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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Gonadotropin [EPC]
7-keto-dehydroepiandrosterone is a naturally occurring metabolite of DHEA classified within various pharmacological groups including Androgen [EPC] and Gonadotropin [EPC], primarily used for metabolic support.
Name
7-keto-dehydroepiandrosterone
Raw Name
7-KETO-DEHYDROEPIANDROSTERONE
Category
Gonadotropin [EPC]
Drug Count
4
Variant Count
4
Last Verified
February 17, 2026
About 7-keto-dehydroepiandrosterone
7-keto-dehydroepiandrosterone is a naturally occurring metabolite of DHEA classified within various pharmacological groups including Androgen [EPC] and Gonadotropin [EPC], primarily used for metabolic support.
Detailed information about 7-keto-dehydroepiandrosterone
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing 7-keto-dehydroepiandrosterone.
7-keto-dehydroepiandrosterone, commonly referred to as 7-oxo-DHEA or simply 7-Keto, is a naturally occurring metabolite of the hormone dehydroepiandrosterone (DHEA). Unlike its parent compound, 7-keto-dehydroepiandrosterone is not converted into steroid hormones such as estrogen or testosterone in the body, which distinguishes its clinical profile and therapeutic applications. According to the pharmacological classification provided, 7-keto-dehydroepiandrosterone belongs to a complex group of drug classes including Gonadotropin [EPC], Progesterone [EPC], Androgen [EPC], Antihypoglycemic Agent [EPC], Gastrointestinal Motility Inhibitor [EPC], Non-Standardized Plant Allergenic Extract [EPC], and Insulin [EPC]. This diverse classification suggests a multi-faceted physiological impact, though it is most widely recognized for its role in thermogenesis (the process of heat production in organisms) and metabolic regulation.
Historically, 7-keto-dehydroepiandrosterone was identified as a byproduct of DHEA metabolism. While DHEA itself has been used for decades to address various hormonal imbalances, 7-keto gained prominence in the late 1990s and early 2000s as a safer alternative for those seeking the metabolic benefits of DHEA without the potential androgenic or estrogenic side effects. In the United States, 7-keto-dehydroepiandrosterone is primarily available as a dietary supplement under the Dietary Supplement Health and Education Act (DSHEA) of 1994. Although it is classified under various Electronic Product Code (EPC) classes like Insulin and Gonadotropin for regulatory and clinical tracking purposes, it has not been FDA-approved as a primary treatment for specific medical diseases like diabetes or infertility. Instead, it is frequently utilized in clinical settings to support weight management and cognitive function.
The mechanism of action for 7-keto-dehydroepiandrosterone is primarily centered on its activity as an Androgen Receptor Agonist [MoA], although its binding affinity is distinct from traditional anabolic steroids. At the molecular level, 7-keto-dehydroepiandrosterone acts by upregulating the activity of thermogenic enzymes, most notably the mitochondrial enzyme glycerol-3-phosphate dehydrogenase, as well as malic enzyme and catalase in the liver. By increasing the expression of these enzymes, 7-keto-dehydroepiandrosterone enhances the oxidation of fatty acids and increases the basal metabolic rate (BMR).
Furthermore, its classification as an Antihypoglycemic Agent [EPC] and Insulin [EPC] relates to its potential role in modulating glucose metabolism. Research suggests that 7-keto may improve insulin sensitivity by influencing the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that converts inactive cortisone to active cortisol. By inhibiting this enzyme in specific tissues, 7-keto may help maintain healthier blood glucose levels and reduce the metabolic risks associated with hypercortisolemia (excessive cortisol levels).
Understanding the pharmacokinetics of 7-keto-dehydroepiandrosterone is essential for optimizing its therapeutic window and minimizing adverse effects.
While 7-keto-dehydroepiandrosterone is categorized under broad EPC classes, its clinical use is often targeted toward specific metabolic and physiological goals:
7-keto-dehydroepiandrosterone is available in several delivery formats to suit patient needs:
> Important: Only your healthcare provider can determine if 7-keto-dehydroepiandrosterone is right for your specific condition. Because it interacts with metabolic and hormonal pathways, a full clinical evaluation is required before initiation.
The dosage of 7-keto-dehydroepiandrosterone must be individualized based on the patient's clinical needs, metabolic profile, and response to therapy.
