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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Aluminum Zirconium Pentachlorohydrex Gly is a potent OTC antiperspirant agent used to manage excessive sweating. It belongs to the aluminum-zirconium salt class and works by forming temporary plugs within sweat ducts to reduce perspiration.
Name
Aluminum Zirconium Pentachlorohydrex Gly
Raw Name
ALUMINUM ZIRCONIUM PENTACHLOROHYDREX GLY
Category
Other
Drug Count
17
Variant Count
20
Last Verified
February 17, 2026
About Aluminum Zirconium Pentachlorohydrex Gly
Aluminum Zirconium Pentachlorohydrex Gly is a potent OTC antiperspirant agent used to manage excessive sweating. It belongs to the aluminum-zirconium salt class and works by forming temporary plugs within sweat ducts to reduce perspiration.
Detailed information about Aluminum Zirconium Pentachlorohydrex Gly
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Aluminum Zirconium Pentachlorohydrex Gly.
Aluminum Zirconium Pentachlorohydrex Gly is a high-performance active ingredient used primarily in over-the-counter (OTC) antiperspirant formulations. It belongs to a pharmacological class known as aluminum-zirconium salts, which are specifically designed to provide more effective and longer-lasting sweat reduction than traditional aluminum-only salts (like aluminum chlorohydrate). The 'Gly' in its name refers to glycine, an amino acid used as a buffering agent to reduce skin irritation and improve the stability of the complex.
This compound is regulated under the FDA Final Monograph for Antiperspirant Drug Products for Human Use (21 CFR Part 350). It is classified as a Category I active ingredient, meaning it is generally recognized as safe (GRAS) and effective when used according to label directions. Historically, the development of zirconium-containing salts in the 1970s marked a significant advancement in dermatology, offering enhanced sweat suppression for individuals suffering from hyperhidrosis (excessive sweating) or those requiring clinical-strength protection.
To understand how this agent works, one must first understand the physiology of sweating. The human body contains millions of eccrine sweat glands (responsible for thermoregulation) and apocrine glands (found in the underarms and groin). Aluminum Zirconium Pentachlorohydrex Gly works through a physical mechanism rather than a systemic pharmacological one.
When the product is applied to the skin, the salt dissolves in the moisture (sweat) present on the skin surface or within the sweat duct. This creates a solution with a low pH. As the solution enters the sweat duct, it encounters a more neutral pH environment. This change in acidity causes the aluminum and zirconium ions to precipitate out of the solution, forming a gelatinous 'plug' or 'polymer' consisting of metal hydroxide and keratin. This plug physically obstructs the opening of the sweat gland, preventing the secretion of sweat onto the skin surface. Over time, these plugs are naturally shed through the skin's normal exfoliation process or washed away, which is why daily application is typically required to maintain efficacy.
Systemic absorption of Aluminum Zirconium Pentachlorohydrex Gly is extremely low when applied to intact, healthy skin. Studies using radioactive tracers have indicated that less than 0.01% of the aluminum from antiperspirants is absorbed into the bloodstream. Zirconium absorption is even lower, often remaining undetectable in systemic circulation. However, absorption can significantly increase if the skin barrier is compromised (e.g., through shaving nicks, rashes, or broken skin).
Because systemic levels remain negligible in healthy individuals, there is no significant protein binding or distribution to the brain or other organs under normal usage conditions. The blood-brain barrier effectively excludes the trace amounts of aluminum that may enter the blood from topical use.
There is no known hepatic metabolism for this inorganic salt complex. It does not interact with the Cytochrome P450 (CYP) enzyme system.
The tiny fraction of aluminum that is absorbed is primarily eliminated through the kidneys. This is the clinical basis for the FDA-mandated warning for individuals with severe renal impairment. Zirconium is largely excreted via the feces if absorbed, though absorption is rarely clinically relevant.
Aluminum Zirconium Pentachlorohydrex Gly is available in various topical delivery systems, typically in concentrations ranging from 15% to 20%:
> Important: Only your healthcare provider can determine if Aluminum Zirconium Pentachlorohydrex Gly is right for your specific condition, especially if you have sensitive skin or underlying kidney issues.
For the treatment of excessive sweating, Aluminum Zirconium Pentachlorohydrex Gly is typically used once daily. The concentration in OTC products is usually standardized between 15% and 20%.
There is no specific age restriction mandated by the FDA for the use of Aluminum Zirconium Pentachlorohydrex Gly in children; however, it is generally not recommended for use until the onset of puberty when apocrine sweat glands become active.
