Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Aluminum Chlorohydrate is a group of specific aluminum salts used primarily as the active ingredient in over-the-counter antiperspirants. It belongs to the drug class of topical astringents and works by forming temporary physical plugs within the sweat ducts to reduce perspiration.
Name
Aluminum Chlorohydrate
Raw Name
ALUMINUM CHLOROHYDRATE
Category
Other
Drug Count
268
Variant Count
352
Last Verified
February 17, 2026
About Aluminum Chlorohydrate
Aluminum Chlorohydrate is a group of specific aluminum salts used primarily as the active ingredient in over-the-counter antiperspirants. It belongs to the drug class of topical astringents and works by forming temporary physical plugs within the sweat ducts to reduce perspiration.
Detailed information about Aluminum Chlorohydrate
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Aluminum Chlorohydrate.
Aluminum Chlorohydrate is a complex inorganic salt that serves as the primary active ingredient in many over-the-counter (OTC) antiperspirant products. It belongs to a class of compounds known as topical astringents (substances that shrink or constrict body tissues). Unlike deodorants, which merely mask odor or reduce odor-causing bacteria, Aluminum Chlorohydrate is classified by the FDA as an OTC drug because it alters a bodily function—specifically, the production of sweat.
The FDA first established the safety and effectiveness of aluminum-based antiperspirants in the late 1970s, with current standards maintained under the 21 CFR Part 350 monograph. While primarily used for hyperhidrosis (excessive sweating), it is also utilized in clinical settings for minor skin irritations due to its drying properties.
At the molecular level, Aluminum Chlorohydrate functions through a process of polymerization (linking molecules together). When the product is applied to the skin and comes into contact with sweat, the rise in pH (moving from the acidic product to the more neutral sweat) causes the aluminum salts to precipitate. This creates a gel-like substance that forms a temporary physical plug within the distal (outer) portion of the eccrine sweat glands.
These plugs prevent the sweat from reaching the skin's surface. Over time, these plugs are naturally shed through the normal process of skin cell turnover (desquamation), which is why regular application is required to maintain efficacy.
Aluminum Chlorohydrate is available in various topical delivery systems, including:
> Important: Only your healthcare provider can determine if Aluminum Chlorohydrate is right for your specific condition, especially if you suffer from clinical hyperhidrosis.
For the treatment of perspiration, Aluminum Chlorohydrate is typically used in concentrations ranging from 12% to 25% in OTC formulations.
Aluminum Chlorohydrate is generally considered safe for use in children and adolescents when used as directed on product labeling. However, the FDA recommends that parents consult a pediatrician before using medicated antiperspirants on children under the age of 12, primarily to rule out underlying medical causes for excessive sweating.
Patients with severe renal impairment (typically GFR < 30 mL/min) must consult a physician before use. The FDA requires a specific warning on aluminum-containing antiperspirants for this population due to the decreased ability of the kidneys to clear any absorbed aluminum.
No dosage adjustments are required for patients with liver disease, as the drug is not metabolized by the liver.
No specific adjustments are needed unless the patient has significantly reduced kidney function.
If a dose is missed, apply it as soon as remembered, or wait until the next scheduled application. Do not apply double the amount to make up for a missed dose.
Systemic overdose from topical application is virtually impossible in healthy individuals. However, accidental ingestion can cause gastrointestinal irritation, nausea, and vomiting. If ingested, contact a Poison Control Center immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
> Warning: Stop taking Aluminum Chlorohydrate and call your doctor immediately if you experience any of these.
Prolonged use of high-concentration aluminum salts may lead to chronic skin irritation or a change in the local skin microbiome. There is no consistent clinical evidence linking long-term topical aluminum use to systemic diseases like Alzheimer's or breast cancer, according to the American Cancer Society and the Alzheimer's Association (2024).
No FDA black box warnings for Aluminum Chlorohydrate. However, a mandatory label warning exists for individuals with kidney disease.
Report any unusual symptoms to your healthcare provider.
Aluminum Chlorohydrate is intended for external use only. It should never be applied to mucous membranes, eyes, or internal surfaces. If the product enters the eyes, rinse thoroughly with cool water for several minutes.
No FDA black box warnings for Aluminum Chlorohydrate.
Routine laboratory monitoring is not required for the general population. However, patients with known renal failure may have their serum aluminum levels monitored by their nephrologist if they use aluminum-containing products frequently.
