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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Coriandrum Sativum (coriander)
Brand Name
Coriandrum Sativum (coriander)
Generic Name
Coriandrum Sativum (coriander)
Active Ingredient
CorianderCategory
Non-Standardized Food Allergenic Extract [EPC]
Variants
8
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 1 [hp_M]/1 | PELLET | ORAL | 37662-0568 |
| 6 [hp_C]/1 | PELLET | ORAL | 37662-0562 |
| 30 [hp_C]/1 | PELLET | ORAL | 37662-0564 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Coriandrum Sativum (coriander), you must consult a qualified healthcare professional.
| 1 [hp_Q]/1 | PELLET | ORAL | 37662-0569 |
| 100 [hp_C]/1 | PELLET | ORAL | 37662-0565 |
| 200 [hp_C]/1 | PELLET | ORAL | 37662-0566 |
| 12 [hp_C]/1 | PELLET | ORAL | 37662-0563 |
| 500 [hp_C]/1 | PELLET | ORAL | 37662-0567 |
Detailed information about Coriandrum Sativum (coriander)
Coriander (Coriandrum sativum) is utilized in clinical medicine primarily as a non-standardized food and plant allergenic extract. It is indicated for the diagnostic assessment of IgE-mediated hypersensitivity and as a tool in allergy skin testing.
Dosage for Coriander allergenic extract is not standardized by weight like traditional drugs but is instead determined by the method of administration and the concentration of the extract.
Coriander allergenic extract is used in pediatric populations for allergy diagnosis. The procedure is identical to that used in adults, though the number of tests performed in a single session may be limited to minimize discomfort. There is no specific age-based dosage adjustment, but the healthcare provider must ensure the child is able to remain still during the 15–20 minute observation period. Safety and efficacy have been established in children, provided the testing is performed by a trained specialist.
No dosage adjustments are typically required for renal impairment, as the systemic exposure is negligible. However, patients with end-stage renal disease may have altered skin reactivity (uremic pruritus or reduced histamine response), which can complicate the interpretation of the test results.
No dosage adjustments are required for patients with hepatic impairment. The metabolism of the allergenic proteins does not rely on hepatic pathways.
In elderly patients (over 65), the skin may be less reactive to both allergens and the histamine control. Healthcare providers may need to adjust their interpretation of the wheal-and-flare size, as the skin's inflammatory response naturally diminishes with age.
Coriander allergenic extract is never for self-administration. It must be administered by a qualified healthcare professional, such as an allergist or a nurse trained in allergy testing.
As this is a diagnostic test performed during a scheduled office visit, there is no 'missed dose' in the traditional sense. If a testing appointment is missed, it should be rescheduled. If a specific skin test site fails to produce a reaction due to poor technique, the test may be repeated on a different area of the skin.
An 'overdose' in the context of allergenic extracts refers to the administration of too much extract or an overly concentrated extract, which can lead to a severe systemic reaction (anaphylaxis).
> Important: Follow your healthcare provider's instructions regarding medications to avoid before the test. Do not adjust your current medications without medical guidance.
The most common 'side effects' of Coriander allergenic extract are actually the intended results of a positive diagnostic test. These occur at the site of administration:
Coriander allergenic extract is intended for diagnostic use only and must be used with extreme caution in patients with a history of severe spice allergies. Because the extract is non-standardized, its potency can vary between batches, which may affect the intensity of the skin reaction. Patients must be monitored for at least 30 minutes following administration to ensure safety.
No FDA black box warnings for Coriander. However, the class-wide warning for allergenic extracts states: 'Allergenic extracts can cause severe life-threatening systemic reactions, including anaphylaxis. They should only be administered by healthcare professionals prepared to manage such reactions.'
There are no drugs that are strictly 'contraindicated' in the sense of causing a toxic chemical reaction, but certain drugs must be stopped because they make the test uninterpretable or dangerous:
Coriander allergenic extract must NEVER be used in the following circumstances:
Coriander allergenic extract is classified as FDA Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. It is not known whether the extract can cause fetal harm or affect reproduction capacity. Most allergists recommend postponing diagnostic skin testing until after delivery, as a systemic reaction (anaphylaxis) in the mother can lead to fetal hypoxia (lack of oxygen) and other serious complications. If testing is deemed essential, it should be done with extreme caution.
It is not known whether the allergenic proteins from coriander extract are excreted in human milk. However, because the amount used in skin testing is so small and systemic absorption is minimal, it is highly unlikely to affect a nursing infant. The primary concern remains the mother's potential for a systemic reaction. Generally, breastfeeding is not considered a contraindication for skin testing.
Skin testing with Coriander extract is safe and effective in children, including infants. However, the 'wheal' response may be smaller in children under the age of two compared to older children. The healthcare provider must take extra care to explain the procedure to the child and ensure they do not rub the test sites, which could spread the allergen and cause a false-positive result or increased irritation.
