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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Aluminum Zirconium Trichlorohydrex Gly is an over-the-counter active ingredient used in antiperspirants. It belongs to the aluminum-zirconium salt class and works by forming temporary plugs in sweat ducts to reduce perspiration.
Name
Aluminum Zirconium Trichlorohydrex Gly
Raw Name
ALUMINUM ZIRCONIUM TRICHLOROHYDREX GLY
Category
Other
Drug Count
58
Variant Count
71
Last Verified
February 17, 2026
About Aluminum Zirconium Trichlorohydrex Gly
Aluminum Zirconium Trichlorohydrex Gly is an over-the-counter active ingredient used in antiperspirants. It belongs to the aluminum-zirconium salt class and works by forming temporary plugs in sweat ducts to reduce perspiration.
Detailed information about Aluminum Zirconium Trichlorohydrex Gly
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Aluminum Zirconium Trichlorohydrex Gly.
Aluminum Zirconium Trichlorohydrex Gly is a complex coordination compound that serves as a potent active ingredient in over-the-counter (OTC) antiperspirant products. It belongs to a pharmacological class known as aluminum-zirconium salts, specifically the 'hydrex' group, which indicates a specific level of hydration and chemical stability. In clinical terms, it is an astringent (a substance that causes the contraction of body tissues) and an antiperspirant (a substance that reduces the production of sweat).
This ingredient was developed to provide a more effective and less irritating alternative to older aluminum-only salts, such as aluminum chloride or aluminum chlorohydrate. The addition of zirconium increases the efficacy of the sweat-blocking mechanism, while the 'Gly' component—which stands for glycine (an amino acid)—acts as a buffering agent. This buffering is crucial because it helps maintain a more skin-friendly pH, reducing the risk of the acidic irritation commonly associated with high-strength aluminum salts.
The U.S. Food and Drug Administration (FDA) regulates this substance under the Final Monograph for Antiperspirant Drug Products for Over-the-Counter Human Use, which was finalized in 2003. According to these regulations, Aluminum Zirconium Trichlorohydrex Gly is recognized as safe and effective (GRASE) when used within specific concentration limits (typically up to 20% on an anhydrous basis). It is primarily indicated for the treatment of hyperhidrosis (excessive sweating) and general underarm wetness reduction.
At the molecular level, Aluminum Zirconium Trichlorohydrex Gly functions through a physical rather than a biochemical mechanism. When the product is applied to the skin, the salt dissolves in the moisture (sweat) present on the skin's surface or within the sweat duct. This creates a solution with a slightly acidic pH. As the sweat glands continue to produce moisture, the pH of the solution rises.
This change in pH causes the aluminum-zirconium complex to undergo a process called polymerization (the joining of small molecules into a large network). This results in the formation of a physical gel-like plug or 'precipitate' within the distal (outer) portion of the eccrine sweat gland duct. These plugs act as temporary barriers that prevent sweat from reaching the surface of the skin. Over time, these plugs are naturally shed through the normal process of epidermal turnover (skin cell shedding) or are washed away during bathing, which is why daily application is typically required for maintained efficacy.
Unlike systemic medications, the pharmacokinetics of Aluminum Zirconium Trichlorohydrex Gly are characterized by minimal systemic absorption, as the drug is intended for local topical action.
Aluminum Zirconium Trichlorohydrex Gly is FDA-approved for the following indications:
Off-label, healthcare providers may occasionally suggest use on other areas of the body (such as the hands or feet), though the FDA monograph specifically covers axillary use. Patients should consult a dermatologist before applying antiperspirants to non-axillary regions, as the skin sensitivity in those areas differs significantly.
This active ingredient is highly versatile and is found in various delivery systems, including:
> Important: Only your healthcare provider can determine if Aluminum Zirconium Trichlorohydrex Gly is right for your specific condition, especially if you suffer from chronic skin conditions or kidney disease.
