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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Hypromellose 2208 (15000 Mpa.s) is a high-viscosity cellulose-based polymer used as an ophthalmic lubricant for dry eyes and as a critical controlled-release agent in oral medications.
Name
Hypromellose 2208 (15000 Mpa.s)
Raw Name
HYPROMELLOSE 2208 (15000 MPA.S)
Category
Other
Drug Count
5
Variant Count
5
Last Verified
February 17, 2026
RxCUI
1147664, 1540361
UNII
Z78RG6M2N2
About Hypromellose 2208 (15000 Mpa.s)
Hypromellose 2208 (15000 Mpa.s) is a high-viscosity cellulose-based polymer used as an ophthalmic lubricant for dry eyes and as a critical controlled-release agent in oral medications.
Detailed information about Hypromellose 2208 (15000 Mpa.s)
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Hypromellose 2208 (15000 Mpa.s).
Hypromellose 2208 (15000 Mpa.s), also known by the chemical name hydroxypropyl methylcellulose (HPMC), is a semi-synthetic, inert, viscoelastic polymer used extensively in clinical medicine and pharmaceutical science. It belongs to a class of compounds known as cellulose ethers. The specific nomenclature '2208' refers to the chemical substitution pattern: approximately 22% methoxyl groups and 8% hydroxypropyl groups. The '15000 Mpa.s' designation indicates the viscosity of a 2% aqueous solution at 20°C, marking it as a high-viscosity grade.
In clinical practice, Hypromellose 2208 serves two primary roles. First, it is an active therapeutic agent in ophthalmology, where it functions as an ocular lubricant (artificial tears) to manage keratoconjunctivitis sicca (dry eye syndrome). Second, it is a foundational 'functional excipient' in oral drug delivery. In this capacity, it creates a hydrophilic matrix system that controls the release rate of active drugs, ensuring a steady therapeutic level in the bloodstream over 12 to 24 hours. The FDA has categorized Hypromellose as 'Generally Recognized as Safe' (GRAS), and it has been a staple in pharmacopeias (USP/NF, EP, JP) for decades due to its biocompatibility and non-toxic profile.
The mechanism of action for Hypromellose 2208 (15000 Mpa.s) is primarily physical rather than biochemical. When used as an ophthalmic lubricant, the polymer exhibits mucoadhesive properties, meaning it binds to the mucin layer of the corneal epithelium. This action stabilizes the tear film and increases the 'break-up time' (the time it takes for dry spots to appear on the eye). Because of its high viscosity (15000 Mpa.s), it provides a thick, protective shield over the ocular surface, reducing friction during blinking and preventing moisture evaporation. This is particularly effective for patients with aqueous-deficient dry eye.
In oral tablet formulations, Hypromellose 2208 works through a 'swelling and erosion' mechanism. When a tablet containing this polymer reaches the gastrointestinal tract, the HPMC particles on the surface hydrate to form a viscous gel layer. This gel layer acts as a diffusion barrier. The active drug must dissolve and then slowly diffuse through this thick gel to enter the systemic circulation. As the outer layers of the gel eventually erode, new layers hydrate, maintaining a constant release profile. The high viscosity of the 15000 Mpa.s grade is specifically chosen when a very slow, sustained release of a highly soluble drug is required.
Hypromellose 2208 (15000 Mpa.s) is FDA-approved and clinically indicated for several specific uses:
> Important: Only your healthcare provider can determine if Hypromellose 2208 (15000 Mpa.s) is right for your specific condition.
The standard adult dosage for Hypromellose 2208 (15000 Mpa.s) ophthalmic solution is 1 to 2 drops instilled into the affected eye(s) as needed. Many patients find relief with 3 to 4 applications daily; however, because the substance is non-pharmacological and inert, it may be used more frequently if directed by a physician. For severe cases, a thicker gel form may be applied once daily, usually at bedtime, to provide prolonged lubrication through the night.
