50% Dextrose

The dosage of Dextrose is highly individualized based on the patient's age, weight, clinical condition, and fluid/electrolyte balance.

• For Acute Hypoglycemia: The standard adult dose is 10 to 25 grams of Dextrose (typically 20 to 50 mL of a 50% solution) administered slowly via a large peripheral vein or central line. This may be repeated based on follow-up blood glucose monitoring.
• For Maintenance Fluid (Hydration): Dextrose 5% (D5W) is often infused at rates of 50 to 125 mL per hour, depending on the patient’s size and hydration status.
• For Hyperkalemia (High Potassium): 25 to 50 grams of Dextrose is usually given alongside 10 units of regular insulin to facilitate the intracellular shift of potassium.
• For Calculi Dissolution: Solutions are typically used for continuous or intermittent bladder irrigation as directed by a urologist, often involving 30 to 60 mL of specialized solution multiple times per day.

Pediatric dosing requires extreme precision to avoid fluid overload or dangerous spikes in blood sugar.

• Neonatal Hypoglycemia: 200 to 500 mg/kg (2 to 5 mL/kg of a 10% Dextrose solution) is the standard emergency dose.
• Infants and Children: For acute hypoglycemia, 0.5 to 1 gram/kg (using 10% or 25% concentrations) is common. High concentrations like D50W are generally avoided in small children due to the risk of vein irritation and brain hemorrhage.

Renal Impairment

Patients with kidney disease are at high risk for fluid overload. Healthcare providers must monitor 'ins and outs' (fluid intake vs. urine output) closely. Dextrose levels may need to be reduced if the patient is unable to excrete the water volume associated with the sugar infusion.

Hepatic Impairment

In patients with severe liver disease (cirrhosis), the liver's ability to store and release glycogen is impaired. These patients may require more frequent Dextrose infusions but must be monitored for the development of cerebral edema (brain swelling).

Elderly Patients

Older adults often have reduced cardiac and renal reserve. Dosing should start at the lower end of the range to prevent heart failure exacerbations or pulmonary edema (fluid in the lungs).

Dextrose is almost exclusively administered by healthcare professionals in a clinical setting when given intravenously.

• IV Administration: High concentrations (above 10%) should ideally be administered through a central venous catheter to prevent thrombophlebitis (vein inflammation).
• Oral Use: If using Dextrose tablets or gels at home for hypoglycemia, follow the '15-15 Rule': consume 15 grams of Dextrose, wait 15 minutes, and re-check blood sugar. Repeat if levels remain below 70 mg/dL.
• Storage: IV bags should be stored at room temperature (25°C/77°F) and protected from extreme heat or freezing. Do not use the solution if it is discolored or contains particles.

In a hospital setting, Dextrose is usually given as a continuous infusion. If an infusion is interrupted, your nurse or doctor will restart it as soon as possible. For home-use oral Dextrose, a 'missed dose' is not applicable as it is used on an as-needed basis for low blood sugar symptoms.

An overdose of Dextrose (hyperglycemia) can lead to a condition called hyperosmolar hyperglycemic state (HHS).

• Symptoms: Extreme thirst, frequent urination, confusion, blurred vision, and in severe cases, seizures or coma.
• Emergency Measures: If an overdose occurs, the infusion is stopped immediately. Insulin is administered to lower blood sugar, and isotonic fluids (like Normal Saline) are given to correct dehydration and electrolyte imbalances.

> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or stop an infusion without medical guidance, as sudden cessation can lead to 'rebound hypoglycemia'.

Most side effects associated with Dextrose are related to the concentration of the sugar and the volume of fluid administered.

• Injection Site Irritation: Patients often report a warm sensation, stinging, or redness at the site of the IV. This is common with D5W and very common with higher concentrations like D50W.
• Glycosuria: Sugar appearing in the urine. This happens when the blood sugar level rises too quickly for the kidneys to reabsorb it. It may feel like an increased urge to urinate shortly after the infusion starts.
• Fluid Retention: Mild swelling (edema) in the hands or ankles due to the water content of the IV fluid.

• Hyperglycemia: High blood sugar, which may cause symptoms like dry mouth, a fruity odor on the breath, or blurred vision. This is more frequent in patients with undiagnosed or poorly controlled diabetes.
• Electrolyte Imbalance: Dextrose infusions can cause a drop in blood levels of potassium, magnesium, and phosphorus as these minerals move into the cells along with the sugar.
• Thrombophlebitis: Inflammation of the vein used for the IV, which may feel like a hard, painful cord under the skin.

