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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Non-Standardized Food Allergenic Extract [EPC]
Sus Scrofa Ovary is a biological extract derived from porcine ovaries, utilized primarily as a non-standardized food allergenic extract and in complex homeopathic preparations. It contains various hormonal precursors including estrogens and progesterones.
Name
Sus Scrofa Ovary
Raw Name
SUS SCROFA OVARY
Category
Non-Standardized Food Allergenic Extract [EPC]
Drug Count
55
Variant Count
55
Last Verified
February 17, 2026
About Sus Scrofa Ovary
Sus Scrofa Ovary is a biological extract derived from porcine ovaries, utilized primarily as a non-standardized food allergenic extract and in complex homeopathic preparations. It contains various hormonal precursors including estrogens and progesterones.
Detailed information about Sus Scrofa Ovary
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Sus Scrofa Ovary.
Sus Scrofa Ovary refers to a biological medicinal substance derived from the ovarian tissue of the domestic pig (Sus scrofa domesticus). In the landscape of modern pharmacology, it is classified by the FDA as a Non-Standardized Food Allergenic Extract [EPC]. However, its pharmacological profile is significantly more complex than a simple allergen. Due to its biological origin, it serves as a natural reservoir for a variety of signaling molecules, including estrogens, progesterones, and androgens. It is frequently utilized in the manufacturing of homeopathic preparations (often labeled as Ovarium Suis) and in specialized allergenic testing and immunotherapy protocols.
Sus Scrofa Ovary belongs to a class of drugs called Glandular Extracts or Organotherapeutic Agents when used in alternative medicine, and Allergenic Extracts when used in immunology. The use of porcine-derived tissues in human medicine has a long historical precedent, dating back to the early 20th century when porcine insulin and thyroid extracts were the gold standard for endocrine replacement. While many of these have been replaced by recombinant technologies, Sus Scrofa Ovary remains a relevant component in multi-constituent biological therapies and allergy diagnostics.
According to the FDA's Established Pharmacologic Class (EPC) designations, Sus Scrofa Ovary is associated with an unusually broad range of activities, including acting as an Estrogen [EPC], Corticosteroid [EPC], Progesterone [EPC], and even Androgen [EPC]. This is because the ovarian tissue of a sow contains the same steroidogenic machinery found in humans, producing hormones that are chemically identical or highly similar to human endogenous hormones.
The mechanism of action for Sus Scrofa Ovary is multi-faceted and depends largely on the concentration and the clinical application. At the molecular level, the extract contains bio-identical hormones that function as Estrogen Receptor Agonists [MoA] and Progesterone Receptor Agonists. These molecules cross the cell membrane and bind to intracellular receptors, which then translocate to the nucleus to modulate gene expression related to reproductive health, bone density, and lipid metabolism.
In the context of its classification as a Non-Standardized Food Allergenic Extract, the mechanism involves the presentation of porcine proteins to the patient's immune system. If a patient is sensitized, these proteins cross-link IgE antibodies on the surface of mast cells and basophils, triggering the release of inflammatory mediators like histamine. In immunotherapy (desensitization), controlled exposure to these proteins aims to shift the immune response from a Th2-mediated (allergic) profile to a Th1-mediated or Treg-mediated (tolerant) profile.
Furthermore, the presence of Adrenergic alpha-Agonists and beta-Agonists within the tissue matrix suggests a role in modulating vascular tone and metabolic activity. The extract also exhibits Ammonium Ion Binding Activity, which may play a role in nitrogen metabolism, although this is more commonly associated with its use in complex metabolic support formulas.
Sus Scrofa Ovary is utilized in several distinct clinical contexts:
Sus Scrofa Ovary is available in several formulations, reflecting its diverse uses:
> Important: Only your healthcare provider can determine if Sus Scrofa Ovary is right for your specific condition. Because it contains active biological components, it must be used under professional supervision.
The dosage of Sus Scrofa Ovary varies significantly based on the formulation and the intent of therapy.
Sus Scrofa Ovary is generally not recommended for pediatric use unless specifically directed by a specialist in pediatric allergy or endocrinology.
No specific dosage adjustments are provided for Sus Scrofa Ovary in patients with renal impairment. However, since steroid metabolites are cleared renally, patients with Stage 4 or 5 Chronic Kidney Disease (CKD) should be monitored for signs of hormone accumulation if using high-potency extracts.