When Hypromellose 2208 is part of a tablet matrix, the dosage is determined by the active drug (e.g., Metoprolol ER, Carbamazepine XR). Patients must follow the specific dosing schedule for that medication. The presence of the 15000 Mpa.s polymer ensures that the dose is delivered over a 12-to-24-hour period.
Hypromellose 2208 is generally considered safe for pediatric use when used as an ocular lubricant. The dosage is typically the same as the adult dose (1-2 drops as needed). However, clinical data in infants is limited, and a pediatrician should be consulted before use in children under 6 years of age. When used as an excipient in oral tablets, the safety profile is tied to the active drug, and pediatric use must follow the specific drug's guidelines.
No dosage adjustments are required for patients with renal (kidney) impairment. Since Hypromellose 2208 is not systemically absorbed and is not cleared by the kidneys, renal function does not affect its safety or efficacy.
No dosage adjustments are required for patients with hepatic (liver) impairment. The polymer does not undergo hepatic metabolism and does not interact with liver enzyme systems.
No specific dosage adjustments are necessary for elderly patients. In fact, Hypromellose 2208 is frequently prescribed to the geriatric population due to the high prevalence of age-related dry eye (keratoconjunctivitis sicca).
If you are taking a medication that contains Hypromellose 2208 (15000 Mpa.s) as a controlled-release agent, you must swallow the tablet whole. Do not crush, chew, or split the tablet unless specifically instructed by your doctor. Breaking the tablet destroys the 15000 Mpa.s polymer matrix, leading to 'dose dumping,' where the entire 24-hour dose of the active drug is released at once, which can be dangerous.
For eye drops, apply the missed dose as soon as you remember. If it is almost time for your next application, skip the missed dose. For oral tablets containing HPMC, follow the specific instructions for the active medication. Do not double the dose to catch up.
An overdose of Hypromellose 2208 is highly unlikely and generally not life-threatening. Ocular overdose may result in temporary blurred vision or a sticky sensation in the eye, which can be resolved by rinsing the eye with lukewarm water or saline. If an oral tablet containing the HPMC matrix is crushed and swallowed, seek emergency medical attention immediately, as the danger lies in the rapid release of the active medication, not the Hypromellose itself.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Hypromellose 2208 (15000 Mpa.s) is exceptionally well-tolerated, but because of its high viscosity, certain local effects are common:
> Warning: Stop taking Hypromellose 2208 (15000 Mpa.s) and call your doctor immediately if you experience any of these.
There are no known systemic long-term side effects associated with Hypromellose 2208. Long-term use in the eye is generally considered safe. However, if the formulation contains preservatives (such as Benzalkonium Chloride), chronic use (more than 4-6 times daily) may lead to 'preservative-induced epitheliopathy,' a condition where the surface of the eye becomes irritated by the preservative itself. In such cases, patients are often switched to preservative-free single-use vials.
There are no FDA black box warnings for Hypromellose 2208 (15000 Mpa.s). It is considered one of the safest substances used in pharmaceutical manufacturing and clinical ophthalmology.
Report any unusual symptoms to your healthcare provider.
Hypromellose 2208 (15000 Mpa.s) is intended for topical ophthalmic use or as an inactive component of oral tablets. It should never be injected. If you are using the eye drops, ensure the solution is clear and the bottle is not damaged before use. If the solution changes color or becomes cloudy, discard it immediately.
No FDA black box warnings for Hypromellose 2208 (15000 Mpa.s).
While Hypromellose is a carbohydrate-based polymer and is generally non-immunogenic, some patients may be allergic to the preservatives used in multi-dose bottles. If you have a known allergy to Benzalkonium Chloride (BAK) or Thimerosal, you must use preservative-free versions of Hypromellose 2208.
The most significant risk with Hypromellose eye drops is bacterial contamination of the dropper bottle. Touching the tip to any surface can introduce Pseudomonas aeruginosa or other dangerous bacteria, which can lead to corneal ulcers and permanent vision loss. Always keep the cap tightly closed when not in use.
