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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Metoclopramide
Generic Name
Metoclopramide
Active Ingredient
MetoclopramideCategory
Other
Salt Form
Hydrochloride
Variants
54
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 5 mg/1 | TABLET | ORAL | 71335-1259 |
| 5 mg/5mL | SOLUTION | ORAL | 17856-1190 |
| 5 mg/1 | TABLET | ORAL | 51079-886 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Metoclopramide, you must consult a qualified healthcare professional.
| 5 mg/1 | TABLET | ORAL | 62559-295 |
| 10 mg/1 | TABLET | ORAL | 68788-7930 |
| 5 mg/1 | TABLET | ORAL | 63187-404 |
| 10 mg/1 | TABLET | ORAL | 70518-1193 |
| 10 mg/1 | TABLET | ORAL | 70518-4541 |
| 5 mg/mL | INJECTION, SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 71872-7346 |
| 5 mg/mL | INJECTION, SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 0409-3414 |
| 10 mg/1 | TABLET | ORAL | 50228-233 |
| 10 mg/1 | TABLET | ORAL | 51079-888 |
+ 38 more variants
Detailed information about Metoclopramide
Metoclopramide is a potent dopamine-2 receptor antagonist and prokinetic agent used to treat gastroesophageal reflux disease (GERD) and diabetic gastroparesis by enhancing gastric motility.
Dosage for metoclopramide must be carefully individualized by a healthcare professional. The general guidelines for adults are as follows:
Metoclopramide is not generally recommended for use in pediatric patients due to an increased risk of extrapyramidal symptoms (involuntary muscle movements) and tardive dyskinesia. However, in specific clinical circumstances, a specialist may prescribe it. Dosing is strictly weight-based (typically 0.1 mg/kg to 0.15 mg/kg per dose). Use in neonates is contraindicated due to the risk of methemoglobinemia (a blood disorder).
Because metoclopramide is primarily cleared by the kidneys, patients with reduced kidney function are at a higher risk of drug accumulation and toxicity. For patients with a Creatinine Clearance (CrCl) below 60 mL/min, healthcare providers typically reduce the dose by 50%. Patients on dialysis may also require significant dose adjustments as the drug is not efficiently removed by hemodialysis.
While the liver metabolizes metoclopramide, the impact of liver disease on its clearance is less pronounced than renal disease. However, in cases of severe hepatic impairment (Child-Pugh Class C), doctors may monitor patients more closely for side effects and adjust doses as necessary.
Older adults are at a significantly higher risk for developing tardive dyskinesia and Parkinsonian-like symptoms. Clinical guidelines suggest starting at the lowest possible dose (e.g., 5 mg) and avoiding long-term use in this population.
To ensure maximum efficacy and safety, follow these administration guidelines:
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose (i.e., your next meal), skip the missed dose and resume your regular schedule. Do not 'double up' or take two doses at once to make up for a missed one, as this increases the risk of acute muscle reactions.
An overdose of metoclopramide can be life-threatening. Symptoms of overdose include:
In the event of a suspected overdose, seek emergency medical attention or contact a Poison Control Center immediately. Treatment usually involves supportive care and the administration of anticholinergic drugs (like diphenhydramine) to reverse muscle spasms.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance. Long-term use (over 12 weeks) is strictly discouraged.
Many patients taking metoclopramide experience mild to moderate side effects as the body adjusts to the medication. These often include:
Metoclopramide is a potent medication that requires careful medical supervision. It is not a simple 'stomach medicine' but a drug that significantly impacts the central nervous system. Patients must be screened for history of movement disorders, mental health conditions, and kidney function before starting therapy.
Metoclopramide can cause tardive dyskinesia (TD), a serious movement disorder that is often irreversible. The risk of developing TD increases with the duration of treatment and the total cumulative dose. For this reason, metoclopramide should be used for the shortest duration possible, usually not exceeding 12 weeks. Elderly patients, especially older women, are at the highest risk. If symptoms of TD appear (such as involuntary lip-smacking, tongue protrusion, or rapid limb movements), the drug must be discontinued immediately under medical supervision.
Certain medications should never be taken with metoclopramide due to the risk of severe adverse reactions:
Metoclopramide must NEVER be used in the following situations:
Metoclopramide is generally classified as FDA Pregnancy Category B. This means that animal studies have failed to demonstrate a risk to the fetus, and there are no adequate, well-controlled studies in pregnant women. It is frequently used off-label for severe pregnancy-related nausea (hyperemesis gravidarum) when other treatments fail. However, it should only be used during pregnancy if clearly needed. Use in the third trimester may theoretically pose a risk of extrapyramidal symptoms in the newborn, though data is limited.
Metoclopramide is excreted into breast milk. While it has been used to increase milk supply (by raising prolactin), this is not an FDA-approved use. The drug can cause side effects in the nursing infant, such as jitteriness or sedation. Most clinical guidelines suggest that the risk to the infant and the mother (specifically the risk of postpartum depression) often outweighs the benefits of using it for lactation stimulation.