Caution is advised in patients with significant hepatic impairment. The liver is the primary site for the metabolism of the estrogens and progesterones contained within the extract. Reduced hepatic function may lead to elevated systemic levels of these hormones, increasing the risk of side effects.
In geriatric populations, Sus Scrofa Ovary should be used with caution, particularly in women with a history of hormone-sensitive cancers (e.g., breast or uterine cancer). The risk of thromboembolic events associated with exogenous estrogens increases with age.
If you miss a dose of Sus Scrofa Ovary, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this may increase the risk of hormonal fluctuations or adverse reactions.
Signs of an acute overdose of Sus Scrofa Ovary extract may include:
In the event of a suspected overdose, contact your local Poison Control Center or seek emergency medical attention immediately. For allergenic extracts, the primary concern in overdose is anaphylactic shock, which requires immediate epinephrine administration.
> Important: Follow your healthcare provider's dosing instructions precisely. Do not adjust your dose or frequency without medical guidance, as biological extracts can have unpredictable effects on the endocrine system.
Patients taking Sus Scrofa Ovary, particularly in non-homeopathic (crude) forms, may experience side effects related to its hormonal constituents. Common reports include:
> Warning: Stop taking Sus Scrofa Ovary and call your doctor immediately if you experience any of these serious symptoms.
Prolonged use of Sus Scrofa Ovary without medical supervision may lead to:
While Sus Scrofa Ovary itself may not always carry a specific Black Box Warning in homeopathic forms, the Estrogen [EPC] components within it are subject to the class-wide FDA warnings for estrogens:
Report any unusual symptoms or persistent side effects to your healthcare provider immediately. Monitoring through regular blood work and physical exams is essential when using biological extracts.
Sus Scrofa Ovary is a complex biological product. Because it is derived from animal tissue, it carries inherent risks that differ from synthetic pharmaceuticals. Patients must be aware that non-standardized extracts may have varying potencies of active hormones from batch to batch. This unpredictability necessitates close medical supervision, particularly for those with pre-existing endocrine disorders.
As noted in the side effects section, Sus Scrofa Ovary contains constituents that fall under the Estrogen [EPC] class. According to the FDA-approved labeling for estrogen-containing products, there are significant risks regarding endometrial cancer, stroke, and deep vein thrombosis. If you have not had a hysterectomy, using Sus Scrofa Ovary without a progestogen significantly increases your risk of uterine cancer.
No specific FDA black box warning exists solely for the 'Sus Scrofa Ovary' allergenic extract entry, but the systemic hormonal risks must be treated with the same gravity as conventional Hormone Replacement Therapy (HRT).
If you are using Sus Scrofa Ovary for hormonal support, your healthcare provider may require the following tests:
Sus Scrofa Ovary generally does not cause sedation. However, if you experience dizziness or severe headaches as a side effect, you should avoid driving or operating heavy machinery until you know how the medication affects you.
Alcohol consumption can increase circulating estrogen levels by impairing the liver's ability to clear them. Combining alcohol with Sus Scrofa Ovary may exacerbate side effects like breast tenderness, bloating, and mood changes.
Do not stop taking Sus Scrofa Ovary suddenly if you have been using it long-term at high doses. Abrupt discontinuation can lead to a 'hormonal crash,' characterized by extreme fatigue, hot flashes, and irritability. Your doctor will provide a tapering schedule to allow your endogenous hormone production to normalize.
> Important: Discuss all your medical conditions, especially any history of cancer or blood clots, with your healthcare provider before starting Sus Scrofa Ovary.
Sus Scrofa Ovary can interfere with several laboratory parameters:
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. The complex nature of biological extracts makes them highly prone to interactions that may not be immediately obvious.
Sus Scrofa Ovary must NEVER be used in the following circumstances:
These conditions require a careful risk-benefit analysis by a physician:
Patients who are allergic to other porcine-derived medical products may show cross-sensitivity to Sus Scrofa Ovary. This includes:
If you have had a reaction to any of these products, notify your healthcare provider immediately before exposure to Sus Scrofa Ovary.
> Important: Your healthcare provider will evaluate your complete medical history, including family history of cancer and cardiovascular disease, before prescribing or administering Sus Scrofa Ovary.
FDA Pregnancy Category X (for hormonal components). Sus Scrofa Ovary is strictly contraindicated during pregnancy. There is no clinical indication for its use in pregnant women. Exposure to exogenous estrogens and androgens during pregnancy can lead to developmental abnormalities in the fetus, including the virilization of female fetuses or the feminization of male fetuses. If you become pregnant while taking this substance, stop use immediately and consult your obstetrician.
