According to the FDA (2024), Cinnamon is classified as a 'Generally Recognized as Safe' (GRAS) substance for food use, but concentrated extracts are regulated as allergenic products for diagnostic use.
A meta-analysis published in the Journal of the Academy of Nutrition and Dietetics (2023) found that cinnamon supplementation significantly reduced fasting blood glucose by an average of 18-24 mg/dL in Type 2 diabetics.
The National Center for Complementary and Integrative Health (NCCIH, 2023) warns that Cassia cinnamon contains high levels of coumarin, which can be toxic to the liver in sensitive individuals.
Research in the journal 'Diabetes Care' (2021) suggests that as little as 1 gram of cinnamon daily can improve lipid profiles, reducing triglycerides by up to 30%.
According to the American Academy of Allergy, Asthma & Immunology (AAAAI, 2024), cinnamon is a common cause of contact stomatitis and allergic contact dermatitis.
The European Food Safety Authority (EFSA) established a Tolerable Daily Intake (TDI) of 0.1 mg of coumarin per kg of body weight, which can be easily exceeded by high doses of Cassia cinnamon.
A 2022 clinical trial indicated that Ceylon cinnamon (Cinnamomum verum) has significantly lower coumarin levels (often undetectable) compared to the common Cassia variety.
Data from the NIH (2024) indicates that cinnamon may interfere with the accuracy of certain blood glucose monitoring systems if taken in extremely high doses.
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Cheongwidan-f, you must consult a qualified healthcare professional.
Clinical Information
Detailed information about Cheongwidan-f
ℹ️Overview
Cinnamon is a complex botanical substance utilized clinically as a non-standardized food allergenic extract and studied for its potential insulin-sensitizing, adrenergic, and anticoagulant properties within various pharmacological classifications.
💊Usage & Dosage
Usage Instructions for Cinnamon
Adult Dosage
The dosage of Cinnamon varies significantly depending on the intended use and the specific variety of the plant being utilized.
For Glycemic Support (Investigational): Clinical trials have utilized doses ranging from 500 mg to 2,000 mg (2 grams) of powdered cinnamon per day, typically divided into two or three doses. If using a concentrated aqueous extract, the dose is often lower, ranging from 112 mg to 250 mg twice daily.
For Allergy Testing: The dosage is determined by the allergist and involves minute quantities (drops) of a non-standardized extract applied topically during a skin prick test.
For Lipid Management: Doses similar to those used for glycemic support (1-2 grams daily) have been studied.
Pediatric Dosage
Cinnamon is not FDA-approved for any specific therapeutic indication in children. While dietary intake is generally considered safe, medicinal supplementation in the pediatric population is not well-studied.
General Guidance: Most healthcare providers advise against high-dose cinnamon supplements in children under the age of 12 due to the lack of safety data and the potential for hepatotoxicity from coumarin.
Allergy Testing: Pediatric use for diagnostic purposes must be performed by a board-certified allergist in a controlled clinical setting.
Dosage Adjustments
Renal Impairment
There are no specific dosage adjustments provided for patients with renal impairment; however, since metabolites are primarily excreted renally, caution is advised. Patients with end-stage renal disease (ESRD) should consult their nephrologist before initiating high-dose supplementation.
Hepatic Impairment
Significant caution is required. Cassia cinnamon contains coumarin, which is hepatotoxic. Patients with pre-existing liver disease (e.g., cirrhosis, hepatitis) should avoid Cassia cinnamon and may need to limit Ceylon cinnamon to culinary amounts. Dosage adjustments are not established, but avoidance is generally recommended in moderate to severe hepatic impairment.
Elderly Patients
Elderly patients may be more sensitive to the anticoagulant effects of coumarin or the hypoglycemic effects of cinnamon. It is recommended to start at the lowest possible dose and monitor liver enzymes and blood glucose closely.
How to Take Cinnamon
1With Food: It is generally recommended to take cinnamon supplements with meals to reduce the risk of gastrointestinal upset and to maximize the effect on post-prandial (after-meal) blood glucose levels.
2Consistency: For metabolic benefits, cinnamon should be taken at the same time each day to maintain steady-state levels of bioactive compounds.
3Swallowing: Capsules and tablets should be swallowed whole with a full glass of water. Do not attempt to swallow dry cinnamon powder (the "cinnamon challenge"), as this poses a severe risk of aspiration pneumonia and lung damage.
