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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Brompheniramine is a first-generation antihistamine of the alkylamine class used to treat symptoms of allergic rhinitis and the common cold. It works by competitively inhibiting H1 receptors to reduce sneezing, rhinorrhea, and ocular itching.
Name
Brompheniramine
Raw Name
BROMPHENIRAMINE MALEATE
Category
Other
Salt Form
Maleate
Drug Count
62
Variant Count
81
Last Verified
February 17, 2026
RxCUI
1090463, 2676758, 1357010, 1053258, 2683421, 2685263, 1098498, 1148155, 1663612, 1423702
UNII
IXA7C9ZN03, 9D2RTI9KYH, 04JA59TNSJ, 6V9V2RYJ8N
About Brompheniramine
Brompheniramine is a first-generation antihistamine of the alkylamine class used to treat symptoms of allergic rhinitis and the common cold. It works by competitively inhibiting H1 receptors to reduce sneezing, rhinorrhea, and ocular itching.
Detailed information about Brompheniramine
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Brompheniramine.
Brompheniramine, specifically Brompheniramine Maleate, is a potent first-generation antihistamine belonging to the alkylamine derivative class. Originally approved by the U.S. Food and Drug Administration (FDA) in the mid-20th century, it has remained a cornerstone in the symptomatic treatment of upper respiratory allergies and the common cold. Unlike newer, second-generation antihistamines (such as loratadine or cetirizine), Brompheniramine is known for its ability to cross the blood-brain barrier, which results in significant sedative effects. However, this same property often makes it effective for patients who require relief from nighttime allergy symptoms that interfere with sleep.
According to clinical pharmacology guidelines, Brompheniramine is classified as a histamine H1-receptor antagonist. It is primarily used to alleviate symptoms such as sneezing, rhinorrhea (runny nose), itchy or watery eyes, and itching of the nose or throat. While it was once primarily available by prescription, it is now widely found in over-the-counter (OTC) multi-symptom cold and allergy medications, often combined with decongestants like phenylephrine or cough suppressants like dextromethorphan. Healthcare providers typically recommend Brompheniramine for the management of seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis.
At the molecular level, Brompheniramine acts as a competitive antagonist at the H1-receptor sites in the effector cells of the gastrointestinal tract, blood vessels, and respiratory tract. Histamine is a naturally occurring chemical in the body that, when released during an allergic reaction, binds to H1 receptors, causing vasodilation (widening of blood vessels), increased capillary permeability (leading to swelling and fluid leakage), and stimulation of sensory nerve endings (causing itching). By binding to these receptors without activating them, Brompheniramine prevents histamine from exerting its effects.
Furthermore, Brompheniramine possesses significant anticholinergic (drying) properties. It inhibits the action of acetylcholine at muscarinic receptors. This secondary mechanism is responsible for the "drying effect" that helps reduce nasal secretions and watery eyes, which is particularly beneficial for patients suffering from the profuse rhinorrhea associated with the common cold. However, this same anticholinergic activity is responsible for many of the drug's common side effects, such as dry mouth and urinary retention.
Understanding the pharmacokinetics of Brompheniramine is essential for determining appropriate dosing intervals and predicting potential drug-drug interactions.
Brompheniramine is FDA-approved for the following indications:
Off-label, some clinicians have utilized Brompheniramine in the management of certain types of pruritus (itching) that do not respond to other treatments, though this use should only occur under strict medical supervision.
Brompheniramine is available in several formulations to accommodate different patient needs:
> Important: Only your healthcare provider can determine if Brompheniramine is right for your specific condition. Always read the label of OTC products carefully to ensure you are not duplicating active ingredients.
For the treatment of allergic rhinitis or symptoms of the common cold, the standard adult dosage for Brompheniramine maleate is as follows:
Pediatric dosing must be calculated carefully based on age and, in some cases, weight. Parents should always use the measuring device provided with the medication.
Patients with significant renal (kidney) impairment may experience decreased clearance of Brompheniramine metabolites. While specific GFR-based dosing scales are not standardized for this drug, healthcare providers may recommend longer dosing intervals or a reduced total daily dose to prevent accumulation.
Since Brompheniramine is extensively metabolized by the liver, patients with hepatic cirrhosis or liver failure should use this medication with extreme caution. A lower starting dose is often warranted to avoid toxicity.