• Hyperosmolar Syndrome: A dangerous state of dehydration caused by extremely high blood sugar levels.
• Pulmonary Edema: Fluid backing up into the lungs, causing shortness of breath and a cough. This occurs primarily in patients with pre-existing heart or kidney failure.
• Allergic Reactions: While rare (since glucose is native to the body), reactions can occur due to the source of the Dextrose (often corn) or the plastic packaging.

> Warning: Stop taking Dextrose and call your doctor immediately if you experience any of these serious symptoms.

• Severe Shortness of Breath: This may indicate fluid overload or heart failure. Clinical context: The heart cannot pump the extra fluid volume provided by the IV.
• Confusion or Seizures: These can be signs of severe electrolyte shifts (like low sodium) or Wernicke’s encephalopathy in malnourished patients.
• Fever and Chills: These may indicate an infection at the IV site or 'pyrogenic reaction' from the solution itself.
• Anaphylaxis: Symptoms include hives, swelling of the face or throat, and difficulty breathing. This is often linked to a corn allergy.
• Extreme Thirst and Rapid Heartbeat: Signs of severe hyperglycemia or dehydration.

Prolonged use of high-concentration Dextrose (as seen in TPN) can lead to:

• Liver Steatosis (Fatty Liver): Excessive sugar intake can cause the liver to convert glucose into fat, leading to liver enlargement and dysfunction.
• Vitamin Deficiencies: Specifically, B-vitamin (thiamine) depletion. The body requires thiamine to process Dextrose; constant Dextrose without thiamine can lead to permanent neurological damage.
• Essential Fatty Acid Deficiency: If Dextrose is used as the sole calorie source without supplemental lipids.

No FDA black box warnings are currently issued for Dextrose. However, clinical guidelines emphasize that Dextrose solutions without electrolytes should not be administered simultaneously with blood through the same infusion set, as this can cause the red blood cells to clump (pseudoagglutination).

Report any unusual symptoms to your healthcare provider. Monitoring of blood glucose and electrolytes is standard practice during Dextrose therapy to mitigate these risks.

Dextrose is generally safe when used appropriately, but it is a potent metabolic agent. Patients must be aware that Dextrose is not 'just sugar water'—it significantly impacts fluid balance, insulin production, and electrolyte levels. According to the FDA, Dextrose solutions should be used with caution in patients with known subclinical or overt diabetes mellitus, as it can precipitate severe hyperglycemia.

No FDA black box warnings for Dextrose. It is one of the most widely used and well-tolerated substances in clinical medicine when administered under professional supervision.

• Allergic Reactions / Anaphylaxis Risk: Most Dextrose is derived from corn. Patients with a severe corn allergy may experience anaphylactic reactions. Always inform your provider of any food or grain allergies before receiving an infusion.
• Wernicke’s Encephalopathy: In malnourished patients or chronic alcohol users, a Dextrose 'load' can acutely deplete the body's remaining thiamine (Vitamin B1) stores. This can cause sudden brain dysfunction. Providers typically 'banana bag' these patients (adding thiamine and multivitamins to the IV).
• Fluid Overload: Dextrose provides 'free water' once the sugar is metabolized. This can be dangerous for patients with Congestive Heart Failure (CHF) or end-stage renal disease (ESRD), leading to fluid in the lungs or brain.
• Hyperosmolarity: High-concentration Dextrose (D25, D50) is highly osmotic. If it leaks out of the vein (extravasation), it can cause tissue necrosis (cell death) and skin sloughing.

While receiving Dextrose, especially at high concentrations or for long periods, the following lab tests are required:

1. 1Blood Glucose: Often checked every 1 to 6 hours to ensure levels stay within a safe range.
2. 2Serum Electrolytes: Monitoring sodium, potassium, and phosphorus levels to prevent 'Refeeding Syndrome'.
3. 3Fluid Balance: Strict monitoring of weight and urinary output.
4. 4Liver Function Tests (LFTs): For patients on long-term IV nutrition.

Standard Dextrose infusions do not typically impair the ability to drive. However, if you are receiving Dextrose for a hypoglycemic event, you should not drive until your blood sugar has stabilized and you are no longer feeling dizzy, confused, or shaky.