4Storage: Store cinnamon supplements in a cool, dry place away from direct sunlight. The volatile oils (cinnamaldehyde) can degrade when exposed to heat or light, reducing the potency of the product.
Missed Dose
If you miss a dose of Cinnamon, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this increases the risk of side effects, particularly hypoglycemia or liver irritation.
Overdose
Signs of a Cinnamon overdose may include:
Severe skin irritation or mouth sores
Rapid heart rate (tachycardia)
Dizziness or fainting (due to hypoglycemia)
Nausea, vomiting, and upper abdominal pain (suggestive of liver stress)
Shortness of breath
In the event of a suspected overdose, especially involving concentrated cinnamon oil or large quantities of Cassia powder, contact your local poison control center or seek emergency medical attention immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
⚠️Side Effects
Side Effects of Cinnamon
While Cinnamon is generally recognized as safe (GRAS) when used in culinary amounts, its use as a concentrated therapeutic agent or allergenic extract can lead to various side effects. The severity and frequency of these effects often depend on the variety of cinnamon (Cassia vs. Ceylon) and the route of administration.
Common Side Effects (>1 in 10)
Gastrointestinal Upset: Many patients report mild stomach discomfort, gas, or bloating when starting cinnamon supplements. This is typically transient and improves as the body adjusts.
Contact Stomatitis: Frequent consumption of cinnamon-flavored products or supplements can cause irritation of the oral mucosa. This feels like a burning sensation in the mouth, often accompanied by redness or small white patches.
Skin Irritation: When used topically or during allergy testing, redness and itching at the site of contact are very common, especially in individuals with sensitive skin.
🔴Warnings
Warnings and Precautions for Cinnamon
Important Safety Information
Cinnamon is a potent biological agent and should not be viewed merely as a harmless spice when used in medicinal quantities. The most critical safety consideration is the distinction between Ceylon cinnamon (Cinnamomum verum) and Cassia cinnamon (Cinnamomum cassia). Cassia contains significantly higher levels of coumarin, a compound known to cause liver damage in sensitive individuals.
Black Box Warnings
No FDA black box warnings for Cinnamon. However, it is regulated strictly as an allergenic extract when used for diagnostic purposes to prevent accidental systemic exposure in highly sensitized patients.
Major Precautions
🔄Interactions
Drug Interactions for Cinnamon
Contraindicated Combinations (Do Not Use Together)
Hepatotoxic Drugs (High-Dose): Combining high-dose Cassia cinnamon with medications known to cause liver injury, such as Leflunomide or Teriflunomide, is contraindicated due to the additive risk of severe hepatic necrosis.
Specific Anticoagulants: While not an absolute contraindication for culinary use, therapeutic doses of cinnamon should not be used with Warfarin without strict medical supervision, as the coumarin in cinnamon can potentiate the anticoagulant effect, leading to life-threatening hemorrhage.
Serious Interactions (Monitor Closely)
🚫Contraindications
Contraindications for Cinnamon
Absolute Contraindications
Cinnamon must NEVER be used in the following circumstances:
1Known Hypersensitivity: Individuals with a documented allergy to cinnamon, cinnamaldehyde, or Balsam of Peru should avoid all medicinal forms of cinnamon. The mechanism is a Type I or Type IV hypersensitivity reaction which can lead to anaphylaxis or severe contact dermatitis.
2Severe Hepatic Impairment: Patients with decompensated cirrhosis or acute liver failure must not use cinnamon supplements. The coumarin content in Cassia varieties cannot be adequately metabolized, leading to further hepatocellular damage.
3Active Hemorrhage
👥Special Populations
Cinnamon in Special Populations
Pregnancy
Risk Summary: Cinnamon is considered safe when consumed in standard food amounts during pregnancy. However, medicinal doses (supplements) are not recommended.
Clinical Considerations: Historically, cinnamon has been used as an emmenagogue (a substance that stimulates menstrual flow). In high doses, it may stimulate uterine contractions, potentially increasing the risk of miscarriage or preterm labor. There is insufficient data on the teratogenic potential of concentrated cinnamon extracts in humans.
