Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
After Bite Kids
Generic Name
Sodium Bicarbonate
Active Ingredient
Sodium BicarbonateCategory
Proton Pump Inhibitor [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 1.04 g/20g | CREAM | TOPICAL | 44224-1117 |
Detailed information about After Bite Kids
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for After Bite Kids, you must consult a qualified healthcare professional.
Sodium Bicarbonate is a systemic alkalinizing agent used to treat metabolic acidosis, urinary acidification, and heartburn. It belongs to the pharmacological class of alkalinizing agents and is often used as a buffer in combination with other medications.
Dosage for Sodium Bicarbonate must be highly individualized based on the condition being treated and the patient's acid-base status.
Sodium Bicarbonate should be used with extreme caution in children.
Patients with renal impairment are at high risk for sodium retention and metabolic alkalosis. Sodium Bicarbonate should be used with extreme caution in patients with Stage 4 or 5 Chronic Kidney Disease or those on dialysis. Frequent monitoring of serum electrolytes (sodium, potassium, calcium) is mandatory.
No specific dose adjustments are required for hepatic impairment; however, patients with cirrhosis and ascites are often on sodium-restricted diets. The high sodium content of Sodium Bicarbonate (approx. 274 mg of sodium per 1000 mg of NaHCO3) can exacerbate fluid retention and edema.
Patients over 65 years of age should use lower doses. The maximum daily antacid dose is reduced because the elderly are more susceptible to systemic alkalosis and fluid overload. Renal function should be assessed before initiating long-term therapy.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
Signs of Sodium Bicarbonate overdose include severe headache, nausea, vomiting, irritability, muscle weakness, and swelling of the feet or lower legs. In severe cases, it can lead to metabolic alkalosis, characterized by tetany (muscle spasms), seizures, and cardiac arrhythmias. If an overdose is suspected, contact a Poison Control Center or seek emergency medical attention immediately.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking this medication without medical guidance, as it can cause a rebound effect in stomach acid or a dangerous shift in blood pH.
When used as an antacid or for short-term buffering, the most common side effects are related to the chemical reaction in the stomach:
> Warning: Stop taking Sodium Bicarbonate and call your doctor immediately if you experience any of these symptoms:
Chronic use of Sodium Bicarbonate can lead to several complications:
No FDA black box warnings are currently issued for Sodium Bicarbonate. However, it is considered a high-alert medication in intravenous form due to the risk of severe electrolyte shifts and tissue necrosis if extravasation (leaking into surrounding tissue) occurs during injection.
Report any unusual symptoms to your healthcare provider. Monitoring of blood chemistry is essential for anyone using this medication on a long-term basis.
Sodium Bicarbonate is a potent chemical agent that affects the body's acid-base balance and electrolyte status. It should never be viewed as 'just baking soda' when used for medical purposes. Patients must be aware that this medication contains significant amounts of sodium, which can negatively impact blood pressure and fluid balance. It is not intended for long-term use as an antacid (more than 2 weeks) unless specifically directed by a physician for a chronic condition like kidney disease.
There are no FDA black box warnings for Sodium Bicarbonate. It is generally recognized as safe (GRAS) when used according to standard medical guidelines, though its use in emergency IV settings is strictly controlled.
If you are taking Sodium Bicarbonate for more than a few days, your healthcare provider will likely require regular blood tests, including:
Sodium Bicarbonate typically does not cause drowsiness or impair cognitive function. However, if you experience side effects like confusion or muscle twitching due to alkalosis, you should avoid driving and contact your doctor immediately.
Alcohol should be avoided or strictly limited while taking Sodium Bicarbonate. Alcohol can increase gastric acid production, worsening the condition being treated, and may also contribute to dehydration and electrolyte imbalances.
Do not stop taking Sodium Bicarbonate suddenly if you are using it for a chronic condition like metabolic acidosis. Sudden discontinuation can cause your blood pH to drop rapidly (rebound acidosis). Your doctor will provide a tapering schedule if the medication needs to be stopped.
> Important: Discuss all your medical conditions, especially heart or kidney problems, with your healthcare provider before starting Sodium Bicarbonate.
Sodium Bicarbonate should not be used concurrently with certain medications due to the risk of severe adverse effects:
Sodium Bicarbonate can affect the results of several laboratory tests:
For each major interaction, the mechanism usually involves either a change in gastric pH affecting absorption or a change in urinary pH affecting excretion. Management typically involves spacing the doses of the two medications by at least 2 to 4 hours.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking to prevent dangerous interactions.