Metoclopramide is not FDA-approved for use in pediatric patients for GERD or gastroparesis. Children are at a much higher risk for developing acute dystonic reactions (muscle spasms). If used in a hospital setting for chemotherapy-induced nausea, dosing must be extremely precise and monitored by a pediatric specialist. It is strictly contraindicated in neonates due to the risk of methemoglobinemia.
Metoclopramide is a substituted benzamide that functions as a potent Dopamine-2 (D2) receptor antagonist. In the periphery (the gut), it blocks D2 receptors on enteric neurons, which normally inhibit acetylcholine release. By removing this 'brake,' it increases the release of acetylcholine, leading to enhanced gastric smooth muscle contraction. Centrally, it crosses the blood-brain barrier to block D2 receptors in the Chemoreceptor Trigger Zone (CTZ) of the medulla, providing its anti-emetic effect. It also possesses 5-HT4 agonistic activity (further stimulating motility) and 5-HT3 antagonistic activity at high concentrations.
Common questions about Metoclopramide
Metoclopramide is primarily used to treat gastroesophageal reflux disease (GERD) and diabetic gastroparesis, a condition where the stomach empties too slowly. It works as a prokinetic agent, meaning it enhances the contractions of the stomach and intestines to move food along more quickly. Additionally, it is used in clinical settings to prevent nausea and vomiting caused by surgery or chemotherapy. Because it blocks dopamine receptors in the brain's vomiting center, it is a highly effective anti-emetic. It is generally intended for short-term use, typically not exceeding 12 weeks of treatment.
The most common side effects of metoclopramide include significant drowsiness, fatigue, and restlessness. Many patients report a feeling of 'inner jitters' or an inability to sit still, known as akathisia. Other frequent issues include dizziness, headache, and diarrhea due to the increased speed of digestion. Because the drug affects dopamine, it can also cause hormonal changes leading to breast tenderness or discharge in both men and women. While many of these effects are mild, they can be bothersome enough to require a dose adjustment by a healthcare provider.
No, you should strictly avoid drinking alcohol while taking metoclopramide. Alcohol significantly increases the sedative effects of the medication, which can lead to extreme drowsiness, impaired coordination, and a higher risk of accidents. Furthermore, metoclopramide speeds up the rate at which the stomach empties into the small intestine. Since alcohol is absorbed primarily in the small intestine, taking it with metoclopramide can cause your blood alcohol levels to rise much faster than usual, leading to rapid and unpredictable intoxication. Always consult your doctor about lifestyle restrictions while on this medication.
Metoclopramide is often used during pregnancy to treat severe nausea and vomiting (hyperemesis gravidarum) when other first-line treatments have failed. It is classified as Category B, meaning there is no evidence of harm to the fetus in animal studies, but human data is somewhat limited. While it is generally considered one of the safer options for severe morning sickness, it should only be used under the strict supervision of an obstetrician. There is a theoretical risk of the baby having temporary muscle tremors if the mother takes the drug near the time of delivery. Your doctor will weigh the benefits of controlling severe vomiting against these potential risks.
The time it takes for metoclopramide to work depends on the formulation and the symptom being treated. When taken orally, the drug typically begins to work within 30 to 60 minutes, which is why it is usually taken 30 minutes before a meal. If administered by intramuscular injection, it works in about 10 to 15 minutes, and an intravenous dose can work in as little as 1 to 3 minutes. For chronic conditions like gastroparesis, it may take a few days of consistent dosing to feel the full therapeutic benefit. Always follow the specific timing instructions provided by your pharmacist.
You should not stop taking metoclopramide suddenly if you have been using it for more than a few weeks. Abrupt discontinuation can sometimes lead to 'withdrawal' symptoms, which may include dizziness, nervousness, headache, and a return of severe nausea. If you have been on the medication for an extended period, your healthcare provider will likely suggest a tapering schedule to gradually lower your dose. This helps your body and brain adjust to the changing dopamine levels. Always talk to your doctor before making any changes to how you take your prescribed medication.
If you miss a dose of metoclopramide, take it as soon as you remember, provided it is not too close to your next scheduled dose. If it is almost time for your next meal and next dose, simply skip the missed one and continue with your regular schedule. Never take two doses at the same time to make up for a missed one, as this significantly increases the risk of acute muscle spasms or severe drowsiness. Since the drug is most effective when taken before meals, missing the 'pre-meal' window may reduce its effectiveness for that specific meal. Consistency is key for managing motility disorders.
Metoclopramide is not typically associated with direct weight gain as a metabolic side effect. However, because it successfully treats gastroparesis and nausea, patients may find they are able to eat more comfortably and consume more calories, which can lead to weight gain. In some cases, the drug can cause fluid retention (edema) due to its effect on certain hormones, which might appear as a slight increase on the scale. If you notice rapid weight gain or swelling in your hands and feet, you should contact your healthcare provider. It is important to distinguish between healthy weight recovery and abnormal fluid retention.
