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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Ailanthus Altissima Whole, derived from the Tree of Heaven, is a botanical substance used primarily in traditional and homeopathic medicine for various inflammatory and infectious conditions, though it lacks FDA approval for therapeutic claims.
Name
Ailanthus Altissima Whole
Raw Name
AILANTHUS ALTISSIMA WHOLE
Category
Other
Drug Count
3
Variant Count
3
Last Verified
February 17, 2026
About Ailanthus Altissima Whole
Ailanthus Altissima Whole, derived from the Tree of Heaven, is a botanical substance used primarily in traditional and homeopathic medicine for various inflammatory and infectious conditions, though it lacks FDA approval for therapeutic claims.
Detailed information about Ailanthus Altissima Whole
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Ailanthus Altissima Whole.
Ailanthus Altissima Whole refers to the utilization of the entire plant—including the bark, leaves, and roots—of the Ailanthus altissima tree, commonly known as the 'Tree of Heaven.' In the context of clinical pharmacology and traditional medicine, this botanical agent belongs to a class of substances often categorized as phytochemical-rich herbals or homeopathic mother tinctures. It is important to note that Ailanthus Altissima Whole is not currently approved by the U.S. Food and Drug Administration (FDA) for the treatment, cure, or prevention of any disease. Instead, it is typically found in the marketplace as a dietary supplement or a homeopathic preparation listed in the Homeopathic Pharmacopoeia of the United States (HPUS).
Historically, the plant has roots in Traditional Chinese Medicine (TCM), where it is known as 'Chun Pi.' While TCM often focuses on the root bark, 'Whole' plant preparations aim to capture the full synergistic profile of the tree’s secondary metabolites. These include a diverse array of quassinoids (bitter compounds), alkaloids, and terpenes. From a pharmacological standpoint, these compounds are studied for their potential antimicrobial, anti-inflammatory, and even antineoplastic (cancer-fighting) properties, although clinical evidence in humans remains significantly limited.
The mechanism of action for Ailanthus Altissima Whole is complex and multifaceted due to the presence of numerous bioactive molecules. The primary active constituents are quassinoids, most notably ailanthone. At the molecular level, ailanthone has been observed in laboratory settings to inhibit the expression of various inflammatory mediators. Specifically, it appears to modulate the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway, which is a major regulator of the immune response. By inhibiting this pathway, the substance may reduce the production of pro-inflammatory cytokines such as TNF-alpha and interleukin-6 (IL-6).
Furthermore, research published in journals such as Molecules suggests that extracts from the whole plant may exert pro-apoptotic effects (programmed cell death) on certain malignant cell lines. This is thought to occur through the activation of caspases and the down-regulation of anti-apoptotic proteins like Bcl-2. In antimicrobial contexts, the alkaloids present in the whole plant may disrupt the cell membrane integrity of certain bacteria and parasites, although these effects are primarily documented in vitro (outside a living organism).
Because Ailanthus Altissima Whole is a complex botanical mixture rather than a single purified chemical entity, its pharmacokinetic profile is not as clearly defined as synthetic pharmaceuticals. However, based on studies of its primary marker compound, ailanthone, the following parameters are generally understood:
While not FDA-approved, Ailanthus Altissima Whole is traditionally used in various systems of medicine for the following conditions:
Ailanthus Altissima Whole is available in several specialized preparations:
> Important: Only your healthcare provider can determine if Ailanthus Altissima Whole is right for your specific condition. Botanical products can vary significantly in potency and purity.
There is no standardized FDA-approved dosage for Ailanthus Altissima Whole. Dosing is typically determined by the practitioner's philosophy (e.g., homeopathic vs. herbalist) and the specific formulation used.
Ailanthus Altissima Whole is generally not recommended for use in children under the age of 12 due to the presence of potent alkaloids and a lack of safety data. Some homeopathic practitioners may use highly diluted (30C or higher) forms for children, but this must only be done under strict medical supervision. The raw or concentrated extract is considered potentially toxic to the developing hepatic and renal systems of pediatric patients.
Because the metabolites of Ailanthus Altissima are primarily excreted via the kidneys, individuals with a glomerular filtration rate (GFR) below 60 mL/min should exercise extreme caution. Dose reductions of at least 50% are typically advised by clinical herbalists, or the substance should be avoided entirely to prevent accumulation and toxicity.
