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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Methyl Salicylate
Brand Name
Avon Foot Works Arthritis Achy Foot And Muscle
Generic Name
Methyl Salicylate
Active Ingredient
Methyl SalicylateCategory
Non-Standardized Plant Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 25 mg/g | CREAM | TOPICAL | 68577-194 |
Detailed information about Avon Foot Works Arthritis Achy Foot And Muscle
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Avon Foot Works Arthritis Achy Foot And Muscle, you must consult a qualified healthcare professional.
Methyl Salicylate is a topical analgesic and counter-irritant used to provide temporary relief from minor aches and pains of muscles and joints. It belongs to the salicylate family and is frequently found in over-the-counter external pain relief products.
For adults and children 12 years of age and older, healthcare providers typically suggest the following:
While topical application results in low systemic levels, patients with severe renal impairment should use Methyl Salicylate with caution, as the kidneys are the primary route for salicylate excretion.
No specific dosage adjustments are typically required for topical use, though the liver is responsible for the metabolism of absorbed salicylates.
Elderly patients may have thinner skin, which can increase the rate of absorption. Use the lowest effective amount to minimize systemic risks.
If you miss a dose, apply it as soon as you remember. If it is almost time for the next application, skip the missed dose. Do not double the amount applied to 'make up' for a missed dose.
Signs of systemic salicylate overdose (salicylism) include tinnitus (ringing in the ears), nausea, vomiting, dizziness, and rapid breathing. If ingestion occurs or if systemic symptoms develop from over-application, contact a Poison Control Center or seek emergency medical attention immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Most patients tolerate topical Methyl Salicylate well, but common localized reactions include:
> Warning: Stop taking Methyl Salicylate and call your doctor immediately if you experience any of these.
Prolonged or excessive use over large body areas can lead to chronic salicylate toxicity. This may manifest as persistent gastrointestinal upset, metabolic acidosis, or kidney dysfunction. Long-term use on the same skin site may lead to permanent skin thinning or chronic irritation.
No FDA black box warnings currently exist for Methyl Salicylate. However, the FDA issued a safety communication in 2012 warning that certain over-the-counter topical muscle and joint pain relievers can cause rare but serious chemical burns.
Report any unusual symptoms to your healthcare provider.
Methyl Salicylate is for external use only. It should never be ingested, as oil of wintergreen is highly concentrated; one teaspoon of 98% methyl salicylate is equivalent to approximately 21 adult aspirin tablets and can be fatal to a child.
No FDA black box warnings for Methyl Salicylate.
For most users, routine lab monitoring is not required. However, for those using high concentrations over large areas or those with renal impairment, healthcare providers may monitor:
Methyl Salicylate is not known to interfere with the ability to drive or operate machinery.
While there is no direct interaction between topical Methyl Salicylate and alcohol, excessive alcohol consumption can increase the risk of gastrointestinal bleeding when combined with systemic salicylates.
There are no tapering requirements for topical Methyl Salicylate. If pain persists for more than 7 days or clears up and occurs again within a few days, discontinue use and consult a physician.
> Important: Discuss all your medical conditions with your healthcare provider before starting Methyl Salicylate.
There are no known significant food interactions with topical Methyl Salicylate. However, maintaining a consistent diet is important if systemic absorption occurs and affects other medications.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients sensitive to other salicylates (like Salsalate or Choline Salicylate) or NSAIDs (like Celecoxib or Diclofenac) may experience similar allergic reactions to Methyl Salicylate.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Methyl Salicylate.
FDA Pregnancy Category C (D in 3rd Trimester). During the first and second trimesters, Methyl Salicylate should be used only if the potential benefit justifies the potential risk to the fetus. According to data from the NIH, use in the third trimester is generally avoided because salicylates may cause premature closure of the fetal ductus arteriosus and may inhibit uterine contractions.
Salicylates are excreted into breast milk in small amounts. While topical use is unlikely to cause adverse effects in a nursing infant, it is recommended to avoid applying the product to the breast area to prevent direct ingestion by the infant.
Methyl Salicylate is not recommended for children under 12 years of age without medical supervision. The primary concern is the accidental ingestion of wintergreen-scented products, which is a leading cause of pediatric salicylate poisoning. Always use child-resistant packaging.
Clinical studies have not identified significant differences in responses between the elderly and younger patients. However, due to age-related declines in renal function and thinner skin, elderly patients should be monitored for signs of systemic toxicity if using the product chronically.
In patients with severe renal impairment (GFR < 30 mL/min), the excretion of salicylic acid is delayed. While topical absorption is low, cautious use is advised to prevent accumulation.
No specific dose adjustments are provided for hepatic impairment, but patients with severe liver disease should be monitored for signs of salicylate sensitivity.
> Important: Special populations require individualized medical assessment.
Methyl Salicylate acts as a counter-irritant. It targets the Transient Receptor Potential (TRP) ion channels on sensory nerve fibers. Specifically, it activates and then desensitizes TRPM8 (cold receptors) and TRPV1 (heat receptors). This creates a cooling/warming sensation that interferes with the transmission of pain signals via the 'Gate Control' mechanism in the spinal cord. Additionally, once hydrolyzed to salicylic acid, it provides a localized anti-inflammatory effect by inhibiting prostaglandin synthesis through COX-1 and COX-2 enzyme inhibition.
