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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Standardized Chemical Allergen [EPC]
Chloroxylenol is a broad-spectrum antimicrobial chemical used primarily as a topical antiseptic and disinfectant. It belongs to the phenolic class of compounds and is also utilized as a standardized chemical allergen for diagnostic patch testing.
Name
Chloroxylenol
Raw Name
CHLOROXYLENOL
Category
Standardized Chemical Allergen [EPC]
Drug Count
232
Variant Count
245
Last Verified
February 17, 2026
RxCUI
1150812, 2002728, 2689268, 413261, 436367, 1365688, 413257, 1039201, 1042793, 1038961, 1113695, 1043129, 1941461, 1362618, 413262, 2703095, 1435989, 1043032, 199005, 213034, 1356502, 1860597, 413259, 2168394, 1045621, 1045003, 1245176, 1245181, 1053758, 247396, 1537468, 2682820, 1549613
UNII
0F32U78V2Q, U3RSY48JW5
About Chloroxylenol
Chloroxylenol is a broad-spectrum antimicrobial chemical used primarily as a topical antiseptic and disinfectant. It belongs to the phenolic class of compounds and is also utilized as a standardized chemical allergen for diagnostic patch testing.
Detailed information about Chloroxylenol
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Chloroxylenol.
Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is a broad-spectrum antimicrobial chemical compound used primarily as a topical antiseptic and disinfectant. It belongs to a class of drugs called phenolic antiseptics. First developed in the 1920s and popularized in the 1930s, Chloroxylenol has become one of the most widely used household and clinical disinfectants globally. It is the active ingredient in many well-known antiseptic liquids, such as Dettol.
In addition to its role as a disinfectant, Chloroxylenol is classified by the FDA as a Standardized Chemical Allergen [EPC]. In this context, healthcare providers use it in diagnostic patch testing to identify patients who may have a contact allergy (allergic contact dermatitis) to this specific chemical. According to the FDA-approved labeling for diagnostic allergens, it is used to help confirm whether a patient's skin inflammation is caused by exposure to Chloroxylenol in consumer products.
Chloroxylenol works by disrupting the microbial cell wall and inactivating essential cellular enzymes. At the molecular level, its phenolic nature allows it to penetrate the cell membranes of bacteria, fungi, and certain viruses. Once inside, it causes the leakage of intracellular components and precipitates cytoplasmic proteins, leading to the death of the microorganism. It is particularly effective against Gram-positive bacteria, though it also shows activity against Gram-negative bacteria, yeasts, and molds.
Chloroxylenol is utilized in several clinical and consumer settings:
Chloroxylenol is available in various concentrations and formulations, including:
> Important: Only your healthcare provider can determine if Chloroxylenol is right for your specific condition or if you require diagnostic testing for a Chloroxylenol allergy.
Chloroxylenol is generally considered safe for children when used topically and appropriately diluted. However, it should be used with caution in infants, as their skin is more permeable and susceptible to irritation. It is NOT recommended for use on infants under 12 months of age without direct medical supervision.
Because Chloroxylenol is used topically and systemic absorption is minimal, dosage adjustments are generally not required for patients with kidney disease. However, avoid application to large areas of broken skin in patients with severe renal failure.
No specific adjustments are required for topical use in patients with liver disease.
No specific dosage adjustments are necessary, though clinicians should monitor for increased skin sensitivity or dryness, which is more common in geriatric populations.
If you are using Chloroxylenol for wound care and miss a scheduled cleaning, apply it as soon as you remember. If it is almost time for the next application, skip the missed dose and resume your regular schedule.
Topical Overdose: Excessive topical application may lead to skin irritation or chemical burns. Wash the area thoroughly with plain water.
Ingestion: If Chloroxylenol is swallowed, it can be toxic. Symptoms include nausea, vomiting, abdominal pain, and in severe cases, respiratory distress or CNS depression. Seek emergency medical attention or contact a Poison Control Center immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or use the product in a manner not specified on the label without medical guidance.
When used as directed, Chloroxylenol is generally well-tolerated. However, some individuals may experience:
> Warning: Stop using Chloroxylenol and call your doctor immediately if you experience any of these symptoms:
Prolonged or excessive use of Chloroxylenol on the skin can lead to chronic irritant contact dermatitis. There is also a theoretical risk that frequent use of antimicrobial agents could alter the natural microbiome of the skin, though the clinical significance of this for Chloroxylenol is not fully established.
No FDA black box warnings currently exist for Chloroxylenol. It is generally recognized as safe (GRAS) for its intended topical antiseptic uses when used according to label directions.
Report any unusual symptoms or persistent skin irritation to your healthcare provider.
Chloroxylenol is for external use only. It is highly toxic if ingested and can cause severe irritation if it comes into contact with the eyes or the middle ear. Patients with known sensitivities to phenolic compounds should exercise extreme caution.