Coriander allergenic extract acts as a diagnostic antigen. Its primary molecular mechanism involves the Type I Hypersensitivity reaction. The extract contains specific proteins (allergens) such as Cori s 1 (a Bet v 1 homolog). When these proteins enter the skin, they bind to the Fab portion of specific IgE antibodies that are already attached to the surface of mast cells via the FcεRI receptor. This binding causes the receptors to cluster (cross-link), which triggers an influx of calcium ions into the mast cell. This calcium influx causes the mast cell to release its granules, containing histamine and other inflammatory mediators, into the surrounding tissue.
Common questions about Coriandrum Sativum (coriander)
Coriander allergenic extract is a diagnostic tool used by healthcare providers to determine if a person has an IgE-mediated allergy to coriander. It is most commonly used in skin prick testing, where a tiny amount of the extract is introduced into the skin to see if a localized allergic reaction occurs. This test helps doctors confirm if symptoms like hives, swelling, or digestive issues after eating coriander are due to a true allergy. It is also used to investigate 'Oral Allergy Syndrome,' where people with pollen allergies react to certain fruits and spices. The extract is not a treatment or a medication to be taken regularly.
The most common side effects are localized to the site of the skin test and include itching, redness, and a raised bump called a wheal. These reactions are actually the signs of a positive test result and indicate that the person is sensitized to coriander. Some patients may also experience mild swelling or a warm sensation at the test site. These local symptoms typically peak within 20 minutes and disappear within an hour or two. In rare cases, a 'late-phase' reaction may cause the swelling to return several hours later. Systemic side effects like hives on other parts of the body are very rare.
While there is no direct chemical interaction between alcohol and coriander extract, it is generally recommended to avoid alcohol for at least 24 hours before and after allergy testing. Alcohol can cause blood vessels to dilate (expand), which might increase the size of the skin reaction or cause the allergen to be absorbed into the bloodstream more quickly. Furthermore, alcohol can sometimes trigger non-allergic skin flushing, which can make it difficult for the doctor to read the test results accurately. If you have consumed alcohol recently, be sure to inform your allergist before the procedure begins. Always follow the specific pre-test instructions provided by your clinic.
Allergy skin testing with Coriander extract is generally avoided during pregnancy unless the diagnostic information is absolutely critical for the mother's health. While the extract itself does not harm the fetus, a rare systemic allergic reaction (anaphylaxis) in the mother could cause a dangerous drop in blood pressure or oxygen levels, which poses a significant risk to the baby. Additionally, the medications used to treat a severe reaction, such as epinephrine, are used with caution during pregnancy. Most allergists prefer to wait until after delivery to perform skin tests. If testing is required, a blood test (Serum IgE) is often preferred as it carries no risk of a systemic reaction.
A skin prick test using Coriander extract is one of the fastest diagnostic procedures in medicine, typically providing results within 15 to 20 minutes. Once the extract is applied and the skin is pricked, the healthcare provider will wait for the immune system to respond. During this time, you will be asked not to scratch or touch the area. If you are allergic, you will usually start to feel itching within 5 minutes, followed by the appearance of a red, raised bump. The doctor will measure the size of this bump at the 20-minute mark to determine the final result. The entire office visit, including preparation and observation, usually takes about an hour.
Since Coriander allergenic extract is only used for a one-time diagnostic test and is not a daily medication, there is no concern about 'stopping' it suddenly. There are no withdrawal symptoms or physical dependencies associated with this product. Once the skin test is completed and the results are recorded, the extract is wiped off the skin, and no further doses are administered. If you were undergoing 'allergy shots' (immunotherapy) that included coriander, stopping those would require a discussion with your doctor, but for the diagnostic extract, there is no long-term use to discontinue.
Because Coriander extract is administered only by a healthcare professional during a scheduled diagnostic appointment, you cannot 'miss a dose' in the way you might miss a pill at home. If you miss your appointment for allergy testing, simply call your doctor's office to reschedule. It is important to remember that you must be off certain medications, like antihistamines, for several days before the new appointment for the test to be accurate. If the doctor accidentally misses a spot during the testing procedure, they can simply re-apply the extract to a different area of the skin during the same visit.
No, Coriander allergenic extract does not cause weight gain. It is used in minute quantities for diagnostic purposes and does not contain any hormones, calories, or metabolic-altering substances. Even if a person has a significant allergic reaction to the test, the inflammatory response is temporary and does not affect the body's fat storage or appetite. There is no clinical evidence linking coriander extract or coriander allergy to changes in body weight. Any weight changes you experience would be due to other factors, such as diet, exercise, or other unrelated medical conditions.
Coriander extract can be 'taken' (administered) while you are on most medications, but many drugs will interfere with the accuracy of the test. Antihistamines, certain antidepressants (TCAs), and some heartburn medications (H2 blockers) can prevent the skin from reacting to the extract, leading to a false-negative result. More importantly, beta-blockers used for heart conditions can make it dangerous to treat a reaction if one occurs. You must provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and supplements you are taking so they can tell you which ones to stop before the test.