The onset of the counter-irritant effect is typically rapid (within 5-15 minutes). The duration of effect usually lasts for 3 to 6 hours. Unlike systemic NSAIDs, the pharmacodynamic effect is largely localized to the site of application and the immediate underlying tissues.
| Parameter | Value |
|---|---|
| Bioavailability | 10-20% (Percutaneous, varies by site) |
| Protein Binding | 80-90% (as Salicylic Acid) |
| Half-life | 2-4 hours (at low doses) |
| Tmax | 1-2 hours (Topical application) |
| Metabolism | Esterases (Skin/Liver) to Salicylic Acid |
| Excretion | Renal (95% as metabolites) |
Methyl Salicylate is classified as a topical salicylate analgesic. It is often grouped with other counter-irritants like Menthol and Camphor in over-the-counter pain relief formulations.
Common questions about Avon Foot Works Arthritis Achy Foot And Muscle
Methyl Salicylate is primarily used for the temporary relief of minor aches and pains in the muscles and joints. It is commonly recommended for conditions such as arthritis, simple backaches, strains, sprains, and bruises. The medication works as a counter-irritant, providing a warming or cooling sensation that helps distract the brain from underlying pain. It is found in many over-the-counter creams, gels, and patches. Always consult a healthcare provider if pain persists for more than seven days.
The most common side effects of Methyl Salicylate are localized skin reactions at the site of application. These include redness, itching, a mild burning sensation, or stinging. These effects are usually temporary and are part of the drug's mechanism as a counter-irritant. However, if you experience severe blistering, swelling, or persistent pain, you should stop using the product immediately. Always wash your hands after application to prevent spreading the medication to sensitive areas like the eyes.
There is no known direct interaction between topically applied Methyl Salicylate and moderate alcohol consumption. However, if the medication is absorbed systemically in large amounts, it acts similarly to aspirin, which can increase the risk of stomach irritation when combined with alcohol. Chronic heavy drinkers should consult their doctor before using large amounts of salicylate-based products. For occasional topical use on small areas, alcohol is generally not a concern. Always prioritize the advice of your healthcare provider regarding alcohol use.
Methyl Salicylate should be used with caution during pregnancy and only under the guidance of a healthcare provider. It is particularly important to avoid use during the third trimester, as salicylates can cause complications for the fetus, such as premature closure of a vital heart vessel (the ductus arteriosus). There is also a risk of prolonged labor or increased bleeding during delivery. During the first and second trimesters, it should only be used if the benefits clearly outweigh the risks. Always discuss topical medications with your obstetrician.
Methyl Salicylate typically begins to work very quickly, often within 5 to 15 minutes of application. The initial sensation is usually one of cooling or warming, followed by a reduction in the perception of deep-seated pain. The maximum effect is generally reached within an hour of application. Because it is a topical treatment, the relief is localized to the area where the cream or patch was applied. If you do not feel relief after several applications, consult your doctor for a different pain management strategy.
Yes, you can stop using Methyl Salicylate suddenly without experiencing withdrawal symptoms. Since it is applied topically for symptom relief rather than for chronic systemic conditions, there is no need for a tapering schedule. If your symptoms return after stopping, it may indicate that the underlying condition still requires treatment. You should stop use and contact a doctor if your condition worsens or if symptoms persist for more than 7 days. Always follow the specific duration of use recommended on the product packaging.
If you miss a dose of Methyl Salicylate, apply it as soon as you remember, provided it is not too close to your next scheduled application. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not apply extra medication or use a larger amount to make up for the missed dose, as this increases the risk of skin irritation or systemic absorption. Consistency is helpful for managing pain, but safety is the priority. Consult your healthcare provider if you are unsure about your dosing schedule.
There is no clinical evidence to suggest that Methyl Salicylate causes weight gain. Because it is applied topically and very little of the drug typically reaches the systemic circulation, it does not affect metabolism or appetite in the way some oral medications might. Any sudden weight gain while using this medication is likely unrelated and should be discussed with a healthcare provider. If you notice swelling in your legs or feet (edema), this could be a sign of a different medical issue. Always report significant physical changes to your doctor.
Methyl Salicylate can interact with certain medications, most notably blood thinners like warfarin (Coumadin). Even when applied to the skin, enough salicylate can be absorbed to increase the risk of bleeding in patients on anticoagulants. It should also be used cautiously with oral NSAIDs like ibuprofen or aspirin to avoid additive side effects. Always inform your healthcare provider about all medications you are using, including over-the-counter drugs and supplements. They can help you determine if a topical salicylate is safe for your specific regimen.
Yes, Methyl Salicylate is widely available as a generic product and is an active ingredient in many store-brand topical pain relievers. It is often sold in combination with other ingredients like menthol or camphor. Generic versions are required by the FDA to have the same quality and efficacy as brand-name products. You can find these in various forms, including creams, liniments, and patches, at most pharmacies and grocery stores. Choosing a generic version can often be a cost-effective way to manage minor musculoskeletal pain.
Other drugs with the same active ingredient (Methyl Salicylate)