Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Honeysuckle Flower, Forsythia Fruit, Mentha Herb
Brand Name
Han Shin Anticam
Generic Name
Honeysuckle Flower, Forsythia Fruit, Mentha Herb
Active Ingredient
Forsythia Suspensa FruitCategory
Non-Standardized Plant Allergenic Extract [EPC]
Variants
2
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 710 mg/1 | CAPSULE | ORAL | 73466-0035 |
| 710 mg/1 | CAPSULE | ORAL | 72988-0054 |
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Han Shin Anticam, you must consult a qualified healthcare professional.
Detailed information about Han Shin Anticam
Forsythia Suspensa Fruit is a pharmacological agent classified as a Non-Standardized Plant Allergenic Extract [EPC], used primarily in diagnostic allergy testing and as a component in complex botanical formulations.
The dosage of Forsythia Suspensa Fruit varies significantly based on the delivery method and the clinical objective.
For diagnostic purposes, the extract is typically used in its concentrated form (e.g., 1:10 or 1:20 w/v). A single drop (approximately 0.05 mL) is applied to the skin, and a sterile lancet is used to prick the epidermis. The results are interpreted by a healthcare professional after 15 to 20 minutes.
When used as a dietary supplement or as part of a botanical formulation, the typical adult dosage of the dried fruit ranges from 6 to 15 grams per day, usually prepared as a decoction or taken in divided doses as a standardized extract. If using a standardized extract (often standardized to Phillyrin content), doses of 100 mg to 300 mg twice daily are common in clinical literature, though these are not FDA-standardized doses.
Forsythia Suspensa Fruit extracts may be used in children for allergy testing under the strict supervision of a pediatric allergist. The procedure is identical to adult testing, though the number of simultaneous tests may be limited to minimize patient discomfort and the risk of systemic reactions.
Forsythia Suspensa Fruit is NOT FDA-approved for therapeutic use in children. While it is used in traditional pediatric medicine in some cultures, the safety and efficacy have not been established in large-scale pediatric clinical trials. Dosage in children is typically calculated based on weight or body surface area (BSA), often using Clark’s Rule or Young’s Rule, but this must only be performed by a specialized healthcare provider.
Specific dosage adjustments for patients with renal impairment have not been formally established. However, since the metabolites of Forsythia lignans are primarily excreted by the kidneys, caution is advised. Patients with a Creatinine Clearance (CrCl) below 30 mL/min may require a reduction in oral dosage to prevent accumulation of metabolites.
As the liver is the primary site of metabolism for Forsythia constituents, patients with significant hepatic impairment (Child-Pugh Class B or C) should be monitored closely. There is a theoretical risk of increased systemic exposure to bioactive lignans in these populations.
Clinical studies have not identified specific differences in response between elderly and younger patients. However, given the higher prevalence of cardiovascular disease in the elderly, caution is required when using allergenic extracts due to the potential need for emergency epinephrine, which can carry higher risks in older adults.
If you miss a dose of an oral Forsythia supplement, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up. For missed immunotherapy injections, contact your allergist immediately, as the dosing schedule may need to be adjusted to maintain safety.
Symptoms of an oral overdose may include severe nausea, vomiting, diarrhea, and abdominal pain. In the context of allergenic extracts, an 'overdose' (excessive antigenic load) may manifest as a systemic allergic reaction or anaphylaxis.
In the event of a suspected overdose or systemic reaction, seek emergency medical attention immediately. Treatment for systemic reactions includes the administration of epinephrine, antihistamines, and corticosteroids, along with supportive care for airway management and blood pressure stabilization.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
When Forsythia Suspensa Fruit is used in diagnostic allergy testing, local reactions are the most frequent occurrence. These are typically expected and indicate a positive test result rather than an adverse event in the traditional sense.