The concept of 'generic' vs. 'brand name' is slightly different for allergenic extracts. Coriander extract is produced by several different biological laboratories (such as ALK, Stallergenes Greer, or HollisterStier). While they may not be marketed with 'brand names' like Lipitor or Advil, they are all considered 'Non-Standardized Food Allergenic Extracts.' Because they are non-standardized, one manufacturer's extract may have a slightly different protein concentration than another's. Your allergist will typically use the extract they have found to be most reliable in their clinical practice. It is not a product you would buy at a pharmacy with a generic prescription.
While rare during skin prick testing, systemic reactions can be life-threatening.
> Warning: Stop the procedure and call for emergency help immediately if you experience any of these:
There are no known long-term side effects associated with the one-time diagnostic use of Coriander allergenic extract. It does not accumulate in the body, nor does it cause chronic organ damage. Repeated testing over many years is generally considered safe, though it does not provide therapeutic benefit.
Currently, the FDA does not mandate a specific 'Black Box Warning' for Coriander allergenic extract specifically, but all allergenic extracts carry a general warning regarding the risk of Severe Systemic Reactions. The labeling emphasizes that these products must only be used by physicians who are exceptionally experienced in the treatment of anaphylaxis and that epinephrine must be immediately available.
Report any unusual symptoms or delayed reactions to your healthcare provider immediately.
No long-term lab tests are required for the use of this extract. However, the following monitoring is mandatory during the procedure:
Coriander allergenic extract does not typically affect the ability to drive or operate machinery. However, if a patient experiences a vasovagal reaction (fainting) or a systemic allergic reaction requiring medication (like diphenhydramine, which causes drowsiness), they should not drive until the effects have completely worn off.
There is no direct interaction between alcohol and coriander extract. However, alcohol consumption can increase blood flow to the skin (vasodilation), which might theoretically increase the size of the skin reaction or the speed of systemic absorption. It is best to avoid alcohol for 24 hours before and after the test.
As this is a one-time diagnostic test, there are no tapering requirements or withdrawal syndromes. If the testing is stopped midway due to a reaction, no special withdrawal protocol is needed.
> Important: Discuss all your medical conditions, especially heart or lung problems, with your healthcare provider before starting Coriander testing.
Coriander extract administration does not interfere with standard blood chemistry or hematology tests. However, it is the 'lab test' itself. The results of the skin test are used to confirm or rule out sensitization found in Serum IgE (ImmunoCAP) testing.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially those for allergies, depression, or blood pressure.
Patients who are sensitive to Coriander may show cross-sensitivity to other members of the Apiaceae family (celery, carrot, caraway, dill, parsley) and to Birch Pollen (Bet v 1 protein). This is known as the 'Pollen-Food Allergy Syndrome.' A positive test to coriander may occur in a patient who is primarily allergic to birch pollen due to these shared protein structures.
> Important: Your healthcare provider will evaluate your complete medical history and current respiratory status before performing any skin tests.
In patients over the age of 65, the skin tends to be thinner and less reactive. Studies have shown that the histamine (positive control) response decreases with age, which can lead to smaller wheal sizes for allergens as well. Physicians should use a lower threshold for what constitutes a 'positive' result in this population. Additionally, the prevalence of underlying cardiovascular disease in the elderly increases the risk associated with a systemic reaction.
No specific studies have been conducted in patients with renal impairment. However, since the proteins are not significantly absorbed into the systemic circulation, no dosage adjustment is necessary. Patients on dialysis may have altered skin physiology, which should be noted by the clinician.
No dosage adjustments are required. The liver is not involved in the processing or elimination of the small amounts of protein used in skin prick testing.
> Important: Special populations require individualized medical assessment to ensure that the diagnostic benefits of testing outweigh the potential risks.
| Parameter | Value |
|---|---|
| Bioavailability | < 1% (localized to skin) |
| Protein Binding | N/A (binds to IgE on mast cells) |
| Half-life | 1-2 hours (local tissue residence) |
| Tmax | 15-20 minutes (for wheal formation) |
| Metabolism | Local tissue proteases |
| Excretion | Lymphatic drainage |
The extract is a complex mixture of proteins, glycoproteins, and polysaccharides. The primary allergenic component in coriander seeds is often a 17-kDa protein. The extract is typically prepared in a solution of 0.9% Sodium Chloride, 0.4% Phenol (as a preservative), and optionally 50% Glycerin (as a stabilizer).
Coriander belongs to the class of Non-Standardized Allergenic Extracts. It is grouped with other spice extracts like mustard, cumin, and fennel. Unlike 'Standardized' extracts (like Ragweed or Honey Bee Venom), the biological potency of Coriander extract is not measured in Bioequivalent Allergy Units (BAU).