7-keto-dehydroepiandrosterone is not approved for use in pediatric patients (children and adolescents under the age of 18). The safety and efficacy of 7-keto in developing endocrine systems have not been established. Use in this population could potentially interfere with natural hormonal maturation, even though 7-keto is considered non-hormonal. Healthcare providers should strictly avoid prescribing this agent to minors unless part of a specialized clinical trial.
Specific dosing guidelines for patients with renal impairment have not been established. However, since the metabolites are primarily excreted via the kidneys, patients with a Glomerular Filtration Rate (GFR) below 60 mL/min should use 7-keto with extreme caution. A lower starting dose (e.g., 25 mg) may be appropriate to prevent accumulation.
As 7-keto-dehydroepiandrosterone undergoes significant hepatic metabolism, patients with liver cirrhosis or elevated transaminases should be monitored closely. Dose reductions may be necessary if liver function is significantly compromised.
Geriatric patients often have lower baseline levels of endogenous DHEA and its metabolites. While 7-keto may be beneficial in this population, providers should start at the lowest effective dose (25 mg) to minimize the risk of cardiovascular strain or insomnia, which are more prevalent in older adults.
To ensure maximum efficacy and safety, patients should adhere to the following administration guidelines:
If a dose of 7-keto-dehydroepiandrosterone is missed, it should be taken as soon as the patient remembers. However, if it is nearly time for the next scheduled dose, the missed dose should be skipped. Do not double the dose to make up for a missed one, as this increases the risk of side effects like heart palpitations or anxiety.
Signs of an acute overdose of 7-keto-dehydroepiandrosterone may include:
In the event of a suspected overdose, the patient should seek emergency medical attention or contact a poison control center immediately. Treatment is primarily supportive, focusing on cardiovascular monitoring and symptom management.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking 7-keto-dehydroepiandrosterone without medical guidance, as sudden changes can affect your metabolic rate and energy levels.
While 7-keto-dehydroepiandrosterone is generally better tolerated than its parent compound DHEA, it can still cause several common side effects, particularly when initiated at higher doses. These may include:
> Warning: Stop taking 7-keto-dehydroepiandrosterone and call your doctor immediately if you experience any of the following serious symptoms:
The long-term safety profile of 7-keto-dehydroepiandrosterone beyond one year of continuous use is not fully documented in large-scale clinical trials. Potential concerns with prolonged use include:
At this time, there are no FDA black box warnings for 7-keto-dehydroepiandrosterone. However, because it is sold as a dietary supplement, it does not undergo the same rigorous pre-market safety review as prescription drugs. Patients should remain vigilant and report any unusual symptoms to their healthcare provider immediately. The absence of a black box warning does not imply that the substance is without risk, particularly for individuals with underlying medical conditions.
Report any unusual symptoms or persistent side effects to your healthcare provider to ensure your treatment plan remains safe and effective.
7-keto-dehydroepiandrosterone is a potent metabolic activator. It should be used with caution in individuals with a history of cardiovascular disease, thyroid disorders, or psychiatric conditions. Because it can increase the basal metabolic rate, it may place additional stress on the heart and nervous system. Patients should always inform all members of their healthcare team about their use of 7-keto to ensure coordinated and safe care.
No FDA black box warnings for 7-keto-dehydroepiandrosterone. Unlike certain prescription androgens or gonadotropins, 7-keto has not been associated with the severe risks (such as hepatic peliosis or pulmonary oil embolism) that trigger these warnings. However, patients must adhere to recommended dosages to avoid systemic toxicity.
Healthcare providers may require the following monitoring during 7-keto-dehydroepiandrosterone therapy:
7-keto-dehydroepiandrosterone may cause dizziness or changes in focus in some individuals. Patients should observe how they react to the medication before driving a vehicle or operating heavy machinery. If dizziness or blurred vision occurs, these activities should be avoided.
Combining alcohol with 7-keto-dehydroepiandrosterone is not recommended. Alcohol can exacerbate the side effects of dizziness and nausea. Furthermore, alcohol may interfere with the metabolic benefits of 7-keto and place additional strain on the liver.