There are no known effects on the ability to drive or operate machinery.
There are no known direct interactions between topical Aluminum Chlorohydrate and alcohol consumption.
If a rash or irritation develops, discontinue use immediately. There are no withdrawal symptoms associated with stopping Aluminum Chlorohydrate, though excessive sweating will likely return within 48 to 72 hours as the sweat duct plugs are naturally shed.
> Important: Discuss all your medical conditions with your healthcare provider before starting Aluminum Chlorohydrate.
There are no known systemic drug-drug contraindications for topical Aluminum Chlorohydrate. However, it should not be used simultaneously on the same patch of skin with other highly acidic topical treatments.
There are no known food or beverage interactions with topical Aluminum Chlorohydrate.
No significant interactions with herbal supplements have been clinically documented for the topical form of this ingredient.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients who react to Aluminum Zirconium Tetrachlorohydrex Gly or Aluminum Chloride are likely to exhibit cross-sensitivity to Aluminum Chlorohydrate due to the shared aluminum ion.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Aluminum Chlorohydrate.
FDA Pregnancy Category: Not Formally Assigned. Aluminum Chlorohydrate is generally considered safe during pregnancy because systemic absorption is negligible (<0.01%). There is no evidence of teratogenicity (birth defects) in human or animal studies following topical application. However, pregnant individuals should consult their obstetrician before starting any new medicated product.
Aluminum Chlorohydrate is unlikely to pass into breast milk in any significant quantity. It is considered compatible with breastfeeding. Care should be taken to ensure the product is not applied directly to the breast or nipple area to avoid accidental ingestion by the nursing infant.
Safety and efficacy have been established in children. However, use in children under 12 should be supervised by an adult. If a child experiences significant irritation, use should be discontinued immediately.
No specific concerns have been identified for the elderly population, provided renal function is adequate for the clearance of trace aluminum amounts. Skin in older adults may be thinner and more prone to irritation.
As per FDA 21 CFR 350.50, the label must state "Ask a doctor before use if you have kidney disease." In patients with end-stage renal disease (ESRD), there is a theoretical risk of aluminum toxicity, which can lead to osteomalacia (bone softening) or encephalopathy, though this is primarily associated with oral aluminum intake.
No special precautions are required for patients with liver disease.
> Important: Special populations require individualized medical assessment.
Aluminum Chlorohydrate acts as a topical antiperspirant by forming a physical barrier. When applied, the salts dissolve in sweat or skin moisture. The resulting solution has a low pH. As it mixes with the higher-pH sweat in the duct, the aluminum ions undergo hydrolysis and polymerization, forming a metal-hydroxide gel. This gel creates a "plug" in the sweat gland's duct, mechanically obstructing the secretion of sweat.
| Parameter | Value |
|---|---|
| Bioavailability | <0.012% (Topical) |
| Protein Binding | N/A (Negligible systemic levels) |
| Half-life | N/A (Local action) |
| Tmax | N/A |
| Metabolism | None (Systemically inert) |
| Excretion | Renal (Trace amounts) |
Aluminum Chlorohydrate is classified as a topical antiperspirant and an inorganic salt astringent. It is related to other aluminum salts such as Aluminum Zirconium and Aluminum Chloride.
Medications containing this ingredient
Babaria Oat Fresh Deodorant And Antiperspirant Liquid Roll-on
Gerigentle Aloe Dry Anti Perspirant Deodorant Body
Lumiste Cool Man
Gandh Protect Antiperspirant Deodorant Roll On
Avon Feelin Fresh Essence
Avon Rare Jade
Avon Haiku
Avon Far Away Roll-on Anti-perspirant Deodorant
Avon Odyssey Roll-on Anti-perspirant Deodorant
Arrid Extra Extra Dry Xx
Ban
Roll On Anti Perspirant
+ 38 more drugs
Common questions about Aluminum Chlorohydrate
Aluminum Chlorohydrate is primarily used as the active ingredient in over-the-counter antiperspirants to reduce underarm wetness and control excessive sweating. It works by creating temporary physical plugs in the sweat ducts, which prevents perspiration from reaching the skin's surface. Beyond hygiene, it is sometimes used by dermatologists for its astringent properties to dry out minor skin irritations. It is one of the most common ingredients in roll-on and stick antiperspirants due to its balance of efficacy and low irritation potential. Your healthcare provider may recommend specific concentrations if you suffer from clinical hyperhidrosis.
