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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Bone Stim Liquescence
Brand Name
Bone Stim Liquescence
Generic Name
Bone Stim Liquescence
Active Ingredient
Anhydrous DibasicCategory
Standardized Chemical Allergen [EPC]
Salt Form
Calcium Phosphate
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 4 [hp_X]/118mL | LIQUID | ORAL | 63083-3005 |
Detailed information about Bone Stim Liquescence
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Bone Stim Liquescence, you must consult a qualified healthcare professional.
Anhydrous Dibasic Calcium Phosphate is a mineral supplement and pharmaceutical agent used as a source of calcium and phosphorus, and as a standardized chemical allergen in diagnostic testing.
For the treatment of calcium and phosphorus deficiency, the standard adult dosage of Anhydrous Dibasic typically ranges from 500 mg to 1500 mg per day, administered in divided doses. When used as a dietary supplement to meet the Recommended Dietary Allowance (RDA), doses are usually lower, often around 250 mg to 500 mg daily, depending on dietary intake.
In the context of osteoporosis prevention, healthcare providers may recommend 1000 mg to 1200 mg of elemental calcium daily, which requires calculating the specific amount of Anhydrous Dibasic needed to reach those elemental targets. For diagnostic allergy testing, the dosage is standardized within the patch test kit and applied by a healthcare professional according to established protocols.
Pediatric dosing must be strictly supervised by a pediatrician. For children aged 1 to 3 years, the RDA for calcium is approximately 700 mg; for ages 4 to 8, it is 1000 mg; and for adolescents aged 9 to 18, it is 1300 mg. Anhydrous Dibasic may be used to meet these requirements if dietary sources are insufficient. However, it is not typically the first-line form of calcium for infants unless specifically formulated in a prescribed metabolic formula.
Patients with chronic kidney disease (CKD) require extreme caution. In advanced renal impairment (Stage 4 or 5), the kidneys cannot effectively excrete phosphorus, leading to hyperphosphatemia. Since Anhydrous Dibasic contains phosphorus, it may be contraindicated or require significant dose reduction. Serum calcium and phosphorus levels must be monitored every 2 to 4 weeks during initiation.
No specific dose adjustments are generally required for patients with liver disease, as the mineral is not metabolized by the liver. However, patients with cholestatic liver disease may have impaired Vitamin D absorption, which indirectly affects the efficacy of Anhydrous Dibasic.
Geriatric patients often have lower gastric acid secretion (achlorhydria), which can reduce the dissolution and absorption of anhydrous salts. Healthcare providers may recommend taking the supplement with a meal to enhance absorption or switching to a more soluble form if serum levels do not improve.
To maximize the benefit of Anhydrous Dibasic, patients should follow these specific instructions:
If you miss a dose of Anhydrous Dibasic, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not 'double up' or take two doses at once, as this increases the risk of gastrointestinal upset and hypercalcemia.
An overdose of Anhydrous Dibasic can lead to acute hypercalcemia. Symptoms include severe nausea, vomiting, constipation, confusion, lethargy, and in extreme cases, cardiac arrhythmias or coma. If an overdose is suspected, contact a poison control center or seek emergency medical attention immediately. Treatment typically involves vigorous intravenous hydration with normal saline and the administration of loop diuretics to promote calcium excretion.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance, as improper mineral balance can lead to serious cardiovascular and renal complications.
The most frequently reported side effects associated with Anhydrous Dibasic are gastrointestinal in nature. Because calcium can slow the transit time of the digestive tract, constipation is a very common occurrence. Patients may describe a feeling of fullness, difficulty passing stools, or hard, dry stools. This typically persists as long as the supplement is taken but can be managed with increased fiber and water intake.
Additionally, some patients experience abdominal gas or bloating. This occurs as the calcium phosphate interacts with stomach acid and intestinal enzymes, occasionally releasing small amounts of gas or altering the local osmotic balance. These symptoms are usually mild and tend to diminish as the body adjusts to the supplement over 1-2 weeks.
