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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Olea Europaea, Flos
Brand Name
Bio Olive 30c, 60c, 200c
Generic Name
Olea Europaea, Flos
Active Ingredient
Olea Europaea FlowerCategory
Standardized Insect Venom Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 30 [hp_C]/mL | LIQUID | ORAL | 43857-0666 |
Detailed information about Bio Olive 30c, 60c, 200c
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Bio Olive 30c, 60c, 200c, you must consult a qualified healthcare professional.
Olea Europaea Flower is a standardized allergenic extract used for the diagnosis and treatment of olive pollen allergies. It belongs to a diverse group of allergenic extracts and acts through complex immunological desensitization pathways.
Dosage for Olea Europaea Flower is highly individualized and is not based on a standard 'one-size-fits-all' milligram amount. Instead, it is measured in units of biological activity, such as Protein Nitrogen Units (PNU), Bioequivalent Allergy Units (BAU), or weight/volume (w/v) concentrations.
Olea Europaea Flower extracts are generally considered safe for use in children, typically those aged 5 years and older. Dosing protocols for children are generally the same as for adults, though the physician may choose a more cautious (slower) build-up phase. The safety and efficacy in children under the age of 5 have not been extensively established, and the risk-benefit ratio must be carefully weighed due to the difficulty of communicating symptoms of anaphylaxis in very young children.
No specific dosage adjustments are required for patients with renal impairment, as the proteins are metabolized proteolytically. However, the patient's overall health status should be stable before administration.
No dosage adjustments are necessary for patients with hepatic impairment. The liver does not play a primary role in the clearance of injected allergenic proteins.
Caution is advised when treating elderly patients. Healthcare providers must assess the patient's cardiovascular reserve, as the use of epinephrine (the primary treatment for overdose/anaphylaxis) may be riskier in patients with underlying heart disease or hypertension.
Olea Europaea Flower extract is never self-administered by the patient. It must be administered by a trained healthcare professional in a medical facility.
If a dose is missed during the build-up phase, the next dose may need to be reduced or the previous dose repeated to maintain safety. If a dose is missed during the maintenance phase, the healthcare provider will determine if the dose needs to be adjusted based on how much time has passed (e.g., if more than 6-8 weeks have passed, the dose is often reduced).
An overdose of Olea Europaea Flower extract is defined as the administration of a dose that exceeds the patient's current tolerance level. Signs of an overdose include:
Emergency Measures: If an overdose occurs, the healthcare provider will immediately stop the injection, administer epinephrine (adrenaline), and may provide antihistamines, corticosteroids, and oxygen. In severe cases, emergency transport to a hospital is required.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance. Always inform your doctor if you feel unwell on the day of your scheduled injection.
Most patients receiving Olea Europaea Flower immunotherapy will experience some form of local reaction. These are generally not dangerous but can be uncomfortable.
> Warning: Stop taking Olea Europaea Flower and call your doctor immediately if you experience any of these. These symptoms may indicate the onset of anaphylaxis.
Long-term use of Olea Europaea Flower immunotherapy (3-5 years) is generally well-tolerated. There is no evidence that it causes autoimmune diseases or chronic organ damage. The most common 'long-term' effect is the successful development of immunological tolerance, meaning the patient no longer reacts to olive pollen. However, some patients may develop a persistent sensitivity to the injection site, characterized by small, hard nodules (granulomas) under the skin, though this is rare with modern aqueous extracts.
Olea Europaea Flower extracts, like all allergenic extracts, can cause severe, life-threatening systemic allergic reactions, including anaphylaxis.
Report any unusual symptoms to your healthcare provider, even if they seem minor at the time.
Olea Europaea Flower is a potent biological agent. Its use requires strict adherence to safety protocols to minimize the risk of systemic reactions. Patients must be in their baseline state of health on the day of the injection. If you are experiencing an asthma flare-up, a fever, or a severe respiratory infection, your healthcare provider will likely postpone your dose.