The most frequently reported side effects are localized to the area of application and include mild skin irritation, stinging, or redness. These symptoms often occur if the product is applied to damp skin or skin that has been recently shaved. Some users may also experience itching (pruritus) or excessive dryness of the skin. In most cases, these side effects are temporary and resolve on their own once the product is washed off. If you develop a persistent rash or severe burning, you should stop using the product and consult a healthcare professional.
Yes, there are no known contraindications or direct drug interactions between topical Aluminum Chlorohydrate and the consumption of alcohol. Because Aluminum Chlorohydrate is applied to the skin and has extremely low systemic absorption, it does not interact with the way your body processes alcohol. However, excessive alcohol consumption can sometimes trigger increased sweating in certain individuals, which might affect the perceived efficacy of the antiperspirant. Always use the product as directed on the label and discuss any concerns with your doctor. Maintaining overall health is important when managing conditions like excessive sweating.
Aluminum Chlorohydrate is generally considered safe for use during pregnancy by most medical professionals. Research indicates that the amount of aluminum absorbed through the skin from antiperspirants is less than 0.01%, which is significantly less than the amount typically absorbed from daily food intake. There is no evidence to suggest that topical use of these salts causes harm to a developing fetus. However, because every pregnancy is unique, it is always best to confirm with your obstetrician before continuing use. They can provide personalized guidance based on your specific health history.
You may notice a slight reduction in sweat within a few hours of the first application, but the full effect usually takes several days to develop. Most clinical guidelines suggest applying the product nightly for three to five days to allow the "plugs" in the sweat ducts to build up effectively. Once the desired level of sweat control is achieved, you can often reduce application to every other day or as needed. Applying the product at night is particularly effective because your sweat glands are less active during sleep. If you do not see improvement after a week of consistent use, consult your healthcare provider.
Yes, you can stop using Aluminum Chlorohydrate at any time without experiencing withdrawal symptoms or physical side effects. Because it is a topical treatment that works mechanically rather than systemically, there is no need to taper off the product. However, you should expect that your normal level of perspiration will return within two to three days after you stop application. This happens because the temporary plugs in your sweat ducts are naturally shed during the normal exfoliation of your skin cells. If you were using it for a medical condition like hyperhidrosis, your symptoms will likely return to their baseline level.
If you miss a scheduled application of Aluminum Chlorohydrate, simply apply it as soon as you remember, provided the skin is dry. If it is almost time for your next scheduled application, you can skip the missed dose and return to your regular routine. There is no need to apply extra product to make up for a missed dose, as the sweat-blocking plugs are formed gradually over time. Consistency is key for the best results, especially during the first week of use. If you miss several doses, you may notice a temporary increase in sweating until the product's effect is re-established.
There is no clinical evidence or biological mechanism that suggests topical Aluminum Chlorohydrate causes weight gain. Because the drug is not absorbed into the bloodstream in significant amounts, it does not affect your metabolism, hormones, or appetite. Any changes in weight while using an antiperspirant are likely due to other factors such as diet, exercise, or underlying medical conditions. If you experience sudden or unexplained weight changes, it is important to discuss them with your healthcare provider to determine the cause. This product is strictly for the localized control of perspiration.
Aluminum Chlorohydrate is generally safe to use alongside oral medications because it does not enter the systemic circulation in meaningful amounts. However, you should be cautious when using other topical medications on the same area of skin. For example, using prescription acne treatments or retinoids in the same area as an aluminum-based antiperspirant can increase skin irritation. It is always a good idea to inform your doctor or pharmacist about all products you are using, including over-the-counter creams and sprays. They can help you coordinate an application schedule that minimizes the risk of skin reactions.
Aluminum Chlorohydrate is the active ingredient in many different brands of antiperspirants and is widely available in generic or store-brand versions. Because it is an over-the-counter drug monograph ingredient, many manufacturers produce it under various names. Generic versions are required by the FDA to meet the same safety and efficacy standards as name-brand products. You can find it in various forms, such as roll-ons, sticks, and sprays, often at a lower cost than heavily advertised brands. Check the 'Drug Facts' label on the packaging to verify that Aluminum Chlorohydrate is the listed active ingredient.