These effects are more likely to occur with systemic (oral) administration or during the build-up phase of immunotherapy:
Forsythia Suspensa Fruit must be handled with caution, particularly in individuals with a known history of severe allergies or asthma. Because it is a non-standardized extract, the concentration of specific proteins can vary between lots, which may affect the intensity of the immune response. Patients should always inform their healthcare provider of any previous reactions to plant extracts or members of the Oleaceae family (such as olive, ash, or privet).
No FDA black box warnings specifically named for 'Forsythia Suspensa Fruit' exist; however, as noted in the side effects section, it falls under the stringent safety guidelines for all allergenic extracts. The primary risk is Anaphylaxis. Healthcare providers must ensure that patients are hemodynamically stable and that their asthma is well-controlled before administering diagnostic tests or immunotherapy involving this extract.
Forsythia Suspensa Fruit must NEVER be used in the following circumstances:
Healthcare providers must perform a careful risk-benefit analysis in these cases:
There are no adequate and well-controlled studies of Forsythia Suspensa Fruit in pregnant women. Animal reproduction studies have not been conducted. The primary concern during pregnancy is not direct teratogenicity of the extract's constituents, but rather the risk of maternal anaphylaxis. Anaphylaxis can lead to systemic hypotension in the mother, resulting in placental hypoperfusion and fetal hypoxia (lack of oxygen to the fetus), which can cause fetal distress or death. Consequently, diagnostic skin testing and the initiation of immunotherapy are typically deferred until the postpartum period.
It is not known whether the constituents of Forsythia Suspensa Fruit or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised. However, since the systemic absorption of diagnostic extracts is minimal, the risk to the nursing infant is likely low. For oral supplements, the lack of safety data suggests that breastfeeding women should avoid use unless the potential benefit outweighs the unknown risk.
Forsythia Suspensa Fruit acts as a complex biological agent. As an Allergenic Extract, its primary molecular mechanism involves the binding of specific fungal or plant proteins to membrane-bound IgE on mast cells and basophils. This triggers the Type I Hypersensitivity cascade.
In a therapeutic/botanical context, its lignan constituents, specifically Phillyrin, act as anti-inflammatory agents. Phillyrin has been shown to inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thereby reducing the production of nitric oxide and prostaglandins. Furthermore, Forsythoside A exhibits potent antioxidant activity by scavenging free radicals and upregulating endogenous antioxidant enzymes like superoxide dismutase (SOD).
Common questions about Han Shin Anticam
Forsythia Suspensa Fruit is primarily used by medical professionals as an allergenic extract to diagnose allergies to plants in the Oleaceae family through skin testing. In traditional and complementary medicine, it is also used for its anti-inflammatory and antimicrobial properties to treat symptoms of the common cold, fever, and sore throat. It is often a key ingredient in botanical formulas designed to 'clear heat' and detoxify the body. However, it is important to note that its use as a therapeutic drug is not standardized by the FDA in the same way as conventional pharmaceuticals. Always consult a healthcare provider before using it for any medical condition.
The most common side effects depend on how the substance is administered. When used for allergy skin testing, the most frequent side effects are local itching, redness, and a raised bump (wheal) at the site of the test, which typically resolve within a few hours. When taken orally as a supplement, common side effects include mild gastrointestinal upset, such as nausea, abdominal bloating, or diarrhea. Some individuals may also experience mild headaches or dizziness. If these symptoms persist or worsen, you should contact your healthcare provider immediately. Rare but serious allergic reactions can occur and require emergency medical attention.
There is no known direct chemical interaction between Forsythia Suspensa Fruit and alcohol. However, healthcare providers generally recommend avoiding alcohol when undergoing allergy testing or when dealing with an inflammatory illness. Alcohol can cause blood vessels to dilate, which might potentially worsen a local or systemic allergic reaction. Additionally, alcohol can irritate the stomach lining, potentially increasing the risk of gastrointestinal side effects from oral Forsythia supplements. To ensure the most accurate test results and the safest experience, it is best to abstain from alcohol for at least 24 hours before and after use.