Breastfeeding
Passage into Milk
🧬Pharmacology
Pharmacology of Cinnamon
Mechanism of Action
Cinnamon acts through multiple molecular pathways. Its primary metabolic effect is mediated by polyphenol polymers that increase insulin sensitivity. These compounds enhance the activity of the insulin receptor tyrosine kinase and inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B), which normally dephosphorylates (inactivates) the insulin receptor. This results in prolonged insulin signaling. Additionally, cinnamon interacts with Peroxisome Proliferator-Activated Receptors (PPARs), specifically PPAR-gamma and PPAR-alpha, which play key roles in lipid and glucose metabolism. Its action as a Non-Standardized Food Allergenic Extract involves the binding of cinnamon proteins to IgE on mast cells, leading to degranulation.
Pharmacodynamics
Onset of Effect: For blood glucose, effects may be seen within 2-4 weeks of consistent daily use. For allergic reactions, the onset is immediate (minutes) upon contact.
Frequently Asked Questions
Common questions about Cheongwidan-f
What is Cinnamon used for?
In a clinical setting, Cinnamon is primarily used as a non-standardized food allergenic extract to diagnose hypersensitivity through skin prick or blood testing. Beyond diagnostics, it is frequently used as a complementary supplement to help manage blood sugar levels in patients with Type 2 diabetes or metabolic syndrome. Some research also suggests it may assist in lowering cholesterol and providing antioxidant support. However, it is not a replacement for standard medical treatments like insulin or metformin. You should always consult your healthcare provider before using cinnamon for any therapeutic purpose to ensure it is appropriate for your specific health needs.
What are the most common side effects of Cinnamon?
The most common side effects of Cinnamon include gastrointestinal issues such as bloating, gas, and stomach cramps, especially when taken on an empty stomach. Many people also experience oral irritation or 'cinnamon breath,' which can manifest as a burning sensation or small sores in the mouth (stomatitis). When applied to the skin, it can cause redness, itching, or a localized rash. While these are generally mild, they can be bothersome and may require a reduction in dosage. If these symptoms persist or worsen, it is important to stop use and speak with a medical professional.
Can I drink alcohol while taking Cinnamon?
Drinking alcohol while taking medicinal doses of Cinnamon is generally discouraged, particularly if you are using Cassia cinnamon. Both alcohol and the coumarin found in Cassia cinnamon are processed by the liver, and combining them can significantly increase the risk of liver strain or hepatotoxicity. Additionally, alcohol can interfere with blood sugar levels, either causing them to drop too low or spike, which complicates the management of diabetes if you are using cinnamon for that purpose. For these reasons, it is best to limit or avoid alcohol consumption while on a cinnamon regimen. Always discuss your alcohol intake with your doctor when starting new supplements.
Is Cinnamon safe during pregnancy?
Cinnamon is considered safe when used in the small amounts typically found in food and baked goods during pregnancy. However, taking concentrated cinnamon supplements or high medicinal doses is not recommended for pregnant women. This is because cinnamon can act as an emmenagogue, potentially stimulating uterine blood flow and contractions, which could pose a risk to the pregnancy. There is also a lack of comprehensive clinical data regarding the safety of high-dose cinnamon extracts on fetal development. To be safe, pregnant women should stick to culinary use and avoid therapeutic supplementation unless specifically directed by their obstetrician.
How long does it take for Cinnamon to work?
The time it takes for Cinnamon to show effects depends on what you are using it for. For allergy testing, the reaction is almost immediate, typically occurring within 15 to 30 minutes of skin contact. For metabolic purposes, such as lowering blood sugar or improving insulin sensitivity, it usually takes consistent daily use for about 2 to 4 weeks before a measurable difference is seen in fasting glucose levels. Changes in long-term markers like Hemoglobin A1c may take up to 3 months to become apparent. It is important to maintain a consistent dosing schedule and not expect immediate results for chronic health conditions.
Can I stop taking Cinnamon suddenly?
Yes, you can generally stop taking Cinnamon suddenly without experiencing physical withdrawal symptoms, as it is not an addictive substance. However, if you have been using it to help manage a chronic condition like Type 2 diabetes, stopping it abruptly may cause your blood sugar levels to rise. This could interfere with your overall treatment plan and glycemic control. It is always advisable to inform your healthcare provider before stopping any supplement that you have been using for a medical reason. They can help you monitor your health and adjust your other medications if necessary.
What should I do if I miss a dose of Cinnamon?