According to the Beers Criteria (a guideline for safe medication use in seniors), first-generation antihistamines like Brompheniramine should generally be avoided in the elderly. This is due to the high risk of anticholinergic side effects, including confusion, dizziness, blurred vision, and increased fall risk. If use is necessary, the lowest effective dose should be initiated.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to catch up, as this significantly increases the risk of CNS depression and anticholinergic toxicity.
Signs of a Brompheniramine overdose may include extreme drowsiness, dilated pupils, flushed skin, fever, hallucinations, tremors, or seizures. In severe cases, respiratory failure or cardiovascular collapse may occur. In the event of a suspected overdose, contact a poison control center immediately or seek emergency medical attention. Anticholinergic toxicity is often managed in a hospital setting with supportive care and, occasionally, the administration of physostigmine in life-threatening cases.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or frequency without medical guidance.
Because Brompheniramine is a first-generation antihistamine, side effects are relatively common, particularly those affecting the central nervous system and the autonomic nervous system. The most frequently reported side effect is somnolence (drowsiness). Patients often describe this as a "heavy" or "foggy" feeling that can impair mental alertness. This effect typically begins within 30 to 60 minutes of ingestion and may last for several hours.
Other common side effects include:
> Warning: Stop taking Brompheniramine and call your doctor immediately if you experience any of the following serious reactions:
Prolonged use of Brompheniramine is generally discouraged without medical supervision. Chronic use of first-generation antihistamines has been investigated in epidemiological studies for a potential link to cognitive decline in older adults, though a direct causal relationship specifically for Brompheniramine requires further study. Additionally, chronic use can lead to tolerance, where the drug becomes less effective over time, or rebound congestion if used in combination with nasal decongestants.
There are currently no FDA black box warnings specifically for Brompheniramine maleate. However, it carries significant class-wide warnings regarding its use in neonates and young children due to the risk of fatal respiratory depression. Most manufacturers include prominent warnings against use in children under 2 to 6 years of age depending on the specific formulation and regional regulations.
Report any unusual symptoms or persistent side effects to your healthcare provider to ensure continued safety during treatment.
Brompheniramine is a potent medication that requires careful use. The most critical safety point is the risk of Central Nervous System (CNS) depression. This medication significantly impairs the ability to perform tasks requiring mental alertness. Patients should not drive, operate heavy machinery, or engage in hazardous activities until they are certain how Brompheniramine affects them. This impairment can occur even if the patient does not feel subjectively "sleepy."
No FDA black box warnings for Brompheniramine. However, clinicians emphasize that it should never be used in premature infants or neonates due to an increased susceptibility to the anticholinergic effects and the potential for respiratory distress.
For short-term use of OTC Brompheniramine, routine lab monitoring is usually not required. However, for patients taking the medication long-term or those with underlying health conditions, healthcare providers may monitor:
As noted, Brompheniramine causes significant impairment. The sedative effect is often compared to alcohol consumption. Patients are strongly advised to avoid driving or operating dangerous equipment for at least 8 to 12 hours after a dose, or until the effects have completely worn off.
Alcohol must be strictly avoided while taking Brompheniramine. Alcohol acts as a synergistic CNS depressant, meaning it multiplies the sedative effects of the antihistamine. This combination can lead to severe respiratory depression, profound lethargy, and an increased risk of accidents.
While Brompheniramine does not typically require a tapering schedule for short-term use, stopping the medication after prolonged, high-dose use may occasionally result in mild "rebound" symptoms, such as increased nasal congestion or insomnia. If you have been taking this medication daily for several weeks, consult your doctor before stopping.
> Important: Discuss all your medical conditions, especially respiratory, ocular, or urinary issues, with your healthcare provider before starting Brompheniramine.
For each interaction, the primary management strategy is to avoid the combination or have a healthcare provider adjust the dosage and monitor for signs of excessive sedation or anticholinergic toxicity.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including those purchased over-the-counter.
Brompheniramine must NEVER be used in the following circumstances:
These conditions require a careful risk-benefit analysis by a physician:
Patients who have had a reaction to Chlorpheniramine, Dexchlorpheniramine, or Triprolidine may also react to Brompheniramine, as these all belong to the alkylamine chemical class. If you have a history of reacting to any "cold and allergy" liquid or tablet, verify the active ingredients with a pharmacist.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of breathing problems or eye disease, before prescribing Brompheniramine.
