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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Standardized Chemical Allergen [EPC]
Isopropyl Alcohol is a widely used antiseptic and standardized chemical allergen utilized for skin preparation, disinfection, and diagnostic allergy testing. It belongs to the class of antiseptic and chemical allergen agents.
Name
Isopropyl Alcohol
Raw Name
ISOPROPYL ALCOHOL
Category
Standardized Chemical Allergen [EPC]
Drug Count
364
Variant Count
655
Last Verified
February 17, 2026
RxCUI
1039900, 808520, 1539800, 797544, 582901, 895749, 1014638, 2717558, 616456, 631799, 1052725, 2667820, 2667826, 2712548, 1191171, 1366736, 858726, 998282, 402481, 692866, 1090522, 2700214, 2712447, 2600350, 2629724, 1918214, 581698, 2287034, 1666879, 2287160, 1044190
UNII
ND2M416302, 3K9958V90M, 344S277G0Z, 597E9BI3Z3, QN83US2B0N, 3QPI1U3FV8, T7EU0O9VPP, 14255EXE39, EB41QIU6JL, I753WB2F1M, 5EM498GW35, T4V6TWG28D, 24WE03BX2T, GFD7C86Q1W, A2I8C7HI9T, 25X51I8RD4, WV9CM0O67Z, HIE492ZZ3T, 7YC686GQ8F, SMD1X3XO9M, 6DC9Q167V3, Z8IX2SC1OH, TLM2976OFR, S0FAJ1R9CD, R0ZB2556P8, 059QF0KO0R, 3NY3SM6B8U, U3RSY48JW5, 85H0HZU99M, L7T10EIP3A, MOR84MUD8E, 213N3S8275, 6E43AWY083, F2VW3D43YT, B697894SGQ, O414PZ4LPZ, 7X6O37OK2I, N863NB338G, 1P9D0Z171K, 9M7A3K4339, 0A5MM307FC, 9M64UO4C25, 936JST6JCN, A4VZ22K1WT, L837108USY, PDC6A3C0OX, FCZ5MH785I, W2ZU1RY8B0, M629807ATL, D81QY6I88E, 4Y5P7MUD51, 95OOS7VE0Y, VIF565UC2G, 5138Q19F1X, 2V52R0NHXW, 147D247K3P, 0WT12SX38S, R9QTB5E82N, 6K23F1TT52, 33X04XA5AT
About Isopropyl Alcohol
Isopropyl Alcohol is a widely used antiseptic and standardized chemical allergen utilized for skin preparation, disinfection, and diagnostic allergy testing. It belongs to the class of antiseptic and chemical allergen agents.
Detailed information about Isopropyl Alcohol
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Isopropyl Alcohol.
Isopropyl Alcohol (IPA), also known as isopropanol or 2-propanol, is a colorless, flammable chemical compound with a strong odor. In a clinical context, it is classified primarily as an Antiseptic [EPC] and a Standardized Chemical Allergen [EPC]. As an antiseptic, it is most commonly found in concentrations of 70% to 91% for topical use. As a standardized chemical allergen, it is utilized in diagnostic patch testing to identify contact dermatitis or hypersensitivity reactions in patients.
According to the FDA-approved monographs for over-the-counter (OTC) topical antimicrobials, Isopropyl Alcohol has been a staple in clinical settings for decades. It is used to prepare the skin prior to injections or surgical procedures to reduce the bacterial load and minimize the risk of infection. While it is highly effective against vegetative bacteria and fungi, it is not sporicidal (does not kill bacterial spores).
At the molecular level, Isopropyl Alcohol exerts its antimicrobial effect through the denaturation of proteins. When the alcohol molecules penetrate the cell wall of a microorganism, they disrupt the hydrogen bonding between amino acids, causing the proteins to lose their structure and functionality. This leads to the rapid collapse of the cell membrane and the death of the pathogen.
In its role as a Standardized Chemical Allergen, Isopropyl Alcohol serves as a diagnostic tool. When applied to the skin under controlled conditions (patch testing), it can trigger a delayed-type hypersensitivity reaction (Type IV) in sensitized individuals. This allows healthcare providers to identify specific substances causing allergic contact dermatitis.
> Important: Only your healthcare provider can determine if Isopropyl Alcohol is right for your specific condition or diagnostic needs.
Isopropyl Alcohol should be used with extreme caution in pediatric populations, especially neonates. Their skin is thinner and more permeable, increasing the risk of systemic absorption and alcohol toxicity.
No dosage adjustment is required for topical application. However, in cases of systemic toxicity (ingestion), renal clearance of the metabolite acetone may be impaired in patients with kidney disease.
No adjustment for topical use. In systemic poisoning, hepatic impairment may slow the metabolism of Isopropyl Alcohol to acetone.
Elderly patients often have thinner, more fragile skin. Frequent use may lead to excessive dryness or skin breakdown.