If you miss a dose of Cinnamon, you should take it as soon as you remember, provided it is not too close to your next scheduled dose. If it is nearly time for your next dose, simply skip the missed one and continue with your regular routine. You should never take two doses at once to make up for a missed one, as this can increase the risk of side effects like hypoglycemia or liver irritation. Maintaining a consistent schedule helps keep the levels of active compounds steady in your system. Setting a daily reminder on your phone can help you stay on track with your supplementation.
Does Cinnamon cause weight gain?
There is no clinical evidence to suggest that Cinnamon causes weight gain; in fact, some studies suggest it may assist with weight management. By improving insulin sensitivity and helping to regulate blood sugar levels, cinnamon may reduce insulin spikes, which are often associated with fat storage. Some research also indicates that cinnamon might have a slight thermogenic effect, potentially boosting metabolism. However, cinnamon is not a 'magic pill' for weight loss and should be used in conjunction with a healthy diet and exercise. If you notice unexpected weight gain while taking cinnamon, you should consult your doctor to rule out other underlying causes.
Can Cinnamon be taken with other medications?
Cinnamon can interact with several types of medications, so caution is necessary. It most notably interacts with diabetes drugs, such as insulin and metformin, where it can cause blood sugar to drop dangerously low. It also interacts with blood thinners like warfarin and heart medications like statins, potentially increasing the risk of bleeding or liver issues. Because of these potential interactions, it is vital to provide your doctor or pharmacist with a full list of all medications and supplements you are currently taking. They can help you determine if cinnamon is safe for you and if any dosage adjustments are needed for your other prescriptions.
Is Cinnamon available as a generic?
Cinnamon is a natural botanical substance and is not 'patented' in the way that pharmaceutical drugs are, so it is widely available from many different manufacturers. You can find it as a generic store-brand supplement or as a branded product in various forms like capsules, powders, and extracts. When choosing a product, it is important to look for high-quality supplements that have been third-party tested for purity and potency. Additionally, check whether the product is 'Ceylon' or 'Cassia' cinnamon, as this significantly affects the coumarin content and safety profile. Your healthcare provider can often recommend a reputable brand or specific type of extract.
Similar Medications
Other drugs with the same active ingredient (Cinnamon)
Hypoglycemia: In patients already taking diabetes medications, cinnamon may lower blood sugar too much. Symptoms include shakiness, sweating, confusion, and palpitations.
Diarrhea: High doses of cinnamon can irritate the lining of the intestines, leading to loose stools.
Dizziness: Some users report a feeling of lightheadedness, which may be related to changes in blood pressure or glucose levels.
Rare Side Effects (less than 1 in 100)
Hepatotoxicity: This is the most concerning rare side effect, primarily associated with Cassia cinnamon. Coumarin can cause inflammation of the liver, leading to elevated liver enzymes. In rare cases, this can progress to clinical hepatitis or liver failure.
Severe Allergic Reactions (Anaphylaxis): Although rare, some individuals may experience a systemic allergic reaction characterized by hives, swelling of the face or throat, and difficulty breathing.
Photosensitivity: Some compounds in cinnamon may make the skin more sensitive to sunlight, increasing the risk of sunburn.
Serious Side Effects — Seek Immediate Medical Attention
> Warning: Stop taking Cinnamon and call your doctor immediately if you experience any of these.
Jaundice: Yellowing of the eyes or skin, which is a hallmark sign of liver dysfunction.
Dark Urine: Often an early indicator of liver stress or rhabdomyolysis (though the latter is extremely rare with cinnamon).
Persistent Abdominal Pain: Specifically in the upper right quadrant, which may indicate liver inflammation.
Severe Skin Rash: A widespread, blistering, or peeling rash could indicate a severe hypersensitivity reaction.
Extreme Hypoglycemia: If you become unresponsive or have a seizure due to low blood sugar.
Long-Term Side Effects
Liver Enzyme Elevation: Chronic use of high-dose Cassia cinnamon can lead to persistent elevations in ALT and AST levels. This usually reverses upon discontinuation but requires monitoring.
Cumulative Anticoagulation: Long-term intake of coumarin-containing cinnamon may slightly increase the risk of bruising or bleeding, especially if combined with other blood thinners.
DNA Damage (Theoretical): High doses of coumarin have shown genotoxic potential in animal models, though the relevance to human dietary intake is debated.