Sodium Bicarbonate must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis by a physician include:
There is no known cross-sensitivity between Sodium Bicarbonate and other drug classes. However, patients who react poorly to other sodium-based salts or alkaline substances should be monitored closely.
> Important: Your healthcare provider will evaluate your complete medical history, including your current electrolyte levels and kidney function, before prescribing Sodium Bicarbonate.
Sodium Bicarbonate is classified as FDA Pregnancy Category C. This means that animal reproduction studies have not been conducted, and it is not known whether Sodium Bicarbonate can cause fetal harm when administered to a pregnant woman. However, its use during pregnancy is generally discouraged for minor indigestion because the high sodium content can lead to fluid retention (edema) in the mother. In cases of severe metabolic acidosis, the benefits may outweigh the risks, but this must be managed in a hospital setting. There is no known teratogenicity (birth defect risk) data, but metabolic shifts in the mother can affect the fetus.
It is not known whether Sodium Bicarbonate is excreted in human milk. However, since bicarbonate and sodium are normal constituents of the body, it is unlikely to have a negative effect on a nursing infant when used in standard, short-term doses. Long-term use or high doses should be avoided by breastfeeding mothers unless directed by a physician, as it could theoretically alter the electrolyte balance of the milk.
Sodium Bicarbonate is not approved for self-medication (OTC use) in children under 12. In clinical settings, it is used for metabolic acidosis, but with extreme caution. In neonates and infants, rapid IV administration of hypertonic Sodium Bicarbonate can cause a sudden shift in osmolality, leading to intracranial hemorrhage (bleeding in the brain). Growth effects from long-term use in children have not been extensively studied, but chronic alkalosis can interfere with normal mineral deposition in bones.
Patients over the age of 65 are at a significantly higher risk for adverse effects. Aging kidneys are less efficient at excreting excess sodium and bicarbonate, making these patients more prone to systemic alkalosis and fluid overload. Geriatric patients are also more likely to be taking concurrent medications (polypharmacy) that interact with Sodium Bicarbonate, such as diuretics or blood pressure medications. Fall risk may increase if the medication causes electrolyte imbalances leading to muscle weakness or confusion.
In patients with a Glomerular Filtration Rate (GFR) below 30 mL/min, the use of Sodium Bicarbonate requires intense monitoring. While it is used therapeutically in CKD to buffer metabolic acid, the risk of 'overshooting' into alkalosis is high. It is not typically cleared by dialysis in a way that allows for rapid correction of an overdose; rather, the dialysate itself is adjusted to manage the patient's bicarbonate levels.
No specific dose adjustments are required for patients with liver disease. However, those with Child-Pugh Class B or C cirrhosis often have significant sodium restrictions to manage ascites. For these patients, even a few grams of Sodium Bicarbonate can represent a dangerous amount of 'hidden' salt.
> Important: Special populations require individualized medical assessment and frequent lab monitoring to ensure safety.
Sodium Bicarbonate acts as a systemic and urinary alkalinizer. After oral or parenteral administration, it increases the concentration of bicarbonate ions (HCO3-) in the plasma. Bicarbonate is the primary buffer in the extracellular fluid of the human body. It reacts with hydrogen ions (H+) to form carbonic acid (H2CO3), which is then rapidly converted by the enzyme carbonic anhydrase into water (H2O) and carbon dioxide (CO2). The CO2 is subsequently eliminated via the lungs. By consuming hydrogen ions, Sodium Bicarbonate effectively raises the pH of the blood and other body fluids.
| Parameter | Value |
|---|---|
| Bioavailability | Rapidly absorbed (Oral) |
| Protein Binding | Negligible |
| Half-life | Variable (Excreted as CO2 and via kidneys) |
| Tmax | 0.5 - 2 hours (Oral) |
| Metabolism | None (Dissociates into ions) |
| Excretion | Renal (Bicarbonate); Pulmonary (CO2) |
Sodium Bicarbonate is categorized as an Alkalinizing Agent. Within the gastrointestinal context, it is a Systemic Antacid. It is distinct from non-systemic antacids like aluminum hydroxide, which are not absorbed into the bloodstream. In the context of combination products, it may be listed under Proton Pump Inhibitor [EPC] due to its role in stabilizing drugs like omeprazole.
Common questions about After Bite Kids
Sodium Bicarbonate is primarily used as an antacid to relieve heartburn and indigestion by neutralizing stomach acid. It is also a critical medical treatment for metabolic acidosis, a condition where the blood becomes too acidic due to kidney disease or other metabolic failures. Additionally, doctors use it to make the urine more alkaline, which helps prevent certain types of kidney stones and assists the body in clearing specific toxins. In emergency medicine, it is sometimes used during cardiac arrest to stabilize blood pH. Finally, it is used off-label in chronic kidney disease to help preserve kidney function by neutralizing the acid produced by the body.