The liver is responsible for processing the quassinoids found in the whole plant. Patients with cirrhosis, hepatitis, or elevated liver enzymes should avoid Ailanthus Altissima Whole, as it may exacerbate liver stress or lead to hepatotoxicity (liver damage).
Geriatric patients often have reduced organ reserve and may be taking multiple medications. For patients over 65, it is recommended to start at the lowest possible dose (e.g., 25% of the standard adult dose) to assess tolerance and monitor for signs of central nervous system depression or gastrointestinal upset.
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one, as this increases the risk of alkaloid-related toxicity.
Signs of an overdose of Ailanthus Altissima Whole include severe nausea, vomiting, dizziness, cold sweats, and a significant drop in heart rate (bradycardia). In extreme cases, it may lead to respiratory depression or stupor. If an overdose is suspected, contact a Poison Control Center immediately or seek emergency medical attention. Treatment is generally supportive, focusing on gastric lavage (stomach pumping) and maintaining airway patency.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance, as botanical concentrations can vary between manufacturers.
Individuals taking Ailanthus Altissima Whole frequently report gastrointestinal disturbances. These are often the result of the plant's high concentration of bitter quassinoids, which stimulate gastric acid secretion. Common symptoms include:
> Warning: Stop taking Ailanthus Altissima Whole and call your doctor immediately if you experience any of these.
Prolonged use of Ailanthus Altissima Whole (beyond 4-6 weeks) is not well-studied and is generally discouraged. Potential long-term risks include:
No FDA black box warnings currently exist for Ailanthus Altissima Whole because it is not an FDA-approved drug. However, many clinical herbalists treat it as a 'low-dose botanical,' meaning it has a narrow therapeutic index and should be treated with the same caution as a drug with a black box warning regarding potential toxicity and organ stress.
Report any unusual symptoms to your healthcare provider. Monitoring of liver and kidney function is advised for anyone using this substance for more than two consecutive weeks.
Ailanthus Altissima Whole is a potent botanical agent that contains bioactive alkaloids and quassinoids. It should never be viewed as a 'mild' herb. Patients must be aware that botanical supplements are not regulated with the same rigor as prescription drugs, and the concentration of active ingredients can vary by as much as 300% between different brands. Always ensure you are using a product from a reputable manufacturer that provides a Certificate of Analysis (CoA).
No FDA black box warnings for Ailanthus Altissima Whole. However, the plant is listed by various toxicological databases as potentially hazardous if consumed in its raw, unprocessed state due to high concentrations of ailanthone.
If your healthcare provider approves the use of Ailanthus Altissima Whole for an extended period, the following monitoring is recommended:
Ailanthus Altissima Whole may cause significant drowsiness, dizziness, or a 'spaced-out' feeling. Do not drive a vehicle, operate heavy machinery, or engage in hazardous activities until you know how this substance affects you. The risk of impairment is higher during the first few days of use or when the dose is increased.
Alcohol should be strictly avoided while taking Ailanthus Altissima Whole. Alcohol can potentiate the sedative effects of the plant's alkaloids and increase the metabolic burden on the liver, significantly raising the risk of hepatotoxicity and central nervous system depression.
While Ailanthus Altissima Whole is not known to be addictive, sudden discontinuation after prolonged use may result in a 'rebound' of inflammatory symptoms. It is generally advised to taper the dose over a period of 5 to 7 days. If you experience severe headaches or irritability during this time, contact your healthcare provider.
> Important: Discuss all your medical conditions, including any history of heart, liver, or kidney disease, with your healthcare provider before starting Ailanthus Altissima Whole.
For each major interaction, the management strategy involves either avoiding the combination or having a healthcare professional perform regular blood work to ensure safety.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter drugs.
Ailanthus Altissima Whole must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis by a physician include:
Patients who are allergic to other members of the Sapindales order may exhibit cross-sensitivity to Ailanthus Altissima Whole. This includes potential reactions in individuals sensitive to citrus fruits or certain types of mahogany wood, although the clinical evidence for this specific cross-reactivity is primarily anecdotal.
> Important: Your healthcare provider will evaluate your complete medical history, including any underlying conditions, before prescribing or recommending Ailanthus Altissima Whole.