As Isopropyl Alcohol is typically used on an as-needed basis for disinfection, missed doses are generally not clinically significant. If using for a specific wound care regimen, apply as soon as remembered.
Signs of systemic overdose (usually via ingestion or inhalation) include dizziness, headache, confusion, nausea, vomiting, and loss of consciousness. In case of ingestion, call 911 or a poison control center immediately. Do not induce vomiting unless told to do so by medical professionals.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your use without medical guidance.
> Warning: Stop using Isopropyl Alcohol and call your doctor immediately if you experience any of these.
Prolonged or chronic topical use can lead to chronic irritant contact dermatitis, characterized by thickened, cracked, and painful skin (lichenification). Chronic inhalation in industrial settings has been linked to respiratory tract irritation.
No FDA black box warnings are currently issued for Isopropyl Alcohol when used as a topical antiseptic. However, it is strictly labeled for external use only to prevent fatal ingestion.
Report any unusual symptoms to your healthcare provider.
Isopropyl Alcohol is intended for external topical use only. It is a potent central nervous system (CNS) depressant if ingested or inhaled in high concentrations.
No FDA black box warnings for Isopropyl Alcohol.
For routine topical use, no specific lab monitoring is required. In cases of suspected toxicity or ingestion, healthcare providers may monitor:
Topical use does not typically affect the ability to drive. However, if symptoms of inhalation toxicity (dizziness, drowsiness) occur, avoid these activities immediately.
Ingestion of ethanol (drinking alcohol) while Isopropyl Alcohol is in the system can potentially complicate the metabolic pathway and increase the risk of CNS depression.
There are no tapering requirements for Isopropyl Alcohol as it is not used systemically. If a skin rash develops, discontinue use immediately.
> Important: Discuss all your medical conditions with your healthcare provider before starting Isopropyl Alcohol.
There are no known food interactions with the topical application of Isopropyl Alcohol.
No significant interactions have been documented for topical use. However, if systemic absorption occurs, herbs with sedative properties (e.g., Valerian, Kava) may increase drowsiness.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients who are sensitive to other alcohols (such as ethanol or n-propanol) may exhibit cross-sensitivity to Isopropyl Alcohol, although this is clinically rare.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Isopropyl Alcohol.
FDA Pregnancy Category: Not formally assigned (OTC).
Topical use on small areas of the skin is generally considered safe during pregnancy as systemic absorption is minimal. However, widespread application or use on broken skin should be avoided. There are no adequate studies on the reproductive effects of Isopropyl Alcohol in humans.
It is unknown if topical Isopropyl Alcohol is excreted in human milk. When used as directed for skin prepping, it is unlikely to pose a risk to the nursing infant. Care should be taken to avoid applying alcohol to the breast or nipple area to prevent the infant from ingesting it during feeding.
Children are at a higher risk for Isopropyl Alcohol toxicity via inhalation and skin absorption. In 2020, the FDA issued warnings regarding the accidental ingestion of hand sanitizers by children. Always keep these products out of reach of children.
Elderly patients may have increased skin sensitivity. Healthcare providers should monitor for signs of skin breakdown or excessive dryness in geriatric patients using alcohol-based products frequently.
In the event of systemic poisoning, the kidneys are responsible for excreting acetone. Patients with end-stage renal disease may require hemodialysis to clear Isopropyl Alcohol and its metabolites from the blood.
Liver disease may slow the conversion of Isopropyl Alcohol to acetone, potentially prolonging the CNS depressant effects in cases of accidental poisoning.
> Important: Special populations require individualized medical assessment.
Isopropyl Alcohol is a rapidly acting antimicrobial agent. Its primary mechanism is the denaturation of proteins and the dissolution of lipid membranes. By disrupting the cell membrane integrity and coagulating cellular proteins, it effectively inactivates bacteria, fungi, and many viruses. It is particularly effective against gram-positive and gram-negative bacteria but lacks activity against bacterial spores.
| Parameter | Value |
|---|---|
| Bioavailability | <1% (Intact Skin) |
| Protein Binding | Negligible |
| Half-life | 2.5 – 8 hours (IPA); 22 hours (Acetone) |
| Tmax | ~30-90 minutes (if ingested) |
| Metabolism | Hepatic (Alcohol Dehydrogenase) |
| Excretion | Renal and Pulmonary |
Isopropyl Alcohol belongs to the class of Aliphatic Alcohols. In a clinical setting, it is categorized as an Antiseptic and a Standardized Chemical Allergen.