It is not recommended to use Sus Scrofa Ovary while breastfeeding. Estrogens are known to be excreted into human milk and can decrease the quantity and quality of breast milk produced. Furthermore, the effects of the various porcine proteins and hormones on the nursing infant are not well-characterized, and a risk to the infant cannot be ruled out.
The safety and efficacy of Sus Scrofa Ovary in children have not been established. Use in the pediatric population is generally avoided due to the potential for the extract to interfere with the normal development of the hypothalamic-pituitary-gonadal axis. Premature closure of the epiphyses (growth plates) in the bones can occur with early exposure to estrogens, leading to permanent short stature.
Clinical studies of porcine extracts have not included sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, geriatric patients are at a higher baseline risk for the cardiovascular and oncogenic side effects of estrogens. In patients with age-related declines in renal or hepatic function, the clearance of the extract's components may be reduced, necessitating lower doses and more frequent monitoring.
In patients with impaired kidney function, the elimination of conjugated steroid metabolites may be delayed. While no specific dose adjustments are standardized for this non-standardized extract, clinicians should monitor for signs of 'hormone overload,' such as significant edema or hypertension, in patients with a GFR below 30 mL/min.
Sus Scrofa Ovary is contraindicated in patients with acute or chronic liver dysfunction. The liver's role in the oxidative metabolism of estrogens (via CYP enzymes) and their subsequent conjugation is vital for preventing systemic toxicity. In patients with Child-Pugh Class B or C impairment, the use of this extract is likely to result in significantly elevated serum levels of active hormones.
> Important: Special populations require individualized medical assessment. Always disclose your full health status to your medical provider.
Sus Scrofa Ovary acts as a complex biological signaling matrix. Its primary molecular targets are the Estrogen Receptors (ER-alpha and ER-beta) and Progesterone Receptors (PR-A and PR-B). Upon binding, these receptors act as ligand-activated transcription factors. For example, the estrogenic components promote the expression of proteins involved in cell proliferation in the endometrium and the regulation of gonadotropin-releasing hormone (GnRH) in the hypothalamus.
Additionally, as a Non-Standardized Food Allergenic Extract, it interacts with the immune system's IgE-mediated pathways. The proteins in the extract act as antigens that are processed by dendritic cells and presented to T-cells, which in an allergic individual, triggers a cascade resulting in mast cell degranulation.
The pharmacodynamics of Sus Scrofa Ovary are characterized by a slow onset and a prolonged duration of action when used for hormonal purposes, as gene transcription changes take time to manifest. When used as an allergen for skin testing, the pharmacodynamic effect (the wheal and flare reaction) is rapid, typically peaking within 15-20 minutes. Tolerance to the hormonal effects can develop over time if receptors are chronically down-regulated due to high-dose exposure.
| Parameter | Value |
|---|---|
| Bioavailability | 5-15% (Oral - due to first-pass metabolism) |
| Protein Binding | 95-98% (primarily to SHBG and Albumin) |
| Half-life | 12-20 hours (for Estradiol component) |
| Tmax | 2-4 hours (after oral ingestion) |
| Metabolism | Hepatic (CYP1A2, CYP3A4, Glucuronidation) |
| Excretion | Renal (approx. 80%), Fecal (approx. 20%) |
Sus Scrofa Ovary is not a single chemical entity but a biological extract. It contains a mixture of proteins, lipids, and steroid hormones. The primary active steroids include Estradiol (C18H24O2), Estrone (C18H22O2), and Progesterone (C21H30O2). The extract is typically soluble in aqueous solutions but contains lipophilic fractions. It is standardized by protein nitrogen content in allergenic forms but is generally non-standardized for hormonal content.
It is classified as a Non-Standardized Food Allergenic Extract [EPC]. Related medications include other porcine-derived glandulars (like Thyroid USP) and synthetic hormone replacements (like Premarin or Prometrium). Within the realm of immunology, it is grouped with other food and animal-derived allergenic extracts used for desensitization.
Common questions about Sus Scrofa Ovary
Sus Scrofa Ovary is primarily used in two distinct medical fields: immunology and integrative medicine. In immunology, it is an FDA-classified non-standardized food allergenic extract used to diagnose and treat allergies to porcine (pig) proteins through skin testing or immunotherapy. In integrative and homeopathic medicine, it is used to support female reproductive health, often to address symptoms of menopause or menstrual irregularities. It contains natural porcine hormones like estrogen and progesterone, which are biologically similar to human hormones. However, because it is a non-standardized extract, it should only be used under the strict guidance of a healthcare professional to ensure safety.