Ailanthus Altissima Whole is classified as Category X equivalent in herbal medicine, meaning it is strictly contraindicated during pregnancy. Research indicates that quassinoids can interfere with protein synthesis and cellular division in the developing fetus. There is a documented risk of spontaneous abortion (miscarriage) and developmental abnormalities. If you become pregnant while taking this substance, stop use immediately and consult your obstetrician.
It is unknown exactly how much of the active alkaloids from Ailanthus Altissima Whole pass into human breast milk, but given their low molecular weight and lipophilic nature, significant transfer is likely. Due to the potential for neurotoxicity and gastrointestinal distress in the infant, breastfeeding mothers should avoid this product. A 'pump and dump' period of at least 48 hours is recommended if a single dose was taken accidentally.
Safety and efficacy have not been established in the pediatric population. The 'Whole' plant extract contains concentrations of ailanthone that are far too potent for the metabolic capacity of children. Use in children is generally considered unsafe and is not recommended by major botanical safety handbooks like the AHPA Botanical Safety Handbook.
Older adults are at an increased risk for side effects due to age-related declines in renal and hepatic clearance. There is also a significantly higher risk of falls due to the dizziness and orthostatic hypotension (blood pressure drop upon standing) associated with this botanical. Polypharmacy (taking multiple medications) in the elderly also makes drug-botanical interactions a primary concern. Geriatric patients should be monitored for signs of confusion or excessive sedation.
In patients with impaired kidney function, the excretion of polar metabolites is delayed. For those with a GFR between 30 and 59 mL/min, a 50% dose reduction is suggested. It is not recommended for patients with a GFR below 30 mL/min or those on hemodialysis, as the clearance characteristics of quassinoids during dialysis are unknown.
For patients with mild hepatic impairment (Child-Pugh Class A), use with extreme caution and frequent monitoring of LFTs. For moderate to severe impairment (Child-Pugh B and C), the use of Ailanthus Altissima Whole is contraindicated due to the high risk of further liver injury and systemic accumulation of toxic alkaloids.
> Important: Special populations require individualized medical assessment. Never start a new supplement regimen in these groups without professional guidance.
Ailanthus Altissima Whole acts through a variety of molecular pathways. The primary active quassinoid, ailanthone, is known to be a potent inhibitor of the eukaryotic translation process. It binds to the 80S ribosome, thereby inhibiting protein synthesis in sensitive cells, which explains its investigated anti-tumor and antiparasitic properties. Additionally, the plant contains canthin-6-one alkaloids, which exhibit antifungal and antibacterial activity by disrupting the cell wall and interfering with DNA replication in pathogens.
In inflammatory models, the whole plant extract has been shown to downregulate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This occurs through the inhibition of the phosphorylation of IκBα, which prevents the translocation of NF-κB into the nucleus, effectively 'turning off' the genetic switches for inflammation.
The onset of action for gastrointestinal symptoms is relatively rapid (1-2 hours), while the systemic anti-inflammatory effects may take several days of consistent dosing to become apparent. The duration of effect for a single dose is typically 4 to 6 hours. There is no evidence of the development of pharmacological tolerance, but the risk of cumulative toxicity increases with the duration of use.
| Parameter | Value |
|---|---|
| Bioavailability | Estimated < 15% (Oral) |
| Protein Binding | Approximately 65-75% |
| Half-life | 2.5 - 4.0 hours |
| Tmax | 1.0 - 1.5 hours |
| Metabolism | Hepatic (CYP3A4 suspected) |
| Excretion | Renal (>70%), Fecal (<20%) |
Ailanthus Altissima Whole is classified as a Botanical Therapeutic Agent or a Homeopathic Mother Tincture. Within the therapeutic hierarchy, it is considered an 'Alterative' and 'Anthelmintic' in traditional herbalism, and a 'Deep-acting Anti-psoric' in some homeopathic traditions.
Medications containing this ingredient
Common questions about Ailanthus Altissima Whole
Ailanthus Altissima Whole is primarily used in traditional and homeopathic medicine to address severe gastrointestinal issues like dysentery and chronic diarrhea. It is also utilized for inflammatory conditions of the throat, such as follicular tonsillitis or infections that cause extreme physical exhaustion. Some practitioners use it for its potential antimicrobial properties against certain parasites and fungi. However, it is essential to remember that these uses are based on traditional practice and are not currently supported by FDA-approved clinical trials. You should always consult a healthcare provider before using it for any medical condition.