No FDA black box warnings for Chloroxylenol.
For standard topical use, routine laboratory monitoring (such as blood counts or liver function tests) is not required. However, if being used as part of a Standardized Chemical Allergen patch test, the healthcare provider will monitor the skin site at 48 and 96 hours to interpret the results.
Topical use of Chloroxylenol does not typically affect the ability to drive or operate machinery.
There are no known direct interactions between topical Chloroxylenol and alcohol consumption. However, alcohol can dry out the skin, potentially worsening any irritation caused by the antiseptic.
If you are using Chloroxylenol to treat a minor infection and the condition does not improve within 7 days, or if it worsens, stop use and consult a healthcare provider.
> Important: Discuss all your medical conditions and known allergies with your healthcare provider before starting Chloroxylenol.
There are no well-documented systemic drug-drug contraindications for topical Chloroxylenol. However, it should not be used simultaneously with other topical antiseptics (such as povidone-iodine) on the same skin area unless directed by a doctor, as they may neutralize each other or cause excessive skin irritation.
There are no known food interactions with topical Chloroxylenol. Because the drug is not intended for oral ingestion, dietary factors do not affect its efficacy or safety.
There are no documented interactions between topical Chloroxylenol and herbal supplements. However, patients using topical herbal preparations (like tea tree oil) should be aware that the combination may increase the likelihood of contact dermatitis.
Chloroxylenol is not known to interfere with common blood or urine laboratory tests. However, its presence on the skin could potentially interfere with certain skin-based diagnostic tests or cultures if the area is not properly cleaned before the sample is taken.
Most interactions involving Chloroxylenol are pharmacodynamic, meaning they occur at the site of application through additive irritation or chemical incompatibility. Because systemic levels remain very low, pharmacokinetic interactions (involving CYP450 enzymes) are highly unlikely.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially other topical treatments.
Chloroxylenol must NEVER be used in the following circumstances:
Conditions requiring careful risk-benefit analysis include:
Patients who are allergic to other phenols, such as triclosan or chlorocresol, may have an increased risk of reacting to Chloroxylenol. Healthcare providers should perform a patch test if cross-sensitivity is suspected.
> Important: Your healthcare provider will evaluate your complete medical history and any known skin sensitivities before recommending Chloroxylenol.
Studies on the use of Chloroxylenol in pregnant women are limited. However, because systemic absorption through intact skin is minimal, it is generally considered low-risk when used as directed for minor wound care. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Avoid application to large areas of the body.
It is not known whether Chloroxylenol is excreted in human milk following topical application. However, systemic levels are unlikely to be high enough to cause issues for a nursing infant. Precaution: Do not apply Chloroxylenol to the breast or nipple area before breastfeeding to prevent the infant from accidentally ingesting the chemical.
Chloroxylenol is used in pediatric populations for hand-washing and wound care. However, infants have a higher surface-area-to-body-weight ratio, which increases the risk of systemic absorption. It should be used sparingly and only under adult supervision in children.
Older adults may have thinner, more fragile skin (atrophic skin). This population is at a higher risk for irritant contact dermatitis. Healthcare providers often recommend using a lower frequency of application or ensuring thorough rinsing after use in elderly patients.
While topical use is generally safe, patients with end-stage renal disease (ESRD) should avoid applying Chloroxylenol to large areas of broken skin, as they may be less able to clear any chemical that enters the bloodstream.
No specific precautions are required for patients with liver disease for standard topical applications.
> Important: Special populations require individualized medical assessment by a qualified professional.
Chloroxylenol is a phenolic disinfectant. Its primary mechanism involves the disruption of the microbial cell membrane. The phenolic hydroxyl group binds to proteins in the bacterial cell wall, altering their structure and increasing permeability. This leads to the leakage of essential intracellular metabolites (like potassium and amino acids) and the eventual lysis (bursting) of the cell. Additionally, it inhibits certain bacterial enzymes involved in the respiratory chain and energy production.
| Parameter | Value |
|---|---|
| Bioavailability | <5% (on intact skin) |
| Protein Binding | Unknown (human) |
| Half-life | 2-3 hours (systemic) |
| Tmax | 1-2 hours (if absorbed) |
| Metabolism | Hepatic (Glucuronidation) |
| Excretion | Renal (>90% as metabolites) |
Chloroxylenol is categorized as a Phenolic Antiseptic. It is related to other disinfectants like thymol and chlorocresol. In the context of allergy diagnostics, it is classified as a Standardized Chemical Allergen [EPC].
