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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Non-Standardized Plant Allergenic Extract [EPC]
Potassium, often administered as Potassium Chloride, is a vital mineral and electrolyte essential for nerve conduction, muscle contraction, and cardiac function. It is primarily used to treat or prevent hypokalemia (low blood potassium levels).
Name
Potassium
Raw Name
POTASSIUM CHLORIDE
Category
Non-Standardized Plant Allergenic Extract [EPC]
Salt Form
Chloride
Drug Count
680
Variant Count
1302
Last Verified
February 17, 2026
RxCUI
847630, 312515, 314182, 198116, 1038800, 1801294, 1801298, 800644, 800648, 615099, 615100, 615107, 615111, 630796, 1863605, 1863607, 1863973, 800985, 800988, 312507, 1860239, 1860241, 1860463, 1860466, 628953, 1038929, 1086243, 309318, 1038841, 199376, 199381, 898490, 403888, 603281, 603282, 898517, 430174, 1423814, 1867544, 637365, 312504, 315183, 2682752, 2603764, 847014, 204520, 827351, 827353, 309317, 800808, 800812, 237367, 403890, 637551, 966920, 801054, 847627, 1863975, 1863988, 801109, 801357, 312529, 847628, 1117536, 1001689, 1120068, 242429, 237381, 1426152, 1801295, 1866190, 800925, 800928, 1860132, 1860136, 1860139, 312544, 2390767, 2734000, 2734004, 966914, 967023, 847626, 807396, 801112, 1536601, 312541, 2693253, 806392, 309783, 2566844, 801442, 801445, 544597, 1871155, 2665269, 2665275, 1086474, 832731, 1801299, 309786, 806396, 847617, 979099, 967012, 312539, 1111703, 628958, 832718, 801451, 204913, 2729280, 2729282, 1001690, 2390768, 966916, 966922, 1870431, 847621, 801024, 1189629, 1867547, 801005, 801009, 999717, 2728724
UNII
M4I0D6VV5M, 660YQ98I10, 451W47IQ8X, TU7HW0W0QT, O3B55K4YKI, E934B3V59H, CI71S98N1Z, 91GQH8I5F7, HF539G9L3Q, 1K573LC5TV, ETJ7Z6XBU4, 70WT22SF4B, 0YPR65R21J, 91D9GV0Z28, 53Y84VPS2W, 2H1576D5WG, 2FXJ6SW4PK, O80TY208ZW, WQZ3G9PF0H, T7S323PKJS, 62I3C8233L, 6P669D8HQ8, 639KR60Q1Q, 27YLU75U4W, OSD78555ZM, 95IT3W8JZE, U0NQ8555JD, 01Q9PC255D, S7V92P67HO, 23H32AOH17, 1C4QK22F9J, 36XQ854NWW, N94C2U587S, 269XH13919, RU45X2JN0Z, 8ZYQ1474W7, WR1WPI7EW8, PQ6CK8PD0R, 01YAE03M7J, 6SO6U10H04, H0G9379FGK, 1C6V77QF41, P6YC3EG204, SFW1D987QV, 935E97BOY8, 3A3U0GI71G, 68Y4CF58BV, LX22YL083G, 02F3473H9O, 4J9FJ0HL51, 593YOG76RN, NVG71ZZ7P0, R6Q3791S76, 395A3P448Z, DSS8V86H3Y, 59677RXH25, 514B9K0L10, 08A7Y81S1P, T42P99266K, 411VRN1TV4, RP8496915M, W2469WNO6U, X7BCI5P86H, 11T9HCO30O, P4A66LQ3QJ, 5405K23S50, AB6MNQ6J6L, 7PGE2DJ8QM, 3G7U72W8DA, GR686LBA74, 33X04XA5AT, 8MDF5V39QO, 5SL0G7R0OK, 2968PHW8QP, EE90ONI6FF, LC7F2W7I5B, 3K9958V90M, DIF093I037, 30KYC7MIAI, Q59QU6N72Q, G6W4F0V8Z3, 206GF3GB41, 608DGJ6815, C62OO7VD9K, 7YNJ3PO35Z, 4WRK2153H3, 4PW41QCO2M, 46627O600J, 4VB4Y46AHD, GKN429M9VS, 4GB5DQR532, C8CV8867O8, 1NT28V9397, 4G174V5051, 6L5ZL09795, 7E889U5RNN, 9H58JRT35E, 1DP6Y6B65Z, 96WE91N25T, 19FUJ2C58T, XK4IUX8MNB, 