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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Avobenzone, Homosalate, Octisalate And Octocrylene
Brand Name
La Roche Posay Laboratoire Dermatologique Toleraine Double Repair Matte Moisturizer Uv Broad Spectrum Spf 30 For Oily, Combination Skin
Generic Name
Avobenzone, Homosalate, Octisalate And Octocrylene
Active Ingredient
AvobenzoneCategory
Non-Standardized Chemical Allergen [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 30 mg/mL | CREAM | TOPICAL | 49967-387 |
Detailed information about La Roche Posay Laboratoire Dermatologique Toleraine Double Repair Matte Moisturizer Uv Broad Spectrum Spf 30 For Oily, Combination Skin
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for La Roche Posay Laboratoire Dermatologique Toleraine Double Repair Matte Moisturizer Uv Broad Spectrum Spf 30 For Oily, Combination Skin, you must consult a qualified healthcare professional.
Avobenzone is a dibenzoylmethane derivative primarily used as a broad-spectrum UVA sunscreen filter. It is pharmacologically classified as a non-standardized chemical allergen and nitrogen binding agent used in various topical and systemic clinical contexts.
For general photoprotection, healthcare providers recommend the following:
No dosage adjustments are typically required for topical use in patients with kidney disease, as systemic absorption is minimal.
No specific adjustments are documented for topical application; however, patients with severe liver failure should consult their doctor if using large-surface-area applications daily.
Elderly patients may have thinner skin (atrophic skin), which could potentially increase systemic absorption. Use as directed, but monitor for localized skin reactions.
Avobenzone is for external use only.
If you forget to apply Avobenzone before going outdoors, apply it as soon as you remember. However, be aware that protection is not immediate; seek shade until the product has had time to set (approximately 15 minutes).
Topical overdose is unlikely. However, if accidental ingestion occurs, symptoms may include gastrointestinal irritation. In cases of ingestion, contact a Poison Control Center immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Most individuals tolerate Avobenzone well. However, because it is a Non-Standardized Chemical Allergen, some users may experience:
Avobenzone is highly effective for UVA protection but requires stabilization. It should not be used on broken, damaged, or infected skin. Patients with a history of multiple chemical sensitivities should perform a 'patch test' on a small area of skin before widespread use.
No FDA black box warnings for Avobenzone.
FDA Pregnancy Category: Not formally assigned for topical sunscreens, but generally considered acceptable.
Avobenzone has been detected in human breast milk in trace amounts following heavy topical use. However, the clinical significance for the nursing infant is unknown. To minimize exposure, avoid applying Avobenzone directly to the nipple area before breastfeeding.
Approved for use in children over 6 months of age. Because children have a higher surface-area-to-body-mass ratio, they may absorb more of the chemical systemically. Use with caution and emphasize physical shading.
Avobenzone acts as a UVA filter by absorbing ultraviolet radiation in the 320–400 nm range. It possesses an enol-keto tautomerism; upon UV exposure, it absorbs a photon and transitions from the chelated enol form to the unchelated diketo form. Furthermore, its classification as an Adenosine Receptor Agonist suggests it may play a role in modulating cellular signaling pathways related to inflammation and nitrogen binding.
Common questions about La Roche Posay Laboratoire Dermatologique Toleraine Double Repair Matte Moisturizer Uv Broad Spectrum Spf 30 For Oily, Combination Skin
Avobenzone is primarily used as an active ingredient in sunscreens to provide broad-spectrum protection against Ultraviolet A (UVA) rays. These rays are responsible for deep skin damage, premature aging, and an increased risk of skin cancer. By absorbing these rays and converting them into harmless heat, Avobenzone helps prevent sunburn and long-term solar damage. It is often combined with other ingredients to ensure the product also protects against UVB rays. Your healthcare provider may recommend it as part of a daily skincare routine to prevent photocarcinogenesis.
The most common side effects of Avobenzone are localized skin reactions, such as redness, itching, or a mild stinging sensation at the site of application. Because it is classified as a chemical allergen, some individuals may develop contact dermatitis, which appears as an itchy rash or small bumps. These symptoms usually resolve once the product is washed off and use is discontinued. In rare cases, it can cause eye irritation if the product migrates into the eyes. Always consult a doctor if a skin reaction persists or becomes severe.
There are currently no known clinical interactions between the topical use of Avobenzone and the consumption of alcohol. Since Avobenzone is applied to the skin and very little enters the bloodstream, it does not interfere with the way your body processes alcohol. However, alcohol consumption can sometimes lead to skin flushing or dehydration, which might make your skin more sensitive to topical products. It is always wise to stay hydrated and monitor your skin's reaction if you are using new skincare products. Talk to your healthcare provider if you have concerns about alcohol and your specific medications.
Avobenzone is generally considered safe for use during pregnancy when applied topically as directed. While some systemic absorption has been documented in recent studies, the levels found in the blood are typically very low and have not been linked to birth defects in humans. The American College of Obstetricians and Gynecologists (ACOG) generally supports the use of sunscreen to prevent the 'mask of pregnancy' (melasma). However, if you have concerns, you may choose to use 'physical' sunscreens containing zinc oxide or titanium dioxide instead. Always discuss your prenatal skincare routine with your OB-GYN.