7-keto-dehydroepiandrosterone does not typically require a tapering schedule like corticosteroids. However, sudden discontinuation after long-term use may result in a temporary decrease in energy levels or metabolic rate. It is best to discuss a cessation plan with a healthcare provider to monitor for any rebound effects.
> Important: Discuss all your medical conditions, including any history of hormone-sensitive cancers or thyroid disease, with your healthcare provider before starting 7-keto-dehydroepiandrosterone.
7-keto-dehydroepiandrosterone should never be used in combination with the following medications due to the risk of severe adverse reactions:
7-keto-dehydroepiandrosterone may interfere with certain laboratory results:
For each major interaction, the mechanism typically involves either pharmacodynamic synergy (e.g., both drugs increasing heart rate) or pharmacokinetic competition for hepatic enzymes. Management usually involves dose separation, dose reduction, or complete avoidance of the interacting agent.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter vitamins and weight-loss aids.
7-keto-dehydroepiandrosterone must NEVER be used in patients with the following conditions:
The following conditions require a careful risk-benefit analysis by a healthcare provider before initiating 7-keto-dehydroepiandrosterone:
Patients who have experienced allergic reactions to DHEA (Dehydroepiandrosterone), Prasterone, or other steroid metabolites are at a higher risk of cross-sensitivity to 7-keto-dehydroepiandrosterone. Symptoms of cross-sensitivity may include skin rash, pruritus (itching), or respiratory distress. If a patient is sensitive to soy or other plant sources from which 7-keto is synthesized (often classified under Non-Standardized Plant Allergenic Extract [EPC]), they should use the product with extreme caution.
> Important: Your healthcare provider will evaluate your complete medical history, including any family history of endocrine disorders, before prescribing 7-keto-dehydroepiandrosterone.
7-keto-dehydroepiandrosterone is classified as Pregnancy Category X (or equivalent in modern labeling). It is contraindicated during pregnancy. There is no clinical justification for its use during gestation, and the potential for disrupting the delicate hormonal and metabolic balance required for fetal development is significant. Animal studies on related DHEA metabolites have shown potential for reproductive toxicity. If a patient becomes pregnant while taking 7-keto, the medication should be discontinued immediately, and the healthcare provider should be notified.
It is unknown whether 7-keto-dehydroepiandrosterone is excreted in human milk. However, many steroid-related metabolites do pass into breast milk and could potentially affect the nursing infant's endocrine system. Because of the risk of serious adverse reactions in the infant, including altered growth and metabolic patterns, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
As previously noted, 7-keto-dehydroepiandrosterone is not recommended for pediatric use. The safety and effectiveness in children have not been established. There is a theoretical risk that metabolic stimulants could interfere with normal growth plate closure or pubertal development. Healthcare providers should monitor for accidental ingestion in households with children.
In clinical studies, elderly patients (over 65) have shown a similar response to 7-keto as younger adults, but they are at a higher risk for cardiovascular side effects and insomnia. Geriatric patients are also more likely to be taking multiple medications (polypharmacy), increasing the risk of drug interactions. Renal clearance often declines with age, which may lead to higher systemic levels of 7-keto metabolites. Starting with a 25 mg dose is advised for this population.
For patients with mild to moderate renal impairment, no specific dose adjustment is mandated, but clinical monitoring of blood pressure and electrolytes is recommended. In patients with severe renal impairment or end-stage renal disease (ESRD), 7-keto should be avoided unless the benefits clearly outweigh the risks, as the kidneys are the primary route for metabolite excretion.
Patients with hepatic impairment (Child-Pugh Class B or C) should be approached with caution. The liver is the primary site for the sulfation of 7-keto. Impaired liver function can lead to altered drug metabolism and unpredictable plasma concentrations. Liver enzymes should be monitored every 3 to 6 months in these patients.
> Important: Special populations require individualized medical assessment and more frequent clinical follow-up to ensure safety and efficacy.
7-keto-dehydroepiandrosterone functions primarily as a thermogenic inducer. Its molecular mechanism involves the induction of three key thermogenic enzymes in the liver: mitochondrial glycerol-3-phosphate dehydrogenase, malic enzyme, and catalase. By increasing the activity of these enzymes, 7-keto enhances the thermogenic process, leading to an increase in the basal metabolic rate (BMR) and the utilization of stored fat for energy. Unlike DHEA, it does not bind significantly to the estrogen receptor or the androgen receptor in a way that promotes secondary sexual characteristics, although it is classified as an Androgen Receptor Agonist [MoA] for its specific metabolic signaling pathways.