No FDA black box warnings are uniquely assigned to Olea Europaea Flower as a standalone ingredient, but it falls under the General Black Box Warning for Allergenic Extracts. This warning emphasizes that these products can cause anaphylaxis and must only be administered by physicians trained in the management of life-threatening allergic reactions. Fatalities have occurred, most commonly in patients with poorly controlled asthma.
Olea Europaea Flower does not typically cause sedation. However, if a patient experiences a systemic reaction or receives epinephrine, they should not drive or operate machinery until they have fully recovered and been cleared by a physician.
Alcohol should be avoided for several hours before and after an injection. Alcohol causes vasodilation (widening of blood vessels), which can increase the rate of allergen absorption and potentially trigger a more severe reaction.
Immunotherapy is usually continued for 3 to 5 years. Stopping the treatment prematurely may result in the return of allergy symptoms. There is no 'withdrawal syndrome' associated with stopping Olea Europaea Flower, but the immunological benefits will gradually diminish if the maintenance phase is not completed.
> Important: Discuss all your medical conditions with your healthcare provider before starting Olea Europaea Flower. Ensure they are aware of any history of heart problems or severe asthma.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. A complete list is vital for your safety during immunotherapy.
Olea Europaea Flower must NEVER be used in the following circumstances:
Conditions requiring careful risk-benefit analysis:
Patients allergic to Olea Europaea Flower often show cross-sensitivity to other members of the Oleaceae family, which includes:
If you are highly allergic to one of these, you may have a stronger-than-expected reaction to Olea Europaea Flower extract.
> Important: Your healthcare provider will evaluate your complete medical history, including any heart conditions or breathing problems, before prescribing Olea Europaea Flower.
Pregnancy Category: C (According to traditional FDA labeling).
It is not known whether the allergenic proteins in Olea Europaea Flower are excreted in human milk. However, because these are large proteins that are digested in the infant's gut, the risk to the nursing infant is considered extremely low. The primary consideration is the mother's safety and her ability to manage potential reactions while caring for an infant.
No specific dose adjustments are required. The clearance of the immunological components is not dependent on renal function in a way that would increase toxicity.
No dose adjustments are required. Hepatic function does not affect the safety or efficacy of subcutaneous allergenic extracts.
> Important: Special populations require individualized medical assessment. Always inform your allergist if you are pregnant, planning to become pregnant, or breastfeeding.
Olea Europaea Flower acts as an immunomodulator. Its primary molecular target is the T-lymphocyte population, specifically shifting the balance from Th2 (Pro-allergic) cells to Th1 and T-regulatory (Treg) cells.
| Parameter | Value |
|---|---|
| Bioavailability | N/A (Subcutaneous/Local) |
| Protein Binding | Primarily processed by APCs |
| Half-life | Immunological effect: Years |
| Tmax | Systemic absorption: 1-2 hours |
| Metabolism | Proteolysis (Protease enzymes) |
| Excretion | Renal (as small peptides) |
Olea Europaea Flower is classified as a Standardized Insect Venom Allergenic Extract [EPC] in some regulatory databases, though it is more accurately described as a Pollen Allergenic Extract. It is part of the broader class of Biological Response Modifiers used in desensitization therapy.
Common questions about Bio Olive 30c, 60c, 200c
Olea Europaea Flower extract is primarily used for the diagnosis and treatment of allergies caused by olive tree pollen. In diagnostic settings, it is used in skin prick tests to confirm if a patient is sensitized to this specific allergen. For treatment, it is used in allergen immunotherapy (allergy shots) to help the body build up a tolerance to the pollen over time. This can significantly reduce symptoms like sneezing, itchy eyes, and asthma caused by olive pollen exposure. It is particularly useful for patients who do not get enough relief from standard antihistamines or nasal sprays.
The most common side effects are localized reactions at the site of the injection or skin test. These include redness, swelling, and itching, which usually appear within minutes and fade within a few hours. Some patients may also experience 'large local reactions' where the swelling is several inches wide and lasts for a day or two. Systemic symptoms like mild nasal congestion or fatigue are less common but can occur. Because it is an allergen, there is always a small risk of a serious allergic reaction, which is why it must be given in a doctor's office.