Brompheniramine is generally categorized as FDA Pregnancy Category B or C depending on the specific manufacturer and formulation. This means that while animal studies may not have shown a risk, there are no adequate, well-controlled studies in pregnant women. Some epidemiological data have suggested a possible association between first-trimester antihistamine exposure and certain congenital malformations, though the evidence is not definitive. Healthcare providers typically recommend avoiding Brompheniramine during the third trimester, as antihistamines may cause seizures or irritability in the newborn.
Brompheniramine is known to be excreted in human breast milk. Because of the risk of antihistamines in infants (particularly CNS stimulation or unusual excitability), and because the anticholinergic effects may inhibit lactation (reduce milk supply), use in breastfeeding mothers is generally discouraged. If an antihistamine is required, second-generation options like loratadine are often preferred by pediatricians.
Brompheniramine is approved for use in children 6 years and older. However, the FDA and major pediatric associations warn against the use of multi-symptom cough and cold medicines in children under age 4 (and many manufacturers label for age 6+). In children, Brompheniramine can cause paradoxical excitation, leading to hallucinations, tremors, and insomnia. Overdose in children can be fatal.
Patients over the age of 65 are at a significantly higher risk for adverse effects. The sedative properties increase the risk of falls and hip fractures. The anticholinergic properties can exacerbate pre-existing dementia or cause acute delirium. Furthermore, the long half-life of Brompheniramine (up to 35 hours in some studies) means the drug can stay in an elderly person's system much longer than in a younger adult.
In patients with a Glomerular Filtration Rate (GFR) below 50 mL/min, the clearance of the drug's metabolites is reduced. While it is not removed significantly by hemodialysis, the systemic effects may be prolonged. Dosing should be cautious, starting at the lowest possible range.
Because the liver is the primary site of metabolism via the CYP450 system, patients with Child-Pugh Class B or C hepatic impairment should be monitored closely. Reduced dosing frequency (e.g., every 8-12 hours instead of every 4-6) may be necessary to prevent CNS toxicity.
> Important: Special populations require individualized medical assessment. Always consult a specialist if you are pregnant, nursing, or over age 65.
Brompheniramine is an H1-receptor antagonist. It works by competing with free histamine for binding at H1-receptor sites on effector cells. It is specifically an inverse agonist, meaning it binds to the inactive state of the H1 receptor and stabilizes it, thereby preventing the receptor from shifting to its active state. This inhibits the typical allergic response, including capillary permeability and smooth muscle contraction. Its secondary mechanism involves the competitive inhibition of muscarinic acetylcholine receptors, which provides the drying effect on the nasal mucosa.
The onset of action for Brompheniramine is typically 15 to 30 minutes, with the maximum therapeutic effect occurring at the same time as peak plasma levels (2-5 hours). The duration of the antihistaminic effect can last up to 24 hours in some individuals, though symptomatic relief usually necessitates dosing every 4 to 6 hours for immediate-release forms. Tolerance to the sedative effects may develop after several days of continuous use, but the anti-allergy effects generally persist.
| Parameter | Value |
|---|---|
| Bioavailability | ~70-80% |
| Protein Binding | 39% - 45% |
| Half-life | 24.9 hours (range 12-35) |
| Tmax | 2 - 5 hours |
| Metabolism | Hepatic (CYP2D6, N-dealkylation) |
| Excretion | Renal (primarily as metabolites) |
Brompheniramine belongs to the Alkylamine class of first-generation antihistamines. Related medications in this class include chlorpheniramine, dexchlorpheniramine, and triprolidine. These are characterized by having less sedative potential than the ethanolamine class (like diphenhydramine) but still significantly more than second-generation antihistamines.
Medications containing this ingredient
Dimaphen Dm
Signature Care Childrens Cold And Cough
Topcare Childrens Cold And Cough
Equaline Childrens Cold And Cough
Rompe Pecho Sf Flu
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, And Dextromethorphan Hydrobromide
Cvs Childrens Cold And Allergy
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+ 37 more drugs
Common questions about Brompheniramine
Brompheniramine is primarily used to relieve symptoms associated with the common cold and allergic rhinitis, such as hay fever. It is effective at reducing sneezing, a runny nose, and itchy or watery eyes by blocking the effects of histamine in the body. Additionally, its anticholinergic properties help dry up nasal secretions, which is helpful for those with a persistent "drippy" nose. Healthcare providers may also recommend it for the treatment of mild allergic skin reactions like hives. It is often found in combination with other medications to treat multi-symptom respiratory illnesses.