The pharmacodynamic effect of 7-keto-dehydroepiandrosterone is dose-dependent. A single 100 mg dose can significantly increase the expression of thermogenic enzymes within hours. The duration of the metabolic boost typically lasts for 8 to 12 hours. Tolerance to the thermogenic effects has not been widely reported in short-term studies (up to 8 weeks), but long-term pharmacodynamic data is limited.
| Parameter | Value |
|---|---|
| Bioavailability | Approximately 50-70% (Oral) |
| Protein Binding | 80-90% (Primarily Albumin) |
| Half-life | 2.2 to 5.0 hours |
| Tmax | 2.0 to 3.0 hours |
| Metabolism | Hepatic (Sulfation) |
| Excretion | Renal (90%), Fecal (<5%) |
7-keto-dehydroepiandrosterone is classified within the Androgen [EPC] and Gonadotropin [EPC] classes. While it shares structural similarities with other androgens like testosterone or DHEA, its lack of sex-hormone conversion makes it unique. It is often grouped with other metabolic enhancers and thermogenic agents in clinical literature.
Medications containing this ingredient
Common questions about 7-keto-dehydroepiandrosterone
7-keto-dehydroepiandrosterone is primarily used as a metabolic support agent to assist with weight management and fat loss. It works by increasing the activity of thermogenic enzymes in the liver, which raises the basal metabolic rate and helps the body burn more calories. Beyond weight loss, it is sometimes used to support cognitive function and memory, as well as to boost the immune system in older adults. Some healthcare providers may also suggest it for its potential to improve insulin sensitivity and support healthy blood sugar levels. However, it is important to note that it should be used as part of a comprehensive plan that includes diet and exercise. Always consult your doctor before starting 7-keto to ensure it is appropriate for your specific health needs.
The most frequently reported side effects of 7-keto-dehydroepiandrosterone include nausea, dizziness, and insomnia. Because the supplement increases metabolism and heat production, some users may also experience increased sweating or a feeling of being overly warm. Mild headaches and irritability are also common, particularly during the first few days of treatment as the body adjusts. While 7-keto does not convert to sex hormones, some individuals still report minor skin changes such as oiliness or acne. Most of these side effects are dose-dependent and often resolve if the dosage is reduced. If you experience persistent or bothersome side effects, you should discuss them with your healthcare provider. Seeking medical advice is essential if you notice any changes in your heart rate or blood pressure.
It is generally advised to avoid or significantly limit alcohol consumption while taking 7-keto-dehydroepiandrosterone. Alcohol can worsen common side effects like dizziness, nausea, and headaches, making the supplement harder to tolerate. Additionally, alcohol is a metabolic depressant and can counteract the thermogenic benefits that 7-keto is intended to provide. Both alcohol and 7-keto are processed by the liver, so combining them may increase the metabolic load on this organ. For those using 7-keto for weight management, alcohol adds empty calories that can hinder progress toward health goals. If you do choose to drink, it is important to do so in moderation and monitor how your body responds. Always inform your doctor about your alcohol intake when discussing your supplement regimen.
7-keto-dehydroepiandrosterone is not considered safe for use during pregnancy and is generally contraindicated. There is a lack of rigorous clinical data regarding its effects on a developing fetus, and the potential for disrupting maternal or fetal hormonal balance is a significant concern. Because it is a metabolite of a steroid hormone, it could theoretically interfere with the complex endocrine changes necessary for a healthy pregnancy. Most medical guidelines recommend stopping all non-essential supplements, including 7-keto, once pregnancy is confirmed or if you are planning to become pregnant. Using this supplement while pregnant could pose unknown risks to the baby's development. If you have been taking 7-keto and discover you are pregnant, contact your obstetrician immediately for guidance. Your doctor can help you manage your metabolic health through safer, proven methods during this time.