Forsythia Suspensa Fruit is generally not recommended during pregnancy unless specifically directed by a physician. It is classified by the FDA as Pregnancy Category C, meaning there is a lack of comprehensive human data to guarantee its safety. The primary concern is the risk of a systemic allergic reaction (anaphylaxis), which could lead to a dangerous drop in blood pressure and reduced oxygen flow to the fetus. For this reason, elective allergy testing and new herbal regimens are typically postponed until after the baby is born. Pregnant women should always discuss any supplements or diagnostic procedures with their obstetrician first.
The timeframe for Forsythia Suspensa Fruit to work depends on its use. For diagnostic allergy testing, the effect is almost immediate, with a visible skin reaction occurring within 15 to 20 minutes. If taken orally for symptoms of a cold or fever, marker compounds like phillyrin reach peak levels in the blood within 1 to 2 hours. However, it may take several doses over 24 to 48 hours before a noticeable reduction in symptoms like fever or inflammation occurs. In the case of long-term immunotherapy, it can take several months of regular treatment to see a significant decrease in allergy symptoms.
Yes, oral supplements of Forsythia Suspensa Fruit can typically be stopped suddenly without causing withdrawal symptoms or physical dependence. Unlike some prescription medications, it does not require a gradual tapering process. However, if you are using Forsythia as part of a long-term allergy immunotherapy program, stopping suddenly may cause you to lose the progress you have made in reducing your sensitivity to allergens. If you are considering stopping a treatment plan involving Forsythia, you should first discuss your reasons and any potential alternatives with your healthcare provider.
If you miss a dose of an oral Forsythia supplement, take it as soon as you remember, provided it is not too close to your next scheduled dose. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule; never take two doses at once to make up for a missed one. If you miss an appointment for an allergy immunotherapy injection involving Forsythia, contact your allergist's office immediately. They will determine if your next dose needs to be adjusted to ensure you do not have an adverse reaction after the break in treatment.
There is currently no clinical evidence to suggest that Forsythia Suspensa Fruit causes weight gain. Its primary bioactive components, such as lignans and glycosides, are not known to affect metabolic rate, appetite, or fat storage in a way that would lead to increased body weight. In fact, because it can sometimes cause mild diarrhea or gastrointestinal upset in sensitive individuals, it is more likely to cause temporary weight loss if side effects are severe. If you experience unexplained weight changes while taking this or any other supplement, you should consult your doctor to rule out other underlying causes.
Forsythia Suspensa Fruit can interact with several types of medications, so it should be used with caution. The most serious interactions occur with beta-blockers and MAO inhibitors, which can interfere with the treatment of a severe allergic reaction. There is also a theoretical risk of increased bleeding if taken with anticoagulants like Warfarin or antiplatelet drugs like Aspirin. Additionally, because Forsythia may lower blood sugar, it could potentially enhance the effects of diabetes medications. Always provide your healthcare provider with a complete list of all medications and supplements you are currently taking to avoid dangerous interactions.
Because Forsythia Suspensa Fruit is a natural botanical product and a non-standardized extract, the concept of 'generic' vs. 'brand name' does not apply in the same way it does for synthetic drugs. It is available from various manufacturers under different labels, often as 'Lian Qiao' or as part of multi-herb formulas. For diagnostic use, different laboratory suppliers produce their own versions of the extract, which are considered interchangeable only under the guidance of an allergist. When purchasing oral supplements, it is important to choose a reputable manufacturer that provides third-party testing for purity and potency.
Other drugs with the same active ingredient (Forsythia Suspensa Fruit)
> Warning: Stop taking Forsythia Suspensa Fruit and call your doctor immediately if you experience any of these symptoms, as they may indicate a life-threatening systemic reaction (anaphylaxis).
Data on the long-term use of Forsythia Suspensa Fruit are limited. In the context of immunotherapy, long-term use is intended to modify the immune system favorably. However, prolonged oral use of high doses could theoretically lead to:
While Forsythia Suspensa Fruit specifically may not have an individual black box warning, the class of Non-Standardized Plant Allergenic Extracts often carries a general warning regarding the risk of severe systemic reactions.