> Warning: Stop taking Anhydrous Dibasic and call your doctor immediately if you experience any of these serious symptoms.
Prolonged use of high-dose Anhydrous Dibasic may lead to vascular calcification, where calcium deposits build up in the walls of the arteries, potentially increasing the risk of cardiovascular disease. This is a particular concern in patients with pre-existing kidney disease. Long-term use can also lead to chronic constipation and may interfere with the absorption of other essential minerals like magnesium and iron, potentially leading to secondary deficiencies over several months or years.
Currently, there are no FDA black box warnings for Anhydrous Dibasic Calcium Phosphate. It is generally considered safe when used according to recommended guidelines. However, its safety profile is contingent upon the patient's renal function and baseline electrolyte status.
Report any unusual symptoms to your healthcare provider. Monitoring of blood levels may be necessary for those on long-term therapy to ensure the dosage remains within a safe therapeutic window.
Anhydrous Dibasic is a potent mineral agent that must be used with a clear understanding of your current health status. It is not merely a 'vitamin' but a bioactive compound that can significantly alter the body's electrolyte balance. Patients must be aware that excessive intake of calcium and phosphorus can lead to soft tissue calcification, where minerals deposit in the heart, lungs, and kidneys instead of the bones.
No FDA black box warnings for Anhydrous Dibasic. It is classified as a mineral supplement and a standardized allergen with a well-established safety profile when administered under professional supervision.
If you are taking Anhydrous Dibasic for a medical condition, your healthcare provider will likely require periodic lab tests:
Anhydrous Dibasic does not typically cause drowsiness or cognitive impairment. It is generally safe to drive or operate machinery while taking this supplement. However, if you experience symptoms of hypercalcemia such as confusion or extreme lethargy, you should cease these activities and contact your doctor.
Moderate alcohol consumption does not directly interact with Anhydrous Dibasic. However, chronic heavy alcohol use can impair the liver's ability to process Vitamin D and can interfere with the absorption of calcium in the gut, rendering the supplement less effective. It is best to limit alcohol intake to ensure optimal bone health.
There is no 'withdrawal syndrome' associated with stopping Anhydrous Dibasic. However, if you are taking it for a chronic condition like osteoporosis or hypoparathyroidism, stopping suddenly may lead to a rapid decline in bone density or a dangerous drop in serum calcium levels. Always consult your doctor before discontinuing a prescribed supplement regimen.
> Important: Discuss all your medical conditions, especially any history of kidney stones or heart disease, with your healthcare provider before starting Anhydrous Dibasic.
Anhydrous Dibasic can affect the results of several laboratory tests:
For each major interaction, the mechanism involves either chelation (the formation of a non-absorbable complex) or pharmacodynamic synergy (where both substances affect the same physiological system, like the heart's rhythm). Management typically involves staggered dosing or frequent blood monitoring.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter antacids.
Anhydrous Dibasic must NEVER be used in the following circumstances:
Conditions requiring careful risk-benefit analysis include:
Patients who have had an allergic reaction to other calcium salts (such as calcium carbonate or calcium citrate) are unlikely to be allergic to the calcium itself but may be sensitive to the phosphate component or the binders used in a specific brand's tablet. In the context of the Standardized Chemical Allergen [EPC], if a patient has a known allergy to phosphate minerals, they should not undergo patch testing with this substance.
> Important: Your healthcare provider will evaluate your complete medical history, including your kidney function and previous stone history, before prescribing Anhydrous Dibasic.
Anhydrous Dibasic is generally considered safe and is often essential during pregnancy. The developing fetus requires significant amounts of calcium for skeletal development, especially during the third trimester. According to the FDA, calcium supplements are frequently used to meet the increased RDA of 1000 mg to 1300 mg daily. There is no evidence of teratogenicity (birth defects). However, excessive doses must be avoided to prevent maternal hypercalcemia, which can lead to complications like preeclampsia or neonatal hypocalcemia.
