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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Biotitum
Generic Name
Biotitum
Active Ingredient
BiotinCategory
Central Nervous System Stimulant [EPC]
Variants
8
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Biotitum, you must consult a qualified healthcare professional.
| 30 [hp_C]/1 | PELLET | ORAL | 63545-632 |
| 100 [hp_C]/1 | PELLET | ORAL | 63545-633 |
| 500 [hp_C]/1 | PELLET | ORAL | 63545-635 |
| 6 [hp_C]/1 | PELLET | ORAL | 63545-630 |
| 1 [hp_Q]/1 | PELLET | ORAL | 63545-638 |
Detailed information about Biotitum
Biotin, also known as Vitamin B7, is a water-soluble B-complex vitamin essential for carboxylase enzyme function. It plays a vital role in fatty acid synthesis, gluconeogenesis, and amino acid metabolism, and is a member of the Vitamin B Complex [EPC] drug class.
Dosage for Biotin varies significantly based on the indication and the patient's nutritional status. For general health maintenance, the National Academy of Medicine suggests an Adequate Intake (AI) of 30 mcg per day for adults over the age of 19.
Pediatric dosing is strictly based on age and should only be administered under the guidance of a pediatrician. The Adequate Intake (AI) levels are as follows:
For genetic metabolic disorders in children, doses are significantly higher and must be individualized by a specialist in pediatric genetics or metabolism.
Biotin is primarily excreted by the kidneys. While there are no specific FDA-mandated dose adjustments for mild to moderate renal impairment, patients with end-stage renal disease (ESRD) or those on dialysis should be monitored closely. Some studies suggest that Biotin levels may be lower in hemodialysis patients, potentially requiring supplementation, but high doses should be avoided to prevent accumulation of metabolites.
Since the liver is a primary storage site for Biotin and involved in its conversion to active cofactors, severe hepatic impairment may affect Biotin utilization. However, standard dose adjustments are not typically required for patients with liver disease unless a secondary malabsorption syndrome is present.
Geriatric patients often have reduced gastric acid secretion and may be taking multiple medications that interfere with Biotin absorption (e.g., proton pump inhibitors). Healthcare providers generally recommend sticking to the AI of 30 mcg/day unless a deficiency is clinically suspected. Consideration should be given to the increased risk of lab interference in this population, as they are more likely to undergo frequent diagnostic testing.
Biotin can be taken with or without food. However, taking it with a meal may improve absorption and reduce the likelihood of mild gastrointestinal upset.
If you miss a dose of Biotin, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed one. Since Biotin is a water-soluble vitamin, a single missed dose is unlikely to have a significant clinical impact.
Biotin is generally considered non-toxic, even at very high doses, because it is water-soluble and excess amounts are readily excreted in the urine. There have been no reported cases of life-threatening Biotin toxicity in humans. However, an overdose may result in:
In the event of an intentional massive overdose, contact your local poison control center or seek emergency medical attention. The primary risk of 'overdose' is not systemic toxicity but the profound interference with critical diagnostic blood tests.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance. Always inform your doctor if you are taking more than the standard recommended daily intake.
Biotin is exceptionally well-tolerated by the vast majority of patients. When taken at the recommended daily intake levels (30 mcg), side effects are virtually non-existent. However, at higher supplemental doses (e.g., 5,000 mcg or more), some patients may report:
These symptoms are usually transient and do not require discontinuation of the supplement. Taking the supplement with food often mitigates these issues.
The most critical warning regarding Biotin is its potential to significantly interfere with clinical laboratory tests. Biotin is used in many lab assays (tests) because of its strong ability to bind to specific proteins (streptavidin). If a patient has high levels of Biotin in their blood, it can cause the lab results to be either falsely high or falsely low, depending on the design of the test. This has led to serious adverse events, including at least one reported death where a patient's troponin (a marker of heart attack) was falsely suppressed by Biotin, leading to a missed diagnosis.
No FDA black box warnings for Biotin. However, the FDA Safety Communication serves as a high-level alert for all healthcare providers and patients regarding the 'Biotin-Streptavidin' interaction in diagnostic testing.
There are no known 'absolute' drug-drug contraindications where Biotin causes a lethal or highly toxic chemical reaction. However, the combination of high-dose Biotin and certain diagnostic assays is considered a 'clinical contraindication' because it prevents accurate medical diagnosis.
Biotin is essential during pregnancy for normal fetal development. The FDA and the National Academy of Medicine have set the Adequate Intake (AI) for pregnant women at 30 mcg per day.
Biotin is a natural component of human breast milk. The AI for lactating women is 35 mcg per day.
Biotin functions as a covalently bound coenzyme for five human carboxylases. The biochemical mechanism involves a two-step reaction. First, Biotin is attached to the epsilon-amino group of a specific lysine residue on the apocarboxylase enzyme, a process catalyzed by holocarboxylase synthetase. Second, the biotinylated enzyme (holocarboxylase) uses ATP to 'activate' bicarbonate into a carboxybiotin intermediate. This activated CO2 is then transferred to a substrate.