For the majority of adults, Aluminum Zirconium Trichlorohydrex Gly is used in concentrations ranging from 10% to 20%. The 'standard' dose is the application of a thin layer to the underarm area once daily. For 'Clinical Strength' products, which often contain the maximum 20% concentration, a single application at bedtime is frequently recommended. This timing is strategic: sweat production is at its lowest during sleep, allowing the salt complexes to enter the sweat ducts and form plugs more effectively without being washed away by active perspiration.
Aluminum Zirconium Trichlorohydrex Gly is generally considered safe for use in adolescents who have reached puberty. Most manufacturers recommend use in children aged 12 years and older. For children under 12, the safety and efficacy of zirconium-based salts have not been extensively studied in a clinical setting.
If a child is experiencing premature or excessive sweating, parents should consult a pediatrician to rule out underlying endocrine (hormonal) issues before starting a regimen of Aluminum Zirconium Trichlorohydrex Gly. If approved by a doctor, the application method remains the same as for adults, though a lower concentration may be advised to prevent skin irritation.
There is no specific 'dosage adjustment' for patients with kidney disease because the product is not intended for systemic use. However, the FDA mandates a specific warning for this population. Patients with a glomerular filtration rate (GFR) significantly below normal (typically Stage 4 or 5 chronic kidney disease) should consult their physician before use. If the kidneys cannot efficiently clear the tiny amounts of aluminum that might be absorbed, there is a theoretical risk of accumulation.
No dosage adjustments are required for patients with liver disease, as the compound does not undergo hepatic metabolism or clearance.
Older adults may have thinner, more fragile skin (atrophic skin). While the dosage remains the same, elderly patients should be monitored for increased skin irritation or breakdown, which could lead to higher-than-intended absorption.
To maximize the efficacy of Aluminum Zirconium Trichlorohydrex Gly and minimize the risk of side effects, follow these clinical guidelines:
If a daily application is missed, simply apply the product at the next scheduled time. There is no need to 'double apply' or use more product than usual. Missing a single dose may result in a temporary increase in perspiration as some of the existing plugs begin to shed.
Systemic overdose from topical application is virtually impossible in individuals with healthy kidney function. However, accidental ingestion can occur, particularly in pediatric settings.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or application frequency without medical guidance.
Most users tolerate Aluminum Zirconium Trichlorohydrex Gly well. However, minor localized reactions are common, particularly when the product is applied to sensitive skin.
> Warning: Stop using Aluminum Zirconium Trichlorohydrex Gly and call your doctor immediately if you experience any of the following:
There has been significant public debate regarding the long-term effects of aluminum-based antiperspirants, specifically concerning Alzheimer's disease and breast cancer.
There are currently no FDA Black Box Warnings for Aluminum Zirconium Trichlorohydrex Gly. It is considered safe for the general population when used as directed on the OTC label.
Report any unusual symptoms to your healthcare provider. If you suspect an adverse reaction, you may also report it to the FDA's MedWatch program.
Aluminum Zirconium Trichlorohydrex Gly is intended for external use only. It should never be ingested or applied to mucous membranes (such as the eyes, nose, or mouth). The most critical safety consideration is the integrity of the skin barrier at the site of application. Applying this compound to broken, irritated, or recently shaved skin significantly increases the risk of localized irritation and, to a lesser extent, systemic absorption.
No FDA black box warnings for Aluminum Zirconium Trichlorohydrex Gly. This ingredient is regulated under the OTC monograph system and does not carry the highest level of FDA warning reserved for prescription drugs with life-threatening risks.
The most significant clinical precaution involves patients with renal (kidney) impairment. The FDA requires the label to state: 'Ask a doctor before use if you have kidney disease.' This is because the kidneys are the primary route for eliminating aluminum from the body. In individuals with advanced stage chronic kidney disease (CKD), the small amount of aluminum that may be absorbed through the skin could theoretically accumulate in the body, potentially leading to bone or neurological complications over many years. While the risk is considered very low for topical products, medical clearance is necessary for this specific population.