It is strongly advised to avoid alcohol for several hours before and after receiving an Olea Europaea Flower injection. Alcohol causes your blood vessels to dilate (expand), which can speed up the absorption of the allergen into your bloodstream. This increased absorption rate significantly raises the risk of a systemic allergic reaction or anaphylaxis. Additionally, alcohol can mask the early symptoms of a reaction, making it harder for you or your doctor to identify a problem. Always stay hydrated with water instead on the day of your treatment.
Immunotherapy with Olea Europaea Flower is generally not started during pregnancy because of the risk of anaphylaxis, which could be dangerous for both the mother and the developing baby. However, if a woman is already on a stable maintenance dose and is tolerating the injections well, her allergist may decide to continue the treatment at that same dose. The dose is almost never increased during pregnancy to avoid the risk of a new reaction. If you are planning to become pregnant, discuss your immunotherapy schedule with your doctor beforehand. The extract itself is not known to cause birth defects, but the reaction to it is the primary concern.
The benefits of Olea Europaea Flower immunotherapy are not immediate and require a significant time commitment. Most patients begin to notice a reduction in their allergy symptoms during the first 'maintenance' phase, which usually occurs 3 to 6 months after starting the injections. Maximum effectiveness is typically reached after 12 to 18 months of consistent treatment. To achieve long-lasting or permanent relief, the treatment is usually continued for a total of 3 to 5 years. Skipping doses can significantly delay the onset of the therapeutic effect.
Yes, you can stop taking Olea Europaea Flower injections at any time without experiencing physical withdrawal symptoms, as it is not an addictive medication. However, stopping the treatment before the recommended 3-5 year course is finished will likely result in your allergy symptoms returning over time. The 'tolerance' your immune system has built up may fade without the completion of the maintenance phase. If you need to stop due to side effects or lifestyle changes, always consult your allergist first to see if a modified schedule is possible. Sudden discontinuation during the build-up phase is common but results in no long-term benefit.
If you miss a scheduled injection of Olea Europaea Flower, contact your allergist's office as soon as possible to reschedule. Do not attempt to 'double up' on your next dose. If you are in the build-up phase and miss a dose, your doctor may need to repeat the previous dose or even reduce the dose slightly to ensure your safety. If you are in the maintenance phase and miss a dose by only a week or two, you can usually continue with your regular dose. However, if several weeks have passed, a dose reduction is often necessary to prevent a systemic reaction.
There is no clinical evidence to suggest that Olea Europaea Flower extracts cause weight gain. The extract consists of small amounts of proteins and glycoproteins that do not affect the body's metabolism or appetite. Unlike oral corticosteroids (such as prednisone), which are sometimes used to treat severe allergies and are known to cause weight gain, allergen immunotherapy works through a completely different immunological pathway. If you notice weight changes while on this treatment, it is likely due to other factors or medications, and you should discuss it with your healthcare provider.
Olea Europaea Flower can be taken alongside most common medications, but there are critical exceptions. You must inform your doctor if you are taking beta-blockers (often prescribed for high blood pressure or heart issues), as these can make an allergic reaction much harder to treat. ACE inhibitors and certain antidepressants (MAOIs) can also increase the risk or severity of a reaction. Most allergy medications like antihistamines and nasal steroids are fine to continue during treatment, though antihistamines must be stopped before diagnostic skin testing to ensure accurate results.
Olea Europaea Flower is a biological product, and the concept of 'generic' is slightly different than for chemical drugs. There are several different manufacturers that produce olive pollen extracts (such as ALK-Abelló, Greer Laboratories, or HollisterStier). While these extracts all contain Olea europaea proteins, they may be standardized differently (e.g., some use PNU, others use w/v). Therefore, they are not always considered directly interchangeable. Your allergist will typically stick with one manufacturer's extract throughout your treatment to ensure consistent dosing and potency.
Other drugs with the same active ingredient (Olea Europaea Flower)