Key enzymes include:
Common questions about Biotitum
Biotin is primarily used to treat or prevent Biotin deficiency, which can cause symptoms like hair thinning, skin rashes, and neurological issues. It is a critical cofactor for enzymes that help the body break down fats, carbohydrates, and proteins for energy. Many healthcare providers also recommend it off-label to improve the strength of brittle nails and the health of hair, although these benefits are most noticeable in people who have low Biotin levels. Additionally, it is used in high doses to treat rare genetic conditions like Biotinidase deficiency. Always consult your doctor to see if Biotin is appropriate for your specific health needs.
Biotin is generally very safe and side effects are rare when taken at recommended doses. Some people may experience mild gastrointestinal issues such as nausea, stomach cramping, or diarrhea, especially when taking high-dose supplements on an empty stomach. There are also reports of 'biotin-induced acne,' which some believe happens because Biotin can interfere with the absorption of Vitamin B5 in the gut. Allergic reactions, though very rare, can occur and may present as a skin rash or itching. If you experience any severe symptoms like difficulty breathing, you should seek medical attention immediately.
While there is no dangerous interaction between Biotin and alcohol, chronic alcohol consumption can interfere with how your body absorbs the vitamin. Alcohol can damage the lining of the digestive tract and inhibit the transporters responsible for moving Biotin from the gut into the bloodstream. This means that if you drink alcohol excessively, your Biotin supplement may be less effective. For the best results, it is recommended to limit alcohol intake while trying to correct a vitamin deficiency. Always discuss your alcohol consumption with your healthcare provider when starting a new supplement.
Biotin is considered safe and is an essential nutrient during pregnancy, as it supports the rapid cell division of the growing fetus. Most prenatal vitamins contain an appropriate amount of Biotin (usually around 30 to 300 mcg), which is well within the safe range. However, pregnant women should avoid taking very high doses of Biotin (such as those found in 'mega-dose' beauty supplements) unless specifically instructed by their doctor. Some studies suggest that the body breaks down Biotin faster during pregnancy, making adequate intake even more important. Always talk to your obstetrician before adding any new supplements to your routine.
The time it takes for Biotin to show visible results depends on what you are treating. For metabolic issues or correcting a deficiency, biochemical improvements in the blood can happen within a few days. However, for cosmetic concerns like hair growth or nail strength, it typically takes 3 to 6 months of consistent daily use to see a noticeable difference. This is because hair and nails grow slowly, and the new, stronger tissue must grow out from the root. If you do not see any changes after six months, you should consult your doctor to investigate other potential causes for your symptoms.
For most people taking Biotin as a general nutritional supplement, it is perfectly safe to stop taking it suddenly without any withdrawal symptoms. Since Biotin is a water-soluble vitamin, your body does not become 'addicted' to it. However, if you are taking Biotin to treat a specific medical condition like Biotinidase deficiency, stopping the medication can lead to serious health complications, including seizures and skin problems. In such cases, you must never stop or change your dose without direct supervision from your healthcare provider. For everyone else, stopping the supplement simply means your blood levels will return to their baseline within a few days.
If you miss a dose of Biotin, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, it is better to skip the missed dose and just take your next one at the regular time. You should never take two doses at once to 'catch up,' as this can increase the risk of mild stomach upset. Because Biotin is a vitamin that stays in your system for about a day, missing a single dose occasionally will not significantly impact your overall health or the effectiveness of the supplement. Consistency is helpful, but an occasional missed dose is not a cause for concern.
There is no scientific evidence to suggest that Biotin causes weight gain. In fact, because Biotin is a key component of the enzymes that break down fats and carbohydrates, it is often associated with a healthy metabolism. Some people mistakenly believe it causes weight gain because it is a 'B-vitamin,' and some B-vitamins are known to increase appetite in people who were previously deficient. However, Biotin itself does not contain calories and does not alter the body's fat storage mechanisms in a way that would lead to weight gain. If you notice unexpected weight changes, you should speak with your doctor to find the underlying cause.
Biotin can be taken with many medications, but there are some important exceptions. Certain anti-seizure medications, such as phenytoin and carbamazepine, can lower the levels of Biotin in your body by interfering with its absorption. Conversely, taking high doses of Biotin can interfere with the results of many important blood tests, including those for heart attacks and thyroid function. It is also worth noting that other supplements like Alpha-Lipoic Acid may compete with Biotin for absorption. You should always provide your doctor with a full list of all medications and supplements you are taking to ensure there are no interactions.