Patients with a known history of sensitivity to aluminum or zirconium should avoid this product. Anaphylaxis is exceptionally rare, but contact dermatitis is a known risk. If a rash develops, discontinue use immediately.
Individuals with chronic skin conditions such as eczema, psoriasis, or hidradenitis suppurativa (a chronic inflammatory skin condition involving 'boils' in the underarms) should consult a dermatologist before use. The astringent nature of the salt can exacerbate dryness and inflammation in compromised skin.
For the general healthy consumer, no specific laboratory monitoring (such as blood counts or liver function tests) is required for the use of Aluminum Zirconium Trichlorohydrex Gly. However, patients with Stage 4 or 5 kidney disease who use aluminum-containing products may have their serum aluminum levels monitored by their nephrologist as part of their routine care.
There are no known effects of Aluminum Zirconium Trichlorohydrex Gly on the ability to drive or operate heavy machinery. The drug does not cross the blood-brain barrier in significant amounts and has no sedative or cognitive effects.
There are no known direct interactions between topical Aluminum Zirconium Trichlorohydrex Gly and the consumption of alcohol. Alcohol does not affect the efficacy of the antiperspirant, nor does the antiperspirant alter the metabolism of alcohol.
There is no 'withdrawal' syndrome associated with Aluminum Zirconium Trichlorohydrex Gly. If you stop using the product, your sweat production will simply return to its baseline level as the existing plugs are naturally shed from the sweat ducts, typically within 24 to 48 hours.
> Important: Discuss all your medical conditions, especially any history of kidney problems or skin sensitivities, with your healthcare provider before starting Aluminum Zirconium Trichlorohydrex Gly.
There are no known systemic drug-drug interactions that are classified as 'Contraindicated' for Aluminum Zirconium Trichlorohydrex Gly due to its extremely low systemic absorption. However, it should not be used simultaneously with other potent topical astringents or medicated washes (like high-strength benzoyl peroxide) on the same area of skin, as this can lead to severe skin peeling and chemical burns.
If you are using prescription topical retinoids (such as Tretinoin or Adapalene) for axillary skin issues, use Aluminum Zirconium Trichlorohydrex Gly with extreme caution. Retinoids thin the stratum corneum (the outermost layer of skin), which can dramatically increase the irritation potential and absorption of aluminum salts.
Using topical antibiotics (like Clindamycin solution for acne or hidradenitis) alongside antiperspirants may alter the skin's microbiome. While not dangerous, the acidic pH of the antiperspirant might reduce the stability of certain antibiotic formulations.
There are no known food interactions with topical Aluminum Zirconium Trichlorohydrex Gly. Unlike oral medications, the absorption of this compound is not affected by diet, including grapefruit juice, dairy, or high-fat meals.
There are no documented interactions between Aluminum Zirconium Trichlorohydrex Gly and common herbal supplements such as St. John's Wort, Ginkgo Biloba, or Valerian root. Because the drug does not enter the bloodstream in significant amounts, it does not interact with the hepatic enzymes (like CYP3A4) that typically process these supplements.
If you are undergoing a skin biopsy in the axillary region, inform your doctor if you have recently applied an antiperspirant. The metallic salts can sometimes interfere with the staining process used in pathology labs.
This is a critical interaction. Aluminum and zirconium are metals and can appear as 'microcalcifications' on a mammogram. This can lead to a false-positive result, suggesting the presence of breast cancer when none exists.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially if you are scheduled for any medical imaging or skin procedures.
Aluminum Zirconium Trichlorohydrex Gly must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis before use include:
Patients who are sensitive to Aluminum Chlorohydrate or Aluminum Chloride are highly likely to experience cross-sensitivity with Aluminum Zirconium Trichlorohydrex Gly. While the 'Gly' (glycine) makes it less irritating, the core aluminum ion remains the same. There is no known cross-sensitivity between these metal salts and common allergens like latex, nuts, or sulfa drugs.