The most common side effects are related to the gas produced when the medication reacts with stomach acid, leading to belching, flatulence, and a feeling of bloating or fullness. Some patients may also experience mild nausea or a salty taste in the mouth. Because it contains a high amount of sodium, it can cause the body to retain water, leading to mild swelling in the hands or feet. These symptoms are usually temporary and occur shortly after taking the dose. If these effects persist or worsen, you should contact your healthcare provider for guidance.
It is generally recommended to avoid or limit alcohol consumption while using Sodium Bicarbonate. Alcohol can irritate the stomach lining and increase the production of gastric acid, which may counteract the benefits of the medication if you are taking it for heartburn. Furthermore, alcohol can contribute to dehydration and affect the body's electrolyte balance, which is already being modified by the Sodium Bicarbonate. Combining the two may increase the risk of stomach upset and nausea. Always consult your doctor about your alcohol intake when starting a new medication.
Sodium Bicarbonate is categorized as FDA Pregnancy Category C, meaning its safety has not been fully established through controlled studies in humans. It is generally not recommended for use as a routine antacid during pregnancy because its high sodium content can cause fluid retention and swelling, which are already common issues in pregnancy. In rare cases of severe metabolic acidosis, a doctor may determine that it is necessary, but this must be done under strict medical supervision. Pregnant women should always consult their obstetrician before taking any form of Sodium Bicarbonate, including baking soda. Safer alternatives for heartburn are usually recommended first.
When taken orally as an antacid, Sodium Bicarbonate works very quickly, often providing relief from heartburn symptoms within 5 to 15 minutes. Its effect is rapid because it directly neutralizes the acid already present in the stomach. However, the duration of this effect is relatively short, usually lasting only about 30 to 60 minutes. If administered intravenously for metabolic acidosis, the effect on the blood's pH level is almost instantaneous. For long-term conditions like chronic kidney disease, it may take several days of consistent dosing to see a stable improvement in blood bicarbonate levels.
If you are using Sodium Bicarbonate occasionally for heartburn, you can stop taking it whenever it is no longer needed. However, if your doctor has prescribed it for a chronic condition like metabolic acidosis or kidney disease, you should never stop taking it suddenly. Abruptly discontinuing the medication can cause a 'rebound' effect, where your blood becomes dangerously acidic again or your stomach produces excessive amounts of acid. Your healthcare provider will monitor your blood levels and provide a plan to slowly reduce the dose if the medication is no longer required. Always follow your prescribed treatment plan.
If you miss a dose of Sodium Bicarbonate, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the one you missed, as this can lead to an excessive intake of sodium and bicarbonate, potentially causing an electrolyte imbalance. If you are taking it for a serious condition like kidney disease and miss multiple doses, contact your doctor for advice. Consistency is key to maintaining a stable acid-base balance.
Sodium Bicarbonate does not cause an increase in body fat, but it can cause temporary weight gain due to water retention. Because the medication is very high in sodium, it causes the body to hold onto extra water to maintain the proper salt balance. This can lead to swelling (edema) in the legs, ankles, or hands and a corresponding increase on the scale. This effect is particularly common in people with heart or kidney problems. If you notice a sudden weight gain of more than 2-3 pounds in a single day, you should contact your doctor immediately, as it may indicate fluid overload.
Sodium Bicarbonate has many significant drug interactions and should be taken with caution alongside other medications. It changes the pH of both the stomach and the urine, which can alter how other drugs are absorbed or excreted. For example, it can prevent antifungal drugs like ketoconazole from working and can cause certain antibiotics to be less effective. It may also cause some medications to stay in your system for a dangerously long time. As a general rule, you should take other medications at least 2 hours before or after taking Sodium Bicarbonate. Always provide your doctor with a full list of your current medications.
Yes, Sodium Bicarbonate is widely available as a generic medication and is also sold as an over-the-counter supplement. Because it is a simple chemical compound, it is produced by many different manufacturers in various forms, including tablets, powders, and injectable solutions. Generic versions are typically very affordable and are therapeutically equivalent to brand-name versions. When purchasing over-the-counter, ensure you are buying a product labeled for medicinal use rather than standard household baking soda, as medicinal versions are held to stricter purity standards. Your pharmacist can help you select the appropriate generic product.
Other drugs with the same active ingredient (Sodium Bicarbonate)