Black Box Warnings
There are currently no FDA-mandated Black Box Warnings for Cinnamon allergenic extracts or supplements. However, clinical guidelines emphasize the risk of liver injury associated with coumarin-rich varieties.
Report any unusual symptoms to your healthcare provider. Monitoring of liver function is recommended for anyone using high-dose cinnamon supplements for more than 4-6 weeks.
Allergic Reactions / Anaphylaxis Risk
Individuals with a known allergy to Balsam of Peru may have a cross-sensitivity to Cinnamon. Exposure can lead to contact dermatitis, oral stomatitis, or in severe cases, systemic anaphylaxis. Healthcare providers should perform a thorough allergy history before using cinnamon extracts.
Hepatotoxicity (Liver Toxicity)
Due to the coumarin content in Cassia cinnamon, there is a risk of liver injury. This risk is dose-dependent and may be exacerbated in individuals with pre-existing liver conditions or those taking other hepatotoxic medications (e.g., acetaminophen, statins). If you have a history of liver disease, discuss this with your doctor before using cinnamon supplements.
Hypoglycemia (Low Blood Sugar)
Cinnamon has potent insulin-sensitizing effects. While beneficial for many, it can cause dangerously low blood sugar levels in patients taking insulin or oral hypoglycemic agents like sulfonylureas. Frequent blood glucose monitoring is required when initiating cinnamon therapy.
Surgery
Because of its potential anticoagulant properties and its effect on blood sugar, Cinnamon should be discontinued at least two weeks prior to elective surgery. Failure to do so may increase the risk of intraoperative bleeding or difficulty managing blood glucose levels during and after the procedure.
Monitoring Requirements
If you are taking Cinnamon supplements for a chronic condition, your healthcare provider may require the following tests:
Liver Function Tests (LFTs): To monitor for elevations in ALT, AST, and bilirubin, particularly if using Cassia cinnamon.
Hemoglobin A1c and Fasting Glucose: To assess the efficacy of the supplement and ensure blood sugar does not drop too low.
Prothrombin Time (PT/INR): In rare cases where high doses are combined with other anticoagulants.
Driving and Operating Machinery
Cinnamon itself does not typically cause sedation. However, if you experience hypoglycemia (dizziness, blurred vision, shakiness) as a result of taking cinnamon with diabetes medications, your ability to drive or operate heavy machinery may be impaired. Do not engage in these activities until you know how cinnamon affects your blood sugar.
Alcohol Use
Alcohol should be consumed with extreme caution. Both alcohol and coumarin (in Cassia cinnamon) are processed by the liver. Combining them can increase the metabolic strain on the liver and heighten the risk of hepatotoxicity. Furthermore, alcohol can mask the symptoms of hypoglycemia.
Discontinuation
There is no known withdrawal syndrome associated with Cinnamon. However, if you are using it to manage blood sugar, stopping it suddenly may lead to a spike in glucose levels (rebound hyperglycemia). Always consult your doctor before discontinuing a supplement used for a chronic medical condition.
> Important: Discuss all your medical conditions with your healthcare provider before starting Cinnamon.
Diabetes Medications: Cinnamon interacts significantly with Insulin, Metformin, Glyburide, and Pioglitazone. The mechanism is a synergistic pharmacodynamic interaction where both substances lower blood glucose. The clinical consequence is an increased risk of severe hypoglycemia. Management involves frequent glucose monitoring and potential downward titration of the pharmaceutical medication.
Hepatotoxic Agents: Medications like Acetaminophen (Tylenol), Amiodarone, and Methotrexate can have their liver-damaging potential increased when taken with Cassia cinnamon.
Moderate Interactions
Statins: Drugs like Atorvastatin and Simvastatin are processed by the liver. Since cinnamon can also affect liver enzymes, there is a moderate risk of increased side effects from the statins, including myopathy.
Cytochrome P450 2A6 (CYP2A6) Substrates: Coumarin is a substrate for CYP2A6. Cinnamon may compete for this enzyme, potentially increasing the plasma levels of other drugs metabolized by this pathway.
Food Interactions
High-Fat Meals: May increase the absorption of lipid-soluble components of cinnamon, potentially increasing the risk of side effects.
Alcohol: As noted previously, alcohol increases the risk of liver toxicity and can complicate blood sugar management.
Garlic and Ginger: These supplements also have mild anticoagulant properties. Combining them with high-dose cinnamon may further increase the risk of bruising or bleeding.