Hypromellose 2208 (15000 Mpa.s) can interact with soft contact lenses. The high-viscosity polymer and certain preservatives can be absorbed by the lens material, leading to discoloration or irritation. Generally, contact lenses should be removed before instilling the drops and reinserted no sooner than 15 minutes after use.
There are no specific laboratory tests (like blood counts or liver function tests) required for patients using Hypromellose 2208. However, patients using it for chronic dry eye should have regular eye examinations (every 6-12 months) to monitor the health of the corneal surface and ensure that the underlying cause of the dryness is being managed appropriately.
Because Hypromellose 2208 (15000 Mpa.s) is a high-viscosity liquid, it will cause temporary blurring of vision. Do not drive, operate heavy machinery, or perform any activity requiring clear vision until your sight has fully cleared (usually within 5 minutes of application).
There are no known interactions between alcohol and Hypromellose 2208. However, alcohol consumption can exacerbate systemic dehydration, which may worsen the symptoms of dry eye syndrome.
Hypromellose 2208 can be stopped at any time without the need for tapering. There is no withdrawal syndrome. However, if you stop using it for dry eye, your symptoms (burning, redness, irritation) are likely to return immediately.
> Important: Discuss all your medical conditions with your healthcare provider before starting Hypromellose 2208 (15000 Mpa.s).
There are no known absolute drug-drug contraindications for Hypromellose 2208 (15000 Mpa.s). Because it is not systemically absorbed, it does not interfere with the metabolism or action of internal medications.
If you are using other eye drops (e.g., for glaucoma like Timolol or Latanoprost, or antibiotics like Ciprofloxacin), Hypromellose 2208 can interfere with their absorption. Because of its high viscosity (15000 Mpa.s), it creates a physical barrier on the eye. If Hypromellose is applied before another medication, the second medication may not be able to reach the cornea.
Management: Always apply other medicated eye drops first, wait at least 10 minutes, and then apply Hypromellose 2208 as the final step.
Using Hypromellose 2208 simultaneously with other rewetting drops may result in an overly thick film on the eye, causing prolonged blurring. It is best to stick to one type of lubricant at a time.
There are no known food interactions with Hypromellose 2208. It can be taken (as part of a tablet) with or without food. However, for the active drug within the HPMC matrix, follow the specific food requirements (e.g., some ER tablets should not be taken with high-fat meals as it may increase the rate of erosion of the HPMC layer).
No known interactions with St. John’s Wort, Ginkgo, or other common supplements. Supplements that have a diuretic effect (like dandelion root) might worsen dry eye symptoms, but they do not interact chemically with the Hypromellose polymer.
Hypromellose 2208 does not interfere with standard blood or urine laboratory tests. In ophthalmic exams, the presence of the polymer may interfere with the clarity of certain retinal scans or photographs; therefore, it should be used after such diagnostic imaging is completed.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Hypromellose 2208 (15000 Mpa.s) is absolutely contraindicated in patients with a known hypersensitivity (allergy) to Hypromellose or any other cellulose derivative. While rare, an allergic reaction can cause severe ocular inflammation or systemic anaphylaxis.
Many multi-dose bottles of Hypromellose contain Benzalkonium Chloride. Patients with a documented severe allergy to this preservative must not use these formulations. Use of the product in these individuals can cause 'toxic keratopathy,' a serious irritation of the cornea.
While not strictly contraindicated, Hypromellose should be used with caution during an active bacterial, viral, or fungal eye infection. The viscous nature of the 15000 Mpa.s solution may trap infectious organisms against the corneal surface, potentially worsening the infection. A doctor should determine if lubrication is appropriate during anti-infective treatment.
Immediately following eye surgery (e.g., LASIK, cataract surgery), the use of high-viscosity drops like Hypromellose 2208 must be cleared by the surgeon. The thick gel could theoretically interfere with the healing of surgical incisions or flaps.
Patients who are allergic to other cellulose ethers, such as:
...may also experience cross-sensitivity with Hypromellose 2208. If you have had a reaction to any 'artificial tear' product in the past, review the ingredients with your pharmacist.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Hypromellose 2208 (15000 Mpa.s).