> Important: Your healthcare provider will evaluate your complete medical history, including kidney function and skin health, before recommending the use of high-strength antiperspirants.
Aluminum Zirconium Trichlorohydrex Gly is generally considered safe for use during pregnancy. It is classified as an OTC drug, and the FDA has not assigned it a formal Pregnancy Category (like A, B, C, D, X) under the newer labeling rules, but it is traditionally viewed as low-risk.
Use of Aluminum Zirconium Trichlorohydrex Gly is considered compatible with breastfeeding.
Elderly patients can use Aluminum Zirconium Trichlorohydrex Gly safely, but with two primary considerations:
As discussed in the warnings section, renal impairment is the primary concern for this ingredient.
There are no restrictions or special considerations for patients with hepatic (liver) impairment. The liver does not play a role in the processing or elimination of this topical salt.
> Important: Special populations, particularly those with reduced kidney function or pregnant women, require individualized medical assessment to ensure the highest level of safety.
Aluminum Zirconium Trichlorohydrex Gly works through a physical ductal occlusion mechanism. When the salt comes into contact with sweat, it undergoes hydrolysis, a chemical reaction with water that lowers the pH. As the salt moves into the sweat duct, it encounters a more neutral pH environment and the buffering effect of the glycine. This causes the aluminum and zirconium ions to form large, insoluble polymer complexes (precipitates). These complexes aggregate into a 'gel plug' that physically blocks the eccrine sweat gland's opening. This blockage is temporary and occurs in the stratum corneum (the top layer of skin).
| Parameter | Value |
|---|---|
| Bioavailability | <0.012% (Systemic) |
| Protein Binding | N/A (Negligible systemic levels) |
| Half-life | N/A (Topical action) |
| Tmax | N/A (No systemic peak) |
| Metabolism | None |
| Excretion | Renal (for absorbed fraction) |
Aluminum Zirconium Trichlorohydrex Gly is classified as an Antiperspirant / Astringent. It belongs to the broader category of Aluminum-Zirconium salts, which are distinguished from Aluminum-only salts (like Aluminum Chlorohydrate) by their increased efficacy and lower irritation potential due to the glycine buffer.
Medications containing this ingredient
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Emj Antiperspirant Mountain Air 2.6 Oz (73 G)
Emj Antiperspirant Coconut And Driftwood 2.6 Oz (73 G)
Emj Antiperspirant Coconut Vanilla 2.6 Oz (73 G)
Antiperspirant Deodorant
Harrys Extra Strength Antiperspirant Wildlands
Trench Warfare Antiperspirant Deodorant Sawtooth
Brut Warm Amber And Honor Anti-perspirant And Deodorant
Sure Regular Original Solid
Right Guard Sport Antiperspirant Deodorant Invisible Solid Forest Spring
Gillette Clinical Protection Arctic Ice Soft
+ 38 more drugs
Common questions about Aluminum Zirconium Trichlorohydrex Gly
Aluminum Zirconium Trichlorohydrex Gly is primarily used as an active ingredient in over-the-counter antiperspirants to reduce underarm wetness. It is effective for managing everyday perspiration as well as excessive sweating, a condition known as hyperhidrosis. By forming temporary gel-like plugs in the sweat ducts, it prevents moisture from reaching the skin's surface. It is also an astringent, which helps to shrink skin pores and dry the area of application. Most people use it daily as part of their personal hygiene routine to control body odor and sweat stains.
The most common side effects are localized to the area of application and include skin irritation, itching, and redness. Some users may experience a mild stinging sensation, especially if the product is applied immediately after shaving or to damp skin. Over time, the underarm skin may become dry or flaky due to the reduction in moisture. These symptoms are usually mild and can often be managed by ensuring the skin is completely dry before application. If a persistent rash or severe inflammation develops, you should discontinue use and consult a healthcare provider.
