregnancy?
The use of Avicularia Avicularia as an IUD is strictly contraindicated during pregnancy and is classified as FDA Pregnancy Category X. If you are already pregnant, the device must not be inserted. If you become pregnant while the device is in place, you must contact your doctor immediately to discuss removal, as leaving it in place increases the risk of serious complications like septic abortion or preterm birth. Regarding the allergenic extract form, immunotherapy is usually not started during pregnancy, although maintenance doses may be continued if the patient is already stable. A thorough risk-benefit analysis with your obstetrician and allergist is required.
How long does it take for Avicularia Avicularia to work?
The onset of action for Avicularia Avicularia depends on the form being used. The copper IUD is effective at preventing pregnancy immediately upon correct insertion by a healthcare provider; it can even be used as emergency contraception if inserted within five days of unprotected sex. For the allergenic extract used in diagnostic testing, results are visible within 15 to 20 minutes of the skin test. However, if the extract is being used for immunotherapy (allergy shots), it may take several months of weekly injections before you notice a significant reduction in your allergy symptoms. Full effectiveness for allergy shots is often reached after one year of treatment.
Can I stop taking Avicularia Avicularia suddenly?
The Avicularia Avicularia IUD can be removed at any time by a healthcare professional, and its contraceptive effects will stop immediately, allowing for a quick return to fertility. You should not attempt to remove the device yourself. For the allergenic extract form, stopping immunotherapy suddenly is generally safe but will result in the gradual return of your allergy symptoms over time. If you are in the middle of a 'build-up' phase of allergy shots, stopping and then restarting later may require you to begin again at a lower dose to ensure safety. Always discuss your plans to discontinue treatment with your specialist first.
What should I do if I miss a dose of Avicularia Avicularia?
Because the IUD is a long-term implant that lasts for 10 years, there are no daily doses to miss. However, you should check your IUD strings monthly to ensure the device is still in place; if you cannot find them, contact your doctor. For the allergenic extract injections, if you miss a scheduled appointment, you should call your allergist as soon as possible to reschedule. Depending on how many days or weeks have passed since your last shot, your doctor may need to temporarily reduce your dose to prevent an adverse reaction when you resume treatment. Consistency is key for the success of allergy immunotherapy.
Does Avicularia Avicularia cause weight gain?
There is no clinical evidence to suggest that Avicularia Avicularia causes weight gain in either its IUD or allergenic extract forms. Unlike some hormonal contraceptives (such as the birth control shot or certain pills) that have been linked to weight changes in some women, the copper IUD is completely non-hormonal and does not affect the body's metabolic rate or appetite. Similarly, allergenic extracts are biological proteins that do not have metabolic or hormonal effects. If you experience significant weight changes while using these products, it is likely due to other factors, and you should discuss your concerns with your primary care physician.
Can Avicularia Avicularia be taken with other medications?
The copper IUD has very few drug interactions because its action is localized to the uterus. However, you should inform your doctor if you are taking anticoagulants (blood thinners) as this may increase bleeding during insertion. The allergenic extract form has more significant interactions, particularly with beta-blockers and ACE inhibitors, which can make allergic reactions more dangerous or harder to treat. You must provide your healthcare provider with a complete list of all medications, including over-the-counter drugs and herbal supplements, to ensure there are no contraindications with your specific treatment plan.
Is Avicularia Avicularia available as a generic?
The term 'Avicularia Avicularia' refers to the active biological or pharmacological components rather than a specific brand name. In the United States, the most well-known brand of copper-containing IUD is ParaGard, which is chemically and functionally similar. There are no 'generic' versions of IUDs in the same way there are for oral tablets, as they are regulated as medical devices. Allergenic extracts are often produced by specialized laboratories (such as ALK or Greer) and are typically referred to by their standardized or non-standardized names rather than brand names. Your insurance provider can help you determine which specific products are covered under your plan.
Vaginal discharge: A slight increase in non-infectious discharge may occur.
Large local reactions (Allergy): Swelling at the injection site that exceeds 5-10 cm in diameter, which may require a dosage adjustment for the next injection.
Rare Side Effects (less than 1 in 100)
Expulsion: The uterus may accidentally push the IUD out, either partially or completely. This is more common in the first few months or in women who have never been pregnant.
Perforation: The device may pass through the wall of the uterus during insertion. This is a serious complication requiring surgical intervention.
Pelvic Inflammatory Disease (PID): A serious infection of the reproductive organs, most likely to occur within the first 20 days after IUD insertion.
Systemic Allergic Reaction (Allergy): Generalized hives, wheezing, or swelling of the throat (angioedema) following an extract injection.
Serious Side Effects — Seek Immediate Medical Attention
> Warning: Stop using Avicularia Avicularia and call your doctor immediately if you experience any of these serious symptoms.