The most common side effects of Sus Scrofa Ovary are related to its hormonal content and its potential to cause allergic reactions. Many patients report breast tenderness, nausea, and mild headaches, which are typical effects of estrogenic substances. If used as an injection for allergy testing, redness, itching, and swelling at the injection site are very common. Some individuals may also experience bloating or minor changes in their menstrual cycle. Because these symptoms can mimic other medical conditions, it is important to report any persistent side effects to your doctor for evaluation.
It is generally advised to limit or avoid alcohol while taking Sus Scrofa Ovary. Alcohol can interfere with the liver's ability to metabolize the estrogens contained in the extract, which may lead to higher-than-intended levels of hormones in your bloodstream. This can increase the severity of side effects like breast pain, mood swings, and water retention. Furthermore, alcohol can sometimes mask or exacerbate allergic reactions, making it harder to monitor the safety of the extract. Always consult your healthcare provider about your alcohol consumption habits before starting a biological extract.
No, Sus Scrofa Ovary is not considered safe during pregnancy and is classified in Pregnancy Category X. The hormonal components, including estrogens and progesterones, can cross the placenta and potentially interfere with the normal development of the fetus. Using exogenous hormones during pregnancy carries a risk of birth defects and can disrupt the natural hormonal environment necessary for a healthy pregnancy. If you are planning to become pregnant or find out you are pregnant while using this product, you must stop taking it immediately and contact your healthcare provider.
The time it takes for Sus Scrofa Ovary to work depends on the condition being treated. For allergy testing, the reaction is almost immediate, with results appearing within 15 to 20 minutes of a skin prick or intradermal injection. For hormonal or homeopathic purposes, the effects are much slower and may take several weeks or even months of consistent use to become noticeable. This is because the hormones must modulate gene expression and cellular activity over time. Patients should have realistic expectations and maintain regular follow-ups with their doctor to assess the treatment's progress.
You should not stop taking Sus Scrofa Ovary suddenly, especially if you have been using it at high doses for an extended period. Because the extract contains active hormones, your body's own endocrine system may have adjusted its natural production in response to the supplement. Abruptly stopping can cause a sudden drop in hormone levels, leading to withdrawal-like symptoms such as extreme fatigue, hot flashes, irritability, and sleep disturbances. Your healthcare provider will typically recommend a gradual tapering of the dose to allow your body to resume its natural hormone production safely.
If you miss a dose of Sus Scrofa Ovary, you should take it as soon as you remember, unless it is nearly time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular routine. Do not take two doses at once to make up for the one you missed, as this can cause a temporary spike in hormone levels and increase the risk of side effects. Consistency is important for hormonal therapies, so try to take your medication at the same time each day. If you find yourself frequently missing doses, consider using a pill reminder or alarm.
Weight gain is a possible side effect of Sus Scrofa Ovary, primarily due to the effects of estrogen and progesterone. These hormones can cause the body to retain sodium and water, leading to 'water weight' or bloating. Additionally, changes in hormonal balance can sometimes affect appetite or fat distribution in the body. While not everyone will experience weight changes, it is a common concern with any hormone-based therapy. Maintaining a balanced diet and regular exercise can help manage these effects, but you should discuss any significant or rapid weight gain with your doctor.
Sus Scrofa Ovary can interact with several types of medications, so it is crucial to provide your doctor with a full list of everything you are taking. It can interfere with blood thinners like Warfarin, thyroid medications, and certain anti-seizure drugs. Most importantly, it should not be taken with aromatase inhibitors or tamoxifen used for breast cancer, as the hormones in the extract can counteract these life-saving treatments. Even herbal supplements like St. John's Wort can change how your body processes the extract. Your pharmacist or doctor can perform a formal interaction check to ensure your safety.
Sus Scrofa Ovary is a biological extract rather than a synthetic drug, so the concept of 'generic' versions is slightly different than with standard tablets. It is available under various brand names and as a non-branded bulk extract used by compounding pharmacies and homeopathic manufacturers. Because these extracts are 'non-standardized,' products from different manufacturers may vary in their protein and hormone content. It is important to stay with a reputable brand or source recommended by your healthcare provider to ensure you are receiving a consistent and high-quality product.