Metoclopramide has many significant drug interactions, so it must be used cautiously with other medications. It should not be taken with drugs that also affect dopamine, such as antipsychotics or Parkinson’s medications, as this greatly increases the risk of serious movement disorders. It also interacts with anticholinergic drugs and opioids, which slow down the gut and counteract metoclopramide's effects. Because it speeds up stomach emptying, it can also change how your body absorbs other pills, like digoxin or cyclosporine. Always provide your doctor with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are taking.
Yes, metoclopramide is widely available as a generic medication in several forms, including tablets and oral solutions. The generic version is typically much more affordable than brand-name versions like Reglan or Gimoti (the nasal spray). Generic metoclopramide is required by the FDA to have the same active ingredient, strength, dosage form, and route of administration as the brand-name drug. It must also prove bioequivalence, meaning it works in the body the same way. Most insurance plans cover the generic version of metoclopramide for approved indications like GERD and gastroparesis.
Other drugs with the same active ingredient (Metoclopramide)
> Warning: Stop taking Metoclopramide and call your doctor immediately if you experience any of these symptoms.
The most significant risk of long-term use (beyond 12 weeks) is the development of Tardive Dyskinesia. The risk increases with the total cumulative dose and the duration of treatment. In some patients, the movements may persist even after the drug is stopped. Additionally, prolonged elevation of prolactin levels can lead to menstrual irregularities in women and impotence in men.
Metoclopramide carries a FDA Black Box Warning regarding the risk of Tardive Dyskinesia.
Report any unusual symptoms to your healthcare provider immediately. Early detection of movement disorders is critical for preventing permanent damage.
Your healthcare provider may require periodic check-ups to monitor your safety:
Metoclopramide frequently causes drowsiness, dizziness, and blurred vision. You should not drive, operate heavy machinery, or engage in hazardous activities until you know how this medication affects you. The sedative effect is significantly increased if combined with alcohol or other sedating medications.
Alcohol must be avoided while taking metoclopramide. Alcohol increases the sedative effects of the drug and can also speed up the rate at which the stomach empties into the small intestine, potentially increasing the rate of alcohol absorption and leading to faster intoxication.
Do not stop taking metoclopramide abruptly if you have been taking it for an extended period. While it is not traditionally addictive, some patients experience 'withdrawal-like' symptoms, including dizziness, nervousness, and headaches, if the drug is stopped suddenly. Your doctor will provide a tapering schedule to gradually reduce the dose.
> Important: Discuss all your medical conditions with your healthcare provider before starting Metoclopramide, especially if you have a history of depression, Parkinson's disease, or kidney problems.
For each major interaction, the primary mechanism is usually either pharmacodynamic antagonism (drugs doing opposite things) or kinetic alteration (changing how fast other drugs move through the gut). Management typically involves dose adjustment or choosing alternative therapies.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter cold medicines which may contain sedating antihistamines.
Conditions requiring careful risk-benefit analysis by a physician:
Patients who are sensitive to Procainamide or other benzamide derivatives should be monitored closely, as there is a theoretical risk of cross-reactivity, though this is clinically rare.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Metoclopramide. Always disclose any history of stomach surgery or mental health issues.
Elderly patients (65 and older) are the most vulnerable population regarding metoclopramide. They have a higher risk of developing Tardive Dyskinesia, which is often permanent in this age group. Furthermore, reduced kidney function in the elderly can lead to drug accumulation. The 'Beers Criteria' for potentially inappropriate medication use in older adults recommends avoiding metoclopramide unless being used for gastroparesis, and even then, for no longer than 12 weeks.
In patients with moderate to severe renal impairment (CrCl < 60 mL/min), the half-life of metoclopramide can double or triple. This leads to a high risk of 'stacking' doses and developing neurological toxicity. A 50% dose reduction is standard practice for these patients. For those with end-stage renal disease (ESRD), the drug should be used with extreme caution.
Patients with significant liver dysfunction (cirrhosis) may experience increased fluid retention when taking metoclopramide. While the drug is metabolized by the liver, the primary concern in hepatic impairment is the exacerbation of ascites (fluid in the abdomen) rather than a failure to clear the drug.
> Important: Special populations require individualized medical assessment. Always inform your doctor if you are planning to become pregnant or have a history of kidney disease.
| Parameter | Value |
|---|---|
| Bioavailability | ~80% (Oral) |
| Protein Binding | ~30% (Albumin) |
| Half-life | 5 to 6 hours |
| Tmax | 1 to 2 hours |
| Metabolism | Hepatic (Oxidation/Conjugation) |
| Excretion | Renal (85%) |
Metoclopramide is a Prokinetic agent and a Dopamine Antagonist. It is related to other prokinetics like domperidone (not available in the US) and other dopamine antagonists used as antipsychotics, though it is specifically optimized for GI and anti-emetic use.