Individuals with a Glomerular Filtration Rate (GFR) of less than 30 mL/min (Stage 4 or 5 Chronic Kidney Disease) should consult their physician before use. While absorption is low, the kidneys are the primary route of elimination for any absorbed aluminum.
No dosage adjustments are required for patients with liver disease, as the drug is not metabolized by the liver.
No specific dosage adjustments are necessary, though older patients may have thinner skin (atrophy), which could increase the risk of localized irritation.
To achieve the best results and minimize irritation, follow these specific steps:
If you miss an application, simply apply it at the next scheduled time. Do not apply double the amount to make up for a missed dose, as this will only increase the risk of skin irritation without improving efficacy.
Systemic overdose via topical application is virtually impossible in individuals with normal kidney function. However, accidental ingestion can occur, especially in children.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or application frequency without medical guidance.
The most common side effects associated with Aluminum Zirconium Pentachlorohydrex Gly are localized to the site of application. Because the compound is acidic, it can disrupt the skin's natural pH balance.
> Warning: Stop using Aluminum Zirconium Pentachlorohydrex Gly and call your doctor immediately if you experience any of these serious reactions.
There has been significant public debate regarding the long-term use of aluminum-based antiperspirants and their potential link to breast cancer and Alzheimer’s disease. However, according to the American Cancer Society (2023) and the Alzheimer’s Association (2024), there is no consistent scientific evidence to support a causal link between the use of these products and the development of these conditions. The primary long-term side effect remains chronic skin sensitivity or localized skin thickening (lichenification) due to repeated scratching of irritated skin.
No FDA black box warnings exist for Aluminum Zirconium Pentachlorohydrex Gly. It is considered safe for the general population when used as directed on the OTC Drug Facts label.
Report any unusual symptoms or persistent skin changes to your healthcare provider.
Aluminum Zirconium Pentachlorohydrex Gly is for external use only. It must never be applied to the eyes, mouth, or mucous membranes. If the product comes into contact with the eyes, rinse thoroughly with cool water for several minutes.
No FDA black box warnings for Aluminum Zirconium Pentachlorohydrex Gly.
The most critical clinical warning for this ingredient involves patients with renal impairment. The FDA requires the following statement on all aluminum-containing antiperspirants: "Ask a doctor before use if you have kidney disease." This is because the kidneys are responsible for filtering out the small amounts of aluminum that may be absorbed through the skin. In patients with Stage 4 or 5 chronic kidney disease, the body's ability to clear aluminum is compromised, which could theoretically lead to aluminum toxicity over many years of use.
Do not apply this product to skin that is broken, irritated, or recently shaved. The barrier function of the stratum corneum (the outermost layer of skin) is essential for limiting systemic absorption. Applying the salt to open wounds increases the risk of localized infection and systemic uptake.
Patients with a known history of sensitivity to aluminum or zirconium salts should avoid this product. Cross-sensitivity between different types of aluminum salts (e.g., chlorohydrate vs. zirconium complexes) is common.
For the average healthy consumer, no laboratory monitoring is required. However, for patients with hyperhidrosis who are using 'clinical strength' versions under medical advice, the following may be monitored:
There are no known effects of Aluminum Zirconium Pentachlorohydrex Gly on the ability to drive or operate heavy machinery. It does not cause drowsiness or cognitive impairment.
There are no known direct interactions between topical Aluminum Zirconium Pentachlorohydrex Gly and alcohol consumption. However, alcohol can increase peripheral vasodilation and sweating, which may temporarily reduce the perceived efficacy of the antiperspirant.
There are no withdrawal symptoms associated with stopping this product. However, users should expect a return of sweat production to baseline levels within 24 to 48 hours after the last application as the plugs are naturally shed from the sweat ducts.
> Important: Discuss all your medical conditions, especially any history of kidney disease or skin allergies, with your healthcare provider before starting Aluminum Zirconium Pentachlorohydrex Gly.
There are no known absolute drug-drug contraindications for the topical use of Aluminum Zirconium Pentachlorohydrex Gly. However, it should not be used simultaneously on the same area of skin with other potent topical medications (such as high-potency steroid creams) unless directed by a doctor, as the antiperspirant may alter the absorption of the other medication.
Using Aluminum Zirconium Pentachlorohydrex Gly alongside topical retinoids (like tretinoin) or benzoyl peroxide can lead to extreme skin dryness and irritation. The combination of the astringent properties of the aluminum salt and the exfoliating properties of acne medications can compromise the skin barrier.
Products containing high concentrations of alcohol, salicylic acid, or alpha-hydroxy acids (AHAs) may increase the stinging sensation and irritation caused by the aluminum zirconium complex.