Summary of Class Warning: Allergenic extracts can cause severe life-threatening systemic reactions, including anaphylaxis. Patients should be observed for at least 30 minutes following administration. These agents should only be administered by clinicians trained in the management of anaphylaxis and in facilities equipped with emergency supplies (epinephrine, oxygen, IV fluids). Patients with unstable asthma or those taking beta-blockers may be at increased risk for severe outcomes.
Report any unusual symptoms to your healthcare provider.
Forsythia Suspensa Fruit generally does not cause sedation. However, if a patient experiences a systemic reaction or receives epinephrine, they should not drive or operate machinery until they have been cleared by a medical professional and are certain that all symptoms and treatment side effects have resolved.
There is no direct contraindication between Forsythia and alcohol; however, alcohol consumption can increase peripheral vasodilation, which might theoretically worsen the symptoms of an allergic reaction or increase the rate of absorption of oral constituents. It is advisable to avoid alcohol for 24 hours surrounding allergy testing.
Oral Forsythia supplements do not typically require a tapering period and can be stopped abruptly. However, discontinuation of an immunotherapy regimen should be discussed with an allergist, as stopping the treatment may result in the loss of previously gained immunological tolerance.
> Important: Discuss all your medical conditions with your healthcare provider before starting Forsythia Suspensa Fruit.
Most interactions with Forsythia Suspensa Fruit are pharmacodynamic (affecting the body's response to the drug) rather than pharmacokinetic (affecting the drug's levels). The most critical interactions involve the body's ability to respond to emergency treatments (like epinephrine) rather than the metabolism of the fruit's constituents themselves.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients allergic to Forsythia Suspensa Fruit may exhibit cross-reactivity with other members of the Oleaceae family. This includes:
If a patient is known to be highly sensitive to olive pollen, the clinician should use a higher dilution of the Forsythia extract for initial testing to ensure safety.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Forsythia Suspensa Fruit.
Safety and effectiveness in children below the age of 2 have not been established. In older children, Forsythia extract is primarily used for diagnostic purposes. Pediatric patients may be more susceptible to the psychological stress of skin testing, which can occasionally trigger vasovagal syncope (fainting). Therapeutic use in children should be approached with extreme caution due to the lack of standardized pediatric dosing and the potential for gastrointestinal side effects.
Clinical studies of Forsythia Suspensa Fruit did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range. The primary concern in the geriatric population is the presence of underlying cardiovascular or pulmonary disease, which increases the risk of complications if a systemic allergic reaction occurs.
In patients with impaired renal function, the clearance of lignan metabolites may be reduced. While no specific GFR-based (Glomerular Filtration Rate) adjustments are published, clinicians should monitor for signs of cumulative toxicity if oral forms are used over an extended period. Diagnostic testing remains safe as it does not rely on renal clearance.
Patients with hepatic impairment may have altered metabolism of the bioactive compounds in Forsythia. In the absence of specific data, oral use should be avoided in patients with severe hepatic dysfunction (Child-Pugh C). No adjustments are needed for diagnostic skin testing.
> Important: Special populations require individualized medical assessment.
| Parameter | Value |
|---|---|
| Bioavailability | 15-25% (Oral, Phillyrin) |
| Protein Binding | 45-55% |
| Half-life | 2.5 - 4.2 hours |
| Tmax | 1.2 - 2.0 hours |
| Metabolism | Hepatic (CYP3A4 involvement) |
| Excretion | Renal 70%, Fecal 20% |
Forsythia Suspensa Fruit is classified as a Non-Standardized Plant Allergenic Extract. It belongs to the broader therapeutic category of Allergenics, which includes other plant extracts (like Ragweed or Oak), food extracts, and insect venoms used for diagnosis and immunotherapy.