Alcohol inhibits the liver's ability to release glucose (gluconeogenesis). If you are using Dextrose to treat hypoglycemia, alcohol consumption can make the Dextrose less effective and lead to 'rebound' lows. Chronic alcohol users are at the highest risk for Wernicke’s encephalopathy when receiving Dextrose.

Abruptly stopping a high-concentration Dextrose infusion (like D10W or TPN) can cause the body's high insulin levels to crash the blood sugar, leading to severe hypoglycemia. Healthcare providers typically taper the infusion rate over several hours or switch to a lower concentration (like D5W) before stopping entirely.

> Important: Discuss all your medical conditions, especially diabetes, heart disease, and kidney problems, with your healthcare provider before starting Dextrose.

• Blood Products (Coadministration): Dextrose solutions without electrolytes (like D5W) must NEVER be infused through the same tubing as whole blood or packed red blood cells. The lack of electrolytes causes the red cells to swell and clump (pseudoagglutination), which can lead to fatal transfusion reactions.

• Corticosteroids (e.g., Prednisone, Dexamethasone): These medications naturally increase blood sugar levels. When used with Dextrose, they can cause extreme hyperglycemia that is difficult to control even with insulin.
• Insulin: While often used together, insulin directly opposes the effect of Dextrose. Close monitoring is required to prevent rapid swings between high and low blood sugar.

• Diuretics (e.g., Furosemide, Hydrochlorothiazide): Diuretics can cause the body to lose potassium. Dextrose infusions also tend to lower blood potassium. Combining them can lead to severe hypokalemia (low potassium), which can cause heart rhythm disturbances.
• Lithium: Dextrose infusions can change the way the kidneys excrete lithium, potentially leading to lithium toxicity or reduced effectiveness of the psychiatric medication.

There are no specific food interactions with intravenous Dextrose. However, for patients using oral Dextrose for hypoglycemia, consuming high-fat foods (like chocolate or pizza) alongside Dextrose can slow the absorption of the sugar, delaying the recovery from low blood sugar.

• St. John’s Wort: May theoretically affect glucose metabolism, though the clinical significance with IV Dextrose is low.
• Magnesium Supplements: Since Dextrose can lower magnesium levels, patients on supplements may need their doses adjusted during prolonged Dextrose therapy.
• Chromium: Sometimes taken for blood sugar control, chromium can increase insulin sensitivity and may enhance the glucose-lowering effect of any insulin given alongside Dextrose.

• Creatinine Tests: High levels of Dextrose in the blood can interfere with certain laboratory methods (like the Jaffe reaction) used to measure serum creatinine, potentially giving a false reading of kidney function.
• Urinalysis: Dextrose will cause a positive result for 'glucose' on a urine dipstick, which is expected but should be noted by the lab.

For each major interaction, the mechanism usually involves either a pharmacodynamic interaction (opposing or additive effects on blood sugar) or a physical incompatibility (clumping of blood cells). Management strategies always include frequent bedside glucose monitoring and adjusting the infusion rate or insulin dose accordingly.

> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, as well as any history of corn allergy.

Dextrose must NEVER be used in the following circumstances:

• Severe Hyperglycemia: If blood sugar is already dangerously high (e.g., in Diabetic Ketoacidosis), adding more Dextrose will worsen the condition and increase the risk of coma.
• Corn Allergy: Since most medical-grade Dextrose is derived from corn starch, patients with a documented anaphylactic allergy to corn products should avoid Dextrose infusions unless no alternative exists and they are under extreme supervision.
• Intracranial or Intraspinal Hemorrhage: In the setting of a 'brain bleed' or acute stroke, high blood sugar can worsen brain swelling (edema) and increase the area of brain damage. Dextrose is generally avoided in these patients unless they are also hypoglycemic.
• Delirium Tremens (with Dehydration): If the patient is severely dehydrated and in alcohol withdrawal, Dextrose without electrolytes can worsen the metabolic state.

Conditions requiring careful risk-benefit analysis include:

• Known Diabetes Mellitus: Requires very careful monitoring and likely insulin coverage.
• Congestive Heart Failure: The fluid volume associated with Dextrose infusions can trigger an acute flare-up of heart failure.
• Severe Malnutrition: Risk of 'Refeeding Syndrome', where the sudden introduction of sugar causes a fatal drop in electrolytes.
• Low Blood Sodium (Hyponatremia): Dextrose in water (D5W) acts like 'free water' once the sugar is used, which can further dilute blood sodium and cause brain swelling.