The most frequent side effect of Brompheniramine is significant drowsiness or sedation, which occurs because the drug easily enters the brain. Many patients also experience "anticholinergic" effects, which include a very dry mouth, blurred vision, and constipation. Dizziness and a feeling of mental cloudiness are also quite common, especially during the first few days of treatment. In some cases, it can cause a thickening of mucus in the lungs, making it harder to clear the throat. Because of these effects, it is often taken at night rather than during the day.
No, you should strictly avoid alcohol while taking Brompheniramine. Alcohol is a central nervous system depressant that acts synergistically with Brompheniramine, meaning it significantly intensifies the drug's sedative effects. This combination can lead to extreme lethargy, impaired motor skills, and even dangerous respiratory depression. Drinking alcohol while on this medication greatly increases the risk of accidents, falls, and severe over-sedation. Always check the labels of other liquid medications, as some may contain small amounts of alcohol that could also interact.
Brompheniramine should only be used during pregnancy if clearly needed and under the direct supervision of a healthcare provider. It is generally classified as Category B or C, meaning there is limited high-quality data on its safety in humans. Some studies have raised concerns about antihistamine use in the first trimester, though the risks are not fully established. It is especially important to avoid use in the third trimester, as it may cause adverse effects like irritability or seizures in the newborn. Most doctors prefer to recommend older, more studied antihistamines or saline nasal sprays for pregnant patients.
Brompheniramine typically begins to work within 15 to 30 minutes after oral administration. You will likely feel a reduction in sneezing and itching relatively quickly, though the peak effect of the medication usually occurs between 2 and 5 hours after the dose is taken. The duration of action is quite long compared to other first-generation antihistamines, often providing relief for 4 to 6 hours with immediate-release forms and up to 12 hours with extended-release versions. If you do not feel relief within an hour, do not take an extra dose; wait for the medication to reach its full effect.
Yes, for most people taking Brompheniramine for short-term allergy or cold relief, it can be stopped suddenly without significant withdrawal symptoms. Unlike some other classes of medication, it does not typically cause physical dependence. However, if you have been using it daily for a very long period, you might experience a temporary return of allergy symptoms, sometimes called "rebound" congestion or itching. If you are using a combination product that contains other ingredients, you should check with your doctor before stopping. It is always best to use the medication only for as long as symptoms persist.
If you miss a dose of Brompheniramine, take it as soon as you remember, provided it is not almost time for your next scheduled dose. If you are within an hour or two of your next dose, it is safer to skip the missed dose entirely and continue with your regular schedule. Never take two doses at the same time to make up for a missed one, as this can lead to an overdose and severe side effects like extreme drowsiness or heart palpitations. Setting a timer or using a pillbox can help you stay on track with your dosing schedule. If you are unsure, consult your pharmacist.
While weight gain is not a commonly reported side effect for short-term use of Brompheniramine, some antihistamines have been linked to increased appetite and weight gain with long-term use. This is thought to occur because histamine receptors in the brain play a role in regulating hunger and satiety. If the H1 receptor is blocked for long periods, it may lead to increased food intake. However, since Brompheniramine is usually used for short durations (days to weeks) for cold or allergy symptoms, significant weight gain is unlikely for most patients. If you notice unusual weight changes, discuss them with your doctor.
Brompheniramine has several significant drug interactions that require caution. It should never be taken with MAOIs, and it should be used very carefully with other sedating medications like opioids, sleep aids, or anti-anxiety drugs. Many over-the-counter cold and flu medicines already contain an antihistamine, so taking Brompheniramine alongside them could lead to an accidental overdose. It can also interact with certain antidepressants and blood pressure medications. Always provide your healthcare provider or pharmacist with a full list of all medications and supplements you are currently taking before starting Brompheniramine.
Yes, Brompheniramine maleate is widely available as a generic medication. It is often sold under various store brands as an "Allergy Relief" or "Cold Relief" liquid or tablet. Generic versions are required by the FDA to have the same active ingredient, strength, and dosage form as the brand-name versions, making them a cost-effective alternative. You can find it as a standalone ingredient, though it is very frequently found as part of a generic multi-symptom cold formula. Always check the "Drug Facts" label on the back of the package to confirm that Brompheniramine is the active ingredient.