There are no known food interactions with topical Aluminum Zirconium Pentachlorohydrex Gly. Unlike oral aluminum-containing antacids, which can interact with citrus juices (increasing aluminum absorption), the topical route does not present this risk due to the minimal systemic uptake.
There are no documented interactions between this antiperspirant agent and herbal supplements such as St. John's Wort or Ginkgo Biloba.
This is a critical interaction for patients. Aluminum-based antiperspirants can appear as 'microcalcifications' (small white spots) on a mammogram. These spots can be mistaken for signs of breast cancer, leading to unnecessary anxiety or follow-up procedures.
In theory, very high levels of systemic aluminum can interfere with certain bone imaging agents, though this is not clinically relevant for topical antiperspirant users with normal kidney function.
> Important: Tell your doctor about ALL medications, supplements, and topical products you are taking, especially if you are scheduled for diagnostic imaging.
While the FDA allows use with a doctor's permission, many clinicians consider Stage 5 Chronic Kidney Disease (End-Stage Renal Disease) an absolute contraindication for high-concentration aluminum-zirconium salts due to the risk of accumulation. Aluminum is a known neurotoxin and bone toxin in patients who cannot excrete it.
Individuals who have experienced anaphylaxis or severe allergic contact dermatitis in response to aluminum zirconium compounds must never use the product. The mechanism is an immune-mediated Type IV hypersensitivity reaction to the metal ions.
Patients with active eczema in the axillary region should avoid use until the skin has healed. The impaired barrier of eczematous skin allows for deeper penetration of the salt, leading to severe pain and potential worsening of the dermatitis.
Do not use on the underarm area following procedures such as lymph node biopsies or axillary surgery until the incision is completely closed and the surgeon provides clearance.
Patients sensitive to Aluminum Chlorohydrate may also react to Aluminum Zirconium Pentachlorohydrex Gly. While the molecules are different, the shared aluminum ion is often the culprit for the irritation or allergic response.
> Important: Your healthcare provider will evaluate your complete medical history, including kidney function and skin health, before prescribing or recommending Aluminum Zirconium Pentachlorohydrex Gly.
Aluminum Zirconium Pentachlorohydrex Gly is generally considered safe for use during pregnancy.
It is considered safe to use Aluminum Zirconium Pentachlorohydrex Gly while breastfeeding.
As noted throughout this guide, the FDA mandates a warning for this population. In patients with severe impairment, the small amount of aluminum that is absorbed cannot be efficiently cleared. While the risk of toxicity from a deodorant is extremely low compared to aluminum-containing medications (like certain antacids), caution is advised.
No special considerations are required for patients with liver disease, as the liver does not play a role in the processing or elimination of aluminum or zirconium salts.
> Important: Special populations require individualized medical assessment. Always consult with a healthcare provider regarding the use of OTC drugs during pregnancy or in the presence of chronic illness.
Aluminum Zirconium Pentachlorohydrex Gly acts as an inorganic astringent. The molecular mechanism involves the formation of a physical barrier within the eccrine sweat glands. When the complex (Al-Zr-OH-Cl-Gly) contacts sweat, it undergoes a hydrolysis reaction. This reaction is pH-dependent. The acidic salt (pH ~3.0-4.0) reacts with the more neutral environment of the sweat duct, causing the metal ions to cross-link with proteins (keratin) in the duct wall. This creates a polymeric 'plug' that effectively seals the duct. This process is known as 'ductal occlusion.'
| Parameter | Value |
|---|---|
| Bioavailability | < 0.01% (Topical) |
| Protein Binding | Minimal (Systemic) |
| Half-life | ~24 hours (for absorbed Al) |
| Tmax | N/A (Topical) |
| Metabolism | None |
| Excretion | Renal (Aluminum), Fecal (Zirconium) |
Aluminum Zirconium Pentachlorohydrex Gly is classified as an Antiperspirant Astringent. It is distinct from 'Deodorants,' which are classified as cosmetics and only contain antimicrobial agents or fragrances to mask odor without reducing sweat production.
Medications containing this ingredient
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Common questions about Aluminum Zirconium Pentachlorohydrex Gly
Aluminum Zirconium Pentachlorohydrex Gly is primarily used as an active ingredient in antiperspirants to reduce excessive underarm sweating, a condition known as axillary hyperhidrosis. It works by forming temporary plugs in the sweat ducts, which physically prevent sweat from reaching the skin's surface. This not only keeps the area dry but also helps reduce body odor by limiting the moisture that bacteria need to thrive. It is commonly found in 'clinical strength' products because it is more effective at sweat suppression than standard aluminum chlorohydrate. Most people use it daily to maintain consistent protection against perspiration.