There is a known cross-sensitivity between Dextrose and other corn-derived products. There is no cross-sensitivity with other sugars like fructose or galactose, but medical-grade versions of those are rarely used as primary IV fluids.

> Important: Your healthcare provider will evaluate your complete medical history, including any history of stroke or heart disease, before prescribing Dextrose.

Dextrose is classified as FDA Pregnancy Category C (under the old system, though still used in clinical practice). It is widely used during labor and delivery to provide energy to the mother and prevent ketosis. However, if the mother has Gestational Diabetes, high-concentration Dextrose can cause the fetus to produce excess insulin, leading to severe hypoglycemia in the newborn immediately after birth. A 2022 study in the American Journal of Obstetrics and Gynecology highlighted that careful glucose management during labor is essential for neonatal safety.

Dextrose is a natural component of breast milk (as lactose is broken down into glucose and galactose). Intravenous Dextrose given to a mother does not pose a risk to the nursing infant. It is considered compatible with breastfeeding.

Dextrose is a life-saving medication for neonates (newborns), who have very small glycogen stores. However, children are much more sensitive to 'osmotic shifts'. Using D50W in a child can cause the blood to become too 'thick' (hyperosmolar), which can lead to brain bleeds (intraventricular hemorrhage). Pediatric concentrations are usually limited to 10% or 25%.

Elderly patients are at a higher risk for 'silent' fluid overload. They may not show typical signs of heart failure until it is advanced. Furthermore, the elderly often take multiple medications (polypharmacy) like beta-blockers, which can mask the symptoms of low blood sugar, making the need for Dextrose monitoring even more critical.

In patients with a GFR (Glomerular Filtration Rate) below 30 mL/min, the kidneys cannot effectively manage large fluid volumes. Dextrose infusions must be concentrated (e.g., using D10W instead of D5W) to provide the same calories in half the volume of water. Dextrose is generally cleared during dialysis, but patients may need Dextrose added to their dialysate to prevent their blood sugar from dropping during the procedure.

Patients with liver failure (Child-Pugh Class C) often have 'fasting hypoglycemia' because their liver cannot store sugar. These patients require a constant, slow drip of Dextrose. However, because they are also prone to fluid retention (ascites), the volume must be strictly controlled.

> Important: Special populations require individualized medical assessment and frequent lab monitoring to ensure safety.

Dextrose acts as a direct metabolic substrate. Once it enters the cell via GLUT transporters, it is phosphorylated by the enzyme hexokinase to form glucose-6-phosphate. This molecule then enters the glycolytic pathway to produce pyruvate, which is then converted into Acetyl-CoA for the citric acid cycle (Krebs cycle). This process generates NADH and FADH2, which power the electron transport chain to produce ATP. In its role as a Calcium Chelating Activity [MoA], the Dextrose in anticoagulant solutions provides the energy needed for the sodium-potassium pump in red blood cell membranes, maintaining cell integrity during storage.

The onset of action for IV Dextrose in treating hypoglycemia is nearly instantaneous (less than 1 minute). The duration of effect depends on the patient's underlying metabolic rate and insulin levels but typically lasts 30 to 60 minutes. Dextrose also has an osmotic effect; high concentrations draw water out of the cells and into the bloodstream, which can temporarily increase blood pressure and reduce brain swelling (though this is more common with Mannitol).

| Parameter | Value |

|---|---|

| Bioavailability | 100% (IV); ~90% (Oral) |

| Protein Binding | 0% |

| Half-life | Varies (metabolized rapidly as needed) |

| Tmax | Immediate (IV); 15-30 mins (Oral) |

| Metabolism | Glycolysis / Krebs Cycle |

| Excretion | Renal 0% (unless >180 mg/dL blood level) |

• Molecular Formula: C6H12O6 · H2O
• Molecular Weight: 198.17 g/mol (monohydrate)
• Solubility: Highly soluble in water (approx. 1000 g/L)
• Structure: A six-carbon aldehyde sugar (aldohexose) in a pyranose ring form.

Dextrose is a carbohydrate and a glycemic agent. It is often grouped with other parenteral nutrients like amino acids and intralipids. In the context of the provided EPC tags, it serves as a stabilizer and metabolic substrate in specialized urological and hematological solutions.