1WZA4Y92EX, Q4EWM09M3O, 39981FM375, 8P29O5P7XU, 7S82P3R43Z, 5EF0HWI5WU, EL5GJ3U77E, 1MBW07J51Q, G39P120JQT, DD5FO1WKFU, VB06AV5US8, V1V998DC17, VSW71SS07I, G0R4UBI2ZZ, 53GH7MZT1R, 2E32821G6I, 11E6VI8VEG, 1TH8Q20J0U, O2630F3XDR, 3C18L6RJAZ, C88X29Y479, 324Y4038G2, YFH4WC535J, Q1RGP4UB73, 8E272251DI, 2H03479QVR, 70FD1KFU70, C5H0QJ6V7F, 3JYG22FD73, 3M5V3D1X36, T7J046YI2B, QHH4HVF5QE, YHA2XLJ956, H6241UJ22B, 6GLA1946WX, BK9092J5MP, 789U1901C5, K848JZ4886, 3T8H1794QW, F5452U54PN, 1HG84L3525, 535G2ABX9M, 88XHZ13131, 79Y1949PYO, 82KK5J435E, P3026TK92O, ADL68M27WD, 69O1DAO10G, FYF75V7FDY, 9679TC07X4, 98PI200987, TWH5125Q6F, 9YY2F980SV, 81AH48963U, YF0S03R447, 7OV03QG267, 8ID597Z82X, 5TWQ1V240M, I76KB35JEV, U751HEX436, 3M4G523W1G, 6CA025Y4FG, 1PIP394IID, L0PFEMQ1DT, 6RV024OAUQ, 387GMG9FH5, D1JT611TNE, J41CSQ7QDS, Q51BO43MG4, E4GA8884NN, 398IYQ16YV, R763EBH88T, H6J53HEX8E, N9288CD508, DL6OZ476V3, 597E9BI3Z3, S003A158SB, J61BY05EGY, 4N9P6CC1DX, 72T9EZC2VX, ZW3Z11D0JV, 3POA0Q644U, R9HH0NDE2E, 1314JZ2X6W, JC71GJ1F3L, BQN1B9B9HA, T4423S18FM, 9N1RM2S62C, CT03BSA18U, 0JXZ63016V, C9TD27U172, 75O014T1HG, S546YLW6E6, 41CN475O7F, 279O8I0433, 7M867G6T1U, 1C89KKC04E, QDL83WN8C2, 6IO182RP7A, DJO934BRBD, 9W34L2CQ9A, NJ5VT0FKLJ, T90W4582DU, 32MP823R8S, ZXE7LB03WC, 2HU33I03UY, 4H5RSU087I, 3IXW0F6P8W, 1W0775VX6E, C9642I91WL, I57ERU2601, 0B24UR1O1S, 46G3W789Q3, X67Z2963PI, 492225Q21H, 604NK4250S, 151F45R21P, 9CQ6C00G3C, 7IIH57D9E0, Q7MU1F4GLY, 877L01IZ0P, 21W82Q764G, QU52J3A5B3, 6NAF1689IO, KPS1B1162N, AHW6F0T2X0, 91QY4PXU8Q, IHN2NQ5OF9, 4K7Z7K7SWG, J10PD1AQ0N, 9I4XB1GP2B, 3029988O2T, F1T8QT9U8B, YKH834O4BH, V0S6H36980, ZZ4AG7L7VM, G59M7S0WS3, 7114SV0MYK, JWF5YAW3QW, QNS6W5US1Z, 0ORO6NCA4M, KL498O6790, P47W069U38, M2776SWB29, 7JM57I419K, 8XEJ88V2T8, TE7660XO1C, 466251J72G, P6J2SFT80O, 7GL3G1COB3, 9Y3J3362RY, 92AMN5J79Y, 0B4FDL9I6P, C46FS57S0X, N9E3X5056Q, A150AY412V, T8BEA5064F, R5L488RY0Q, A9R10K3F2F, W00LYS4T26, BR1SN1JS2W, 25X51I8RD4, 19F5HK2737, TLM2976OFR, 8K0I04919X, 3LE3D9D6OY, K72I3DEX9B, 4FLT4T3WUN, 2NVP93XVQ3, 8EKI9QEE2H, QGY289M89Q, T9F9ZW799A, 01WNS05SFO, 7ZO132YX2X, 97K9E28344, 29SUH5R3HU, 4550K0SC9B, 1Q73Q2JULR, QI7G114Y98, C4MO6809HU, ZI0T668SF1, 7LP2MPO46S, 8L70Q75FXE, 28WIH9KKYG, 2URQ2N32W3, GW89581OWR, GAN16C9B8O, T42NAD2KHC, AE28F7PNPL, 2679MF687A, CLF5YFS11O, 394XK0IH40, 1T6N4D9YV6, 12H3K5QKN9, KV2JZ1BI6Z, 333DO1RDJY, X66NSO3N35, U6WSN5SQ1Z, H35KS68EE7, G2M7P15E5P, 36KCS0R750, JC9WZ4FK68, LC1V549NOM, L6L8KA2AA0, 9Q24RAI43V, OO7ZBU9703, 1TI1O9028K, 93PH5Q8M7E, 10464S0TAA, M6936L953C, XTC0D02P6C, K20Y81ACO3, F79059A38U, QG07G580U0, 28M1820ACT, 0J8NV9V5Q8, K0Q6REZ9JC, SBV4XY874G, 947UNF3Z6O, N20HL7Q941, 25B1Y14T8N, 433OSF3U8A, YEA9P21S8N, 01G9XEA93N, 3G0H8C9362, 993QHL78E6, Q28R5GF371, 0HK2GZK66E, X2N6E405GV, 01800C6E6B, 4QQN74LH4O, C21158IIRK, QTT17582CB, RGL5YE86CZ, 2WTB3V159F, 8VP54WOT4I, 2P299V784P, 9PP1T3TC5U, K2A74U428F, 