Herbal/Supplement Interactions
Alpha-Lipoic Acid / Chromium: These supplements also lower blood sugar. Combining them with cinnamon significantly increases the risk of hypoglycemia.
Red Yeast Rice: Often used for cholesterol, this can be hard on the liver. Combining it with Cassia cinnamon increases the risk of hepatic strain.
St. John's Wort: May induce liver enzymes that change the rate at which cinnamon's bioactive compounds are metabolized.
Lab Test Interactions
Liver Function Tests: Cinnamon can cause false elevations or clinically significant increases in ALT, AST, and Bilirubin.
Blood Glucose Tests: May show lower-than-expected results.
Coagulation Panels (PT/INR): May be prolonged in individuals consuming large amounts of Cassia cinnamon.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. The interaction between botanical extracts and pharmaceutical drugs can be unpredictable.
: Due to the potential anticoagulant effects of coumarin, cinnamon should not be used by patients with active bleeding disorders or major internal bleeding.
Mild to Moderate Liver Disease: Such as Non-Alcoholic Fatty Liver Disease (NAFLD). The potential for hepatotoxicity may outweigh the metabolic benefits.
Planned Surgery: As mentioned, the risk of bleeding and glycemic instability makes cinnamon use risky in the perioperative period.
Pregnancy: High medicinal doses are relatively contraindicated due to the potential for uterine stimulation (emmenagogue effects).
Peptic Ulcer Disease: Cinnamon can irritate the gastric mucosa, potentially worsening ulcers or gastritis.
Cross-Sensitivity
Patients should be aware of potential cross-reactions with:
Balsam of Peru: Frequently used in perfumes and topical medications.
Cloves and Nutmeg: May share similar aromatic compounds that trigger allergic responses.
Synthetic Fragrances: Many contain cinnamal, which can trigger reactions in cinnamon-sensitive individuals.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing or recommending Cinnamon extracts.
: It is unknown if the bioactive components of cinnamon, such as cinnamaldehyde or coumarin, are excreted in human breast milk.
Effects on Infant: While culinary use is likely safe, high-dose supplements could potentially affect the nursing infant's liver or blood sugar. Due to the lack of safety data, nursing mothers are advised to avoid cinnamon supplements.
Pediatric Use
Safety Profile: The safety of high-dose cinnamon has not been established in children.
Specific Risks: Children may be more susceptible to the hepatotoxic effects of coumarin due to their smaller body mass and developing liver enzyme systems. Its use as an allergenic extract is limited to diagnostic settings under strict supervision.
Geriatric Use
Pharmacokinetic Changes: Older adults often have reduced renal and hepatic clearance. This can lead to the accumulation of coumarin metabolites, increasing the risk of liver injury.
Polypharmacy: The elderly are more likely to be on multiple medications (anticoagulants, statins, diabetes meds) that interact with cinnamon. Healthcare providers should perform a thorough medication review before recommending cinnamon to older patients.
Renal Impairment
Dosing: While no specific GFR-based adjustments exist, the kidneys are the primary route of elimination for cinnamon metabolites. In patients with severe renal impairment, monitoring for systemic toxicity is essential.
Dialysis: It is unknown if cinnamon's active components are dialyzable.
Hepatic Impairment
Child-Pugh Classification: Cinnamon (especially Cassia) is generally contraindicated in patients with Child-Pugh Class B or C hepatic impairment. The risk of worsening liver function due to coumarin-induced stress is high. Even in Class A (mild) impairment, extreme caution and frequent LFT monitoring are required.
> Important: Special populations require individualized medical assessment to ensure that the use of any botanical extract does not compromise underlying health conditions.
Duration: The metabolic effects of a single dose typically last 12-24 hours.
Tolerance: There is no evidence of pharmacological tolerance developing with long-term use, though the risk of side effects may increase over time.
Solubility: Volatile oils are lipid-soluble; polyphenols are water-soluble.
Structure: Cinnamaldehyde consists of a phenyl group attached to an unsaturated aldehyde.
Drug Class
Cinnamon is classified as a Non-Standardized Food Allergenic Extract [EPC]. Within the therapeutic realm, it is often grouped with other insulin-sensitizing botanicals like Fenugreek and Bitter Melon, though its specific EPC tags include Central Nervous System Stimulant [EPC] and Anti-coagulant [EPC] due to its complex chemical matrix.