Yes, there are no known interactions between topical Aluminum Zirconium Trichlorohydrex Gly and alcohol consumption. Because the antiperspirant is applied to the skin and has extremely low systemic absorption, it does not enter the bloodstream in amounts that would interact with alcohol metabolism in the liver. Alcohol does not reduce the effectiveness of the sweat-blocking mechanism. However, excessive alcohol consumption can sometimes increase overall body temperature and sweating, which might make any antiperspirant seem less effective. Always use the product as directed regardless of alcohol intake.
Aluminum Zirconium Trichlorohydrex Gly is generally considered safe for use during pregnancy. Scientific studies have shown that the systemic absorption of aluminum through the skin is incredibly low, meaning very little reaches the developing fetus. The amount of aluminum absorbed from an antiperspirant is significantly less than what a person typically absorbs from food and drinking water. Major health organizations do not list antiperspirant use as a risk factor for pregnancy complications. However, as with any product used during pregnancy, it is a good idea to discuss it with your obstetrician if you have concerns.
While you may notice some reduction in sweat after the first use, it typically takes 2 to 7 days of consistent daily application to reach maximum effectiveness. This is because the 'plugs' that block the sweat ducts need time to build up and stabilize. Many clinical-strength products work best when applied at night, allowing the plugs to form while your sweat glands are less active. If you stop using the product, the effect will wear off within a day or two as your skin naturally sheds the plugs. Consistency is key to maintaining the sweat-reducing benefits.
Yes, you can stop using Aluminum Zirconium Trichlorohydrex Gly at any time without experiencing any withdrawal symptoms or 'rebound' effects. Unlike some medications that require a tapering period, this product only works on the surface level of the skin. Once you stop applying it, the existing plugs in your sweat ducts will naturally wash away or be shed with dead skin cells within 24 to 48 hours. At that point, your sweat production will return to its normal, baseline level. There are no long-term changes to your sweat glands caused by stopping the product.
If you miss a daily application of your antiperspirant, there is no cause for concern. Simply apply the product as soon as you remember, or wait until your next scheduled application time. You do not need to apply extra product or 'double up' to make up for the missed dose. You might notice a slight increase in underarm wetness during the day you missed, but the sweat-blocking effect will quickly return once you resume your normal routine. For best results, try to stick to a consistent daily schedule, such as applying it every night before bed.
No, Aluminum Zirconium Trichlorohydrex Gly does not cause weight gain. It is a topical product that acts locally on the sweat glands in the underarm area and does not affect your metabolism, appetite, or hormones. There is no biological mechanism by which a topical antiperspirant could lead to an increase in body fat or weight. If you are experiencing unexplained weight gain, it is likely related to other factors such as diet, exercise, or an underlying medical condition. You should consult your healthcare provider to investigate any significant changes in your weight.
Aluminum Zirconium Trichlorohydrex Gly is generally safe to use alongside most oral medications because it is not absorbed into the bloodstream in significant amounts. However, you should be cautious when using other topical medications on the same area of skin, such as medicated creams for acne or eczema. Applying multiple products to the underarms can increase the risk of skin irritation or change how the other medication is absorbed. If you are using a prescription skin treatment, it is best to apply it at a different time of day than your antiperspirant. Always inform your doctor about all the products you use.
Aluminum Zirconium Trichlorohydrex Gly is the active ingredient found in many different brands of antiperspirants, including both name-brand and 'store-brand' or generic versions. Because it is an over-the-counter ingredient regulated by an FDA monograph, the generic versions are required to meet the same standards for safety and efficacy as the brand-name products. You can find this ingredient in various forms like sticks, gels, and roll-ons at most pharmacies and grocery stores. When shopping, you can check the 'Drug Facts' label on the back of the package to see if it contains this specific active ingredient.