Medications containing this ingredient
Hand Sanitizer Isopropyl Alcohol Antiseptic 75
70% Isopropyl Alcohol
Isopropyl Alcohol
Defense Hand Sanitizer
Alcohol Prep Pads
Isopropyl Alcohol 91 Percent
Non-proprietary Name
Alcohol Cleansing Wipe
Everlit Care Products Prep Pad
Isopropyl Alcohol Cleansing Pad Toallitas Humedas Con Alcohol Isopropilico
Saniiswab
Alcohol Prep Pads Large Sterile
+ 38 more drugs
Common questions about Isopropyl Alcohol
Isopropyl Alcohol is primarily used as a topical antiseptic to disinfect the skin before medical procedures like injections or blood draws. It is also a common ingredient in first-aid kits for cleaning minor cuts and scrapes to prevent infection. In specialized clinical settings, it is used as a standardized chemical allergen for patch testing to diagnose contact allergies. Additionally, it serves as a disinfectant for non-critical medical equipment such as stethoscopes. It should never be used internally or on deep, serious wounds without medical advice.
The most common side effects of Isopropyl Alcohol are localized to the skin and include dryness, redness, and a mild stinging or burning sensation upon application. Because alcohol removes natural oils from the skin, frequent use can lead to flaking or itching. These effects are usually temporary and resolve once use is discontinued. If you experience severe irritation, blistering, or signs of an allergic reaction, you should stop use and consult a healthcare provider. It is important to avoid contact with the eyes, as this can cause significant pain and irritation.
While Isopropyl Alcohol is applied topically and does not usually enter the bloodstream in significant amounts, you should never ingest Isopropyl Alcohol itself, as it is highly toxic. If you are using Isopropyl Alcohol for wound care, there is no known interaction with moderate consumption of dietary ethanol (alcoholic beverages). However, if someone has accidentally ingested Isopropyl Alcohol, drinking ethanol can further complicate the medical emergency and should be avoided. Always consult your doctor if you have concerns about systemic absorption and your lifestyle. Isopropyl Alcohol is metabolized differently than the alcohol found in beverages.
Topical use of Isopropyl Alcohol on small, intact areas of skin is generally considered safe during pregnancy because very little of the chemical reaches the bloodstream. There is no evidence to suggest that routine use for skin disinfection before an injection poses a risk to the developing fetus. However, pregnant individuals should avoid using it over large areas of the body or in poorly ventilated spaces where they might inhale the vapors. As with any product during pregnancy, it is best to discuss its use with your obstetrician. Avoid use on broken or severely irritated skin to minimize any potential for absorption.
Isopropyl Alcohol works almost instantly upon contact with bacteria and fungi by denaturing their proteins. For effective skin disinfection, it is crucial to apply the solution and then allow it to air dry completely, which typically takes 30 to 60 seconds. The drying process is actually part of the antimicrobial action, and wiping it off too early can reduce its effectiveness. It does not provide long-lasting protection, so the skin can become re-contaminated once the alcohol has evaporated. For surgical or high-risk procedures, healthcare providers follow specific timed protocols to ensure maximum sterility.
Yes, you can stop using Isopropyl Alcohol at any time without any risk of withdrawal or physical rebound effects. Since it is a topical antiseptic and not a systemic medication, the body does not develop a dependence on it. If you are using it for a specific skin condition or wound care as directed by a doctor, consult them before stopping to ensure the infection risk is managed. If you stop using it because of a skin rash or irritation, the symptoms typically improve quickly. Always follow the specific duration of use recommended by your healthcare professional.
If you are using Isopropyl Alcohol as part of a regular wound-cleaning routine and you miss a session, simply apply it as soon as you remember. If it is almost time for your next scheduled cleaning, skip the missed application and return to your regular schedule. Do not apply double the amount of alcohol to make up for a missed dose, as this may excessively dry out or irritate the skin. Since its primary purpose is to prevent infection at the time of application, the most important factor is maintaining consistent hygiene. Consult your healthcare provider if you are unsure about your wound care schedule.
No, Isopropyl Alcohol does not cause weight gain. It is used topically and is not involved in the body's metabolic or endocrine processes that regulate weight. Even in cases of accidental systemic absorption, it is a toxin and a CNS depressant, not a substance that provides calories or affects adipose tissue. There are no clinical reports or pharmacological mechanisms that link the use of Isopropyl Alcohol to changes in body weight. If you experience unexpected weight changes, you should discuss them with your healthcare provider to find the underlying cause.
Isopropyl Alcohol is for external use only and does not typically interact with oral medications. However, if you are using other topical creams, ointments, or patches, the alcohol may increase their absorption or cause increased skin irritation if applied to the same area. It is generally recommended to wait until the alcohol has completely dried before applying other topical products. If you are undergoing diagnostic patch testing, your doctor will provide specific instructions on which medications to avoid. Always inform your healthcare provider about all the products you are applying to your skin.
Yes, Isopropyl Alcohol is widely available as a generic product and is found in many over-the-counter antiseptic solutions, wipes, and hand sanitizers. It is one of the most affordable and accessible antiseptic agents on the market. Generic versions are just as effective as brand-name antiseptic wipes or solutions, provided they contain the correct concentration (usually 70%). You can find it in pharmacies, grocery stores, and medical supply outlets. Always check the label to ensure the product is intended for the specific use you require, such as first aid versus surface cleaning.