86M454L2TT, RWG7BD1032, U946SH95EE, W5Y0EFG88O, AEE24M3MQ9, 339NCG44TV, A49OS0F91S, F26P2D4757, KF7Z0E0Q2B, FOP08H143P, 45P3261C7T, O40UQP6WCF, 6YR2608RSU, 197B3Q7T5Q, 5K1UO2888Y, M7T6H7D4IF, 4M1169RWJD, IR986LE7DF, SOI2LOH54Z, MN0RX54EQA, QOI241B01F, 5ENR9SAN1W, ML644HED2V, MA9CQJ3F7F, 714LIU3V6D, J7WWH9M8QS, 7FT6QUT299, N6R0856Z79, KM02613O28, 86Q357L16B, TYK22LML8F, NP3JD65NPY, ZAD9OKH9JC, H7426RGB3L, AAN7QOV9EA, D1YM0P5Z2T, 15443PR153, Y0F0BU8RDU, EBU0U94820, T1UDV7ES1A, E1UOL152H7, 0KD7R09EAS, 52ZE5Y9Y82, 97Z1WI3NDX, QK8899250F, B7862WZ632, U1B11I423Z, F06SGE49M6, I38ZP9992A, RWP5GA015D, M911911U02, O9WLL1ZL8S, ML30MJ2U7I, ET3651ZLOU, GM5EY0N07D, 22T8Z09XAK, PR9U2YPF3Q, 5A3Y60049Z, 8KOG53Z5EM, 69404B0LO7, 44448S9773, 2RQ1L9N089, ID3Z1X61WY, H19J064BA5, 4D7G21HDBC, 51FI676N6F, 48FZ1BHO18, S88TT14065, 91MBZ8H3QO, O478WX4004, 5C7J33MJJ1, 1NM3M2487K, OJ17O2WTSM, DUP6W562BM, 94ZLA3W45F, 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About Potassium
Potassium, often administered as Potassium Chloride, is a vital mineral and electrolyte essential for nerve conduction, muscle contraction, and cardiac function. It is primarily used to treat or prevent hypokalemia (low blood potassium levels).
Detailed information about Potassium
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Potassium.
Potassium is a fundamental mineral and the primary intracellular cation (positively charged ion) in the human body. In a clinical context, it is most frequently prescribed as Potassium Chloride. It belongs to the class of medications known as electrolytes. Potassium is critical for maintaining osmotic pressure within cells, acid-base balance, and the transmission of nerve impulses. According to the FDA-approved labeling, potassium supplements are indicated for the therapeutic treatment of patients with hypokalemia, with or without metabolic alkalosis, and for the prevention of hypokalemia in patients who would be at particular risk (e.g., patients taking digitalis glycosides or those with cardiac arrhythmias).
At the molecular level, potassium works by maintaining the resting membrane potential of cells. It is a key player in the sodium-potassium pump (Na+/K+-ATPase), which actively transports potassium into cells and sodium out. This gradient is essential for the excitability of neurons and muscle fibers, particularly the myocardium (heart muscle). By modulating these electrical potentials, potassium ensures regular heart rhythms and effective muscle contractions.
Potassium is FDA-approved for the following indications:
Potassium is available in several dosage forms to suit patient needs:
> Important: Only your healthcare provider can determine if Potassium is right for your specific condition.
Dosage must be individualized based on the serum potassium levels of the patient.
Potassium use in children must be strictly monitored by a pediatrician.