The time it takes for 7-keto-dehydroepiandrosterone to produce noticeable results can vary depending on the individual's metabolism and the specific goal of treatment. For its thermogenic and metabolic effects, some physiological changes, such as a slight increase in body temperature or energy, may be felt within a few days of starting the supplement. However, for significant weight loss or changes in body composition, it typically takes 4 to 8 weeks of consistent use in conjunction with diet and exercise to see measurable results. Cognitive benefits, such as improved memory or focus, may also take several weeks of daily dosing to become apparent. It is important to maintain a consistent schedule and not expect immediate overnight changes. Your healthcare provider can help you set realistic expectations and monitor your progress over time. If you do not see any benefits after two months, your doctor may re-evaluate the dosage or the necessity of the supplement.
Yes, you can generally stop taking 7-keto-dehydroepiandrosterone suddenly without experiencing severe withdrawal symptoms, as it does not typically cause physical dependence. Unlike some prescription hormones or steroids, 7-keto does not significantly suppress the body's natural hormone production, so a tapering period is usually not required. However, some individuals may notice a temporary decrease in their energy levels or a slight slowing of their metabolic rate once they stop taking it. This is simply the body returning to its baseline state without the metabolic boost provided by the supplement. If you have been taking high doses for an extended period, it is always a good idea to discuss your plan to stop with your healthcare provider. They can help you monitor for any rebound effects or changes in your metabolic health. Stopping the supplement should be done in the context of your overall health and wellness goals.
If you miss a dose of 7-keto-dehydroepiandrosterone, you should take it as soon as you remember. However, if it is already close to the time for your next scheduled dose, it is better to skip the missed dose and simply continue with your regular routine. You should never take two doses at the same time to 'make up' for the one you missed, as this can increase the risk of side effects like heart palpitations, anxiety, or insomnia. Maintaining a consistent level of the supplement in your system is important for its metabolic effects, but safety should always come first. To help you remember your doses, you might consider using a pill organizer or setting a daily alarm on your phone. If you find that you are frequently missing doses, talk to your doctor about whether a different dosing schedule might work better for you. Consistent use is key to achieving the desired clinical outcomes.
7-keto-dehydroepiandrosterone is specifically used to prevent weight gain and promote weight loss, so it is very unlikely to cause weight gain when used correctly. Its primary function is to increase the basal metabolic rate, which helps the body burn more calories even at rest. However, if a person experiences an increase in appetite as a side effect and consumes more calories than they burn, weight gain could theoretically occur. Some users might also experience slight water retention or bloating when first starting the supplement, which can appear as a small increase on the scale, but this is not an increase in body fat. It is crucial to remember that 7-keto is not a 'magic pill' and must be combined with a healthy diet and regular physical activity to be effective. If you notice unexpected weight gain while taking this supplement, you should consult your doctor to rule out other underlying medical conditions. They can help you analyze your diet and lifestyle to ensure the supplement is working as intended.
7-keto-dehydroepiandrosterone can interact with several types of medications, so it should only be taken with other drugs under the supervision of a healthcare provider. It is particularly important to be cautious if you are taking thyroid medications, as 7-keto can increase T3 levels and potentially lead to hyperthyroidism. It may also interact with diabetes medications by lowering blood sugar further, increasing the risk of hypoglycemia. Those on blood thinners or blood pressure medications should also be monitored closely, as 7-keto can influence clotting and cardiovascular markers. Even common over-the-counter stimulants or caffeine can interact with 7-keto to cause excessive jitteriness or heart palpitations. Always provide your doctor with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are currently taking. This allows them to screen for potential interactions and adjust your treatment plan for maximum safety. Never start a new medication while on 7-keto without checking with a medical professional first.
7-keto-dehydroepiandrosterone is widely available as a generic dietary supplement and is sold by many different nutritional brand manufacturers. Because it is not a patented prescription drug, there is no single 'brand name' version that holds exclusive rights to the compound. You can find it under the name '7-Keto,' '7-oxo-DHEA,' or '7-keto-dehydroepiandrosterone' at most health food stores, pharmacies, and online retailers. When choosing a generic version, it is important to look for products that have been third-party tested for purity and potency by organizations like the USP or NSF. This ensures that the product actually contains the amount of 7-keto listed on the label and is free from contaminants. While generic versions are generally more affordable, the quality can vary between manufacturers. Your healthcare provider may recommend a specific brand that they trust for its manufacturing standards. Always ensure the product is well-sealed and within its expiration date before use.