Calcium is a natural component of breast milk. Supplementation with Anhydrous Dibasic by the nursing mother does not typically raise milk calcium levels above the physiological range. It is considered safe for use during breastfeeding and may help the mother maintain her own bone density while nursing. No adverse effects have been observed in nursing infants whose mothers took standard doses.
Anhydrous Dibasic is approved for use in children as a mineral supplement. It is particularly important for children with restricted diets or those with conditions like malabsorption syndrome. However, it is NOT approved for use in infants under 1 year of age unless part of a specialized medical formula. Long-term use in children requires monitoring of growth and renal function to ensure that mineral deposition is occurring correctly in the bones and not in soft tissues.
Elderly patients are the primary users of Anhydrous Dibasic for the prevention of osteoporosis. However, this population is at a higher risk for:
As previously noted, renal impairment is a major concern.
No primary adjustments are needed for liver disease. However, clinicians should be aware that patients with end-stage liver disease may have altered protein binding (low albumin), which can make 'total calcium' blood tests misleading. In these cases, 'ionized calcium' levels should be checked instead.
> Important: Special populations require individualized medical assessment and frequent laboratory monitoring to ensure safety.
Anhydrous Dibasic Calcium Phosphate functions as an exogenous source of calcium and phosphorus ions. Upon ingestion, the anhydrous crystal lattice is dissolved by gastric acid. The resulting free calcium ions (Ca2+) are absorbed through the intestinal wall via two pathways: a transcellular active transport mechanism primarily in the duodenum (regulated by Vitamin D) and a paracellular passive diffusion process throughout the rest of the small intestine. Once in the blood, these ions are utilized by the body to maintain the structural integrity of the hydroxyapatite matrix in bones ($Ca_{10}(PO_4)_6(OH)_2$).
The pharmacodynamic effect of Anhydrous Dibasic is the stabilization or increase of serum calcium and phosphorus levels. The onset of action for increasing serum levels is relatively rapid (within 1-2 hours), but the therapeutic effect on bone mineral density takes months of consistent use. The duration of effect is maintained as long as the supplement is taken, with the body’s homeostatic mechanisms (PTH and calcitonin) constantly working to balance these levels.
| Parameter | Value |
|---|---|
| Bioavailability | 25% - 35% (Enhanced by Vitamin D) |
| Protein Binding | 40% (Primarily to Albumin) |
| Half-life | Varies (Serum: hours; Bone: years) |
| Tmax | 1 - 2 hours |
| Metabolism | None (Inorganic Mineral) |
| Excretion | Fecal (approx. 80%), Renal (approx. 20%) |
Anhydrous Dibasic is classified as a Mineral/Electrolyte Supplement. Within the EPC framework, it is also a Standardized Chemical Allergen. It is related to other calcium salts like Calcium Carbonate (which requires more acid for absorption) and Calcium Citrate (which is more soluble and can be taken without food).
Common questions about Bone Stim Liquescence
Anhydrous Dibasic Calcium Phosphate is primarily used as a mineral supplement to treat or prevent deficiencies in calcium and phosphorus. These minerals are essential for maintaining strong bones, healthy teeth, and proper nerve and muscle function. It is also frequently used as a 'filler' or 'binder' in the manufacturing of many other prescription medications to ensure tablet stability. Additionally, in specialized clinical settings, it serves as a standardized allergen used in patch testing to diagnose skin allergies. Your doctor may prescribe it if you have conditions like osteoporosis, osteomalacia, or hypoparathyroidism.
The most common side effects are related to the digestive system, with constipation being the most frequently reported issue. Many patients also experience mild stomach upset, gas, or a feeling of bloating after taking the supplement. These symptoms often occur because calcium can slow down the movement of the intestines. To manage these effects, healthcare providers typically recommend increasing your intake of water and dietary fiber. If these symptoms become severe or are accompanied by intense abdominal pain, you should contact your healthcare provider immediately.