Patients with renal impairment (kidney disease) require extreme caution. Because the kidneys are responsible for potassium excretion, reduced function can lead to life-threatening hyperkalemia (high potassium). Frequent laboratory monitoring is mandatory.
No specific dosage adjustments are generally required for liver disease, though the patient's overall metabolic state should be monitored.
Older adults often have reduced renal function; therefore, healthcare providers typically start at the lower end of the dosing range and monitor kidney function closely.
Potassium should be taken with a full glass of water and with food to reduce the risk of stomach upset or irritation of the esophagus. Extended-release tablets must be swallowed whole; do not crush, chew, or break them unless specifically instructed by your pharmacist, as this can cause a rapid release of the drug. Store at room temperature away from moisture and heat.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
Signs of potassium overdose (hyperkalemia) include muscle weakness, paralysis, irregular heartbeat, chest pain, and cardiac arrest. If an overdose is suspected, contact emergency services or a poison control center immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
> Warning: Stop taking Potassium and call your doctor immediately if you experience any of these.
Prolonged use of potassium supplements without medical supervision can lead to chronic hyperkalemia, which may cause permanent heart rhythm issues or kidney damage. Regular blood tests (BMP or CMP) are necessary for long-term therapy.
No FDA black box warnings currently exist for Potassium Chloride; however, the risk of hyperkalemia in patients with renal impairment is a primary clinical concern that carries similar weight in prescribing decisions.
Report any unusual symptoms to your healthcare provider.
Potassium supplements should only be used under the guidance of a healthcare professional. The most significant risk associated with potassium therapy is hyperkalemia, which can be fatal if not identified and treated promptly.
No FDA black box warnings for Potassium.
Periodic serum potassium determinations are essential. Your doctor may also order regular BUN (Blood Urea Nitrogen) and creatinine tests to monitor kidney function, as well as occasional ECGs (electrocardiograms) to check heart rhythm.
Potassium generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or confusion due to electrolyte shifts, avoid these activities.
Alcohol can irritate the gastrointestinal tract and may increase the risk of stomach upset when taking potassium. Consult your doctor regarding alcohol consumption.
Do not stop taking potassium suddenly if you are taking it for a chronic condition, as this could lead to a rapid drop in potassium levels. Follow a tapering schedule if recommended by your provider.
> Important: Discuss all your medical conditions with your healthcare provider before starting Potassium.
Potassium supplements do not typically interfere with standard laboratory tests, other than the intended effect of raising serum potassium measurements.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Potassium must NEVER be used in the following conditions:
There is no known cross-sensitivity between potassium chloride and other unrelated drug classes, though patients sensitive to certain tablet binders or dyes should check the inactive ingredients.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Potassium.
Potassium is classified as FDA Pregnancy Category C. While potassium is a normal constituent of human milk and blood, it should only be given to a pregnant woman if clearly needed. According to the American College of Obstetricians and Gynecologists (ACOG), maintaining electrolyte balance is crucial, but supplementation must be medically supervised.
Potassium is excreted in human milk. The potassium content of human milk is about 13 mEq/L. Since oral potassium is a natural part of the diet, supplementation at therapeutic doses is generally considered compatible with breastfeeding, provided maternal serum levels are monitored.
Safety and effectiveness in children have been established for the treatment of hypokalemia, but dosing is strictly weight-based. Children are more sensitive to electrolyte shifts and require frequent monitoring.
Clinical studies have shown that elderly patients are at a higher risk of hyperkalemia due to the natural decline in glomerular filtration rate (GFR) associated with aging. Healthcare providers often monitor renal function more frequently in this population.
In patients with a GFR below 30 mL/min, potassium supplementation is generally avoided unless under extreme circumstances with continuous monitoring, as the risk of cardiac arrest from hyperkalemia is significantly elevated.
No specific dose adjustment is needed for patients with liver cirrhosis, though they may have concurrent renal issues (Hepatorenal syndrome) that would complicate potassium use.
> Important: Special populations require individualized medical assessment.
Potassium is the major intracellular cation. It is essential for the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal, and smooth muscle, and the maintenance of normal renal function. It acts as a cofactor in many enzymatic reactions, including those involved in protein synthesis and carbohydrate metabolism.
Following oral administration, the onset of action for potassium replacement is relatively rapid, though the full effect on serum levels may take several days of consistent dosing. The duration of effect is dependent on renal excretion rates. There is no evidence of tolerance development.
| Parameter | Value |
|---|---|
| Bioavailability | >90% (Oral) |
| Protein Binding | Negligible |
| Half-life | Variable (Dependent on renal function) |
| Tmax | 1-2 hours (Immediate release); 4-8 hours (Extended release) |
| Metabolism | None (Elemental) |
| Excretion | Renal 90%, Fecal 10% |
Potassium is classified as an Electrolyte Supplement. Related medications include Potassium Citrate, Potassium Gluconate, and Magnesium-Potassium combinations.