The most frequently reported side effects include gastrointestinal distress such as nausea, stomach cramping, and loose stools. Users also commonly experience dizziness, lightheadedness, and a general sense of lethargy or 'brain fog.' These symptoms are often dose-dependent and result from the plant's potent quassinoid and alkaloid content. If these effects become severe or persistent, it is important to stop taking the supplement and seek medical advice. Some people may also develop a skin rash if they come into physical contact with the liquid extract.
No, you should strictly avoid alcohol while taking Ailanthus Altissima Whole. Alcohol can significantly increase the sedative effects of the plant's alkaloids, leading to dangerous levels of drowsiness and impaired coordination. Furthermore, both alcohol and the active compounds in Ailanthus are processed by the liver, and combining them can place excessive stress on this organ, increasing the risk of liver damage. To ensure your safety, wait at least 48 hours after your last dose of Ailanthus before consuming alcohol. Always discuss your lifestyle habits with your doctor when starting a new botanical agent.
Ailanthus Altissima Whole is considered unsafe during pregnancy and should be strictly avoided. Research in animal models has shown that its active components, particularly quassinoids, can be toxic to a developing fetus and may cause birth defects or miscarriage. There is no established safe dose for pregnant women, and the risks far outweigh any potential benefits. If you are planning to become pregnant or find out you are pregnant, discontinue use immediately. Always prioritize professional medical guidance regarding supplements during pregnancy.
The time it takes for Ailanthus Altissima Whole to work depends on the condition being treated. For acute gastrointestinal issues like diarrhea, some individuals may notice a change within 1 to 3 hours after the first few doses. However, for more systemic inflammatory or infectious conditions, it may take 3 to 5 days of regular use to see a noticeable improvement in symptoms. If your condition does not improve within a week, or if it worsens, you should stop use and consult a healthcare professional. Do not continue use for more than two weeks without medical supervision.
While Ailanthus Altissima Whole does not contain addictive substances like opioids, it is generally best to taper off the dose rather than stopping abruptly if you have been taking it for more than a week. Sudden discontinuation can sometimes lead to a 'rebound' effect where the original inflammatory symptoms return more intensely. A gradual reduction over 3 to 5 days is typically recommended by herbalists to allow the body to readjust. If you experience any new or worsening symptoms during this period, contact your healthcare provider. Always follow the specific instructions provided by your practitioner.
If you miss a dose, you should take it as soon as you remember, provided it is not too close to your next scheduled dose. If your next dose is only a few hours away, skip the missed dose and continue with your regular schedule. You should never take two doses at once to make up for a missed one, as this significantly increases the risk of toxicity and side effects like bradycardia or severe nausea. Consistency is important for effectiveness, but safety should always come first. If you frequently miss doses, consider using a pill reminder or app.
There is currently no clinical evidence to suggest that Ailanthus Altissima Whole causes weight gain. In fact, due to its common side effects of nausea and loss of appetite (anorexia), some individuals might actually experience temporary weight loss while taking it. It does not appear to affect metabolic rate or fat storage in a way that would lead to increased body mass. If you notice unexpected weight changes while taking this supplement, it is more likely related to the underlying condition being treated or other lifestyle factors. Discuss any significant weight fluctuations with your doctor.
Ailanthus Altissima Whole has a high potential for interacting with other medications, particularly those that affect the heart, liver, or central nervous system. It can dangerously interact with blood thinners, heart medications like Digoxin, and any drug that causes sedation, such as benzodiazepines. Because it is metabolized by the liver, it may also change how your body processes other prescription drugs. You must provide your doctor or pharmacist with a full list of all medications and supplements you are taking before starting Ailanthus. This is the only way to ensure that the combination is safe for you.
Because Ailanthus Altissima Whole is a botanical product and not a patented synthetic drug, the concept of 'generic' vs. 'brand name' does not apply in the traditional sense. It is available from many different supplement manufacturers and homeopathic pharmacies under its botanical name. However, quality and concentration can vary wildly between different brands. It is crucial to choose a product that has been third-party tested for purity and potency. Look for labels that mention 'HPUS' for homeopathic versions or those that provide a standardized percentage of active quassinoids.