There is no direct, dangerous interaction between alcohol and Anhydrous Dibasic Calcium Phosphate. However, chronic and excessive alcohol consumption is known to interfere with how your body absorbs calcium and processes Vitamin D, which can make the supplement less effective. Alcohol can also weaken bone structure over time, potentially worsening the condition you are trying to treat. For the best clinical results, it is recommended to limit alcohol intake to moderate levels. Always discuss your lifestyle habits with your doctor to ensure your treatment plan is optimized.
Yes, Anhydrous Dibasic is generally considered safe and is often recommended during pregnancy to support the skeletal development of the growing fetus. Pregnant women have an increased need for calcium, and if dietary intake is insufficient, supplements are a standard part of prenatal care. It is important, however, to stay within the dosage recommended by your obstetrician, as excessive calcium can lead to complications. Most healthcare providers suggest a total daily intake of 1000 mg to 1300 mg of elemental calcium from all sources during pregnancy. Always consult your midwife or doctor before starting any new supplement.
The time it takes for Anhydrous Dibasic to work depends on the goal of treatment. For increasing blood calcium levels, the effects can be seen within 1 to 2 hours after ingestion as the mineral is absorbed into the bloodstream. However, if you are taking it to improve bone density or prevent osteoporosis, it may take several months or even years of consistent use to see measurable changes on a bone density (DEXA) scan. Regular blood tests are often used by doctors to confirm that the supplement is being absorbed and is reaching the target levels in your body.
While stopping Anhydrous Dibasic suddenly does not cause a traditional withdrawal syndrome like some psychiatric or heart medications, it can have negative health consequences. If you are taking it to manage a chronic condition like hypoparathyroidism, stopping abruptly could cause your blood calcium levels to drop dangerously low. If used for osteoporosis, your bone loss may accelerate once the supplement is discontinued. You should always talk to your healthcare provider before stopping the medication so they can evaluate your mineral levels and suggest a safe alternative if needed.
If you miss a dose of Anhydrous Dibasic, you should take it as soon as you remember. If it is already very close to the time for your next scheduled dose, it is better to skip the missed dose entirely and simply take your next dose at the regular time. You should never take two doses at once to make up for a missed one, as this can lead to an upset stomach or a temporary spike in calcium levels. Consistency is key for bone health, so try to take your supplement at the same time each day, ideally with a meal.
There is no clinical evidence to suggest that Anhydrous Dibasic Calcium Phosphate causes weight gain. In fact, some clinical studies have explored the possibility that adequate calcium intake might actually support weight management, although the results are not definitive. If you notice weight changes while taking this supplement, they are likely due to other factors such as diet, exercise, or other medications you may be taking. If you have concerns about your weight, it is best to discuss them with a registered dietitian or your primary care physician.
Anhydrous Dibasic can interact with many other medications, often by preventing them from being absorbed properly. It is known to bind to certain antibiotics (like Ciprofloxacin and Doxycycline), thyroid medications, and osteoporosis drugs (bisphosphonates). To avoid these interactions, it is usually necessary to space your medications several hours apart. For example, you might take your other medication two hours before or four to six hours after your calcium supplement. Always provide your pharmacist with a full list of your medications to check for specific timing requirements.
Yes, Anhydrous Dibasic Calcium Phosphate is widely available as a generic product and is often found in over-the-counter mineral supplements and generic multivitamin formulations. Because it is a standard chemical compound, the generic versions are generally just as effective as brand-name supplements. However, the 'anhydrous' form is specifically chosen for its stability in certain tablet types. When purchasing, check the label to ensure it meets USP (United States Pharmacopeia) standards for quality and purity. Generic versions are typically much more cost-effective for long-term use.
Other drugs with the same active ingredient (Anhydrous Dibasic)