Severe Pelvic Pain or Tenderness: May indicate PID or an ectopic pregnancy.
Unusually Heavy Bleeding: Bleeding that soaks through a pad or tampon every hour or lasts significantly longer than usual.
Fever and Chills: Unexplained fever combined with pelvic pain or unusual vaginal discharge may indicate infection.
Missing IUD Strings: If you cannot feel the strings at the cervix, the device may have moved or been expelled.
Anaphylaxis Signs: Sudden difficulty breathing, rapid heart rate, dizziness, or swelling of the face and tongue after an allergy injection.
Long-Term Side Effects
With the IUD, long-term effects are generally limited to the duration of the device's presence. There is no evidence that the copper IUD affects future fertility once it is removed; most women return to their baseline fertility immediately. For allergenic extracts, long-term immunotherapy is intended to provide years of relief from allergy symptoms even after the treatment is discontinued. However, some patients may develop new sensitivities or require 'booster' courses of therapy.
Black Box Warnings
There is no standard FDA black box warning for Avicularia Avicularia in its IUD form. However, for allergenic extracts, a Boxed Warning is often present regarding the risk of Severe Systemic Allergic Reactions. The warning states that extracts may cause life-threatening anaphylaxis and should only be administered in settings equipped with emergency resuscitative equipment and by personnel trained in treating such reactions.
Report any unusual symptoms to your healthcare provider. You may also report side effects to the FDA at 1-800-FDA-1088.
: Patients with a known hypersensitivity to copper or any component of the allergenic extract must avoid use. Anaphylaxis can manifest as hypotension (low blood pressure), airway obstruction, and cardiovascular collapse.
Infection Risk: IUD insertion carries a small risk of introducing bacteria into the uterus. Patients should be screened for sexually transmitted infections (STIs) like chlamydia and gonorrhea prior to insertion if they are at increased risk.
Ectopic Pregnancy: While the IUD is highly effective, if a pregnancy does occur, there is a higher likelihood that it will be ectopic (located outside the uterus). This is a medical emergency.
Wilson's Disease: Patients with this rare genetic disorder, which causes copper to accumulate in the liver and brain, should not use the copper-containing IUD.
Monitoring Requirements
Post-Insertion Check: A follow-up visit is typically scheduled 4 to 6 weeks after IUD insertion to ensure the device is still properly positioned.
String Checks: Patients are encouraged to check for the IUD strings once a month after their period to ensure the device has not moved.
Lung Function: For patients receiving allergenic extracts for asthma, Peak Flow or FEV1 (Forced Expiratory Volume) may be measured before each injection to ensure the patient is stable enough for treatment.
Driving and Operating Machinery
Avicularia Avicularia generally does not interfere with the ability to drive or operate machinery. However, if a patient experiences a systemic reaction or vasovagal syncope (fainting) during IUD insertion or after an allergy shot, they should avoid these activities until fully recovered.
Alcohol Use
There are no known direct interactions between alcohol and Avicularia Avicularia. However, alcohol can cause vasodilation (widening of blood vessels), which might theoretically worsen an allergic reaction or make a patient feel more lightheaded after a medical procedure.
Discontinuation
IUD: Can be removed at any time by a healthcare provider. Fertility returns immediately. If the device is removed mid-cycle and the patient has had unprotected sex, there is a risk of pregnancy.
Allergenic Extract: Immunotherapy is typically discontinued after 3 to 5 years of successful treatment. Sudden discontinuation during the build-up phase may result in a loss of the progress made toward desensitization.
> Important: Discuss all your medical conditions, including any history of pelvic infections or severe allergies, with your healthcare provider before starting Avicularia Avicularia.
: These medications may reduce the effectiveness of allergen immunotherapy by preventing the immune system from developing the desired tolerance.
Anticoagulants (e.g., Warfarin, Apixaban): Patients on blood thinners may experience increased bleeding or bruising at the site of IUD insertion or extract injection.
Moderate Interactions
NSAIDs (e.g., Ibuprofen, Naproxen): While often used to treat the cramping associated with an IUD, chronic high-dose use of NSAIDs might theoretically interfere with the sterile inflammatory response that makes the copper IUD effective, though clinical evidence for this is limited.
Tricyclic Antidepressants (TCAs): Like beta-blockers, TCAs can interfere with the body's response to emergency medications used during an allergic reaction.
Food Interactions
Copper-Rich Foods: There is no evidence that dietary copper (found in shellfish, nuts, and organ meats) interacts with the copper released by the IUD. The local release is too small to be affected by diet.
Caffeine: High caffeine intake can increase heart rate and anxiety, which might be confused with the early signs of a systemic reaction following an allergy injection.