Medications containing this ingredient
Junipercleandishsoap Lemon
Kleenline Essentials Antibacterial Lotionskin Cleanser
Eversoft Foaming Hand
Safeguard Antibacterial Hand Wash
Simplify Antibacterial Hand
Provon Foaming Antimicrobial Handwash With Moisturizers
Micrell Antibacterial Foam Handwash
Gojo Ultra Mild Antimicrobial Ltn Sp With Chloroxylenol
Gojo Pcmx E-2 Sanitizing Ltn Sp
Provon Antimicrobial Ltn Sp With 0.3% Pcmx
Digiclean E
Ecocare 270
+ 38 more drugs
Common questions about Chloroxylenol
Chloroxylenol is primarily used as an antiseptic and disinfectant to prevent infection in minor cuts, scrapes, and burns. It is also a common active ingredient in surgical hand scrubs and medicated soaps used by healthcare professionals. In a diagnostic setting, it is used as a standardized chemical allergen in patch tests to identify patients with contact allergies. Additionally, it is used in household cleaning products to disinfect surfaces and laundry. Always consult a healthcare provider for the appropriate clinical use of this compound.
The most common side effects associated with Chloroxylenol are localized skin reactions, such as redness, itching, or a mild stinging sensation at the site of application. Some individuals may experience dry or flaky skin, especially with frequent use in soaps. While generally safe, it can cause contact dermatitis in sensitive individuals. If you notice a persistent rash or severe irritation, you should stop using the product and contact your doctor. Serious allergic reactions are rare but require immediate medical attention.
Since Chloroxylenol is applied topically to the skin and very little is absorbed into the bloodstream, there is no known interaction with alcohol consumption. You do not need to avoid alcohol while using Chloroxylenol for wound care or hygiene. However, keep in mind that alcohol can dehydrate the skin, which might increase the risk of irritation if you are already sensitive to the antiseptic. If you have concerns about how your medications interact with alcohol, it is best to discuss them with your healthcare provider.
Chloroxylenol is generally considered safe for use during pregnancy when applied topically to small areas for short periods, such as for cleaning a minor cut. Because systemic absorption through the skin is very low, it is unlikely to pose a significant risk to the developing fetus. However, pregnant women should avoid applying it to large areas of the body or using it excessively. There are no well-controlled studies in pregnant humans, so it is always advisable to consult your obstetrician before using any medicated product. Your doctor can help weigh the benefits of preventing infection against any theoretical risks.
Chloroxylenol begins working almost immediately upon contact with microorganisms. As an antiseptic, it can significantly reduce the number of bacteria on the skin within 30 to 60 seconds of application. For surgical hand scrubs, a contact time of at least two minutes is typically recommended to ensure maximum efficacy. While it kills bacteria quickly, it also provides a residual effect that helps keep the bacterial count low for several hours. For treating minor skin infections, you should see signs of healing within a few days of regular use.
Yes, you can stop using Chloroxylenol at any time, as it is a topical antiseptic and does not cause physical dependence or withdrawal symptoms. Unlike oral antibiotics, there is no requirement to complete a specific "course" to prevent systemic resistance, although you should continue use until the minor wound has sufficiently healed. If you are using it as part of a prescribed hygiene regimen, consult your doctor before stopping. If you stop use because of a skin reaction, the irritation should typically resolve within a few days. Always follow your healthcare provider's advice regarding the duration of treatment.
If you miss an application of Chloroxylenol while treating a minor wound, simply apply it as soon as you remember. If it is nearly time for your next scheduled cleaning, skip the missed application and continue with your regular routine. Do not apply double the amount to make up for a missed dose, as this may increase the risk of skin irritation. Consistency helps prevent infection, but a single missed application is unlikely to cause significant issues. If you have questions about your wound care schedule, contact your healthcare provider for guidance.
There is no evidence to suggest that Chloroxylenol causes weight gain. Because it is a topical antiseptic with minimal systemic absorption, it does not affect the metabolic processes or hormonal balances that typically lead to changes in body weight. Any weight changes observed while using this product would likely be due to other factors, such as diet, lifestyle, or other medications. If you experience unexpected weight gain, you should discuss it with your healthcare provider to identify the underlying cause. Chloroxylenol is strictly for external use and does not have systemic metabolic effects.
Chloroxylenol is generally safe to use alongside oral medications because it is applied topically and does not enter the bloodstream in significant amounts. However, you should be cautious when using other topical products, such as medicated creams, ointments, or other antiseptics, on the same area of skin. Combining different topical chemicals can sometimes cause excessive irritation or interfere with how well each product works. Always inform your doctor about all the products you are using, including over-the-counter creams and herbal supplements. Your healthcare provider can ensure that your combination of treatments is safe and effective.
Yes, Chloroxylenol is widely available as a generic product and is found in many different brands of antiseptic liquids, soaps, and wound care kits. You can often find it labeled as 'Antiseptic Liquid' or by its chemical name, PCMX. Generic versions are required by the FDA to have the same quality and efficacy as brand-name products for the same intended use. Because it is an older, well-established compound, generic versions are typically very affordable and available without a prescription. Check the active ingredients list on the product packaging to confirm the presence of Chloroxylenol.