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Common questions about Potassium
Potassium supplements are primarily used to treat or prevent hypokalemia, a condition where blood potassium levels are too low. This condition can occur due to the use of certain diuretics, chronic diarrhea, or specific kidney disorders. Potassium is vital for the healthy functioning of the heart, muscles, and nervous system. Your healthcare provider may prescribe it to ensure your heart maintains a regular rhythm and your muscles contract properly. It is also used in patients who are at high risk of complications from low potassium, such as those with existing heart disease.
The most common side effects of oral potassium supplements include nausea, vomiting, gas, and stomach pain. These symptoms occur because potassium salts can be irritating to the lining of the gastrointestinal tract. Some patients may also experience mild diarrhea. To minimize these effects, it is highly recommended to take the medication with a full meal and a large glass of water. If these symptoms become severe or persistent, you should contact your healthcare provider to discuss a possible dose adjustment or a change in the formulation.
While there is no direct chemical interaction between alcohol and potassium, drinking alcohol can increase the risk of gastrointestinal irritation. Alcohol acts as a diuretic, which can affect your body's fluid balance and potentially complicate the management of your potassium levels. For some patients, heavy alcohol use can also impair kidney function, making potassium supplementation more dangerous. It is best to consult your doctor about whether moderate alcohol consumption is safe for you while on this medication. Always prioritize hydration with water over alcoholic beverages.
Potassium is generally considered safe during pregnancy when used under medical supervision to correct a deficiency. It is a naturally occurring mineral that is essential for both the mother and the developing fetus. However, self-supplementation is not recommended, as excessively high levels can be dangerous. Your doctor will likely monitor your blood levels more frequently during pregnancy to ensure the dosage is appropriate. According to the FDA, it should only be used if the benefits clearly outweigh the potential risks to the fetus.
The time it takes for potassium to work depends on the method of administration and the severity of the deficiency. For oral supplements, blood levels may begin to rise within a few hours, but it often takes several days of consistent dosing to fully correct a chronic deficiency. If potassium is given intravenously in a hospital setting, the effects on heart rhythm and serum levels are almost immediate. Your doctor will use follow-up blood tests to determine how well the treatment is working. Do not increase your dose if you don't feel an immediate difference.
You should not stop taking potassium supplements without consulting your healthcare provider, especially if you are also taking diuretics or heart medications. Stopping suddenly can cause your potassium levels to drop rapidly, which may lead to muscle weakness or dangerous heart arrhythmias. Your doctor will typically monitor your blood levels and may gradually reduce your dose if the supplement is no longer needed. Always ensure you have enough medication to last through weekends or holidays to avoid an unplanned interruption in therapy. If you experience any new symptoms after stopping, contact your doctor immediately.
If you miss a dose of potassium, take it as soon as you remember, provided it is not too close to your next scheduled dose. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take two doses at once to make up for a missed one, as this can cause a temporary spike in potassium levels. Consistency is key to maintaining stable electrolyte levels in your blood. If you frequently forget your doses, consider using a pill organizer or a mobile reminder app.
Potassium itself does not cause weight gain and has no caloric value. In fact, potassium helps regulate fluid balance in the body, which can sometimes reduce water retention. However, if you are taking potassium for a condition like heart failure, changes in your weight might be related to your underlying condition rather than the supplement. Significant or sudden weight gain should always be reported to your doctor, as it could indicate worsening heart or kidney function. Always track your weight if instructed by your healthcare provider while managing electrolyte issues.
Potassium can interact with several common medications, some of which can be very dangerous. Taking potassium with ACE inhibitors, ARBs, or potassium-sparing diuretics can lead to dangerously high levels of potassium in the blood. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can also affect how your kidneys handle potassium. It is vital to provide your doctor and pharmacist with a complete list of all medications, including over-the-counter drugs and herbal supplements. They will check for these interactions to ensure your treatment plan is safe.
Yes, potassium chloride is widely available as a generic medication in many forms, including extended-release tablets, capsules, and oral solutions. Generic versions are typically much more affordable than brand-name versions like K-Dur or Micro-K and are required by the FDA to be bioequivalent. This means the generic version must work in the same way and provide the same clinical benefits as the brand-name drug. Most insurance plans cover generic potassium supplements. Check with your pharmacist to ensure you are receiving the most cost-effective version of your prescription.