The most frequent side effects are localized skin reactions, including redness, stinging, and itching at the site of application. These symptoms often occur if the product is applied to damp skin or immediately after shaving, as the acidic nature of the salt can irritate the skin barrier. Some users may also notice dry or flaky skin in the underarm area. While these effects are generally mild and temporary, persistent irritation may indicate a contact allergy. To minimize these risks, it is recommended to apply the product to completely dry skin and avoid use on broken or recently shaved areas.
Yes, you can consume alcohol while using Aluminum Zirconium Pentachlorohydrex Gly, as there are no known direct chemical interactions between the two. Because the antiperspirant is applied topically and has negligible systemic absorption, alcohol in the bloodstream does not affect the drug's safety profile. However, it is worth noting that alcohol consumption can cause blood vessels to dilate and increase body temperature, which may lead to increased sweating. This could potentially make it feel like the antiperspirant is less effective, but it does not constitute a dangerous medical interaction.
Aluminum Zirconium Pentachlorohydrex Gly is generally considered safe for use during pregnancy by the medical community. Scientific studies have shown that the systemic absorption of aluminum through the skin is extremely low, typically less than 0.01%, which means there is no significant exposure to the developing fetus. Major health organizations, including the American Cancer Society, have found no evidence linking topical aluminum use to adverse pregnancy outcomes. However, as with any product used during pregnancy, it is always a good practice to inform your obstetrician about the personal care products you are using. If you have concerns, you can opt for aluminum-free deodorants, though they will not prevent sweating.
While you may notice some reduction in moisture after the first application, it typically takes 2 to 7 days of consistent daily use to reach maximum effectiveness. This is because the 'plugs' that block the sweat ducts need to build up and stabilize within the glands. For the best results, healthcare providers often recommend applying the product at night before bed. During sleep, your sweat rate is at its lowest, which allows the aluminum zirconium complex to enter the ducts and form more effective plugs without being washed away by active perspiration. Once the maximum effect is reached, daily maintenance is required to replace plugs that are naturally shed.
Yes, you can stop using Aluminum Zirconium Pentachlorohydrex Gly at any time without experiencing any medical withdrawal symptoms or 'rebound' effects. Since the product works through a physical blocking mechanism rather than by altering your body's internal chemistry, stopping use simply means the sweat duct plugs will eventually be shed. You can expect your normal sweating patterns to return within 24 to 48 hours after your last application. There is no need to taper off the product; however, if you were using it for severe hyperhidrosis, your symptoms of excessive sweating will return quickly once the product is discontinued.
If you miss an application of Aluminum Zirconium Pentachlorohydrex Gly, there is no cause for concern. Simply apply the product at your next regularly scheduled time, which is usually the following evening or morning. You do not need to apply extra product or 'double up' to compensate for the missed dose, as applying too much can increase the risk of skin irritation without providing additional sweat protection. Your sweat protection may slightly decrease for a day, but it will quickly return to normal once you resume your regular application schedule.
There is no scientific evidence or biological mechanism to suggest that Aluminum Zirconium Pentachlorohydrex Gly causes weight gain. The product is applied topically to a very small area of the body and does not enter the bloodstream in significant amounts. It does not affect hormones, metabolism, or appetite, which are the primary drivers of weight change. Any changes in weight you experience while using this product are likely due to other factors such as diet, exercise, or unrelated medical conditions. If you are concerned about sudden weight changes, you should consult your healthcare provider for a thorough evaluation.
Aluminum Zirconium Pentachlorohydrex Gly is safe to use alongside almost all oral medications, as it is not absorbed into the system in amounts that could cause drug-drug interactions. However, you should be cautious when using other topical products on the same area of skin. For example, using it with medicated acne creams or prescription-strength steroid ointments in the underarm area could lead to increased skin irritation or altered absorption of the other medication. It is also important to avoid wearing it during a mammogram, as the aluminum can show up on the imaging and interfere with the results. Always inform your doctor about all products you apply to your skin.
Aluminum Zirconium Pentachlorohydrex Gly is the chemical name of the active ingredient itself and is available in a wide variety of both brand-name and generic (store-brand) antiperspirant products. Because it is an over-the-counter (OTC) drug regulated by an FDA monograph rather than a patent-protected prescription drug, many manufacturers produce 'clinical strength' or 'extra effective' versions using this exact ingredient. When shopping, you can check the 'Active Ingredients' section of the Drug Facts label to see if a generic version contains the same percentage of Aluminum Zirconium Pentachlorohydrex Gly as a more expensive brand-name equivalent.