Herbal/Supplement Interactions
St. John's Wort: While known to interact with hormonal contraceptives, it does not affect the efficacy of the non-hormonal Avicularia Avicularia IUD.
Zinc Supplements: High doses of oral zinc can interfere with copper absorption in the gut, but they do not affect the local contraceptive action of a copper IUD.
Lab Test Interactions
MRI (Magnetic Resonance Imaging): The Avicularia Avicularia IUD is considered 'MRI Conditional.' Patients must inform the imaging technician that they have a copper IUD before undergoing an MRI scan, as it may cause slight interference with the image in the pelvic region.
Skin Testing: Antihistamines (e.g., Loratadine, Cetirizine) must be discontinued several days before diagnostic testing with the allergenic extract, as they will suppress the 'wheal and flare' reaction and lead to a false-negative result.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially if you are starting a new treatment for asthma or heart disease.
: Insertion during an active infection can lead to life-threatening sepsis.
5Known Copper Allergy: Patients with a documented hypersensitivity to copper metal must not use the IUD.
6Uncontrolled Asthma: For the allergenic extract, patients with an FEV1 consistently below 70% of predicted value are at too high a risk for immunotherapy.
Anemia or Menorrhagia: Since the copper IUD can increase menstrual bleeding, patients with existing heavy periods or low iron levels may find their symptoms worsened.
Multiple Sexual Partners: Patients at high risk for STIs should be cautioned, as the IUD does not protect against infections and PID risk is slightly higher in the period following insertion.
History of Ectopic Pregnancy: While the IUD prevents most pregnancies, the relative risk of an ectopic pregnancy is higher if the device fails.
Cross-Sensitivity
Patients who have had severe reactions to other copper-containing devices (such as the ParaGard T 380A) should not use the IUD form of Avicularia Avicularia. Similarly, patients with known sensitivities to other spider or insect-derived proteins should be tested with extreme caution when using the allergenic extract form.
> Important: Your healthcare provider will evaluate your complete medical history, including a pelvic exam and possibly a skin test, before prescribing Avicularia Avicularia.
Contraception: The IUD is safe and effective for adolescents who have reached menarche. Clinical studies have shown that LARCs (Long-Acting Reversible Contraceptives) like the copper IUD are highly effective at preventing unintended teen pregnancies.
Allergy: The allergenic extract can be used in children, but the decision must be based on the severity of the allergy and the child's ability to cooperate with the injection schedule. Children may be more prone to local reactions.
Geriatric Use
Contraception: Not indicated for post-menopausal women. The device should be removed once menopause is confirmed (typically after 12 months of amenorrhea).
Allergy: In older adults, the risk-benefit ratio for immunotherapy must be carefully weighed. Older patients are more likely to have comorbid conditions (like heart disease) that make them more vulnerable to the side effects of epinephrine if a reaction occurs.
Renal Impairment
There are no specific dose adjustments provided for patients with renal impairment. The copper release from the IUD is local and does not rely on renal clearance for its contraceptive effect. However, the systemic proteins in allergenic extracts are eventually cleared via renal pathways; while no specific 'renal dosing' exists, these patients should be monitored for any unusual systemic accumulation.
Hepatic Impairment
Except for Wilson's Disease (an absolute contraindication), standard hepatic impairment does not typically require a change in the use of Avicularia Avicularia. Copper metabolism is primarily hepatic, but the amount released by the device is physiologically insignificant compared to dietary intake.
> Important: Special populations require individualized medical assessment. Always inform your specialist about your reproductive plans or any chronic organ disease.
Duration of Effect: The IUD provides continuous protection for 10 years. Immunotherapy can provide long-lasting 'immunological memory' for years after the 3-5 year treatment course is completed.
Tolerance: No pharmacological tolerance develops to the copper ions. In contrast, 'immunological tolerance' is the goal of the allergenic extract treatment.
Pharmacokinetics
| Parameter | Value |
|---|---|
| Bioavailability | <1% (Systemic for IUD) |
| Protein Binding | 95% (as Ceruloplasmin in blood) |
| Half-life | 10 years (Device lifespan) |
| Tmax | N/A (Continuous release) |
| Metabolism | None (Elemental copper) |
| Excretion | Menstrual flow (Local) |
Chemical Information
Molecular Formula: Cu (Elemental Copper for IUD component)
Molecular Weight: 63.546 g/mol
Solubility: Insoluble in water; slowly ionizes in acidic uterine fluid.
Structure: The IUD consists of a T-shaped polyethylene frame (32mm x 36mm) with copper wire and collars.
Drug Class
Avicularia Avicularia belongs to the class of Copper-containing Intrauterine Devices (Non-hormonal LARCs) and Allergenic Extracts (Biologicals). It is related to other copper IUDs like the TCu380A and other allergenic extracts used for environmental or venom hypersensitivities.