Hypromellose 2208 (15000 Mpa.s) is not systemically absorbed following ophthalmic or oral administration. Because it does not enter the bloodstream, it cannot cross the placenta to reach the developing fetus. There is no evidence of teratogenicity (birth defects) or reproductive toxicity in human or animal studies. It is generally considered safe for use during all trimesters of pregnancy. However, as with all substances, pregnant women should consult their obstetrician before use.
Hypromellose 2208 is not expected to be excreted in human milk because it is not absorbed into the mother's systemic circulation. There is no known risk to the nursing infant. It is considered compatible with breastfeeding.
Hypromellose 2208 is used in children for the treatment of dry eye associated with conditions like juvenile idiopathic arthritis or environmental factors. It is generally safe; however, the 15000 Mpa.s grade may cause more significant blurring in children, which could be a safety concern during play or school activities. Parents should supervise the administration to ensure the dropper tip does not touch the child's eye.
The elderly are the primary users of Hypromellose 2208 due to the natural decline in tear production with age. There are no specific geriatric risks. However, elderly patients with significant arthritis or tremors may find it difficult to squeeze the bottle or aim the drops correctly. The use of an 'eye drop guide' or assistance from a caregiver may be necessary. Additionally, the temporary blurring of vision may increase the risk of falls in frail patients; they should remain seated until vision clears.
No adjustments are needed. The polymer's large molecular weight prevents renal filtration, and it is not absorbed into the blood.
No adjustments are needed. There is no hepatic metabolism of this polymer.
> Important: Special populations require individualized medical assessment.
Hypromellose 2208 (15000 Mpa.s) is a non-ionic cellulose ether. Its molecular mechanism relies on its high degree of hydration and its ability to form hydrogen bonds with water molecules. In the eye, it acts as a surrogate for the aqueous and mucin layers of the tear film. The hydroxypropyl and methoxyl groups on the cellulose backbone allow the polymer to adhere to the corneal surface (mucoadhesion), providing a stable, lubricating layer that resists being washed away by tears.
In drug delivery, the 15000 Mpa.s grade is critical for its 'gel strength.' When water enters a tablet, the polymer chains relax and expand, creating a dense, 'tortuous' path. Active drug molecules must navigate this complex gel network to be released. The high viscosity ensures the gel is robust enough to withstand the mechanical forces of the stomach and intestines.
The pharmacodynamic effect is immediate upon contact with moisture. The duration of effect for the 15000 Mpa.s grade is longer than lower-viscosity grades (like 4000 Mpa.s) because the thicker gel layer takes longer to dissolve and wash away. There is no development of tolerance; the physical lubricating properties remain constant regardless of how long the product is used.
| Parameter | Value |
|---|---|
| Bioavailability | 0% (Not absorbed) |
| Protein Binding | 0% |
| Half-life | N/A (Local action only) |
| Tmax | Immediate (Ophthalmic) |
| Metabolism | None |
| Excretion | Fecal (Oral); Tears (Ophthalmic) |
Hypromellose 2208 belongs to the therapeutic class of Ophthalmic Lubricants and the functional class of Pharmaceutical Polymers/Excipients.
Medications containing this ingredient
Common questions about Hypromellose 2208 (15000 Mpa.s)
Hypromellose 2208 (15000 Mpa.s) is primarily used as an ocular lubricant to treat dry eye symptoms such as burning, itching, and redness. It works by stabilizing the tear film and providing a protective moisture barrier on the surface of the eye. Additionally, it is used in the pharmaceutical industry to create controlled-release tablets, ensuring that medications are released slowly into the body over many hours. The '15000 Mpa.s' refers to its high viscosity, which makes it particularly effective at providing long-lasting relief and slow drug diffusion. It is also used during certain eye exams to protect the cornea.
The most common side effects are local to the eye and include temporary blurred vision immediately after applying the drops. This occurs because the liquid is quite thick and takes a few moments to spread evenly across the eye surface. Some users may also notice a mild, brief stinging sensation or the formation of small clear crusts on the eyelashes as the polymer dries. These effects are generally harmless and disappear within minutes. Because the drug is not absorbed into the blood, systemic side effects like headache or nausea are extremely rare. If irritation persists, you should consult your eye doctor.