Yes, Biotin is widely available as a generic supplement and is sold under many different brand names. Since it is a naturally occurring vitamin, the generic versions are chemically identical to the 'brand-name' versions found in expensive beauty supplements. You can find generic Biotin in various forms, including tablets, capsules, and liquid drops, at most pharmacies and grocery stores. When choosing a generic, look for products that have been third-party tested (such as by USP or NSF) to ensure the potency and purity of the ingredient. Generic Biotin is an effective and affordable way to ensure you are meeting your nutritional requirements.
Other drugs with the same active ingredient (Biotin)
In some individuals, particularly those taking high-potency 'hair and nail' supplements, the following may occur:
Rarely, individuals may experience more distinct reactions:
While Biotin itself is not typically dangerous, serious reactions can occur, often related to allergic responses or the effects of high doses on underlying conditions.
> Warning: Stop taking Biotin and call your doctor immediately if you experience any of these:
There is little evidence to suggest that long-term use of Biotin at reasonable doses (up to 10 mg/day) causes chronic toxicity. However, the long-term 'masking' effect on laboratory tests is a significant concern. Patients taking high-dose Biotin for years may have undiagnosed conditions (like hyperthyroidism or cardiac strain) because their lab results consistently appear 'normal' or 'false-negative' due to the supplement.
There are currently no FDA Black Box Warnings for Biotin. It is not considered a high-risk medication in the traditional sense. However, the FDA issued a significant Safety Communication in 2017 (updated in 2019) regarding Biotin's interference with laboratory tests, which is considered the most critical safety information associated with this ingredient.
Report any unusual symptoms to your healthcare provider. If you notice a significant change in your skin, digestion, or heart rate after starting Biotin, a clinical evaluation is warranted.
For most healthy individuals, no routine lab monitoring is required for Biotin itself. However, for those on high-dose therapy:
Biotin is not known to cause sedation, dizziness, or cognitive impairment. It is considered safe to drive or operate heavy machinery while taking this supplement.
Chronic alcohol consumption can significantly inhibit the absorption of Biotin. Alcohol interferes with the SMVT transporter in the gut, potentially leading to lower systemic levels of the vitamin. While there is no dangerous interaction between Biotin and alcohol, excessive drinking may render the supplement ineffective.
For general supplementation, Biotin can be stopped abruptly without risk of withdrawal. However, for patients with genetic Biotin-responsive disorders, discontinuation can be life-threatening and must only be done under the care of a metabolic specialist.
> Important: Discuss all your medical conditions with your healthcare provider before starting Biotin, especially if you have upcoming lab tests or a history of thyroid or heart disease.
This is the most significant 'interaction' for Biotin. Biotin interferes with assays that use a biotin-streptavidin link.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. Do not assume 'vitamins' are exempt from drug interaction checks.
There is no documented cross-sensitivity between Biotin and other B-vitamins. However, patients who are sensitive to 'B-complex' supplements should check if their reaction was due to Biotin or another component like Niacin (which causes flushing) or Vitamin B12.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of allergic reactions to vitamins or supplements, before prescribing or recommending Biotin.
Biotin is safe and essential for children. It is used in pediatric populations primarily to treat genetic metabolic disorders or to provide nutritional support in those with restricted diets.
Older adults may be at a slightly higher risk for Biotin deficiency due to age-related changes in diet and gut absorption.
In patients with impaired kidney function, the excretion of Biotin is reduced.
Liver disease does not typically require Biotin dose adjustments. However, since the liver is involved in the storage and activation of many B-vitamins, patients with cirrhosis or hepatitis should have their nutritional status monitored by a healthcare provider.
> Important: Special populations require individualized medical assessment. Always consult with a specialist—such as an obstetrician for pregnancy or a nephrologist for kidney disease—before starting a new supplement regimen.
Biotin's pharmacodynamic effect is primarily restorative. In individuals with adequate Biotin levels, additional Biotin does not significantly 'speed up' metabolism beyond physiological norms. However, in deficiency states, Biotin administration rapidly restores carboxylase activity, correcting metabolic acidosis and improving skin and neurological symptoms. The 'onset' of biochemical improvement occurs within hours, but clinical changes (like hair growth or nail strength) typically take 3 to 6 months of consistent use due to the slow growth cycle of these tissues.
| Parameter | Value |
|---|---|
| Bioavailability | 90% - 100% (Oral) |
| Protein Binding | ~80% (Albumin/Alpha-globulins) |
| Half-life | 10 - 20 hours |
| Tmax | 0.5 - 2 hours |
| Metabolism | Hepatic (minor oxidation of side chain) |
| Excretion | Renal (90% as Biotin and metabolites) |
Biotin is classified as a water-soluble vitamin and a member of the Vitamin B Complex [EPC]. It is also categorized as a 'Nutraceutical' or 'Dietary Supplement' in many regulatory frameworks. In the Anatomical Therapeutic Chemical (ATC) classification system, it is coded as A11HA05 (Other plain vitamin preparations).