Avobenzone typically takes about 15 to 30 minutes to become fully effective after it is applied to the skin. This time allows the product to dry and form a protective film that can effectively absorb UV radiation. If you go directly into the sun or water immediately after application, the product may be wiped or washed away, leaving your skin unprotected. Healthcare providers recommend applying it indoors before heading outside. For the best results, ensure the skin is clean and dry before application.
Yes, you can stop using Avobenzone-containing products at any time without experiencing withdrawal symptoms or physical dependence. However, stopping use will immediately end your protection against harmful UVA rays. This increases your risk of developing a sunburn, sunspots, and long-term skin damage if you spend time outdoors without an alternative form of protection. If you are stopping because of a skin rash, consult your dermatologist for an alternative sunscreen. It is important to maintain consistent sun protection to reduce the risk of skin cancer.
If you forget to apply Avobenzone before going outdoors, you should apply it as soon as you realize the omission. While you wait for the sunscreen to become effective (about 15 minutes), it is best to stay in the shade or wear protective clothing like a wide-brimmed hat and long sleeves. You do not need to 'double up' on the amount applied to make up for the missed application. Simply resume your regular reapplication schedule every two hours. Consistent coverage is the key to preventing UV-induced skin damage.
There is no clinical evidence to suggest that the topical use of Avobenzone causes weight gain. Because Avobenzone is applied to the skin and systemic absorption is minimal, it does not affect the metabolic processes or hormonal balances that typically regulate body weight. Any changes in weight while using sunscreen are likely due to other factors such as diet, exercise, or other medications. If you experience sudden or unexplained weight gain, you should contact your healthcare provider to investigate the underlying cause. Sunscreens are generally considered weight-neutral.
Avobenzone can generally be used alongside most oral medications without any issues. However, when used with other topical treatments, such as acne creams (retinoids) or certain antibiotics that cause photosensitivity, it may lead to increased skin irritation. Some other sunscreen ingredients, like Octinoxate, can also cause Avobenzone to break down more quickly if they are not formulated correctly together. It is always a good idea to inform your doctor or pharmacist about all the products you apply to your skin. They can help you determine the best order of application for your various skin treatments.
Avobenzone is widely available as a 'generic' or store-brand ingredient in thousands of different sunscreen products. Because it is an active ingredient rather than a brand-name drug, you will find it listed in the 'Drug Facts' panel of many sunscreens, from luxury brands to affordable generic versions. The efficacy of Avobenzone is generally the same across these products, provided they are within their expiration date and have been stored properly. When shopping, look for the chemical name 'Avobenzone' or 'Butyl Methoxydibenzoylmethane' on the label. Consult your pharmacist if you need help choosing a stable formulation.
Other drugs with the same active ingredient (Avobenzone)
> Warning: Stop using Avobenzone and call your doctor immediately if you experience any of these:
Prolonged use of Avobenzone is generally considered safe. However, because Avobenzone is photounstable, its breakdown products can sometimes cause cumulative skin sensitization over many years of use. There is ongoing research into the long-term effects of systemic absorption, though no definitive clinical harm has been established as of 2024.
No FDA black box warnings have been issued for Avobenzone. It is generally recognized as safe and effective (GRASE) when used as directed for topical photoprotection.
Report any unusual symptoms to your healthcare provider.
No routine blood tests are required for standard topical use. However, if a patient develops chronic dermatitis, a dermatologist may perform Patch Testing using a standardized allergen series that includes Avobenzone to confirm sensitivity.
Avobenzone does not typically interfere with the ability to drive or operate machinery.
There are no known direct interactions between topical Avobenzone and alcohol consumption.
There are no withdrawal symptoms associated with stopping Avobenzone. However, discontinuing use will immediately remove your protection against UVA radiation, increasing the risk of sunburn and long-term skin damage.
> Important: Discuss all your medical conditions with your healthcare provider before starting Avobenzone.
There are no known food interactions with topically applied Avobenzone. High-fat meals do not affect the absorption of topical formulations.
Avobenzone is not known to interfere with standard clinical laboratory tests (e.g., CBC, Liver Function Tests).
For each major interaction, the primary concern is reduced efficacy (photodegradation) rather than systemic toxicity. Management strategies include using products that are specifically formulated to be 'photostable' and avoiding the mixing of different sunscreen brands on the skin at the same time.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients who react to Avobenzone may also show cross-sensitivity to other chemical UV filters, particularly Isopropyldibenzoylmethane. Always check ingredient labels for related chemical names.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Avobenzone.
No specific restrictions for the elderly. However, older patients should be monitored for skin thinning and increased risk of contact sensitization.
No dosage adjustments are necessary. The small amount of Avobenzone that reaches systemic circulation is unlikely to accumulate to toxic levels in patients with renal failure.
No specific data available. Use with standard caution in patients with severe hepatic dysfunction.
> Important: Special populations require individualized medical assessment.
| Parameter | Value |
|---|---|
| Bioavailability | <1% (Topical) |
| Protein Binding | ~95% (Systemic) |
| Half-life | 1.5 - 8 hours (Systemic) |
| Tmax | 2 - 4 hours (Post-application) |
| Metabolism | Hepatic (Glucuronidation) |
| Excretion | Renal (Primary) |
Avobenzone is a Dibenzoylmethane UV Filter. It is often grouped with other organic sunscreens but stands alone as the primary organic UVA1 absorber approved in the United States.