Yes, there are no known direct interactions between alcohol and Hypromellose 2208 (15000 Mpa.s). Since the polymer is not absorbed into your bloodstream, alcohol cannot interfere with its lubricating properties. However, it is important to note that alcohol is a diuretic and can lead to systemic dehydration. Dehydration often worsens the symptoms of dry eye, potentially making the treatment less effective. For the best results in managing dry eye, it is recommended to stay well-hydrated with water while using this product.
Hypromellose 2208 (15000 Mpa.s) is considered very safe during pregnancy. Because it is a large polymer molecule, it is not absorbed through the eye or the digestive tract into the mother's bloodstream. This means it cannot cross the placenta and has no way of affecting the developing fetus. It has been used for decades without reports of birth defects or other pregnancy complications. Even so, it is always a best practice to inform your healthcare provider about any products you are using while pregnant. It is also safe for use while breastfeeding for the same reasons.
When used as an eye drop, Hypromellose 2208 works almost instantly to provide relief from dryness and irritation. You will feel the lubricating effect as soon as the drop spreads across the eye surface. However, you may experience a few minutes of blurred vision before your sight becomes clear. When it is used as an ingredient in a controlled-release tablet, its 'work' begins as soon as the tablet is swallowed and reaches the stomach, where it starts forming a gel to control the release of the active medication. The full therapeutic effect of the *active* drug in that tablet will depend on its specific properties.
Yes, you can stop using Hypromellose 2208 eye drops suddenly without any risk of withdrawal or physical rebound. It is an inert lubricant, not a hormonal or chemically addictive substance. However, if you are using it to manage a chronic condition like dry eye syndrome, your symptoms will likely return once you stop providing that artificial lubrication. If Hypromellose is a component of a prescription tablet you are taking, you should never stop taking that medication without consulting your doctor, as the *active* ingredient (such as blood pressure medicine) may require a gradual dose reduction.
If you miss a dose of Hypromellose 2208 eye drops, simply apply them as soon as you remember. If it is almost time for your next scheduled application, you can skip the missed dose and return to your regular routine. Because it is a lubricant used 'as needed,' missing a dose is not dangerous, though your eyes may feel dry or uncomfortable in the meantime. If the Hypromellose is part of a controlled-release tablet, follow the specific 'missed dose' instructions for that particular medication. Never use extra eye drops or take double doses of a tablet to make up for a missed one.
No, Hypromellose 2208 (15000 Mpa.s) does not cause weight gain. It is a non-caloric polymer that is not absorbed by the body. Whether applied to the eye or swallowed as part of a tablet, it does not enter the metabolic pathways that regulate weight or fat storage. It is excreted unchanged from the body. If you are experiencing unexplained weight gain while taking a medication that contains Hypromellose, the cause is likely the active drug ingredient or another underlying health condition, and you should discuss this with your healthcare provider.
Hypromellose 2208 is generally safe to use alongside other medications, but timing is important for eye drops. Because this polymer is very thick (15000 Mpa.s), it can create a barrier that prevents other eye drops from being absorbed. You should always apply any medicated eye drops first, wait at least 10 minutes, and then apply the Hypromellose drops last. For oral tablets containing Hypromellose, there are no known drug-drug interactions with the polymer itself. However, always provide your doctor with a full list of all medications and supplements you are using to ensure total safety.
Yes, Hypromellose 2208 is widely available as a generic product. It is the active ingredient in many over-the-counter 'artificial tear' and 'lubricating eye drop' brands. You can often find it as a store-brand equivalent to major labels like Isopto Tears or Gonak. Because it is a well-established and relatively simple polymer to manufacture, generic versions are typically just as effective as brand-name versions. When buying generic, just ensure the concentration and the viscosity (if listed) match what your doctor recommended, and check if the product is 'preservative-free' if you have sensitive eyes.